{"entity": "label", "iuid": "ed7df1a626b04c89ba17504daee2f0d5", "timestamp": "2026-08-11T07:47:03.588Z", "links": {"self": {"href": "https://publications.scilifelab.se/label/BioMaterial%20Interactions%20%28BioMat%29.json"}, "display": {"href": "https://publications.scilifelab.se/label/BioMaterial%20Interactions%20%28BioMat%29"}}, "value": "BioMaterial Interactions (BioMat)", "started": "2013", "ended": "2016", "created": "2017-05-02T12:09:58.087Z", "modified": "2021-03-15T14:15:00.810Z", "accounts": [{"entity": "account", "iuid": "32a436398938412b93e7ddcef018c708", "timestamp": "2026-08-11T07:47:03.588Z", "links": {"self": {"href": "https://publications.scilifelab.se/account/christopher.erdmann%40scilifelab.uu.se.json"}, "display": {"href": "https://publications.scilifelab.se/account/christopher.erdmann%40scilifelab.uu.se"}}, "email": "christopher.erdmann@scilifelab.uu.se", "name": "Christopher Erdmann", "orcid": "", "role": "curator", "status": "enabled", "login": "2024-08-16T11:56:57.787Z", "created": "2024-08-16T10:01:32.844Z", "modified": "2025-10-17T13:05:06.782Z"}, {"entity": "account", "iuid": "3cd11951a51749349ea84ac8fa583867", "timestamp": "2026-08-11T07:47:03.588Z", "links": {"self": {"href": "https://publications.scilifelab.se/account/marjam.ott%40angstrom.uu.se.json"}, "display": {"href": "https://publications.scilifelab.se/account/marjam.ott%40angstrom.uu.se"}}, "email": "marjam.ott@angstrom.uu.se", "name": "Marjam Ott", "orcid": null, "role": "curator", "status": "enabled", "login": null, "created": "2017-05-02T12:10:07.603Z", "modified": "2017-09-18T14:46:40.407Z"}, {"entity": "account", "iuid": "6a38350bd21f4fb6aeeb1530037a99ae", "timestamp": "2026-08-11T07:47:03.588Z", "links": {"self": {"href": "https://publications.scilifelab.se/account/sune.joubert%40scilifelab.uu.se.json"}, "display": {"href": "https://publications.scilifelab.se/account/sune.joubert%40scilifelab.uu.se"}}, "email": "sune.joubert@scilifelab.uu.se", "name": "Sun\u00e9 Joubert", "orcid": "", "role": "curator", "status": "enabled", "login": "2025-10-31T11:15:37.113Z", "created": "2024-08-16T10:01:02.800Z", "modified": "2025-10-31T11:15:37.113Z"}], "publications_count": 18, "publications": [{"entity": "publication", "iuid": "5017d9829ea24c719e82b70d8b45744d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5017d9829ea24c719e82b70d8b45744d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5017d9829ea24c719e82b70d8b45744d"}}, "title": "Hyperelastic Nanocellulose-Reinforced Hydrogel of High Water Content for Ophthalmic Applications.", "authors": [{"family": "Tummala", "given": "Gopi Krishna", "initials": "GK"}, {"family": "Joffre", "given": "Thomas", "initials": "T"}, {"family": "Lopes", "given": "Viviana R", "initials": "VR"}, {"family": "Liszka", "given": "Aneta", "initials": "A"}, {"family": "Buznyk", "given": "Oleksiy", "initials": "O"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fb6fe3555374aec90b2a8b9dfd8016b.json"}}, {"family": "Griffith", "given": "May", "initials": "M"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2016-11-14", "journal": {"volume": "2", "issn": "2373-9878", "issue": "11", "pages": "2072-2079", "title": "ACS Biomater. Sci. Eng.", "issn-l": "2373-9878"}, "abstract": "A nanocellulose-reinforced poly(vinyl alcohol) hydrogel material of exceptionally high water content for ophthalmic applications is presented (>90 wt %), which also features a hitherto unprecedented combination of optical, mechanical, viscoelastic, oxygen permeability, and biocompatibility properties. The hydrogel combines the desired softness with remarkable strain-dependent mechanical strength and thereby demonstrates hyperelastic, rubber-like mechanical properties. The observed unusual mechanical behavior is due to both high water content and the combination of relatively stiff cellulose nanowhiskers entangled in a soft polymer matrix of poly(vinyl alcohol) (PVA), thus mimicking the structural characteristics of the cornea's main constituents, i.e., water and collagen.", "doi": "10.1021/acsbiomaterials.6b00484", "pmid": "33440543", "labels": {"BioMaterial Interactions (BioMat)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-08T07:59:48.331Z", "modified": "2021-07-06T14:00:31.874Z"}, {"entity": "publication", "iuid": "2ffe5135802e43a7b538648d741032d1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2ffe5135802e43a7b538648d741032d1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2ffe5135802e43a7b538648d741032d1"}}, "title": "Rapid