{"entity": "publication", "iuid": "3f3eeca95ed34ac385bdad9bbf4f1a2f", "timestamp": "2026-10-08T10:54:15.035Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3f3eeca95ed34ac385bdad9bbf4f1a2f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3f3eeca95ed34ac385bdad9bbf4f1a2f"}}, "title": "Predicting immune responsiveness in ER-positive breast cancer for personalized therapy: a population-based study.", "authors": [{"family": "Stenmark Tullberg", "given": "Axel", "initials": "A"}, {"family": "Woxlin", "given": "Sara", "initials": "S"}, {"family": "Sj\u00f6lin", "given": "Filippa", "initials": "F"}, {"family": "Ittner", "given": "Ella", "initials": "E"}, {"family": "Kov\u00e0cs", "given": "Anik\u00f2", "initials": "A"}, {"family": "Helou", "given": "Khalil", "initials": "K"}, {"family": "Holmberg", "given": "Erik", "initials": "E"}, {"family": "Karlsson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2025-07-23", "journal": {"title": "NPJ Precis Oncol", "issn": "2397-768X", "volume": "9", "issue": "1", "pages": "250", "issn-l": null}, "abstract": "The immune system's role in estrogen receptor (ER)-positive breast cancer is poorly understood. A population-based cohort of 428 breast cancer patients with clinical and molecular data was analyzed to assess how immune biomarkers can inform treatment decisions. Tumor-intrinsic immune responsiveness and local immune infiltration were quantified, and epithelial cell states were derived using EcoTyper. The interaction between ProliferativeIndex and Immunescore predicted risk of local recurrence in ER-positive tumors (HR 0.56, 95% CI 0.36-0.88, p = 0.012). EcoTyper identified two epithelial cell states, S04 and S05, with distinct immunomodulatory properties. S04 tumors showed higher proliferation, enrichment for M1 macrophages, CD8 effector T-cells, and plasma cells, alongside hypomethylation of immune-related pathways and hypermethylation of the PI3K signaling pathway. In contrast, S05-enriched tumors were associated with fibroblast activation, immune exclusion, and enrichment for glycosylation-related pathways. These findings suggest that epithelial cell states shape immune responsiveness in ER-positive breast cancer and may inform biomarker-driven treatment strategies.", "doi": "10.1038/s41698-025-01035-z", "pmid": "40702082", "labels": {"NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12287262"}, {"db": "pii", "key": "10.1038/s41698-025-01035-z"}], "notes": [], "created": "2025-09-08T07:07:03.551Z", "modified": "2025-09-08T07:07:03.584Z"}