Centre for Cellular Imaging

Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production

Liu Y, Liu Q, Krivoruchko A, Khoomrung S, Nielsen J

Nat Chem Biol - (-) - [2019-12-16; online 2019-12-16]

Endosomal signalling via exosome surface TGFβ-1

Shelke GV, Yin Y, Jang SC, ..., Nilsson JA, Lötvall J

J Extracell Vesicles 8 (1) 1650458 [2019-12-01; online 2019-09-20]

Advanced Light Microscopy (ALM) Centre for Cellular Imaging [Service] Glycoproteomics [Service]

Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

Jang SC, Crescitelli R, Cvjetkovic A, ..., Kalluri R, Lötvall J

J Extracell Vesicles 8 (1) 1635420 [2019-12-01; online 2019-08-27]

Centre for Cellular Imaging [Service] Glycoproteomics [Service]

Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10

Park KS, Svennerholm K, Shelke GV, ..., Gribonika I, Lötvall J

Stem Cell Res Ther 10 (1) - [2019-12-00; online 2019-08-01]

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

van der Post S, Jabbar KS, Birchenough G, ..., Johansson MEV, Hansson GC

Gut 68 (12) 2142-2151 [2019-12-00; online 2019-03-26]

Thickness determines microbial community structure and function in nitrifying biofilms via deterministic assembly

Suarez C, Piculell M, Modin O, ..., Persson F, Hermansson M

Sci Rep 9 (1) - [2019-12-00; online 2019-03-25]

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Gul N, Karlsson J, Tängemo C, ..., Bergö MO, Lindahl P

Sci Rep 9 (1) - [2019-12-00; online 2019-10-11]

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties

Nyström EEL, Arike L, Ehrencrona E, Hansson GC, Johansson MEV

J. Biol. Chem. 294 (45) 17075-17089 [2019-11-08; online 2019-09-29]

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

Volk JK, Nyström EEL, van der Post S, ..., Hansson GC, Birchenough GMH

- 216 (11) 2602-2618 [2019-11-04; online 2019-08-16]

A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding

Fleming CL, Sandoz PA, Inghardt T, ..., Grøtli M, Andréasson J

Angew. Chem. Int. Ed. 58 (42) 15000-15004 [2019-10-14; online 2019-09-05]

Isolation and characterization of microvesicles from mesenchymal stem cells

Mohammadi MR, Riazifar M, Pone EJ, ..., Lotvall J, Zhao W

Methods - (-) - [2019-10-00; online 2019-10-00]

Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells

Wilhelmsson U, Lebkuechner I, Leke R, ..., Pekna M, Pekny M

- 29 (10) 4050-4066 [2019-09-13; online 2019-01-03]

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes

Pablo , Marasek , Pozo-Rodrigálvarez , ..., Pekna , Pekny

Cells 8 (9) 1016 [2019-09-01; online 2019-09-01]

Challenges for CLEM from a Light Microscopy Perspective." Book title: Correlative Imaging, focusing on the future

Anderson K, Nilsson T, Fernandez‐Rodriguez J

John Wiley & Sons Ltd 2 (-) 23-34 [2019-09-01]

Perturbed ovarian and uterine glucocorticoid receptor signaling accompanies the balanced regulation of mitochondrial function and NFκB-mediated inflammation under conditions of hyperandrogenism and insulin resistance

Hu M, Zhang Y, Guo X, ..., Shao LR, Billig H

Life Sciences 232 (-) 116681 [2019-09-00; online 2019-09-00]

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

Schneider H, Berger E, Dolan B, ..., Pelaseyed T, Hansson GC

Biochemical Journal 476 (16) 2281-2295 [2019-08-30; online 2019-08-22]

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology.

Lázaro-Ibáñez E, Lässer C, Shelke GV, ..., García-Rodríguez A, Lötvall J

pii: 1656993 pmc: PMC6719264

J Extracell Vesicles 8 (1) 1656993 [2019-08-27; online 2019-08-27]

Centre for Cellular Imaging [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Trophic transfer of CuO NPs and dissolved Cu from sediment to worms to fish - a proof-of-concept study

Lammel T, Jensen A, Mouneyrac C, ..., Sturve J, Selck H

Environmental Science: Nano 2019 (4) - [2019-08-01]

Mixture toxicity effects and uptake of titanium dioxide (TiO2) nanoparticles and 3,3′,4,4′-tetrachlorobiphenyl (PCB77) in juvenile brown trout following co-exposure via the diet

Lammel T, Wassmur B, Mackevica A, Chen CEL, Sturve J

Aquatic Toxicology 213 (-) 105195 [2019-08-00; online 2019-08-00]

Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress

Babazadeh R, Ahmadpour D, Jia S, ..., Liu B, Nystrom T

Cell Rep 28 (8) 2096-2110.e8 [2019-08-00; online 2019-08-00]

Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte trafficking

Mottahedin A, Joakim Ek C, Truvé K, Hagberg H, Mallard C

Brain, Behavior, and Immunity 79 (-) 216-227 [2019-07-00; online 2019-07-00]

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

Wiel C, Le Gal K, Ibrahim MX, ..., Sayin VI, Bergo MO

Cell 178 (2) 330-345.e22 [2019-07-00; online 2019-07-00]

Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coli

Boge L, Browning KL, Nordström R, ..., Ringstad L, Andersson M

ACS Appl. Mater. Interfaces 11 (24) 21314-21322 [2019-06-19; online 2019-05-23]

Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

Nair S, Sobotka KS, Joshi P, ..., Mallard C, Hagberg H

Glia 67 (6) 1047-1061 [2019-06-00; online 2019-01-13]

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin

Ruiz M, Ståhlman M, Borén J, Pilon M

J. Lipid Res. 60 (5) 995-1004 [2019-05-00; online 2019-03-19]

Endocytosis, intracellular fate, accumulation, and agglomeration of titanium dioxide (TiO2) nanoparticles in the rainbow trout liver cell line RTL-W1

Lammel T, Mackevica A, Johansson BR, Sturve J

Environ Sci Pollut Res 26 (15) 15354-15372 [2019-05-00; online 2019-03-31]

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

Michno W, Nyström S, Wehrli P, ..., Zetterberg H, Hanrieder J

J. Biol. Chem. 294 (17) 6719-6732 [2019-04-26; online 2019-02-27]

Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase

Peter B, Farge G, Pardo-Hernandez C, Tångefjord S, Falkenberg M

Hum Mol Genet 28 (7) 1090-1099 [2019-04-01; online 2018-11-29]

Successful optimization of reconstruction parameters in structured illumination microscopy – A practical guide

Karras C, Smedh M, Förster R, ..., Fernandez-Rodriguez J, Heintzmann R

Optics Communications 436 (-) 69-75 [2019-04-00; online 2019-04-00]

A phototherapeutic fluorescent β-cyclodextrin branched polymer delivering nitric oxide

Malanga M, Seggio M, Kirejev V, ..., Ericson MB, Sortino S

Biomater. Sci. 7 (6) 2272-2276 [2019-00-00; online 2019-00-00]

Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In Vitro

Wang T, Zhang J, Hu M, ..., Shao LR, Billig H

Int. J. Biol. Sci. 15 (3) 714-725 [2019-00-00; online 2019-00-00]

Year 2018

Rainbow Trout Maintain Intestinal Transport and Barrier Functions Following Exposure to Polystyrene Microplastics

Ašmonaitė G, Sundh H, Asker N, Carney Almroth B

Environ. Sci. Technol. 52 (24) 14392-14401 [2018-12-18; online 2018-11-19]

Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

Ruiz M, Bodhicharla R, Svensk E, ..., Boren J, Pilon M

Elife 7 (-) - [2018-12-04; online 2018-12-04]

Confined photo-release of nitric oxide with simultaneous two-photon fluorescence tracking in a cellular system

Thomsen H, Marino N, Conoci S, Sortino S, Ericson MB

Sci Rep 8 (1) - [2018-12-00; online 2018-06-27]

Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization

Nguyen DT, O’Hara M, Graneli C, ..., Althage M, Heydarkhan-Hagvall S

Sci Rep 8 (1) - [2018-12-00; online 2018-05-10]

Abundant fish protein inhibits α-synuclein amyloid formation

Werner T, Kumar R, Horvath I, Scheers N, Wittung-Stafshede P

Sci Rep 8 (1) - [2018-12-00; online 2018-04-03]

The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

Lindström L, Li T, Malycheva D, ..., Rosselló CA, Alvarado-Kristensson M

Commun Biol 1 (1) - [2018-12-00; online 2018-05-03]

Glyco-engineered cell line and computational docking studies reveals enterotoxigenic Escherichia coli CFA/I fimbriae bind to Lewis a glycans

Mottram L, Liu J, Chavan S, ..., Svennerholm AM, Holgersson J

Sci Rep 8 (1) - [2018-12-00; online 2018-07-26]

Looking for a Treatment for Hailey-Hailey Disease: The Importance of Being Consistent in Case Reports

Micaroni M

J Cutan Med Surg 22 (6) 660-660 [2018-11-00; online 2018-10-15]

Exploring photoinactivation of microbial biofilms using laser scanning microscopy and confined 2-photon excitation

Thomsen H, Graf FE, Farewell A, Ericson MB

J. Biophotonics 11 (10) e201800018 [2018-10-00; online 2018-06-19]

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Fernández-Blanco JA, Fakih D, Arike L, ..., Ermund A, Hansson GC

