{"entity": "publication", "iuid": "0c9ac48a608b4e7ab71420ff2c2ec482", "timestamp": "2026-10-26T00:00:36.992Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0c9ac48a608b4e7ab71420ff2c2ec482.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0c9ac48a608b4e7ab71420ff2c2ec482"}}, "title": "Risk of venous thromboembolism after SARS-CoV-2 vaccination-Evidence from genome-wide association study and population-based observational study.", "authors": [{"family": "Attelind", "given": "Sofia", "initials": "S", "orcid": "0000-0002-7631-7376", "researcher": {"href": "https://publications.scilifelab.se/researcher/1544b43ea7d14369a4fb6de3174a1d00.json"}}, {"family": "Eriksson", "given": "Niclas", "initials": "N", "orcid": "0000-0002-2152-4343", "researcher": {"href": "https://publications.scilifelab.se/researcher/64611a83caba46d597f45371b77de26b.json"}}, {"family": "Cavalli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1143-1431", "researcher": {"href": "https://publications.scilifelab.se/researcher/e35211c06385459baee12101121d2a15.json"}}, {"family": "Xu", "given": "Yiyi", "initials": "Y", "orcid": "0000-0001-9106-0049", "researcher": {"href": "https://publications.scilifelab.se/researcher/c730eb2085af441fa8b0240bb07eab6e.json"}}, {"family": "Nyberg", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0892-5668", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a30bf7492d546ebab80c2de33747992.json"}}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-2337-3371", "researcher": {"href": "https://publications.scilifelab.se/researcher/e8d78ab8e73541b1831b2955029d3e3f.json"}}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec07b9869a1f4b77b734c5dc567dc630.json"}}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P", "orcid": "0000-0003-3465-3280", "researcher": {"href": "https://publications.scilifelab.se/researcher/968cb3fe072d4ed09739e8be6668d168.json"}}], "type": "journal article", "published": "2026-09-00", "journal": {"title": "Br J Clin Pharmacol", "issn": "1365-2125", "volume": "92", "issue": "9", "pages": "3246-3256", "issn-l": null}, "abstract": "We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS-CoV-2 vaccines.\n\nWe conducted a genome-wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS-CoV-2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish Medical Products Agency. Two hundred one cases (43% women, 91% Swedish) were compared with 4891 Swedish population controls. Analyses were performed on two candidate variants in coagulation factor II (rs1799963) and coagulation factor V (rs6025), on 14 prespecified candidate genes and across the whole genome. To support the findings, we conducted an observational register study of the Swedish general population with/without a diagnosis of thrombophilia and the risks of venous thromboembolism after SARS-CoV-2 vaccination.\n\nIn the GWAS, the main findings were that the candidate variants of coagulation factors II rs1799963 and V rs6025 were significantly associated with venous thromboembolism (odds ratio [OR] 2.4 [95% confidence interval (CI) 1.2-4.8], p = .015 and OR 1.8 [95% CI 1.3-2.6], p = .0022). No genetic marker passed the significance threshold in the candidate gene analysis or the full genome-wide analysis. In the register study, people with a thrombophilia diagnosis had a five-fold elevated risk of venous thromboembolism within 42 days after vaccination, adjusted for potential confounders, OR 5.06 [95% CI 3.98-6.44].\n\nWell-characterized genetic variants in the genes of coagulation factors II and V were associated with thromboembolism after SARS-CoV-2 immunization. Further research is recommended to elucidate their potential role in vaccine-related thromboembolic events.", "doi": "10.1002/bcp.70614", "pmid": "42204965", "labels": {"National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC13519795"}], "notes": [], "created": "2026-10-23T12:25:28.246Z", "modified": "2026-10-23T12:25:28.419Z"}