{"entity": "publication", "iuid": "45433b3cce4846679af7f62c08acb69b", "timestamp": "2026-04-14T09:41:25.873Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/45433b3cce4846679af7f62c08acb69b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/45433b3cce4846679af7f62c08acb69b"}}, "title": "Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures.", "authors": [{"family": "Sot\u00e1k", "given": "Mat\u00fa\u0161", "initials": "M"}, {"family": "Rajan", "given": "Meenu Rohini", "initials": "MR"}, {"family": "Clark", "given": "Madison", "initials": "M"}, {"family": "Harms", "given": "Matthew", "initials": "M"}, {"family": "Rani", "given": "Alankrita", "initials": "A"}, {"family": "Kraft", "given": "Jamie D", "initials": "JD"}, {"family": "Tandio", "given": "David", "initials": "D"}, {"family": "Shen", "given": "Tong", "initials": "T"}, {"family": "Borkowski", "given": "Kamil", "initials": "K"}, {"family": "Fiehn", "given": "Oliver", "initials": "O"}, {"family": "Newman", "given": "John W", "initials": "JW"}, {"family": "Quiding-J\u00e4rbrink", "given": "Marianne", "initials": "M"}, {"family": "Bi\u00f6rserud", "given": "Christina", "initials": "C"}, {"family": "Apelgren", "given": "Peter", "initials": "P"}, {"family": "Staalesen", "given": "Trude", "initials": "T"}, {"family": "Hagberg", "given": "Carolina E", "initials": "CE"}, {"family": "Boucher", "given": "Jeremie", "initials": "J"}, {"family": "Wallenius", "given": "Ville", "initials": "V"}, {"family": "Lange", "given": "Stephan", "initials": "S"}, {"family": "B\u00f6rgeson", "given": "Emma", "initials": "E"}], "type": "journal article", "published": "2022-07-15", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "25", "issue": "7", "pages": "104602", "issn-l": "2589-0042"}, "abstract": "Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A4, a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammation and subsequently protects against obesity-induced systemic disease in mice. Here, we demonstrate that lipoxins reduce inflammation in 3D-cultured human adipocytes and adipose tissue explants from obese patients. Approximately 50% of patients responded particularly well to lipoxins by reducing inflammatory cytokines and promoting an anti-inflammatory M2 macrophage phenotype. Responding patients were characterized by elevated systemic levels of C-reactive protein, which causes inflammation in cultured human adipocytes. Responders appeared more prone to producing anti-inflammatory oxylipins and displayed elevated prostaglandin D2 levels, which has been interlinked with transcription of lipoxin-generating enzymes. Using explant cultures, this study provides the first proof-of-concept evidence supporting the therapeutic potential of lipoxins in reducing human adipose tissue inflammation. Our data further indicate that lipoxin treatment may require a tailored personalized-medicine approach.", "doi": "10.1016/j.isci.2022.104602", "pmid": "35789845", "labels": {"NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9249816"}, {"db": "pii", "key": "S2589-0042(22)00874-4"}], "notes": [], "created": "2022-11-29T09:47:56.917Z", "modified": "2022-11-29T09:47:56.920Z"}