{"entity": "publication", "iuid": "431bba8f47de417d9d05371783803c07", "timestamp": "2026-07-15T22:34:33.387Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/431bba8f47de417d9d05371783803c07.json"}, "display": {"href": "https://publications.scilifelab.se/publication/431bba8f47de417d9d05371783803c07"}}, "title": "Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.", "authors": [{"family": "Jokinen", "given": "Jussi", "initials": "J"}, {"family": "Bostr\u00f6m", "given": "Adrian E", "initials": "AE"}, {"family": "Dadfar", "given": "Ali", "initials": "A"}, {"family": "Ciuculete", "given": "Diana M", "initials": "DM"}, {"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "\u00c5sberg", "given": "Marie", "initials": "M"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2018-01-00", "journal": {"volume": "27", "issn": "2352-3964", "issue": null, "pages": "123-133", "title": "EBioMedicine", "issn-l": "2352-3964"}, "abstract": "The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was measured in whole blood using the Illumina Infinium Methylation EPIC BeadChip. Subjects were stratified into high-risk and low-risk groups based on the severity of the suicidal behavior. We included CpG sites located within 2000 basepairs away from transcriptional start site of the following HPA-axis coupled genes: corticotropin releasing hormone (CRH), corticotropin releasing hormone binding protein (CRHBP), corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), FK506-binding protein 51 (FKBP5) and the glucocorticoid receptor (NR3C1). The methylation state of two corticotropin releasing hormone (CRH)-associated CpG sites were significantly hypomethylated in the high-risk group of suicide attempters (n=31) (cg19035496 and cg23409074) (p<0.001). Adolescent cohort 1 and 2 consisted of 129 and 93 subjects, respectively, and were stratified by the in silico generated DAWBA measurements of a general psychiatric risk score into high-risk group (>~50% risk) or controls. In adolescent cohort 2, cg19035496 was hypermethylated in subjects with a high general psychiatric risk score. Our results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents.", "doi": "10.1016/j.ebiom.2017.12.018", "pmid": "29277323", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "S2352-3964(17)30499-1"}, {"db": "pmc", "key": "PMC5828554"}], "notes": [], "created": "2018-01-02T15:37:52.855Z", "modified": "2020-01-21T13:56:10.927Z"}