{"entity": "publication", "iuid": "795978f5e49e4146bc9e7b6c2a0f4e67", "timestamp": "2026-07-22T23:25:05.330Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/795978f5e49e4146bc9e7b6c2a0f4e67.json"}, "display": {"href": "https://publications.scilifelab.se/publication/795978f5e49e4146bc9e7b6c2a0f4e67"}}, "title": "Epigenetic changes as prognostic predictors in endometrial carcinomas.", "authors": [{"family": "Farkas", "given": "Sanja A", "initials": "SA"}, {"family": "Sorbe", "given": "Bengt G", "initials": "BG"}, {"family": "Nilsson", "given": "Torbj\u00f6rn K", "initials": "TK"}], "type": "journal article", "published": "2017-01-02", "journal": {"volume": "12", "issn": "1559-2308", "issue": "1", "pages": "19-26", "title": "Epigenetics", "issn-l": "1559-2294"}, "abstract": "Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.", "doi": "10.1080/15592294.2016.1252891", "pmid": "27874289", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC5270631"}], "notes": [], "created": "2017-05-03T13:01:43.385Z", "modified": "2020-01-21T13:56:03.152Z"}