{"entity": "journal", "iuid": "6152503766d14ebda3c166e4004d2516", "timestamp": "2026-07-17T08:17:05.098Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Psychoneuroendocrinology.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Psychoneuroendocrinology"}}, "title": "Psychoneuroendocrinology", "issn": "1873-3360", "issn-l": "0306-4530", "publications_count": 8, "publications": [{"entity": "publication", "iuid": "ae85f675fd00425e8cda03e983022214", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ae85f675fd00425e8cda03e983022214.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ae85f675fd00425e8cda03e983022214"}}, "title": "Associations between sickness behavior, but not inflammatory cytokines, and psychiatric comorbidity in chronic pain.", "authors": [{"family": "\u00c5str\u00f6m Reitan", "given": "Jenny L M", "initials": "JLM"}, {"family": "Karshikoff", "given": "Bianka", "initials": "B"}, {"family": "Holmstr\u00f6m", "given": "Linda", "initials": "L"}, {"family": "Lekander", "given": "Mats", "initials": "M"}, {"family": "Kemani", "given": "Mike K", "initials": "MK"}, {"family": "Wicksell", "given": "Rikard K", "initials": "RK"}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "167", "pages": "107094", "issn-l": "0306-4530"}, "abstract": "Approximately one in five adults experiences chronic pain, often in co-occurrence with depression, insomnia, anxiety, and lower self-rated health. Elevated levels of cytokines, e.g. tumor necrosis factor alpha (TNF-\u03b1), interleukin 6 (IL-6), interleukin 8 (IL-8), and interleukin 10 (IL-10), have been identified in patients with chronic pain. Depression, insufficient sleep, poor self-rated health, and pain intensity have also been associated with inflammatory biomarkers. This study aimed to investigate the interrelationships between inflammatory biomarkers and depression, insomnia, anxiety, self-rated health, sickness behavior, and pain intensity in patients with chronic pain.\n\nSelf-report questionnaires and blood samples analyzed for plasma levels of inflammatory biomarkers were collected from 80 adult patients with chronic pain. Associations between inflammatory biomarkers (TNF-\u03b1, IL-6, IL-8, IL-10, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR)) and depression, insomnia, anxiety, self-rated health, sickness behavior, and pain intensity, were analyzed using bivariate Spearman rank correlation coefficients and regression analyses.\n\nParticipants were mainly women (72.5 %), with a mean age of 50.8 years, and a reported mean pain duration of 16.7 years. There were significant correlations between insomnia and CRP (rs =.26, p <.05); sex and ESR (rs =.29, p <.05); age and IL-6 (rs =.29, p <.05) and IL-8 (rs =.30, p <.05); BMI and IL-6 (rs =.50, p <.001), CRP (rs =.63, p <.001) and ESR (rs =.42, p <.001). Ratings of depression were positively and significantly related to ratings of sickness behavior and anxiety (\u03b2 =.32 and \u03b2 =.40, respectively), explaining 49 % of the total variance in depression ratings. Insomnia was positively and significantly related to sickness behavior (\u03b2 =.37) explaining 31 % of the total variance in insomnia ratings. Inflammatory biomarkers, however, did not contribute significantly to the models.\n\nParticipants reported high levels of symptoms, yet the associations between these ratings and the inflammatory biomarkers were either absent or weak. Also, despite high levels of self-reported sickness behavior, overall the inflammatory status remained within the normal range. Ratings of sickness behavior contributed more than inflammatory markers in explaining ratings of depression and insomnia. The present results point to the complexity of chronic pain, and the challenges of identifying biomarkers that explain symptomatology.", "doi": "10.1016/j.psyneuen.2024.107094", "pmid": "38896989", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "S0306-4530(24)00138-0"}], "notes": [], "created": "2024-11-27T22:22:27.030Z", "modified": "2024-11-27T22:22:27.034Z"}, {"entity": "publication", "iuid": "e632f026baa44e0e80541b5040017234", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e632f026baa44e0e80541b5040017234.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e632f026baa44e0e80541b5040017234"}}, "title": "HPA-axis dysregulation is not associated with accelerated epigenetic aging in patients with hypersexual disorder.", "authors": [{"family": "Bostr\u00f6m", "given": "Adrian Desai E", "initials": "ADE"}, {"family": "Andersson", "given": "Peter", "initials": "P"}, {"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "Savard", "given": "Josephine", "initials": "J"}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M"}, {"family": "\u00d6berg", "given": "Katarina G", "initials": "KG"}, {"family": "Arver", "given": "Stefan", "initials": "S"}, {"family": "Jokinen", "given": "Jussi", "initials": "J"}], "type": "journal article", "published": "2022-04-14", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "141", "pages": "105765", "issn-l": "0306-4530"}, "abstract": "Hypersexual disorder (HD) - a nonparaphilic sexual desire disorder with impulsivity component - was evaluated for inclusion as a diagnosis in the DSM-5 and the diagnosis compulsive sexual behavior disorder is included as an impulse control disorder in the ICD-11. Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity is believed to affect cellular senescence and has been implicated in HD. No previous study investigated HD or HPA-axis dysregulation in relation to measures of epigenetic age (EA) acceleration.\n\nThis study reports on a case-control study set-up from a well-characterized cohort, contrasting EA predictors in relation to 60 HD patients and 33 healthy volunteers (HV) and 19 mixed HD/HV exhibiting dexamethasone suppression test (DST) non-suppression to 73 mixed HD/HV DST controls. The genome-wide methylation pattern was measured in whole blood from 94 subjects using the Illumina Infinium Methylation EPIC BeadChip and preprocessed according to specialized protocols suitable for epigenetic age estimation. The online DNAm Age Calculator (https://dnamage.\n\nucla.edu/) was implemented to retrieve various EA predictors, which were compared between the in-silico generated subgroups.\n\nQuality control analyses indicated strong correlations between the EA measure DNA methylation GrimAge (DNAm GrimAge - the EA clock most reliably associated with mortality risk) and chronological age in all sub-groups. The study was adequately powered to detect differences of 2.5 and 3.0 years in DNAm GrimAge minus age in relation to both HD and HPA-axis dysregulation, respectively. Baseline DNAm GrimAge exceeded chronological age by 2.8 years on average across all samples. No EA acceleration marker was associated with HD or DST suppression status (p > 0.05).\n\nEA acceleration markers shown to be strongly predictive of physiological dysregulation and mortality-risk, are not related to HD or DST non-suppression status (measured after 0.5 mg dexamethasone). The independency of HPA-axis dysregulation to EA acceleration does not support the biological relevance of this dosage-regimen when applied to patients with HD. These findings do not support the notion of accelerated cellular senescence in HD. Studies stratifying DST non-suppressors according to established dosage-regimens in somatic settings are needed to fully elucidate the putative contribution of HPA-axis dysregulation to EA.", "doi": "10.1016/j.psyneuen.2022.105765", "pmid": "35452872", "labels": {"National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "S0306-4530(22)00106-8"}], "notes": [], "created": "2022-05-06T10:18:10.293Z", "modified": "2022-05-06T10:18:10.339Z"}, {"entity": "publication", "iuid": "7c2dbf0e2d434e6187454643c879f6e3", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7c2dbf0e2d434e6187454643c879f6e3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7c2dbf0e2d434e6187454643c879f6e3"}}, "title": "Pregnancy-related hormones and COMT genotype: Associations with maternal working memory.", "authors": [{"family": "Amiel Castro", "given": "Rita", "initials": "R"}, {"family": "Kunovac Kallak", "given": "Theodora", "initials": "T"}, {"family": "Sundstr\u00f6m Poromaa", "given": "Inger", "initials": "I"}, {"family": "Willebrand", "given": "Mimmie", "initials": "M"}, {"family": "Lager", "given": "Susanne", "initials": "S"}, {"family": "Ehlert", "given": "Ulrike", "initials": "U"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "issn-l": "0306-4530", "volume": "132", "issue": null, "pages": "105361"}, "abstract": "Women experience different degrees of subjective cognitive changes during pregnancy. The exact mechanism underlying these changes is unknown, although endocrine alterations and genetics may be contributing factors. We investigated whether multiple pregnancy-related hormones were associated with working memory function assessed with the Digit Span Test (DST) in late pregnancy. Moreover, we examined whether the catechol-O-methyltransferase (COMT) genotype, previously related to working memory, was an effect modifier in this association. In this population-based panel study, we recorded psychiatric history, medication use, socio-demographic characteristics, and psychological well-being, gathered blood and saliva samples, and administered the DST at gestational weeks 35-39 (N = 216). We conducted multivariate linear regressions with DST as outcome, with different hormones and COMT genotype, adjusting for covariates including maternal age, BMI, education, depressive symptoms, and parity. We