{"entity": "publication", "iuid": "63cca50513ae41c2a6fa9fa0b38463f0", "timestamp": "2026-09-12T20:49:14.450Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/63cca50513ae41c2a6fa9fa0b38463f0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/63cca50513ae41c2a6fa9fa0b38463f0"}}, "title": "A variant near the interleukin-6 gene is associated with fat mass in Caucasian men.", "authors": [{"family": "Andersson", "given": "N", "initials": "N"}, {"family": "Strandberg", "given": "L", "initials": "L"}, {"family": "Nilsson", "given": "S", "initials": "S"}, {"family": "Adamovic", "given": "S", "initials": "S"}, {"family": "Karlsson", "given": "M K", "initials": "MK"}, {"family": "Ljunggren", "given": "O", "initials": "O"}, {"family": "Mellstr\u00f6m", "given": "D", "initials": "D"}, {"family": "Lane", "given": "N E", "initials": "NE"}, {"family": "Zmuda", "given": "J M", "initials": "JM"}, {"family": "Nielsen", "given": "C", "initials": "C"}, {"family": "Orwoll", "given": "E", "initials": "E"}, {"family": "Lorentzon", "given": "M", "initials": "M"}, {"family": "Ohlsson", "given": "C", "initials": "C"}, {"family": "Jansson", "given": "J-O", "initials": "JO"}, {"family": "Osteoporotic Fractures in Men MrOS Research Group", "given": null, "initials": null}], "type": "journal article", "published": "2010-06-00", "journal": {"volume": "34", "issn": "1476-5497", "issue": "6", "pages": "1011-1019", "title": "Int J Obes (Lond)", "issn-l": "0307-0565"}, "abstract": "Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity.\n\nTo systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these genes can be associated with obesity.\n\nThe Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-year-old men (n=1049), from the Gothenburg area (Sweden). Major findings were confirmed in two additional cohorts consisting of elderly men from the Osteoporotic Fractures in Men (MrOS) Sweden (n=2851) and MrOS US (n=5611) multicenter population-based studies.\n\nThe genotype distributions and their association with fat mass in different compartments, measured with dual-energy X-ray absorptiometry.\n\nOut of 18 evaluated tag SNPs near the IL6 and IL6R genes, a recently identified SNP rs10242595 G/A (minor allele frequency=29%) 3' of the IL6 gene was negatively associated with the primary outcome total body fat mass (effect size -0.11 standard deviation (s.d.) units per A allele, P=0.02). This negative association with fat mass was also confirmed in the combined MrOS Sweden and MrOS US cohorts (effect size -0.05 s.d. units per A allele, P=0.002). When all three cohorts were combined (n=8927, Caucasian subjects), rs10242595(*)A showed a negative association with total body fat mass (effect size -0.05 s.d. units per A allele, P<0.0002). Furthermore, the rs10242595(*)A was associated with low body mass index (effect size -0.03, P<0.001) and smaller regional fat masses. None of the other SNPs investigated in the GOOD study were reproducibly associated with body fat.\n\nThe IL6 gene polymorphism rs10242595(*)A is associated with decreased fat mass in three combined cohorts of 8927 Caucasian men.", "doi": "10.1038/ijo.2010.27", "pmid": "20157327", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "pii", "key": "ijo201027"}, {"db": "pmc", "key": "PMC2885503"}, {"db": "mid", "key": "NIHMS169541"}], "notes": [], "created": "2017-05-04T15:00:32.234Z", "modified": "2020-01-21T13:56:02.715Z"}