Newcastle Disease Virus Detection Based on Loop-Mediated Isothermal Amplification and Optomagnetic Readout", "authors": [{"family": "Tian", "given": "Bo", "initials": "B"}, {"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Zard\u00e1n G\u00f3mez de la Torre", "given": "Teresa", "initials": "T"}, {"family": "B\u00e1lint", "given": "\u00c1d\u00e1m", "initials": "\u00c1"}, {"family": "Donolato", "given": "Marco", "initials": "M"}, {"family": "Hansen", "given": "Mikkel Fougt", "initials": "MF"}, {"family": "Svedlindh", "given": "Peter", "initials": "P"}, {"family": "Str\u00f6mberg", "given": "Mattias", "initials": "M"}], "type": "journal-article", "published": "2016-10-28", "journal": {"volume": "1", "issn": "2379-3694", "issue": "10", "pages": "1228-1234", "title": "ACS Sens.", "issn-l": "2379-3694"}, "abstract": null, "doi": "10.1021/acssensors.6b00379", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-08T07:59:49.843Z", "modified": "2021-06-21T15:54:40.334Z"}, {"entity": "publication", "iuid": "08b74c12de1a465ab2aaa3b32739bc07", "links": {"self": {"href": "https://publications.scilifelab.se/publication/08b74c12de1a465ab2aaa3b32739bc07.json"}, "display": {"href": "https://publications.scilifelab.se/publication/08b74c12de1a465ab2aaa3b32739bc07"}}, "title": "Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate.", "authors": [{"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Zard\u00e1n G\u00f3mez de la Torre", "given": "Teresa", "initials": "T"}, {"family": "Welch", "given": "Ken", "initials": "K"}, {"family": "Bergstr\u00f6m", "given": "Christel", "initials": "C"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2016-10-10", "journal": {"volume": "93", "issn": "1879-0720", "issue": null, "pages": "468-474", "title": "Eur J Pharm Sci", "issn-l": "0928-0987"}, "abstract": "This work investigates whether the solubility of poorly soluble compounds can be improved by using mesoporous magnesium carbonate (MMC) as the drug delivery system. A solvent evaporation method was used to load structurally diverse model drugs (celecoxib, cinnarizine and griseofulvin) into the pores of MMC. The drug-loaded carrier system was then characterized in terms of porosity, crystallinity, and release profiles by a variety of experimental techniques, including X-ray diffraction, nitrogen adsorption analysis, differential scanning calorimetry, infrared spectroscopy, UV absorption spectroscopy, and thermogravimetric analysis. All three drugs were in a non-crystalline state after loading into the pores of MMC. The concentrations of the drugs in solution over time (a measure of the release rates from loaded MMC) were higher than the corresponding concentrations (dissolution rates) of equal amounts of the crystalline drugs. The release rates were five (celecoxib), three (cinnarizine) and two times (griseofulvin) higher than the dissolution rates of their crystalline counterparts. Supersaturation release profiles were also observed; the areas under the concentration-time curves (0-240min) were 25- (celecoxib), 5- (cinnarizine) and 2-fold (griseofulvin) greater than those of the crystalline drugs. Hence, MMC shows promise as a general drug delivery vehicle for increasing the bioavailability of compounds with dissolution rate- or solubility-limited absorption.", "doi": "10.1016/j.ejps.2016.08.059", "pmid": "27590126", "labels": {"BioMaterial Interactions (BioMat)": "Service"}, "xrefs": [{"db": "pii", "key": "S0928-0987(16)30347-5"}], "notes": [], "created": "2017-05-03T13:02:31.449Z", "modified": "2017-06-12T11:40:02.980Z"}, {"entity": "publication", "iuid": "8edd318fc889495a82986e346d3aa0ca", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8edd318fc889495a82986e346d3aa0ca.