{"entity": "publication", "iuid": "8b7c4d6802d344fb9c124aae688ece80", "timestamp": "2026-03-12T19:17:36.706Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8b7c4d6802d344fb9c124aae688ece80.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8b7c4d6802d344fb9c124aae688ece80"}}, "title": "Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.", "authors": [{"family": "Llona-Minguez", "given": "Sabin", "initials": "S"}, {"family": "H\u00e4ggblad", "given": "Maria", "initials": "M"}, {"family": "Martens", "given": "Ulf", "initials": "U"}, {"family": "Johansson", "given": "Lars", "initials": "L"}, {"family": "Sigmundsson", "given": "Kristmundur", "initials": "K"}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T"}, {"family": "Loseva", "given": "Olga", "initials": "O"}, {"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Lundgren", "given": "Bo", "initials": "B"}, {"family": "Jensen", "given": "Annika Jenmalm", "initials": "AJ"}, {"family": "Scobie", "given": "Martin", "initials": "M"}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3d7256c271ea4adea404d4ff355f804e.json"}}], "type": "journal article", "published": "2017-08-01", "journal": {"volume": "27", "issn": "1464-3405", "issue": "15", "pages": "3219-3225", "title": "Bioorg. Med. Chem. Lett.", "issn-l": "0960-894X"}, "abstract": "Two screening campaigns using commercial (Chembridge DiverSET) and proprietary (Chemical Biology Consortium Sweden, CBCS) compound libraries, revealed a number of pyridone- and pyrimidinone-derived systems as inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). In this letter, we present their preliminary structure-activity-relationships (SAR) and ligand efficiency scores (LE and LLE).", "doi": "10.1016/j.bmcl.2017.06.039", "pmid": "28655422", "labels": {"Chemical Biology Consortium Sweden": "Collaborative", "Drug Discovery and Development": "Service"}, "xrefs": [{"db": "pii", "key": "S0960-894X(17)30641-8"}], "notes": "Biochemical and Cellular Screening", "created": "2017-10-31T13:29:22.883Z", "modified": "2025-10-17T13:05:08.796Z"}