{"entity": "journal", "iuid": "692559a227ef42a1a2a39646b48324b4", "timestamp": "2026-06-17T04:12:22.099Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Scand.%20J.%20Immunol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Scand.%20J.%20Immunol."}}, "title": "Scand. J. Immunol.", "issn": "1365-3083", "issn-l": "0300-9475", "publications_count": 10, "publications": [{"entity": "publication", "iuid": "43f2d1c1d2be4645ac8ecf2d7559b8b7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/43f2d1c1d2be4645ac8ecf2d7559b8b7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/43f2d1c1d2be4645ac8ecf2d7559b8b7"}}, "title": "Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma.", "authors": [{"family": "Qu", "given": "Heshuang", "initials": "H", "orcid": "0000-0001-6011-5588", "researcher": {"href": "https://publications.scilifelab.se/researcher/25c0b095647d4af39ccc62e357fed1c3.json"}}, {"family": "Neog", "given": "Manoj", "initials": "M"}, {"family": "Palmblad", "given": "Karin", "initials": "K"}, {"family": "Sundberg", "given": "Erik", "initials": "E"}, {"family": "L\u00f6vquist", "given": "Alexandra", "initials": "A"}, {"family": "Mel\u00e9n", "given": "Erik", "initials": "E", "orcid": "0000-0002-8248-0663", "researcher": {"href": "https://publications.scilifelab.se/researcher/3af5a23ba0a847778eea300f745cb143.json"}}, {"family": "Aulin", "given": "Cecilia", "initials": "C"}, {"family": "Harris", "given": "Helena Erlandsson", "initials": "HE"}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "102", "issue": "4", "pages": "e70055", "issn-l": "0300-9475"}, "abstract": "Oligoarticular juvenile idiopathic arthritis (oligoJIA) constitutes nearly 60% of all JIA cases. The immune mechanisms involved in the pathogenesis remain incompletely understood. Few proteomic studies have been performed using synovial fluid (SF) samples. We conducted an exploratory analysis of plasma and SF samples to define inflammatory profiles, assess plasma-SF correlation and examine longitudinal variations. Using proximity extension assay (PEA), we profiled 92 immune-related proteins in plasma and Sf from 14 oligoJIA patients (untreated or NSAID-treated) and plasma from 28 age and sex-matched healthy controls. Differentially expressed proteins were analysed using gene ontology (GO) and KEGG pathways via STRING. Plasma proteomic immune profiles from oligoJIA patients were highly overlapping with immune profiles of healthy donors. Six proteins were differentially expressed between the two groups. Overall, plasma and SF protein expressions correlated (r = 0.78), mainly driven by 13 proteins including CCL25, FGF21 and KITLG. However, the differentially expressed proteins in plasma did not correlate with those in SF. Longitudinal analysis of 20 SF and 10 plasma samples from one patient revealed immunosuppressive effects of methotrexate (MTX) with distinct kinetics in plasma and SF. Paired SF samples from five patients revealed that cell chemotaxis was a key feature in early disease, distinguishing it from the persistent phase. Immunoprofiling of SF from patients with oligoJIA identified more disease-relevant characteristics than analysis of plasma samples. Several proteins, but not all, correlated between plasma and SF. Early-phase enrichment of chemotaxis suggests that targeting chemokines may offer therapeutic potential for early disease remission.", "doi": "10.1111/sji.70055", "pmid": "41013715", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12475091"}], "notes": [], "created": "2025-11-24T22:14:09.393Z", "modified": "2025-11-24T22:14:09.654Z"}, {"entity": "publication", "iuid": "a321ba70d5a8449193a0b042ea632cc6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a321ba70d5a8449193a0b042ea632cc6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a321ba70d5a8449193a0b042ea632cc6"}}, "title": "Sex Dependent and Sj\u00f6gren Disease Like Immune Responses Against Phosphoantigens in Balb/C Mice.", "authors": [{"family": "Czwakiel", "given": "Paulina", "initials": "P"}, {"family": "Brindefalk", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Eghbali", "given": "Atiyeh", "initials": "A"}, {"family": "Dircksen", "given": "Heinrich", "initials": "H"}, {"family": "Kamal", "given": "Kahkashan", "initials": "K", "orcid": "0000-0003-0968-7454", "researcher": {"href": "https://publications.scilifelab.se/researcher/56449fc911fd48b98b207c394d635507.json"}}, {"family": "Payandeh", "given": "Zahra", "initials": "Z"}, {"family": "Ozata", "given": "Deniz", "initials": "D", "orcid": "0000-0001-5215-8684", "researcher": {"href": "https://publications.scilifelab.se/researcher/933850bed34c4517b01e915cf8831686.json"}}, {"family": "Troye-Blomberg", "given": "Marita", "initials": "M"}, {"family": "Faye", "given": "Ingrid", "initials": "I", "orcid": "0000-0003-4382-7238", "researcher": {"href": "https://publications.scilifelab.se/researcher/28e762d6a5a845e79a7a107f700a82b5.