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8edd318fc889495a82986e346d3aa0ca"}}, "title": "Reduced oxidative stress in primary human cells by antioxidant released from nanoporous alumina.", "authors": [{"family": "Pujari-Palmer", "given": "Shiuli", "initials": "S"}, {"family": "Pujari-Palmer", "given": "Michael", "initials": "M"}, {"family": "Karlsson Ott", "given": "Marjam", "initials": "M"}], "type": "journal article", "published": "2016-04-00", "journal": {"volume": "104", "issn": "1552-4981", "issue": "3", "pages": "568-575", "title": "J. Biomed. Mater. Res. Part B Appl. Biomater.", "issn-l": "1552-4973"}, "abstract": "Nanoporous alumina elicits different inflammatory responses dependent on pore size, such as increased complement activation and reactive oxygen species (ROS) production, on 200 versus 20 nm pores. In this study, we attempt to further modulate inflammatory cell response by loading nanoporous alumina membranes (20, 100, and 200 nm pores), with an antioxidant, Trolox, for controlled drug release. For mononuclear cells (MNC) no difference in cell response, due to pore size, was seen when cultured on nonloaded membranes. However, when exposed to membranes loaded with Trolox, 100 uM was enough to quench ROS by more than 95% for all pore sizes. Polymorphonuclear cells (PMNC) produced significantly more ROS when exposed to 20 versus 100 nm pores. For Trolox loaded membranes, this trend reversed, due to slower release of antioxidant from the 20 nm pores. Furthermore, Trolox exhibited a unique effect on PMNCs that has not previously been reported: It delayed the production of ROS in a manner distinct from antioxidant activity. The present study confirms that nanoporous alumina is a suitable vehicle for drug delivery, and that Trolox can successfully modulate the inflammatory response of both MNC and PMNCs.", "doi": "10.1002/jbm.b.33427", "pmid": "25952986", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-02T12:58:28.498Z", "modified": "2017-05-30T13:19:11.083Z"}, {"entity": "publication", "iuid": "3439ae0f46a049be9c0313701fc36918", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3439ae0f46a049be9c0313701fc36918.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3439ae0f46a049be9c0313701fc36918"}}, "title": "Transition from Bioinert to Bioactive Material by Tailoring the Biological Cell Response to Carboxylated Nanocellulose.", "authors": [{"family": "Hua", "given": "Kai", "initials": "K"}, {"family": "Rocha", "given": "Igor", "initials": "I"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Gustafsson", "given": "Simon", "initials": "S"}, {"family": "Ning", "given": "Yi", "initials": "Y"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}], "type": "journal article", "published": "2016-03-14", "journal": {"volume": "17", "issn": "1526-4602", "issue": "3", "pages": "1224-1233", "title": "Biomacromolecules", "issn-l": "1525-7797"}, "abstract": "This work presents an insight into the relationship between cell response and physicochemical properties of Cladophora cellulose (CC) by investigating the effect of CC functional group density on the response of model cell lines. CC was carboxylated by electrochemical TEMPO-mediated oxidation. By varying the amount of charge passed through the electrolysis setup, CC materials with different degrees of oxidation were obtained. The effect of carboxyl group density on the material's physicochemical properties was investigated together with the response of human dermal fibroblasts (hDF) and human osteoblastic cells (Saos-2) to the carboxylated CC films. The introduction of carboxyl groups resulted in CC films with decreased specific surface area and smaller total pore volume compared with the unmodified CC (u-CC). While u-CC films presented a porous network of randomly oriented fibers, a compact and aligned fiber pattern was depicted for the carboxylated-CC films. The decrease in surface area and total pore volume, and the orientation and aggregation of the fibers tended to augment parallel to the increase in the carboxyl group density. hDF and Saos-2 cells presented poor cell adhesion and spreading on u-CC, which gradually increased for the carboxylated CC as the degree of oxidation increased. It was found that a threshold value in carboxyl group density needs be reached to obtain a carboxylated-CC film with cytocompatibility comparable to commercial tissue culture material. Hence, this study demonstrates that a normally bioinert nanomaterial can be rendered bioactive by carefully tuning the density of charged groups on the material surface, a finding that not only may contribute to the fundamental understanding of biointerface phenomena, but also to the development of bioinert/bioactive materials.", "doi": "10.1021/acs.biomac.6b00053", "pmid": "26886265", "labels": {"BioMaterial