{"entity": "publication", "iuid": "4f762ac2da69462cae587f44662a03f9", "timestamp": "2026-06-15T07:35:08.002Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4f762ac2da69462cae587f44662a03f9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4f762ac2da69462cae587f44662a03f9"}}, "title": "Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort.", "authors": [{"family": "Korduner", "given": "J", "initials": "J", "orcid": "0000-0003-4132-1516", "researcher": {"href": "https://publications.scilifelab.se/researcher/b91b185ec61548c78609197099113ab0.json"}}, {"family": "Nilsson", "given": "P M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications.scilifelab.se/researcher/f23c2a10ac2a4d73a8f62b94855635f1.json"}}, {"family": "Melander", "given": "O", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Gerl", "given": "M J", "initials": "MJ", "orcid": "0000-0002-8074-7221", "researcher": {"href": "https://publications.scilifelab.se/researcher/e126ba158b6b413d8e234f2b7ddc4720.json"}}, {"family": "Engstr\u00f6m", "given": "G", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Bachus", "given": "E", "initials": "E", "orcid": "0000-0001-8665-6892", "researcher": {"href": "https://publications.scilifelab.se/researcher/f394dc718c604ad68db66e68c21d5385.json"}}, {"family": "Magnusson", "given": "M", "initials": "M", "orcid": "0000-0003-1710-5936", "researcher": {"href": "https://publications.scilifelab.se/researcher/6126a96481bb4c398a6e8ab6fa596b28.json"}}, {"family": "Ottosson", "given": "F", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications.scilifelab.se/researcher/14c6874eea0d4fd59677b024c2ca58bf.json"}}], "type": "journal article", "published": "2021-10-06", "journal": {"title": "J Obes", "issn": "2090-0716", "volume": "2021", "pages": "6616983", "issn-l": null}, "abstract": "Associations between different biomarkers (proteomics, lipidomics, and metabolomics) coupled to either MHO or metabolically unhealthy obese (MUO) individuals were analyzed through principal component analysis (PCA). Subjects were identified from a subsample of 416 obese individuals, selected from the Malm\u00f6 Diet and Cancer study-Cardiovascular arm (MDCS-CV, n = 3,443). They were further divided into MHO (n = 143) and MUO (n = 273) defined by a history of hospitalization, or not, at baseline inclusion, and nonobese subjects (NOC, n = 3,027). Two distinctive principle components (PL2, PP5) were discovered with a significant difference and thus further investigated through their main loadings.\n\nMHO individuals had a more metabolically favorable lipid and glucose profile than MUO subjects, that is, lower levels of traditional blood glucose and triglycerides, as well as a trend of lower metabolically unfavorable lipid biomarkers. PL2 (lipidomics, p=0.02) showed stronger associations of triacylglycerides with MUO, whereas phospholipids correlated with MHO. PP5 (proteomics, p=0.01) included interleukin-1 receptor antagonist (IL-1ra) and leptin with positive relations to MUO and galanin that correlated positively to MHO. The group differences in metabolite profiles were to a large extent explained by factors included in the metabolic syndrome.\n\nCompared to MUO individuals, corresponding MHO individuals present with a more favorable lipid metabolic profile, accompanied by a downregulation of potentially harmful proteomic biomarkers. This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.", "doi": "10.1155/2021/6616983", "pmid": "34659828", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8514926"}], "notes": [], "created": "2021-12-10T10:05:18.577Z", "modified": "2022-12-02T08:54:36.561Z"}