{"entity": "publication", "iuid": "5839d9961fab4e44ae48e05827755293", "timestamp": "2026-07-19T09:33:26.161Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5839d9961fab4e44ae48e05827755293.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5839d9961fab4e44ae48e05827755293"}}, "title": "Evaluating neoantigen-vaccine responses through mechanistic and model-based frameworks.", "authors": [{"family": "Ibrahim", "given": "Eman I K", "initials": "EIK"}, {"family": "Laur\u00e9n", "given": "Ida", "initials": "I"}, {"family": "Veerman", "given": "Rosanne E", "initials": "RE"}, {"family": "J\u00f6nsson", "given": "Siv", "initials": "S"}, {"family": "Ytterberg", "given": "A Jimmy", "initials": "AJ"}, {"family": "Lindqvist", "given": "Annika", "initials": "A"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Friberg", "given": "Lena E", "initials": "LE"}], "type": "journal article", "published": "2026-06-24", "journal": {"title": "NPJ Precis Oncol", "issn": "2397-768X", "volume": "10", "issue": "1", "issn-l": null}, "abstract": "Therapeutic cancer vaccines activate tumor-specific T-cells to reduce tumor burden, yet face challenges when integrating and translating multi-level complex preclinical data into actionable insights. We present a model-based framework to integrate diverse preclinical data, comparing synthetic long peptide vaccines with or without adjuvant stimuli to a vaccine-drug conjugate approach by Adaptable Drug Affinity Conjugate technology. This technology provides modular and rapid conjugate formation via high-affinity binding between a peptide-tagged vaccine antigen and a CD40-targeting antibody, acting as an adjuvant and delivery vehicle. Our developed semi-mechanistic modelling framework successfully linked dosing to tumor dynamics, incorporating four sub-models: pharmacokinetic, peptide uptake by antigen-presenting cells, T-cell response, and tumor growth in TC-1 and MC38 tumors. Model-based simulations highlighted the importance of affinity conjugation on pharmacokinetics and efficacy. Effector T-cells mediated tumor shrinkage. Antibody dose-dependent effects were identified and quantified in the immune-responsive MC38 model. This framework supports rational vaccine optimization and translational decision-making. The graphical abstract was created in https://BioRender.com .", "doi": "10.1038/s41698-026-01579-8", "pmid": "42342810", "labels": {"Drug Discovery and Development": "Collaborative"}, "xrefs": [{"db": "pii", "key": "10.1038/s41698-026-01579-8"}, {"db": "pmc", "key": "PMC13294367"}], "notes": [], "created": "2026-07-18T07:24:56.593Z", "modified": "2026-07-18T07:24:56.597Z"}