Interactions (BioMat)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-03T13:02:31.740Z", "modified": "2017-06-12T11:40:03.156Z"}, {"entity": "publication", "iuid": "1403289355e042c1a751f19dd8f401d8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1403289355e042c1a751f19dd8f401d8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1403289355e042c1a751f19dd8f401d8"}}, "title": "Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols.", "authors": [{"family": "Kumar", "given": "Shailesh", "initials": "S"}, {"family": "Yan", "given": "Jiajie", "initials": "J"}, {"family": "Poon", "given": "Jia-Fei", "initials": "JF"}, {"family": "Singh", "given": "Vijay P", "initials": "VP"}, {"family": "Lu", "given": "Xi", "initials": "X"}, {"family": "Karlsson Ott", "given": "Marjam", "initials": "M"}, {"family": "Engman", "given": "Lars", "initials": "L"}, {"family": "Kumar", "given": "Sangit", "initials": "S"}], "type": "journal article", "published": "2016-03-07", "journal": {"volume": "55", "issn": "1521-3773", "issue": "11", "pages": "3729-3733", "title": "Angew. Chem. Int. Ed. Engl.", "issn-l": "1433-7851"}, "abstract": "Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than \u03b1-tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25\u2005\u03bcm, the ebselenol derivatives showed minimal toxicity in pre-osteoblast MC3T3\u2005cells.", "doi": "10.1002/anie.201510947", "pmid": "26879742", "labels": {"BioMaterial Interactions (BioMat)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-03T13:02:31.157Z", "modified": "2017-06-12T11:40:02.804Z"}, {"entity": "publication", "iuid": "a72acfbdc0a84a53b32af9e94abf9c54", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a72acfbdc0a84a53b32af9e94abf9c54.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a72acfbdc0a84a53b32af9e94abf9c54"}}, "title": "Diffusion-Controlled Drug Release From the Mesoporous Magnesium Carbonate Upsalite(\u00ae).", "authors": [{"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Zard\u00e1n G\u00f3mez de la Torre", "given": "Teresa", "initials": "T"}, {"family": "Forsgren", "given": "Johan", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CA"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2016-02-00", "journal": {"volume": "105", "issn": "1520-6017", "issue": "2", "pages": "657-663", "title": "J Pharm Sci", "issn-l": "0022-3549"}, "abstract": "In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite(\u00ae) was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model compound. The weight of loaded drug corresponded to 30% of the weight of the carrier and the pores were filled to approximately 80%. The incorporated ibuprofen was found to be in an amorphous state and was physisorbed, rather than chemisorbed, to the surfaces of the pore walls. In contrast to ibuprofen in mesoporous silica, there was no detectable drug on the outer surface of the carrier particles. Two ibuprofen doses were loaded into Upsalite(\u00ae) particles with size fractions ranging from 25 \u03bcm to more than 200 \u03bcm. The initial release rate was controlled by the particle size; the dissolution rate of the loaded ibuprofen during this period was more than four times faster than that of the crystalline drug. An extended-release period of about 24 h followed the initial rapid-release period. The features of this extended-release period were dependent on the total drug concentration in the release medium. Detailed analysis of the diffusion of ibuprofen in Upsalite(\u00ae) provided the ibuprofen diffusion coefficient (9.8 \u00d7 10(-8) cm(2)/s), the constrictivity of the diffusion process (0.47) and the tortuosity of the carrier (15). This relatively high tortuosity value indicates that Upsalite(\u00ae) can be used not only to enhance the dissolution rate of poorly soluble drugs but also as a carrier in sustained-release applications by using larger particle sizes or even pellets of the material.", "doi": "10.1002/jps.24553", "pmid": "26087956", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pii", "key": "S0022-3549(15)00037-4"}], "notes": [], "created": "2017-05-02T12:58:15.262Z", "modified": "2017-05-30T13:16:41.201Z"}, {"entity": "publication", "iuid": "cb942a66253b4a4e93a49ab59a8f8256", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cb942a66253b4a4e93a49ab59a8f8256.