{"entity": "journal", "iuid": "e757323dd8fe484995d04db7a9b36044", "timestamp": "2026-07-17T05:48:44.108Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Radiat%20Prot%20Dosimetry.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Radiat%20Prot%20Dosimetry"}}, "title": "Radiat Prot Dosimetry", "issn": "1742-3406", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "2339d2c2c2bf4b31a3d99eb35eeb5f9d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2339d2c2c2bf4b31a3d99eb35eeb5f9d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2339d2c2c2bf4b31a3d99eb35eeb5f9d"}}, "title": "Early proteomic response in thyroid gland after 131I administration in female Balb/c mice.", "authors": [{"family": "Rudqvist", "given": "Nils", "initials": "N"}, {"family": "Spetz", "given": "Johan", "initials": "J"}, {"family": "Sch\u00fcler", "given": "Emil", "initials": "E"}, {"family": "Parris", "given": "Toshima Z", "initials": "TZ"}, {"family": "Langen", "given": "Britta", "initials": "B"}, {"family": "Wallem", "given": "Carina Sihlbom", "initials": "CS"}, {"family": "Helou", "given": "Khalil", "initials": "K"}, {"family": "Forssell-Aronsson", "given": "Eva", "initials": "E", "orcid": "0000-0002-7558-4368", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec65c90d3c3b45e6b51e5609b21398e4.json"}}], "type": "journal article", "published": "2025-08-26", "journal": {"title": "Radiat Prot Dosimetry", "issn": "1742-3406", "volume": "201", "issue": "13-14", "pages": "887-898", "issn-l": null}, "abstract": "131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Data are available via ProteomeXchange with identifier PXD062861. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.", "doi": "10.1093/rpd/ncaf057", "pmid": "40875264", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12392886"}, {"db": "pii", "key": "8242649"}], "notes": [], "created": "2025-10-23T09:43:48.982Z", "modified": "2025-10-23T11:16:25.310Z"}, {"entity": "publication", "iuid": "de5a12f60a4f4c3187b8e9c6307307e2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/de5a12f60a4f4c3187b8e9c6307307e2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/de5a12f60a4f4c3187b8e9c6307307e2"}}, "title": "Short and long-term effects on the thyroid proteome after 131I exposure.", "authors": [{"family": "Bj\u00f6rk", "given": "Klara Insulander", "initials": "KI", "orcid": "0000-0002-8092-0389", "researcher": {"href": "https://publications.scilifelab.se/researcher/867f975e286142a2b97663e099d168fc.json"}}, {"family": "Langen", "given": "Britta", "initials": "B"}, {"family": "Schroff", "given": "Anja", "initials": "A"}, {"family": "Shubbar", "given": "Emman", "initials": "E"}, {"family": "Helou", "given": "Khalil", "initials": "K"}, {"family": "Spetz", "given": "Johan", "initials": "J"}, {"family": "Forssell-Aronsson", "given": "Eva", "initials": "E", "orcid": "0000-0002-7558-4368", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec65c90d3c3b45e6b51e5609b21398e4.json"}}], "type": "journal article", "published": "2025-08-26", "journal": {"title": "Radiat Prot Dosimetry", "issn": "1742-3406", "volume": "201", "issue": "13-14", "pages": "919-933", "issn-l": null}, "abstract": "131I is recognised, both for its significance in nuclear medicine, and for its association with a rise in paediatric but not adult thyroid cancer cases following the Chornobyl accident. However, the detailed radiobiological mechanisms underlying 131I effects on the thyroid remain unknown to date. In the present study, 1 kBq or 100 kBq 131I was administered to mice that were euthanised after 48 h, 3 weeks or 6 months. Thyroid glands were surgically removed, and proteins were extracted and analysed by tandem mass spectrometry. On a group-level, the results showed few alterations in protein abundance, mainly linked to RNA metabolism and DNA damage response. However, individual analysis of protein abundance changes in each animal showed distinct findings suggesting inhibited proliferation in a few individuals across various exposure levels and time points. Future studies should involve larger animal groups to better assess the frequency and variability of proteomic radiation responses.", "doi": "10.1093/rpd/ncaf073", "pmid": "40875266", "labels": {"Glycoproteomics and MS Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12392893"}, {"db": "pii", "key": "8242651"}], "notes": [], "created": "2025-11-20T18:09:02.602Z", "modified": "2025-11-20T18:09:02.814Z"}], "created": "2025-10-23T09:43:49.109Z", "modified": "2025-10-23T09:43:49.109Z"}