{"entity": "publication", "iuid": "44d5cdcaf7f74b68991bab0d20c5fac3", "timestamp": "2026-07-15T23:34:19.935Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/44d5cdcaf7f74b68991bab0d20c5fac3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/44d5cdcaf7f74b68991bab0d20c5fac3"}}, "title": "Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata.", "authors": [{"family": "Atilaw", "given": "Yoseph", "initials": "Y"}, {"family": "Duffy", "given": "Sandra", "initials": "S"}, {"family": "Heydenreich", "given": "Matthias", "initials": "M"}, {"family": "Muiva-Mutisya", "given": "Lois", "initials": "L"}, {"family": "Avery", "given": "Vicky M", "initials": "VM"}, {"family": "Erd\u00e9lyi", "given": "M\u00e1t\u00e9", "initials": "M"}, {"family": "Yenesew", "given": "Abiy", "initials": "A"}], "type": "journal article", "published": "2017-02-20", "journal": {"volume": "22", "issn": "1420-3049", "issue": "2", "pages": "318", "title": "Molecules", "issn-l": "1420-3049"}, "abstract": "In our search for new antiplasmodial agents, the CH\u2082Cl\u2082/CH\u2083OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.", "doi": "10.3390/molecules22020318", "pmid": "28230755", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pii", "key": "molecules22020318"}, {"db": "pmc", "key": "PMC6155904"}], "notes": [], "created": "2017-11-03T16:52:26.802Z", "modified": "2025-10-17T13:04:00.010Z"}