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cb942a66253b4a4e93a49ab59a8f8256"}}, "title": "Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement.", "authors": [{"family": "Mestres", "given": "Gemma", "initials": "G", "orcid": "0000-0001-7462-4236", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ec7d9960e1b4572b4f44d6d0ceeb1c3.json"}}, {"family": "Kugiejko", "given": "Karol", "initials": "K"}, {"family": "Pastorino", "given": "David", "initials": "D"}, {"family": "Unosson", "given": "Johanna", "initials": "J"}, {"family": "\u00d6hman", "given": "Caroline", "initials": "C"}, {"family": "Karlsson Ott", "given": "Marjam", "initials": "M"}, {"family": "Ginebra", "given": "Maria-Pau", "initials": "MP"}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fb6fe3555374aec90b2a8b9dfd8016b.json"}}], "type": "journal article", "published": "2016-01-01", "journal": {"volume": "58", "issn": "1873-0191", "issue": null, "pages": "88-96", "title": "Mater Sci Eng C Mater Biol Appl", "issn-l": "0928-4931"}, "abstract": "Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems. Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest. However, previous studies have commonly evaluated the drug release using pre-set cements only. Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.", "doi": "10.1016/j.msec.2015.08.016", "pmid": "26478290", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pii", "key": "S0928-4931(15)30272-1"}], "notes": [], "created": "2017-05-02T12:57:03.690Z", "modified": "2021-07-06T14:00:31.904Z"}, {"entity": "publication", "iuid": "8ce1003a6731439fa2816358f91fbbfb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8ce1003a6731439fa2816358f91fbbfb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8ce1003a6731439fa2816358f91fbbfb"}}, "title": "Nanocellulose from green algae modulates the in vitro inflammatory response of monocytes/macrophages", "authors": [{"family": "Hua", "given": "Kai", "initials": "K"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}], "type": "journal-article", "published": "2015-12-00", "journal": {"volume": "22", "issn": "0969-0239", "issue": "6", "pages": "3673-3688", "title": "Cellulose", "issn-l": null}, "abstract": null, "doi": "10.1007/s10570-015-0772-2", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-05T12:52:23.992Z", "modified": "2021-06-22T11:35:04.939Z"}, {"entity": "publication", "iuid": "9ab13e468ca244fc9de10dc4df5613db", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9ab13e468ca244fc9de10dc4df5613db.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9ab13e468ca244fc9de10dc4df5613db"}}, "title": "Surface Chemistry of Nanocellulose Fibers Directs Monocyte/Macrophage Response.", "authors": [{"family": "Hua", "given": "Kai", "initials": "K"}, {"family": "\u00c5lander", "given": "Eva", "initials": "E"}, {"family": "Lindstr\u00f6m", "given": "Tom", "initials": "T"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}], "type": "journal article", "published": "2015-09-14", "journal": {"volume": "16", "issn": "1526-4602", "issue": "9", "pages": "2787-2795", "title": "Biomacromolecules", "issn-l": "1525-7797"}, "abstract": "The effect of surface functionalization of nanofibrillated cellulose (NFC) on monocyte/macrophage (MM) behavior is investigated to understand how the physicochemical properties of nanocelluloses influence the interactions of such materials with biological systems. Films of anionic (a-), cationic (c-), and unmodified (u-) NFC were synthesized and characterized in terms of surface charge. THP-1 monocytes were cultured on the surface of the films for 24 h in the presence and absence of lipopolysaccharide, and the cell response was evaluated in terms of cell adhesion, morphology, and secretion of TNF-\u03b1, IL-10, and IL-1ra. The results show that MMs cultured on carboxymethylated-NFC films (a-NFC) are activated toward a proinflammatory phenotype, whereas u-NFC promotes a mild activation of the studied cells. The presence of hydroxypropyltrimethylammonium groups on c-NFC, however, does not promote the activation of MMs, indicating that c-NFC closely behaves as an inert material in terms of MM activation. None of the materials is able to directly activate the MMs toward an anti-inflammatory response. These results may provide a foundation for the design of future NFC-based materials with the ability to control MM activation and may