{"entity": "publication", "iuid": "83806efbc25545839421c1bd304539b4", "timestamp": "2026-07-05T14:33:54.472Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/83806efbc25545839421c1bd304539b4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/83806efbc25545839421c1bd304539b4"}}, "title": "MHC I of the Great Reed Warbler Promotes a Flat Peptide Binding Mode.", "authors": [{"family": "Venskutonyt\u0117", "given": "Raminta", "initials": "R"}, {"family": "Kjellstr\u00f6m", "given": "Sven", "initials": "S"}, {"family": "O'Connor", "given": "Emily Amelia", "initials": "EA"}, {"family": "Westerdahl", "given": "Helena", "initials": "H"}, {"family": "Lindkvist-Petersson", "given": "Karin", "initials": "K", "orcid": "0000-0002-5209-3160", "researcher": {"href": "https://publications.scilifelab.se/researcher/efe1ac8c58f640ba98b97c6a5e52b9d5.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Immunology", "issn": "1365-2567", "volume": "176", "issue": "4", "pages": "508-519", "issn-l": "0019-2805"}, "abstract": "The major histocompatibility complex (MHC) plays a key role in pathogen recognition as part of the adaptive immune system. MHC I gene copy numbers in birds of the order Passeriformes (songbirds) are substantially larger compared to other birds. MHC I diversity and antigen presentation have been carefully characterised in chicken Gallus gallus of the order Galliformes; chickens express few MHC I genes and often present antigens that bulge out of the peptide binding cleft. This observation raises the question of whether MHC I presents antigens in a similar way in species with many MHC genes? Here, we present the X-ray structure of MHC I from the great reed warbler Acrocephalus arundinaceus (Acar3) a long-distance migratory songbird. Structural analysis shows that MHC I binds the antigen in a flat conformation due to a sequentially well-conserved restriction point, acting like a pair of tweezers, within the peptide binding grove, created by Arg97 and Arg155. This more stringent antigen presentation by Acar MHC I molecules may partly explain the high MHC gene copy numbers seen in the great reed warbler.", "doi": "10.1111/imm.70015", "pmid": "40643222", "labels": {"Clinical Proteomics Lund": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12583234"}, {"db": "PDB", "key": "9QG8"}, {"db": "Dryad", "key": "cvdncjtg1"}], "notes": [], "created": "2026-07-01T10:50:43.948Z", "modified": "2026-07-01T10:50:44.013Z"}