{"entity": "publication", "iuid": "2eb04d257d6a465eae2a1bd2c14653b5", "timestamp": "2026-07-18T17:59:19.201Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2eb04d257d6a465eae2a1bd2c14653b5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2eb04d257d6a465eae2a1bd2c14653b5"}}, "title": "A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.", "authors": [{"family": "Crona", "given": "Mikael", "initials": "M"}, {"family": "Cod\u00f3", "given": "Paula", "initials": "P"}, {"family": "Jonna", "given": "Venkateswara Rao", "initials": "VR"}, {"family": "Hofer", "given": "Anders", "initials": "A"}, {"family": "Fernandes", "given": "Aristi P", "initials": "AP"}, {"family": "Tholander", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2016-11-00", "journal": {"volume": "10", "issn": "1878-0261", "issue": "9", "pages": "1375-1386", "title": "Mol Oncol", "issn-l": "1574-7891"}, "abstract": "Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for antiproliferative molecules, and the main target of the approved drug hydroxyurea, few new leads targeted to this enzyme have been developed. We have evaluated a recently identified set of RNR inhibitors with respect to inhibition of the human enzyme and cellular toxicity. One compound, NSC73735, is particularly interesting; it is specific for leukemia cells and is the first identified compound that hinders oligomerization of the mammalian large RNR subunit. Similar to hydroxyurea, it caused a disruption of the cell cycle distribution of cultured HL-60 cells. In contrast to hydroxyurea, the disruption was reversible, indicating higher specificity. NSC73735 thus defines a potential lead candidate for RNR-targeted anticancer drugs, as well as a chemical probe with better selectivity for RNR inhibition than hydroxyurea.", "doi": "10.1016/j.molonc.2016.07.008", "pmid": "27511871", "labels": {"Protein Science Facility (PSF)": "Service"}, "xrefs": [{"db": "pii", "key": "S1574-7891(16)30068-0"}], "notes": [], "created": "2017-05-03T13:02:40.112Z", "modified": "2017-09-06T11:42:09.026Z"}