expand the use of NFC in biomedical applications.", "doi": "10.1021/acs.biomac.5b00727", "pmid": "26247827", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-02T12:57:32.325Z", "modified": "2017-05-30T13:09:47.389Z"}, {"entity": "publication", "iuid": "4dde9ee3fb324d88bcd1277c6d0fd32c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4dde9ee3fb324d88bcd1277c6d0fd32c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4dde9ee3fb324d88bcd1277c6d0fd32c"}}, "title": "In Vitro and In Vivo Response to Low-Modulus PMMA-Based Bone Cement.", "authors": [{"family": "Carlsson", "given": "Elin", "initials": "E"}, {"family": "Mestres", "given": "Gemma", "initials": "G"}, {"family": "Treerattrakoon", "given": "Kiatnida", "initials": "K"}, {"family": "L\u00f3pez", "given": "Alejandro", "initials": "A"}, {"family": "Karlsson Ott", "given": "Marjam", "initials": "M"}, {"family": "Larsson", "given": "Sune", "initials": "S"}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fb6fe3555374aec90b2a8b9dfd8016b.json"}}], "type": "journal article", "published": "2015-08-20", "journal": {"volume": "2015", "issn": "2314-6141", "issue": null, "pages": "594284", "title": "Biomed Res Int", "issn-l": "2314-6133"}, "abstract": "The high stiffness of acrylic bone cements has been hypothesized to contribute to the increased number of fractures encountered after vertebroplasty, which has led to the development of low-modulus cements. However, there is no data available on the in vivo biocompatibility of any low-modulus cement. In this study, the in vitro cytotoxicity and in vivo biocompatibility of two types of low-modulus acrylic cements, one modified with castor oil and one with linoleic acid, were evaluated using human osteoblast-like cells and a rodent model, respectively. While the in vitro cytotoxicity appeared somewhat affected by the castor oil and linoleic acid additions, no difference could be found in the in vivo response to these cements in comparison to the base, commercially available cement, in terms of histology and flow cytometry analysis of the presence of immune cells. Furthermore, the in vivo radiopacity of the cements appeared unaltered. While these results are promising, the mechanical behavior of these cements in vivo remains to be investigated.", "doi": "10.1155/2015/594284", "pmid": "26366415", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pmc", "key": "PMC4558433"}], "notes": [], "created": "2017-05-02T12:56:52.856Z", "modified": "2021-07-06T14:00:31.867Z"}, {"entity": "publication", "iuid": "6be2c429bb0046c6925861734bae9e0f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6be2c429bb0046c6925861734bae9e0f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6be2c429bb0046c6925861734bae9e0f"}}, "title": "Effect of a Bromo Substituent on the Glutathione Peroxidase Activity of a Pyridoxine-like Diselenide.", "authors": [{"family": "Singh", "given": "Vijay P", "initials": "VP"}, {"family": "Poon", "given": "Jia-Fei", "initials": "JF"}, {"family": "Butcher", "given": "Ray J", "initials": "RJ"}, {"family": "Lu", "given": "Xi", "initials": "X"}, {"family": "Mestres", "given": "Gemma", "initials": "G"}, {"family": "Ott", "given": "Marjam Karlsson", "initials": "MK"}, {"family": "Engman", "given": "Lars", "initials": "L"}], "type": "journal article", "published": "2015-08-07", "journal": {"volume": "80", "issn": "1520-6904", "issue": "15", "pages": "7385-7395", "title": "J. Org. Chem.", "issn-l": "0022-3263"}, "abstract": "In search for better mimics of the glutathione peroxidase enzymes, pyridoxine-like diselenides 6 and 11, carrying a 6-bromo substituent, were prepared. Reaction of 2,6-dibromo-3-pyridinol 5 with sodium diselenide provided 6 via aromatic nucleophilic substitution of the 2-bromo substituent. LiAlH4 caused reduction of all four ester groups and returned 11 after acidic workup. The X-ray structure of 6 showed that the dipyridyl diselenide moiety was kept in an almost planar, transoid conformation. According to NBO-analysis, this was due to weak intramolecular Se\u00b7\u00b7\u00b7O (1.1 kcal/mol) and Se\u00b7\u00b7\u00b7N-interactions (2.5 kcal/mol). That the 6-bromo substituent increased the positive charge on selenium was confirmed by NPA-analysis and seen in calculated and observed (77)Se NMR-shifts. Diselenide 6 showed a more than 3-fold higher reactivity than