{"entity": "publication", "iuid": "6aea5c20a9e349c5b122a112cf62160d", "timestamp": "2026-07-15T23:31:57.956Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d"}}, "title": "Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy.", "authors": [{"family": "Lemma", "given": "Mahlet", "initials": "M"}, {"family": "Petkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-8052-9646", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6.json"}}, {"family": "Bekele", "given": "Yonas", "initials": "Y"}, {"family": "Petros", "given": "Beyene", "initials": "B"}, {"family": "Howe", "given": "Rawleigh", "initials": "R"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Proteomes", "issn": "2227-7382", "volume": "8", "issue": "3", "pages": "24", "issn-l": "2227-7382"}, "abstract": "Treatment of HIV-1-infected patients results in improved clinical and immunological conditions, but severe non-AIDS-related conditions still persist. Novel proteomic platforms have identified inflammatory proteins where abundance is dysregulated in adult treated patients, whereas limited data are available in treated HIV-1 infection of children. Using a proteomic plasma profiling approach comprising 92 inflammation-related molecules, we analyzed specimens from 43 vertically HIV-1-infected children receiving antiretroviral treatment (ART) and matched controls in Ethiopia. The infected children were analyzed as a group and separately, according to age of treatment initiation. Proteins displaying a significantly different abundance between groups were hierarchically clustered and presented in heat maps. Random forest analysis was performed to pin-point proteins discriminating between groups; five proteins (STAMBP, CD5, TFG-\u03b1, TRANCE, AXIN1) were the strongest prediction factors for treated HIV-1 infection. TRANCE was previously linked to reduced bone mass levels in HIV-1-infected children. CCL4 chemokine, ligand to HIV-1 co-receptor CCR5, was the most critical protein for successful classification between children who initiated ART at different time points. Our data provide evidence that a dysregulated expression of proteins linked to immunological abnormalities and bone metabolism can be found in HIV-1-infected children with prolonged exposure to ART.", "doi": "10.3390/proteomes8030024", "pmid": "32906648", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "proteomes8030024"}, {"db": "pmc", "key": "PMC7563605"}], "notes": [], "created": "2020-12-10T16:30:02.494Z", "modified": "2021-11-10T12:47:23.760Z"}