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "102", "issue": "3", "pages": "e70052", "issn-l": "0300-9475"}, "abstract": "The initial aim of this study on Balb/C mice was to investigate the putative effects on feeding and appetite of isopentenyl pyrophosphate (IPP) and E-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), also known as phosphoantigens (pAgs). HMBPP was recently shown to increase blood meal appetite in malaria mosquitoes. Both IPP and HMBPP are metabolites produced by the normal gut microbiota and apicomplexan parasites such as Plasmodium. To explore potential effects on appetite, male and female mice were treated by gavage with these metabolites, and body mass and gene expression were monitored in brain, stomach and small intestine at 3 h and 7 weeks. Body mass gain did not clearly differ between pAg-treated and water control mice. However, beginning between 4 and 7 weeks, the salivary glands of IPP-treated males began to swell. With the autoimmune Sj\u00f6gren disease (SjD) in mind, we subsequently investigated the salivary glands after 1, 4 and 7 weeks of IPP treatment. Fast gene set enrichment analysis (FGSEA) of marginal zone B-cell (MZB) transcripts from salivary glands, together with B-cell infiltration in both sexes at 4 weeks, suggested similarities to SjD pathology. Using ELISA, we measured serum autoantibodies against Ro52, Ro60 and La. Multivariate analysis at 7 weeks showed treatment-associated trends: levels of anti-Ro52 and anti-La tended to increase in IPP-treated males, but not in females. Notably, IL-6 serum levels displayed a sex-dependent pattern, and PCA analyses of transcriptomic data from brain, stomach and small intestine-though with some exceptions-also indicated differential responses to pAgs between males and females.", "doi": "10.1111/sji.70052", "pmid": "40898584", "labels": {"Autoimmunity and Serology Profiling": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12405675"}], "notes": [], "created": "2025-09-10T08:38:36.714Z", "modified": "2025-11-07T07:24:59.576Z"}, {"entity": "publication", "iuid": "fcdd1bf8581f4524b781381b94a66ef9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fcdd1bf8581f4524b781381b94a66ef9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fcdd1bf8581f4524b781381b94a66ef9"}}, "title": "Evaluating IL1RA-Autoantibodies Across SARS-CoV-2-Related Diseases.", "authors": [{"family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c155029e86d458cad39ed4c2670c880.json"}}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Cederholm", "given": "Axel", "initials": "A"}, {"family": "Cavalli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1143-1431", "researcher": {"href": "https://publications.scilifelab.se/researcher/e35211c06385459baee12101121d2a15.json"}}, {"family": "Yalcinkaya", "given": "Ahmet", "initials": "A"}, {"family": "COVID\u2010HGE", "given": "", "initials": ""}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bcef4c205904e5db9e36f3aadaa13bb.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Wadelius", "given": "Mia", "initials": "M"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "letter", "published": "2025-07-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "102", "issue": "1", "pages": "e70039", "issn-l": "0300-9475"}, "abstract": null, "doi": "10.1111/sji.70039", "pmid": "40556349", "labels": {"Autoimmunity and Serology Profiling": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12188108"}], "notes": [], "created": "2025-09-10T08:20:51.920Z", "modified": "2025-09-10T08:20:52.252Z"}, {"entity": "publication", "iuid": "9322d91734fa4ade8db29e7f933c0ac0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9322d91734fa4ade8db29e7f933c0ac0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9322d91734fa4ade8db29e7f933c0ac0"}}, "title": "The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.", "authors": [{"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications.scilifelab.se/researcher/54d696167bca4a389807143f84baeafe.json"}}, {"family": "Ask", "given": "Eivind Heggernes", "initials": "EH", "orcid": "0000-0001-8655-1433", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4a3a0f566a342db89c54b87a50d5e5b.