the corresponding des-bromo compound 3a and ebselen when evaluated in the coupled reductase assay. Experiments followed for longer time (2 h) confirmed that diselenide 6 is a better GPx-catalyst than 11. On the basis of (77)Se-NMR experiments, a catalytic mechanism for diselenide 6 was proposed involving selenol, selenosulfide and seleninic acid intermediates. At low concentration (10 \u03bcM) where it showed only minimal toxicity, it could scavenge ROS produced by MNC- and PMNC-cells more efficiently than Trolox.", "doi": "10.1021/acs.joc.5b00797", "pmid": "26133764", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-02T12:58:50.287Z", "modified": "2017-05-30T13:23:06.256Z"}, {"entity": "publication", "iuid": "1e80b05a5795494cac85d4949c7867f6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1e80b05a5795494cac85d4949c7867f6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1e80b05a5795494cac85d4949c7867f6"}}, "title": "Scavenging effect of Trolox released from brushite cements.", "authors": [{"family": "Mestres", "given": "Gemma", "initials": "G"}, {"family": "Santos", "given": "Carlos F", "initials": "CF"}, {"family": "Engman", "given": "Lars", "initials": "L"}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fb6fe3555374aec90b2a8b9dfd8016b.json"}}, {"family": "Ott", "given": "Marjam Karlsson", "initials": "MK"}], "type": "journal article", "published": "2015-01-00", "journal": {"volume": "11", "issn": "1878-7568", "issue": null, "pages": "459-466", "title": "Acta Biomater", "issn-l": "1742-7061"}, "abstract": "In this study a brushite cement was doped with the chain-breaking antioxidant Trolox. The effect of the antioxidant on the physical properties of the cement was evaluated and the release of Trolox was monitored by UV spectroscopy. The ability of the Trolox set free to scavenge reactive oxygen species (ROS) released by macrophages was determined in vitro using a luminol-amplified chemiluminescence assay. Trolox did not modify the crystalline phases of the set cement, which mainly formed crystalline brushite after 7 days in humid conditions. The setting time, compressive strength and morphology of the cement also remained unaltered after the addition of the antioxidant. Trolox was slowly released from the cement following a non-Fickian transport mechanism and nearly 64% of the total amount was released after 3 days. Moreover, the capacity of Trolox to scavenge the ROS released by macrophages increased in a dose-dependent manner. Trolox-loaded cements are expected to reduce some of the first harmful effects of acute inflammation and can thus potentially protect the surrounding tissue during implantation of these as well as other materials used in conjunction.", "doi": "10.1016/j.actbio.2014.09.007", "pmid": "25229765", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pii", "key": "S1742-7061(14)00390-0"}], "notes": [], "created": "2017-05-02T12:57:03.398Z", "modified": "2021-07-06T14:00:31.835Z"}, {"entity": "publication", "iuid": "178c90e4a2274388aae2d784481970f6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/178c90e4a2274388aae2d784481970f6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/178c90e4a2274388aae2d784481970f6"}}, "title": "Cytotoxicity, <i>in Vivo</i> Skin Irritation and Acute Systemic Toxicity of the Mesoporous Magnesium Carbonate Upsalite<sup>®</sup>", "authors": [{"family": "Frykstrand", "given": "Sara", "initials": "S"}, {"family": "Forsgren", "given": "Johan", "initials": "J"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}], "type": "journal-article", "published": "2015-00-00", "journal": {"volume": "06", "issn": "2158-7027", "issue": "04", "pages": "257-266", "title": "JBNB", "issn-l": null}, "abstract": null, "doi": "10.4236/jbnb.2015.64024", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-05T12:56:21.836Z", "modified": "2021-06-22T11:59:16.456Z"}, {"entity": "publication", "iuid": "ab4a874c9aec4d82aa587e462a8a7a8f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ab4a874c9aec4d82aa587e462a8a7a8f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ab4a874c9aec4d82aa587e462a8a7a8f"}}, "title": "Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose.", "authors": [{"family": "Carlsson", "given": "Daniel O", "initials": "DO"}, {"family": "Hua", "given": "Kai", "initials": "K"}, {"family": "Forsgren", "given": "Johan", "initials": "J"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}], "type": "journal