{"entity": "publication", "iuid": "2c0244ff53ae45abbec01053a02856a8", "timestamp": "2026-09-12T20:16:54.997Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2c0244ff53ae45abbec01053a02856a8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2c0244ff53ae45abbec01053a02856a8"}}, "title": "Expression of human leukocyte antigen class I in endocrine and exocrine pancreatic tissue at onset of type 1 diabetes.", "authors": [{"family": "Skog", "given": "Oskar", "initials": "O"}, {"family": "Korsgren", "given": "Stella", "initials": "S"}, {"family": "Wiberg", "given": "Anna", "initials": "A"}, {"family": "Danielsson", "given": "Angelika", "initials": "A"}, {"family": "Edwin", "given": "Bj\u00f8rn", "initials": "B"}, {"family": "Buanes", "given": "Trond", "initials": "T"}, {"family": "Krogvold", "given": "Lars", "initials": "L"}, {"family": "Korsgren", "given": "Olle", "initials": "O"}, {"family": "Dahl-J\u00f8rgensen", "given": "Knut", "initials": "K"}], "type": "journal article", "published": "2015-01-00", "journal": {"volume": "185", "issn": "1525-2191", "issue": "1", "pages": "129-138", "title": "Am. J. Pathol.", "issn-l": "0002-9440"}, "abstract": "The cause of type 1 diabetes remains unknown. To dissect the link between hyperexpression of human leukocyte antigen (HLA) class I on the islet cells, we examined its expression in subjects with recent-onset type 1 diabetes. IHC showed seemingly pronounced hyperexpression in subjects with recent-onset type 1 diabetes, as well as in some nondiabetic subjects. In all subjects, HLA class I expression on exocrine tissue was low. However, no difference in the level of HLA class I expression was found between islet and exocrine tissue using Western blot, flow cytometry, real-time quantitative PCR, or RNA sequencing analyses. Also, the level of HLA class I expression on the messenger level was not increased in islets from subjects with recent-onset type 1 diabetes compared with that in nondiabetic subjects. Consistently, the HLA class I specific enhanceosome (NLRC5) and related transcription factors, as well as interferons, were not enhanced in islets from recent-onset type 1 diabetic subjects. In conclusion, a discrepancy in HLA class I expression in islets assessed by IHC was observed compared with that using quantitative techniques showing similar expression of HLA class I in islets and exocrine tissue in subjects with recent-onset type 1 diabetes, nor could any differences be found between type 1 diabetic and nondiabetic subjects. Results presented provide important clues for a better understanding on how this complex disease develops.", "doi": "10.1016/j.ajpath.2014.09.004", "pmid": "25524212", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (Uppsala Genome Center)": null}, "xrefs": [{"db": "pii", "key": "S0002-9440(14)00548-3"}], "notes": [], "created": "2017-05-02T12:58:12.774Z", "modified": "2020-01-21T13:56:01.273Z"}