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Strunz", "given": "Benedikt", "initials": "B"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Rao Muvva", "given": "Jagadeeswara", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bdd56cf648f4411945163135f9a7140.json"}}, {"family": "Cuapio", "given": "Angelica", "initials": "A", "orcid": "0000-0002-9451-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/8391879473274bc1b14b3f8fea7f9fc9.json"}}, {"family": "Dzidic", "given": "Majda", "initials": "M"}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M"}, {"family": "Garcia", "given": "Marina", "initials": "M"}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Hertwig", "given": "Laura", "initials": "L"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Kvedaraite", "given": "Egle", "initials": "E"}, {"family": "Lourda", "given": "Magda", "initials": "M"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Maucourant", "given": "Christopher", "initials": "C"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A"}, {"family": "Palma Medina", "given": "Laura M", "initials": "LM"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A"}, {"family": "Ponzetta", "given": "Andrea", "initials": "A"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Rooyackers", "given": "Olav", "initials": "O"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Sandberg", "given": "J Tyler", "initials": "JT"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e3185cf86534a96983b39dd93df454a.json"}}, {"family": "Varnaite", "given": "Renata", "initials": "R"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Karolinska KI/K COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Malmberg", "given": "Karl-Johan", "initials": "KJ"}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}], "type": "journal article", "published": "2022-06-02", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "pages": "e13195", "issn-l": "0300-9475"}, "abstract": "The Karolinska KI/K COVID-19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS-CoV-2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS-CoV-2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined na\u00efve patient-groups as they presented with moderate and severe COVID-19 disease. The present Resource Article describes how the Karolinska KI/K COVID-19 Immune Atlas allow scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS-CoV-2 infection in an online setting.", "doi": "10.1111/sji.13195", "pmid": "35652743", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9287045"}], "notes": [], "created": "2022-11-16T17:15:26.201Z", "modified": "2022-11-16T17:15:26.261Z"}, {"entity": "publication", "iuid": "84851b50878d4f5b85ea8fb5174a680f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/84851b50878d4f5b85ea8fb5174a680f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/84851b50878d4f5b85ea8fb5174a680f"}}, "title": "Screening for autoantibody targets in post-vaccination narcolepsy using proteome arrays.", "authors": [{"family": "Lind", "given": "Alexander", "initials": "A", "orcid": "0000-0002-1473-5468", "researcher": {"href": "https://publications.scilifelab.se/researcher/e6124e404ef349dc8d687838cb8eaf92.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D"}, {"family": "Akel", "given": "Omar", "initials": "O"}, {"family": "Ramelius", "given": "Anita", "initials": "A"}, {"family": "Palm", "given": "Lars", "initials": "L"}, {"family": "Lernmark", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O"}, {"family": "Elding Larsson", "given": "Helena", "initials": "H"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "journal article", "published": "2020-04-00", "journal": {"volume": "91", "issn": "1365-3083", "issue": "4", "pages": "e12864", "title": "Scand. J. Immunol.", "issn-l": "0300-9475"}, "abstract": "Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a