{"entity": "publication", "iuid": "3e9d49562b634d1cad36e79e7c808957", "timestamp": "2026-05-10T14:41:53.599Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e9d49562b634d1cad36e79e7c808957.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e9d49562b634d1cad36e79e7c808957"}}, "title": "Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.", "authors": [{"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Voight", "given": "Benjamin F", "initials": "BF"}, {"family": "Teslovich", "given": "Tanya M", "initials": "TM"}, {"family": "Ferreira", "given": "Teresa", "initials": "T"}, {"family": "Segr\u00e8", "given": "Ayellet V", "initials": "AV"}, {"family": "Steinthorsdottir", "given": "Valgerdur", "initials": "V"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ"}, {"family": "Khan", "given": "Hassan", "initials": "H"}, {"family": 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"https://publications.scilifelab.se/researcher/f23c2a10ac2a4d73a8f62b94855635f1.json"}}, {"family": "Deloukas", "given": "Panos", "initials": "P"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Groop", "given": "Leif C", "initials": "LC"}, {"family": "Stefansson", "given": "Kari", "initials": "K"}, {"family": "Hu", "given": "Frank", "initials": "F"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "Dupuis", "given": "Jos\u00e9e", "initials": "J"}, {"family": "Meigs", "given": "James B", "initials": "JB"}, {"family": "Altshuler", "given": "David", "initials": "D"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium", "given": null, "initials": null}], "type": "journal article", "published": "2012-09-00", "journal": {"volume": "44", "issn": "1546-1718", "issue": "9", "pages": "981-990", "title": "Nat. Genet.", "issn-l": "1061-4036"}, "abstract": "To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.", "doi": "10.1038/ng.2383", "pmid": "22885922", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "pii", "key": "ng.2383"}, {"db": "pmc", "key": "PMC3442244"}, {"db": "mid", "key": "UKMS49214"}], "notes": [], "created": "2017-05-04T15:01:05.103Z", "modified": "2021-07-07T15:57:26.586Z"}