High-throughput Genome Engineering (HTGE)

Publications

SciLifeLab National facility since 2017.

7 publications

Year 2020

PubMed DOI Crossref

Designing custom CRISPR libraries for hypothesis-driven drug target discovery.

Iyer VS, Jiang L, Shen Y, ..., Schmierer B, Wermeling F

pii: S2001-0370(20)30362-7 pmc: PMC7479249

Computational and Structural Biotechnology Journal 18 (-) 2237-2246 [2020-08-18; online 2020-08-18]

Bioinformatics Compute and Storage [Service] High-throughput Genome Engineering (HTGE) [Collaborative]

PubMed DOI Crossref

A regulatory role for CHD2 in myelopoiesis.

Shahin Varnoosfaderani F, Palau A, Dong W, ..., Svensson JP, Lennartsson A

Epigenetics 15 (6-7) 1-13 [2020-01-10; online 2020-01-10]

Bioinformatics Compute and Storage [Service] High-throughput Genome Engineering (HTGE) [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Year 2019

PubMed DOI Crossref

Reply to "CRISPR screens are feasible in TP53 wild-type cells".

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

pmc: PMC6686827

Mol. Syst. Biol. 15 (8) e9059 [2019-08-00; online 2019-08-30]

High-throughput Genome Engineering (HTGE) [Collaborative]

PubMed DOI Crossref

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation.

Miller DSJ, Schmierer B, Hill CS

pii: jcs.234039 pmc: PMC6679586

J. Cell. Sci. 132 (14) - [2019-07-15; online 2019-07-15]

High-throughput Genome Engineering (HTGE) [Collaborative]

Year 2018

PubMed DOI Crossref

Contribution of allelic imbalance to colorectal cancer.

Palin K, Pitkänen E, Turunen M, ..., Taipale J, Aaltonen LA

pii: 10.1038/s41467-018-06132-1 pmc: PMC6131244 European Nucleotide Archive: PRJEB25645 European Genome-phenome Archive: EGAS00001002966 European Genome-phenome Archive: EGAS00001003010 Zenodo: https://doi.org/10.5281/zenodo.1222172

Nat Commun 9 (1) 3664 [2018-09-10; online 2018-09-10]

Bioinformatics Compute and Storage [Service] High-throughput Genome Engineering (HTGE) [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

Nat Med - (-) - [2018-06-11; online 2018-06-11]

High-throughput Genome Engineering (HTGE) [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]

Year 2017

PubMed DOI Crossref

CRISPR/Cas9 screening using unique molecular identifiers

Schmierer B, Botla SK, Zhang J, ..., Kivioja T, Taipale J

Mol. Syst. Biol. 13 (10) 945 [2017-10-00; online 2017-10-09]

High-throughput Genome Engineering (HTGE) [Technology development]

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