{"entity": "publication", "iuid": "73591eb545e74c9498be82b00256074b", "timestamp": "2026-08-12T05:25:38.770Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/73591eb545e74c9498be82b00256074b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/73591eb545e74c9498be82b00256074b"}}, "title": "Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death.", "authors": [{"family": "Grufman", "given": "Helena", "initials": "H"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Gon\u00e7alves", "given": "Isabel", "initials": "I"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}], "type": "clinical trial", "published": "2019-10-00", "journal": {"title": "Cytokine", "issn": "1096-0023", "issn-l": "1043-4666", "volume": "122", "issue": null, "pages": "154208"}, "abstract": "IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group.\n\nWe included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year. We measured plasma levels of IL-27, high sensitivity troponin T (hsTNT), C-reactive protein (hsCRP) and cystatin C at baseline and in the 6-week samples. The median follow-up period of the cohort was 2.2 years.\n\nThe incidence of the combined end-point of AMI and cardiovascular death was higher in patients with plasma IL-27 within the top two tertiles both at baseline and after 6 weeks. After correction for cardiovascular risk factors, medication, hsTNT, hsCRP, and eGFR, patients with baseline IL-27 levels within the highest tertile had a significantly elevated risk for the combined end-point compared with the lowest tertile (hazard ratio 2.70, 95% CI 1.06-6.90, p = .038). Additionally, higher baseline IL-27 levels were associated with deleterious left ventricular remodeling and deterioration of systolic and diastolic function during the first year of follow-up.\n\nElevated IL-27 at the time of an ACS is independently related to impaired cardiac function and worse long-term prognosis. Our data warrants further mechanistic studies to elucidate the involvement of IL-27 in cardiac repair and remodeling after ACS.", "doi": "10.1016/j.cyto.2017.11.002", "pmid": "29428559", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "S1043-4666(17)30344-7"}], "notes": [], "created": "2020-01-23T16:03:59.926Z", "modified": "2023-04-14T13:55:55.654Z"}