{"entity": "publication", "iuid": "6ffde39b841646ddabda81c99083c219", "timestamp": "2026-08-09T05:06:26.770Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6ffde39b841646ddabda81c99083c219.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6ffde39b841646ddabda81c99083c219"}}, "title": "Estrogen Receptor \u03b1 Promotes Breast Cancer by Reprogramming Choline Metabolism.", "authors": [{"family": "Jia", "given": "Min", "initials": "M"}, {"family": "Andreassen", "given": "Trygve", "initials": "T"}, {"family": "Jensen", "given": "Lasse", "initials": "L"}, {"family": "Bathen", "given": "Tone Frost", "initials": "TF"}, {"family": "Sinha", "given": "Indranil", "initials": "I"}, {"family": "Gao", "given": "Hui", "initials": "H"}, {"family": "Zhao", "given": "Chunyan", "initials": "C"}, {"family": "Haldosen", "given": "Lars-Arne", "initials": "LA"}, {"family": "Cao", "given": "Yihai", "initials": "Y"}, {"family": "Girnita", "given": "Leonard", "initials": "L"}, {"family": "Moestue", "given": "Siver Andreas", "initials": "SA"}, {"family": "Dahlman-Wright", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2016-10-01", "journal": {"volume": "76", "issn": "1538-7445", "issue": "19", "pages": "5634-5646", "title": "Cancer Res.", "issn-l": "0008-5472"}, "abstract": "Estrogen receptor \u03b1 (ER\u03b1) is a key regulator of breast growth and breast cancer development. Here, we report how ER\u03b1 impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ER\u03b1 with estrogen-induced transcript and metabolic profiling, to demonstrate that ER\u03b1 reprograms metabolism upon estrogen stimulation, including changes in aerobic glycolysis, nucleotide and amino acid synthesis, and choline (Cho) metabolism. Cho phosphotransferase CHPT1, identified as a direct ER\u03b1-regulated gene, was required for estrogen-induced effects on Cho metabolism, including increased phosphatidylcholine synthesis. CHPT1 silencing inhibited anchorage-independent growth and cell proliferation, also suppressing early-stage metastasis of tamoxifen-resistant breast cancer cells in a zebrafish xenograft model. Our results showed that ER\u03b1 promotes metabolic alterations in breast cancer cells mediated by its target CHPT1, which this study implicates as a candidate therapeutic target. Cancer Res; 76(19); 5634-46. \u00a92016 AACR.", "doi": "10.1158/0008-5472.CAN-15-2910", "pmid": "27457520", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "0008-5472.CAN-15-2910"}], "notes": [], "created": "2017-05-03T12:59:41.181Z", "modified": "2025-10-17T13:03:19.343Z"}