{"entity": "publication", "iuid": "10ef11ec442b474e8a990b856f268585", "timestamp": "2026-08-10T22:56:10.982Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/10ef11ec442b474e8a990b856f268585.json"}, "display": {"href": "https://publications.scilifelab.se/publication/10ef11ec442b474e8a990b856f268585"}}, "title": "A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.", "authors": [{"family": "Bandstein", "given": "Marcus", "initials": "M"}, {"family": "Mwinyi", "given": "Jessica", "initials": "J"}, {"family": "Ernst", "given": "Barbara", "initials": "B"}, {"family": "Thurnheer", "given": "Martin", "initials": "M"}, {"family": "Schultes", "given": "Bernd", "initials": "B"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal article", "published": "2016-09-00", "journal": {"volume": "51", "issn": "1502-7708", "issue": "9", "pages": "1050-1055", "title": "Scand. J. Gastroenterol.", "issn-l": "0036-5521"}, "abstract": "Bariatric surgery is the most efficient treatment of severe obesity. We investigated to what extent BMI- or waist-hip ratio (WHR)-related genetic variants are associated with excess BMI loss (EBMIL) two years after Roux-en-Y gastric bypass (RYGB) surgery, and elucidated the affected biological pathways.\n\nTwo-hundred fifty-one obese patients (age: 43\u2009\u00b1\u200910.7, preoperative BMI: 45.1\u2009\u00b1\u20096.1\u2009kg/m(2), 186 women) underwent RYGB surgery and were followed up after two years with regard to BMI. Patients were genotyped for 32 single-nucleotide polymorphisms (SNPs) that were investigated with regard to their impact on response to RYGB and preoperatively measured Three Factor Eating Questionnaire (TFEQ) scores.\n\nHomozygous T carriers of the SNP rs4846567 in proximity to the Lysophospholipase-like 1 (LYPLAL1) gene showed a 7% higher EBMIL compared to wild-type and heterozygous carriers (p\u2009=\u20090.031). TT-allele carriers showed furthermore lower scores for Hunger (74%, p\u2009<\u20090.001), lower Disinhibition (53%, p\u2009<\u20090.001), and higher Cognitive restraint (21%, p\u2009=\u20090.017) than GG/GT carriers in the TFEQ. Patients within the lowest quartile of Hunger scores had a 32% greater EBMIL compared to patients in the highest quartile (p\u2009<\u20090.001).\n\nThe LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following RYGB surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success.", "doi": "10.3109/00365521.2016.1166519", "pmid": "27181159", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC4926774"}], "notes": [], "created": "2017-05-08T07:59:22.437Z", "modified": "2020-01-21T13:56:00.751Z"}