specific loss of hypocretin-producing neurons. The incidence of NT1 increased in Sweden, Finland and Norway following Pandemrix\u00ae-vaccination, initiated to prevent the 2009 influenza pandemic. The pathogenesis of NT1 is poorly understood, and causal links to vaccination are yet to be clarified. The strong association with Human leukocyte antigen (HLA) DQB1*06:02 suggests an autoimmune pathogenesis, but proposed autoantigens remain controversial. We used a two-step approach to identify autoantigens in patients that acquired NT1 after Pandemrix\u00ae-vaccination. Using arrays of more than 9000 full-length human proteins, we screened the sera of 10 patients and 24 healthy subjects for autoantibodies. Identified candidate antigens were expressed in vitro to enable validation studies with radiobinding assays (RBA). The validation cohort included NT1 patients (n = 39), their first-degree relatives (FDR) (n = 66), population controls (n = 188), and disease controls representing multiple sclerosis (n = 100) and FDR to type 1 diabetes patients (n = 41). Reactivity towards previously suggested NT1 autoantigen candidates including Tribbles homolog 2, Prostaglandin D2 receptor, Hypocretin receptor 2 and \u03b1-MSH/proopiomelanocortin was not replicated in the protein array screen. By comparing case to control signals, three novel candidate autoantigens were identified in the protein array screen; LOC401464, PARP3 and FAM63B. However, the RBA did not confirm elevated reactivity towards either of these proteins. In summary, three putative autoantigens in NT1 were identified by protein array screening. Autoantibodies against these candidates could not be verified with independent methods. Further studies are warranted to identify hypothetical autoantigens related to the pathogenesis of Pandemrix\u00ae-induced NT1.", "doi": "10.1111/sji.12864", "pmid": "32056243", "labels": {"Autoimmunity and Serology Profiling": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2020-02-21T15:13:34.020Z", "modified": "2024-01-16T13:48:42.689Z"}, {"entity": "publication", "iuid": "a852a8219c1844f9b9253f6acad4b36c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a852a8219c1844f9b9253f6acad4b36c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a852a8219c1844f9b9253f6acad4b36c"}}, "title": "Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.", "authors": [{"family": "Tang", "given": "Quan", "initials": "Q", "orcid": "0000-0003-4169-577X", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e15598b827d40d095efd0ee09a3691f.json"}}, {"family": "Ramsk\u00f6ld", "given": "Daniel", "initials": "D"}, {"family": "Krystufkova", "given": "Olga", "initials": "O"}, {"family": "Mann", "given": "Herman F", "initials": "HF"}, {"family": "Wick", "given": "Cecilia", "initials": "C"}, {"family": "Dastmalchi", "given": "Maryam", "initials": "M"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications.scilifelab.se/researcher/92e81aa6b0cf4ff0a18b14098bf0fcc1.json"}}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mikes", "given": "Jaromir", "initials": "J"}, {"family": "Alexanderson", "given": "Helene", "initials": "H"}, {"family": "Achour", "given": "Adnane", "initials": "A"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}, {"family": "Vencovsky", "given": "Jiri", "initials": "J"}, {"family": "Lundberg", "given": "Ingrid E", "initials": "IE"}, {"family": "Malmstr\u00f6m", "given": "Vivianne", "initials": "V"}], "type": "journal article", "published": "2019-01-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "issn-l": "0300-9475", "volume": "89", "issue": "1", "pages": "e12732"}, "abstract": "We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub-study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs before and after 6-month abatacept treatment were included in this sub-study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real-life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment-specific changes. We therefore conclude that studies of patient cohorts displaying wide clinical heterogeneity using mass cytometry must be relatively large in order to be suited for discovery research and immune monitoring. Still, we did find some correlations with functional muscle outcome, namely positive correlations between the ratio of CD4+ T cells and CD8+ T cells (CD4/CD8) in peripheral blood samples both at baseline and after treatment with muscle endurance improvement as assessed by the functional index-2 (FI-2) test. Our data suggest that the CD4/CD8 ratio in circulation at time of active disease may be a predictor of treatment efficacy in myositis patients.", "doi": "10.1111/sji.12732", "pmid": "30451307", "labels": {"Cellular Immunomonitoring": "Collaborative", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2018-11-26T22:15:12.272Z", "modified": "2024-01-16T13:48:44.927Z"}, {"entity": "publication", "iuid": "f25799db31874a55adf3d174418bff26", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f25799db31874a55adf3d174418bff26.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f25799db31874a55adf3d174418bff26"}}, "title": "Transcription profiling of peripheral B cells in antibody-positive primary Sj\u00f6gren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature.", "authors": [{"family": "Imgenberg-Kreuz", "given": "J", "initials": "J", "orcid": "0000-0002-7230-8990", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d4c2f630d484ee780c2c12aaabdb939.json"}}, {"family": "Sandling", "given": "J K", "initials": "JK"}, {"family": "Bj\u00f6rk", "given": "A", "initials": "A"}, {"family": "Nordlund", "given": "J", "initials": "J", "orcid": "0000-0001-8699-9959", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddf48c9262134821bcc6ce1180049753.json"}}, {"family": "Kvarnstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Eloranta", "given": "M-L", "initials": "ML"}, {"family": "R\u00f6nnblom", "given": "L", "initials": "L"}, {"family": "Wahren-Herlenius", "given": "M", "initials": "M", "orcid": "0000-0002-0915-7245", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8451e7f5e6e4e4da0bace3dfafaeb38.json"}}, {"family": "Syv\u00e4nen", "given": "A-C", "initials": "AC", "orcid": "0000-0002-9681-9146", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7012e35025543379380cb90efd71243.json"}}, {"family": "Nordmark", "given": "G", "initials": "G", "orcid": "0000-0002-3829-7431", "researcher": {"href": "https://publications.scilifelab.se/researcher/188fda53498740dbb007441cc94bb1ad.json"}}], "type": "journal article", "published": "2018-05-00", "journal": {"volume": "87", "issn": "1365-3083", "issue": "5", "pages": "e12662", "title": "Scand. J. Immunol.", "issn-l": "0300-9475"}, "abstract": "B cells play a key role in the pathogenesis of primary Sj\u00f6gren's syndrome (pSS). The aim of this study was to analyse the transcriptome of CD19+ B cells from patients with pSS and healthy controls to decipher the B cell-specific contribution to pSS. RNA from purified CD19+ B cells from 12 anti-SSA antibody-positive untreated female patients with pSS and 20 healthy blood donors was subjected to whole transcriptome sequencing. A false discovery rate corrected significance threshold of \u03b1 < 0.05 was applied to define differential gene expression. As validation, gene expression in B cells from 17 patients with pSS and 16 healthy controls was analysed using a targeted gene panel. RNA-sequencing identified 4047 differentially expressed autosomal genes in pSS B cells. Upregulated expression of type I and type II interferon (IFN)-induced genes was observed, establishing an IFN signature in pSS B cells. Among the top upregulated and validated genes were CX3CR1, encoding the fractalkine receptor involved in regulation of B-cell malignancies, CCL5/RANTES and CCR1. Increased expression of several members of the TNF superfamily was also identified; TNFSF4/Ox40L, TNFSF10/TRAIL, TNFSF13B/BAFF, TNFRSF17/BCMA as well as S100A8 and -A9/calprotectin, TLR7, STAT1 and STAT2. Among genes with downregulated expression in pSS B cells were SOCS1 and SOCS3, CD70 and TNFAIP3/A20. We conclude that B cells from patients with anti-SSA antibody-positive pSS display immune activation with upregulated expression of chemokines, chemokine receptors and a prominent type I and type II IFN signature, while suppressors of cytokine signalling are downregulated. This adds insight into the autoimmune process and suggests potential targets for future functional