JCI Insight 3 (17) - [2018-09-06; online 2018-09-06]

Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog AdipoR2

Bodhicharla R, Devkota R, Ruiz M, Pilon M

Genetics 210 (1) 189-201 [2018-09-00; online 2018-07-11]

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

Sütt S, Cansby E, Paul A, ..., Enerbäck S, Mahlapuu M

- 238 (3) 187-202 [2018-09-00; online 2018-09-00]

Interactions between monomeric CCTδ and p150 Glued : A novel function for CCTδ at the cell periphery distinct from the protein folding activity of the molecular chaperone CCT

Echbarthi M, Vallin J, Grantham J

Experimental Cell Research 370 (1) 137-149 [2018-09-00; online 2018-09-00]

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

Karimi N, Cvjetkovic A, Jang SC, ..., Lötvall J, Lässer C

Cell. Mol. Life Sci. 75 (15) 2873-2886 [2018-08-00; online 2018-02-13]

Centre for Cellular Imaging [Service] Glycoproteomics [Service]

Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism

Michno W, Kaya I, Nyström S, ..., Zetterberg H, Hanrieder J

Anal. Chem. 90 (13) 8130-8138 [2018-07-03; online 2018-06-00]

Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice

Chen M, Puschmann TB, Marasek P, ..., Wilhelmsson U, Pekny M

Mol Neurobiol 55 (7) 5478-5489 [2018-07-00; online 2017-09-27]

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

Nyström EEL, Birchenough GMH, van der Post S, ..., Hansson GC, Johansson MEV

EBioMedicine 33 (-) 134-143 [2018-07-00; online 2018-07-00]

Assessment of titanium dioxide nanoparticle toxicity in the rainbow trout (Onchorynchus mykiss) liver and gill cell lines RTL-W1 and RTgill-W1 under particular consideration of nanoparticle stability and interference with fluorometric assays

Lammel T, Sturve J

NanoImpact 11 (-) 1-19 [2018-07-00; online 2018-07-00]

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

De Vadder F, Grasset E, Mannerås Holm L, ..., Olofsson LE, Bäckhed F

Proc Natl Acad Sci USA 115 (25) 6458-6463 [2018-06-19; online 2018-06-04]

Expression of ribosomal and actin network proteins and immunochemotherapy resistance in diffuse large B cell lymphoma patients

Bram Ednersson S, Stenson M, Stern M, ..., Hasselblom S, Andersson PO

Br J Haematol 181 (6) 770-781 [2018-06-00; online 2018-05-16]

Centre for Cellular Imaging [Service] Glycoproteomics [Service]

Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats

Hu M, Zhang Y, Feng J, ..., Shao LR, Billig H

- 237 (2) 123-137 [2018-05-00; online 2018-05-00]

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

Trillo-Muyo S, Nilsson HE, Recktenwald CV, ..., Hebert H, Hansson GC

J. Biol. Chem. 293 (15) 5746-5754 [2018-04-13; online 2018-02-13]

Effects of fixation on electrophysiology and structure of human jejunal villi

Casselbrant A, Helander HF

Microsc Res Tech 81 (4) 376-383 [2018-04-00; online 2018-01-11]

The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines. Correction

Hofving T, Arvidsson Y, Almobarak B, ..., Johanson V, Nilsson O

Endocr Relat Cancer 25 (4) X1-X2 [2018-04-00; online 2018-04-00]

The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines

Hofving T, Arvidsson Y, Almobarak B, ..., Johanson V, Nilsson O

Endocr Relat Cancer 25 (3) 367-380 [2018-03-00; online 2018-03-00]

Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation

Wang X, Omar O, Vazirisani F, Thomsen P, Ekström K

PLoS ONE 13 (2) e0193059 [2018-02-15; online 2018-02-15]

Characterization of gamma-tubulin filaments in mammalian cells

Lindström L, Alvarado-Kristensson M

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865 (1) 158-171 [2018-01-00; online 2018-01-00]

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

Schroeder BO, Birchenough GMH, Ståhlman M, ..., Hansson GC, Bäckhed F

Cell Host & Microbe 23 (1) 27-40.e7 [2018-01-00; online 2018-01-00]

Year 2017

Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection

Birchenough GMH, Dalgakiran F, Witcomb LA, ..., Hansson GC, Taylor PW

Sci Rep 7 (1) - [2017-12-00; online 2017-03-06]

MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice

Risal S, Zhang J, Adhikari D, ..., Kaldis P, Liu K

Cell Discov 3 (1) - [2017-12-00; online 2017-02-07]

Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ

Agholme L, Clarin M, Gkanatsiou E, ..., Portelius E, Zetterberg H

Molecular and Cellular Neuroscience 85 (-) 211-219 [2017-12-00; online 2017-12-00]

