{"entity": "publication", "iuid": "7a88ee7a5e464f3eb6f00e07ace967f5", "timestamp": "2026-08-10T23:45:40.688Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7a88ee7a5e464f3eb6f00e07ace967f5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7a88ee7a5e464f3eb6f00e07ace967f5"}}, "title": "Identification of 33 candidate oncogenes by screening for base-specific mutations.", "authors": [{"family": "Tuupanen", "given": "S", "initials": "S"}, {"family": "H\u00e4nninen", "given": "U A", "initials": "UA"}, {"family": "Kondelin", "given": "J", "initials": "J"}, {"family": "von Nandelstadh", "given": "P", "initials": "P"}, {"family": "Cajuso", "given": "T", "initials": "T"}, {"family": "Gylfe", "given": "A E", "initials": "AE"}, {"family": "Katainen", "given": "R", "initials": "R"}, {"family": "Tanskanen", "given": "T", "initials": "T"}, {"family": "Ristolainen", "given": "H", "initials": "H"}, {"family": "B\u00f6hm", "given": "J", "initials": "J"}, {"family": "Mecklin", "given": "J-P", "initials": "JP"}, {"family": "J\u00e4rvinen", "given": "H", "initials": "H"}, {"family": "Renkonen-Sinisalo", "given": "L", "initials": "L"}, {"family": "Andersen", "given": "C L", "initials": "CL"}, {"family": "Taipale", "given": "M", "initials": "M"}, {"family": "Taipale", "given": "J", "initials": "J"}, {"family": "Vahteristo", "given": "P", "initials": "P"}, {"family": "Lehti", "given": "K", "initials": "K"}, {"family": "Pitk\u00e4nen", "given": "E", "initials": "E"}, {"family": "Aaltonen", "given": "L A", "initials": "LA"}], "type": "journal article", "published": "2014-10-14", "journal": {"volume": "111", "issn": "1532-1827", "issue": "8", "pages": "1657-1662", "title": "Br. J. Cancer", "issn-l": "0007-0920"}, "abstract": "Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations.\n\nWe utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs) and searched for base-specific somatic mutation hotspots.\n\nWe identified novel mutation hotspots in 33 genes. Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL. A database search found examples of the hotspot mutations in multiple cancer types.\n\nThis work reveals a variety of new recurrent candidate oncogene mutations to be further scrutinised as potential therapeutic targets.", "doi": "10.1038/bjc.2014.429", "pmid": "25117815", "labels": {"Karolinska High Throughput Center (KHTC)": null}, "xrefs": [{"db": "pii", "key": "bjc2014429"}, {"db": "pmc", "key": "PMC4200084"}], "notes": [], "created": "2017-05-04T14:57:07.198Z", "modified": "2017-05-30T11:44:25.587Z"}