studies.", "doi": "10.1111/sji.12662", "pmid": "29655283", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2018-05-03T11:10:51.391Z", "modified": "2024-01-16T13:48:46.360Z"}, {"entity": "publication", "iuid": "d156d94896ef42ec85ebfcebe517ee2d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d156d94896ef42ec85ebfcebe517ee2d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d156d94896ef42ec85ebfcebe517ee2d"}}, "title": "The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.", "authors": [{"family": "Ganesan", "given": "S", "initials": "S"}, {"family": "Luu", "given": "T T", "initials": "TT"}, {"family": "Chambers", "given": "B J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications.scilifelab.se/researcher/3bdd56cf648f4411945163135f9a7140.json"}}, {"family": "Meinke", "given": "S", "initials": "S"}, {"family": "Brodin", "given": "P", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}, {"family": "Vivier", "given": "E", "initials": "E"}, {"family": "Wetzel", "given": "D M", "initials": "DM"}, {"family": "Koleske", "given": "A J", "initials": "AJ"}, {"family": "Kadri", "given": "N", "initials": "N"}, {"family": "H\u00f6glund", "given": "P", "initials": "P", "orcid": "0000-0002-9233-626X", "researcher": {"href": "https://publications.scilifelab.se/researcher/d7c852c7cc0043b88fa096adf6af92dd.json"}}], "type": "journal article", "published": "2017-09-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "issn-l": "0300-9475", "volume": "86", "issue": "3", "pages": "135-142"}, "abstract": "Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function via disruption of a signalling complex including C3G and c-Cbl, suggesting that NK cell education might involve c-Abl. Mice deficient in c-Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires. Furthermore, c-Abl-deficient NK cells fluxed Ca2+ normally after triggering of ITAM receptors, killed YAC-1 tumour cells efficiently and showed normal, or even slightly elevated, capacity to produce IFN-\u03b3 after activating receptor stimulation. Consistent with these results, c-Abl deficiency in NK cells did not affect NK cell inhibition via the receptors Ly49G2, Ly49A and NKG2A. We conclude that signalling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse.", "doi": "10.1111/sji.12574", "pmid": "28605050", "labels": {"Cellular Immunomonitoring": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC5568956"}, {"db": "mid", "key": "NIHMS883530"}], "notes": [], "created": "2019-03-25T19:56:43.705Z", "modified": "2023-11-28T12:55:14.127Z"}, {"entity": "publication", "iuid": "929ca1f20c3e488aa09c34cafec9ade2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/929ca1f20c3e488aa09c34cafec9ade2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/929ca1f20c3e488aa09c34cafec9ade2"}}, "title": "Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.", "authors": [{"family": "Orhan", "given": "F", "initials": "F"}, {"family": "Bhat", "given": "M", "initials": "M"}, {"family": "Sandberg", "given": "K", "initials": "K", "orcid": "0000-0002-6395-6590", "researcher": {"href": "https://publications.scilifelab.se/researcher/2747d3fe7810406fafc429d9e66225ef.json"}}, {"family": "St\u00e5hl", "given": "S", "initials": "S"}, {"family": "Piehl", "given": "F", "initials": "F"}, {"family": "Karolinska Schizophrenia Project (KaSP) consortium", "given": "", "initials": ""}, {"family": "Svensson", "given": "C", "initials": "C"}, {"family": "Erhardt", "given": "S", "initials": "S"}, {"family": "Schwieler", "given": "L", "initials": "L"}], "type": "journal article", "published": "2016-11-00", "journal": {"volume": "84", "issn": "1365-3083", "issue": "5", "pages": "262-271", "title": "Scand. J. Immunol.", "issn-l": "0300-9475"}, "abstract": "Tryptophan degradation along the kynurenine pathway is of central importance for the immune function. Toll-like receptors (TLRs), representing the first line of immune defence against pathogens, are expressed in various cell types. The most abundant expression is found on monocytes, macrophages and dendritic cells. The aim of this study was to investigate whether stimulation with different TLR ligands induces the kynurenine pathway in human peripheral monocytes. Cell supernatants were analysed using a liquid chromatography/mass spectrometry to measure kynurenine, kynurenic acid (KYNA), quinolinic acid (QUIN) and tryptophan. Stimulation of TLR-2, TLR-3, TLR-4, TLR-7/8 and TLR-9 was found to induce the production of kynurenine, but only stimulation of TLR-3 increased levels of