article", "published": "2014-01-30", "journal": {"volume": "461", "issn": "1873-3476", "issue": "1-2", "pages": "74-81", "title": "Int J Pharm", "issn-l": "0378-5173"}, "abstract": "TEMPO-mediated surface oxidation of mesoporous highly crystalline Cladophora cellulose was used to introduce negative surface charges onto cellulose nanofibrils without significantly altering other structural characteristics. This enabled the investigation of the influence of mesoporous nanocellulose surface charges on aspirin chemical stability to be conducted. The negative surface charges (carboxylate content 0.44\u00b10.01 mmol/g) introduced on the mesoporous crystalline nanocellulose significantly accelerated aspirin degradation, compared to the starting material which had significantly less surface charge (0.06\u00b10.01 mmol/g). This effect followed from an increased aspirin amorphisation ability in mesopores of the oxidized nanocellulose. These results highlight the importance of surface charges in formulating nanocellulose for drug delivery.", "doi": "10.1016/j.ijpharm.2013.11.032", "pmid": "24291076", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pii", "key": "S0378-5173(13)01026-0"}], "notes": [], "created": "2017-05-04T15:03:21.297Z", "modified": "2017-05-30T12:42:41.343Z"}, {"entity": "publication", "iuid": "b09409f18f144eda82898d75c2ddbada", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b09409f18f144eda82898d75c2ddbada.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b09409f18f144eda82898d75c2ddbada"}}, "title": "Translational study between structure and biological response of nanocellulose from wood and green algae", "authors": [{"family": "Hua", "given": "Kai", "initials": "K"}, {"family": "Carlsson", "given": "Daniel O", "initials": "DO"}, {"family": "\u00c5lander", "given": "Eva", "initials": "E"}, {"family": "Lindstr\u00f6m", "given": "Tom", "initials": "T"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Mihranyan", "given": "Albert", "initials": "A"}, {"family": "Ferraz", "given": "Natalia", "initials": "N"}], "type": "journal-article", "published": "2014-00-00", "journal": {"volume": "4", "issn": "2046-2069", "issue": "6", "pages": "2892-2903", "title": "RSC Adv.", "issn-l": "2046-2069"}, "abstract": null, "doi": "10.1039/c3ra45553j", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T15:03:22.409Z", "modified": "2021-06-22T12:03:20.821Z"}, {"entity": "publication", "iuid": "48d66ee62a4f4124b685689730677039", "links": {"self": {"href": "https://publications.scilifelab.se/publication/48d66ee62a4f4124b685689730677039.json"}, "display": {"href": "https://publications.scilifelab.se/publication/48d66ee62a4f4124b685689730677039"}}, "title": "Photocatalysis induces bioactivity of an organic polymer based material", "authors": [{"family": "Cai", "given": "Yanling", "initials": "Y"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Engqvist", "given": "H\u00e5kan", "initials": "H"}, {"family": "Welch", "given": "Ken", "initials": "K"}], "type": "journal-article", "published": "2014-00-00", "journal": {"volume": "4", "issn": "2046-2069", "issue": "101", "pages": "57715-57723", "title": "RSC Adv.", "issn-l": "2046-2069"}, "abstract": null, "doi": "10.1039/c4ra08805k", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T15:03:22.943Z", "modified": "2021-06-22T12:00:20.086Z"}, {"entity": "publication", "iuid": "3d35797c784344df9c41fcae984d9812", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3d35797c784344df9c41fcae984d9812.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3d35797c784344df9c41fcae984d9812"}}, "title": "Disinfection Kinetics and Contribution of Reactive Oxygen Species When Eliminating Bacteria with TiO<sub>2</sub> Induced Photocatalysis", "authors": [{"family": "Cai", "given": "Yanling", "initials": "Y"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}, {"family": "Welch", "given": "Ken", "initials": "K"}], "type": "journal-article", "published": "2014-00-00", "journal": {"volume": "05", "issn": "2158-7027", "issue": "03", "pages": "200-209", "title": "JBNB", "issn-l": null}, "abstract": null, "doi": "10.4236/jbnb.2014.53024", "pmid": null, "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T15:03:21.870Z", "modified": "2021-06-22T12:03:40.898Z"}]}