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

Ribeiro D, Horvath I, Heath N, ..., Forslöw A, Wittung-Stafshede P

Proc Natl Acad Sci USA 114 (42) 11127-11132 [2017-10-17; online 2017-10-02]

Delivery of cyclodextrin polymers to bacterial biofilms — An exploratory study using rhodamine labelled cyclodextrins and multiphoton microscopy

Thomsen H, Benkovics G, Fenyvesi É, ..., Malanga M, Ericson MB

International Journal of Pharmaceutics 531 (2) 650-657 [2017-10-00; online 2017-10-00]

Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin

Sun JB, Holmgren J, Larena M, ..., Bresnick AR, Xiang Z

Front Immunol 8 (-) - [2017-09-11; online 2017-09-11]

The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids

Devkota R, Svensk E, Ruiz M, ..., Borén J, Pilon M

PLoS Genet. 13 (9) e1007004 [2017-09-08; online 2017-09-08]

Membrane trafficking under the microscope, what new imaging technologies have brought to light

Fernandez-Rodriguez J, Nilsson T

CRC Press 1st Edition (-) - [2017-08-01]

Site-specific gene expression analysis of implant-near cells in a soft tissue infection model - Application of laser microdissection to study biomaterial-associated infection

Svensson S, Trobos M, Omar O, Thomsen P

J. Biomed. Mater. Res. 105 (8) 2210-2217 [2017-08-00; online 2017-05-10]

Moderate Expression of SEC16 Increases Protein Secretion by Saccharomyces cerevisiae

Bao J, Huang M, Petranovic D, Nielsen J

Appl Environ Microbiol 83 (14) - [2017-07-15; online 2017-05-05]

Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.

Wilhelmsson U, Andersson D, de Pablo Y, ..., Pekny M, Pekna M

pii: 3111278

Cereb. Cortex 27 (6) 3360-3377 [2017-06-01; online 2017-04-12]

Centre for Cellular Imaging [Service] Fluorescence Tissue Profiling [Collaborative]

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

Monterisi S, Lobo MJ, Livie C, ..., Micaroni M, Zaccolo M

Elife 6 (-) - [2017-05-02; online 2017-05-02]

Histology-Compatible MALDI Mass Spectrometry Based Imaging of Neuronal Lipids for Subsequent Immunofluorescent Staining

Kaya I, Michno W, Brinet D, ..., Zetterberg H, Hanrieder J

Anal. Chem. 89 (8) 4685-4694 [2017-04-18; online 2017-04-06]

Editorial for the special issue on “Golgi-related human disorders”

Micaroni M

Tissue and Cell 49 (2) 131-132 [2017-04-00; online 2017-04-00]

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Morán J, Stokowska A, Walker FR, ..., Hagberg H, Pekna M

Experimental Neurology 290 (-) 74-84 [2017-04-00; online 2017-04-00]

Light-sensing via hydrogen peroxide and a peroxiredoxin

Bodvard K, Peeters K, Roger F, ..., Käll M, Molin M

Nat Commun 8 (1) - [2017-04-00; online 2017-03-24]

An assessment of the importance of exposure routes to the uptake and internal localisation of fluorescent nanoparticles in zebrafish (Danio rerio), using light sheet microscopy

Skjolding LM, Ašmonaitė G, Jølck RI, ..., Baun A, Sturve J

Nanotoxicology 11 (3) 351-359 [2017-03-16; online 2017-03-29]

Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy

Borglin J, Selegård R, Aili D, Ericson MB

Nano Lett. 17 (3) 2102-2108 [2017-03-08; online 2017-02-23]

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Kaya I, Brinet D, Michno W, ..., Blennow K, Hanrieder J

ACS Chem Neurosci 8 (2) 347-355 [2017-02-15; online 2017-01-10]

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

Stokowska A, Atkins AL, Morán J, ..., Dragunow M, Pekna M

Brain 140 (2) 353-369 [2017-02-00; online 2016-12-12]

Endocytic turnover of Rab8 controls cell polarization

Vidal-Quadras M, Holst MR, Francis MK, ..., Martín-Belmonte F, Lundmark R

J Cell Sci - (-) jcs.195420 [2017-01-30; online 2017-01-30]

Cell Cycle and Cell Size Dependent Gene Expression Reveals Distinct Subpopulations at Single-Cell Level

Dolatabadi S, Candia J, Akrap N, ..., Åman P, Ståhlberg A

Front Genet 8 (-) - [2017-01-25; online 2017-01-25]

Copper chaperone Atox1 plays role in breast cancer cell migration

Blockhuys S, Wittung-Stafshede P

Biochemical and Biophysical Research Communications 483 (1) 301-304 [2017-01-00; online 2017-01-00]