further downstream metabolites, such as KYNA and QUIN. Stimulation of TLR-1, TLR-5 and TLR-6 did not induce the kynurenine pathway. Taken together, this study provides novel evidence demonstrating that TLR activation induces a pattern of downstream tryptophan degradation along the kynurenine pathway in monocytes. The results of this study may implicate that TLRs can be used as new drug targets for the regulation of aberrant tryptophan metabolism along this pathway, a potential therapeutic strategy that may be of importance in several disorders.", "doi": "10.1111/sji.12479", "pmid": "27607184", "labels": {"Drug Discovery and Development": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-08T07:56:42.215Z", "modified": "2025-10-17T13:05:09.140Z"}, {"entity": "publication", "iuid": "2a7cc31b9e5c4010a13eeec2c183d3af", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2a7cc31b9e5c4010a13eeec2c183d3af.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2a7cc31b9e5c4010a13eeec2c183d3af"}}, "title": "Association of genes in the NF-\u03baB pathway with antibody-positive primary Sj\u00f6gren's syndrome.", "authors": [{"family": "Nordmark", "given": "Gunnel", "initials": "G"}, {"family": "Wang", "given": "Chuan", "initials": "C"}, {"family": "Vasaitis", "given": "Lilian", "initials": "L"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Theander", "given": "Elke", "initials": "E"}, {"family": "Kvarnstr\u00f6m", "given": "Marika", "initials": "M"}, {"family": "Forsblad-d'Elia", "given": "Helena", "initials": "H"}, {"family": "Jazebi", "given": "Helmi", "initials": "H"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C"}, {"family": "Reksten", "given": "Tove Ragna", "initials": "TR"}, {"family": "Brun", "given": "Johan G", "initials": "JG"}, {"family": "Jonsson", "given": "Malin V", "initials": "MV"}, {"family": "Johnsen", "given": "Svein J", "initials": "SJ"}, {"family": "Wahren-Herlenius", "given": "Marie", "initials": "M"}, {"family": "Omdal", "given": "Roald", "initials": "R"}, {"family": "Jonsson", "given": "Roland", "initials": "R"}, {"family": "Bowman", "given": "Simon", "initials": "S"}, {"family": "Ng", "given": "Wan-Fai", "initials": "WF"}, {"family": "Eloranta", "given": "Maija-Leena", "initials": "ML"}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC", "orcid": "0000-0002-9681-9146", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7012e35025543379380cb90efd71243.json"}}, {"family": "UK Primary Sj\u00f6gren\u2019s Syndrome Registry", "given": null, "initials": null}], "type": "journal article", "published": "2013-11-00", "journal": {"volume": "78", "issn": "1365-3083", "issue": "5", "pages": "447-454", "title": "Scand. J. Immunol.", "issn-l": "0300-9475"}, "abstract": "Primary Sj\u00f6gren's syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-\u03baB in primary SS. NF-\u03baB activation results in inflammation and autoimmunity and is regulated by inhibitory and activating proteins. Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-\u03baB and of IKBKE (IKK\u03b5), which is an NF-\u03baB activator. The aim of this study was to analyse single nucleotide polymorphisms (SNPs) in the IKBKE, NFKB1, TNIP1 and TNFAIP3 genes for association with primary SS. A total of 12 SNPs were genotyped in 1105 patients from Scandinavia (Sweden and Norway, n = 684) and the UK (n = 421) and 4460 controls (Scandinavia, n = 1662, UK, n = 2798). When patients were stratified for the presence of anti-SSA and/or anti-SSB antibodies (n = 868), case-control meta-analysis found an association between antibody-positive primary SS and two SNPs in TNIP1 (P = 3.4 \u00d7 10(-5) , OR = 1.33, 95%CI: 1.16-1.52 for rs3792783 and P = 1.3 \u00d7 10(-3) , OR = 1.21, 95%CI: 1.08-1.36 for rs7708392). A TNIP1 risk haplotype was associated with antibody-positive primary SS (P = 5.7 \u00d7 10(-3) , OR = 1.47, 95%CI: 1.12-1.92). There were no significant associations with IKBKE, NFKB1 or TNFAIP3 in the meta-analysis of the Scandinavian and UK cohorts. We conclude that polymorphisms in TNIP1 are associated with antibody-positive primary SS.", "doi": "10.1111/sji.12101", "pmid": "23944604", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T15:01:30.803Z", "modified": "2021-07-07T15:11:02.362Z"}], "created": "2017-05-09T09:12:17.145Z", "modified": "2020-11-27T13:14:02.144Z"}