repeated these analyses excluding women with elevated depressive symptoms. Higher DST total scores were associated with increased free estradiol concentrations (B = 0.01, p = 0.03; B = 0.01, p = 0.02) in all participants and in participants without depressive symptoms, respectively, whereas DST forward was positively associated with free estradiol only in women without depressive symptoms (B = 0.01, p = 0.04). Lower total testosterone concentrations (B = -0.03, p = 0.01) enhanced DST backward performance in non-depressed women. Maternal higher education was significantly associated with the DST subscales in all participants. No significant differences emerged when considering the COMT genotype. Our results suggest differential associations of free estradiol and total testosterone levels with working memory function in late pregnancy.", "doi": "10.1016/j.psyneuen.2021.105361", "pmid": "34333317", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0306-4530(21)00235-3"}], "notes": [], "created": "2021-08-19T13:41:30.271Z", "modified": "2024-01-16T13:48:38.347Z"}, {"entity": "publication", "iuid": "85d8f32e7cb3417891304b576027fd87", "links": {"self": {"href": "https://publications.scilifelab.se/publication/85d8f32e7cb3417891304b576027fd87.json"}, "display": {"href": "https://publications.scilifelab.se/publication/85d8f32e7cb3417891304b576027fd87"}}, "title": "Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.", "authors": [{"family": "Just", "given": "David", "initials": "D"}, {"family": "Rasmusson", "given": "Annica J", "initials": "AJ"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Noreland", "given": "Maria", "initials": "M"}, {"family": "Malmstr\u00f6m", "given": "Emma", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Psychoneuroendocrinology", "issn": "1873-3360", "volume": "126", "pages": "105162", "issn-l": "0306-4530"}, "abstract": "Growing evidence implies interactions between infections, the immune system and vulnerability for psychiatric disease. This study applies an affinity proteomic-based method to investigate potential disease associated autoantibody signatures in serum from patients from the \"Young Adults\" section of the Department of General Psychiatry at Uppsala University Hospital (n = 395) and population-based controls (n = 102). We found serum levels of antibodies against Lipopolysaccharide Binding Protein (LBP), a protein that is important for mediating innate immune responses involving the toll-like receptor-4 (TLR-4), to be higher in patients compared to controls (Mann Whitney U-test p = 5.248 \u00d7 10-10). The patients were divided into three groups based on their relative levels of autoantibodies against LBP. The distribution of autism spectra disorders (p = 2.0 \u00d7 10-4) and hospital care for an infection as adults (p = 0.036) differed between the anti-LBP groups, with low incidence in the group of patients with the highest levels of anti-LBP who were diagnosed with primarily affective and anxiety disorders. In a sub-group analysis, the controls who screened positive for current or previous psychiatric diagnosis (n = 20) had higher anti-LBP compared to non-psychiatric controls with negative screening for psychiatric disorders (Mann Whitney U-test p = 0.006). Inflammatory markers were found to differ across anti-LBP groups and several pro-inflammatory markers, including IL-1\u03b2, were low in patients with high anti-LBP and serum LBP levels were lowest in patients with the highest levels of antibodies against LBP (p = 3.5 \u00d7 10-5). A cell-based model showed that polyclonal rabbit anti-LBP, obtained through purification via the same protein fragment used in the initial autoantibody analysis, could interfere with LBP signaling since addition of anti-LBP to the assay reduced both IL-1\u03b2 and IL-6 release from activated monocytes in response to LBP and LPS (p = 0.0001 and p = 0.02). This novel finding of antibodies against LBP, where high levels were only found in young adults with psychiatric disease, merits further study. Our results suggest that these antibodies may have relevance for TLR4 based immune responses and vulnerability for both infection and psychiatric disorders.", "doi": "10.1016/j.psyneuen.2021.105162", "pmid": "33578084", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "S0306-4530(21)00036-6"}], "notes": [], "created": "2022-12-02T09:04:34.691Z", "modified": "2022-12-02T09:04:34.694Z"}, {"entity": "publication", "iuid": "aa89d9e0453b418f96e57796adafb08b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aa89d9e0453b418f96e57796adafb08b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aa89d9e0453b418f96e57796adafb08b"}}, "title": "Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders.", "authors": [{"family": "Sundberg", "given": "Isak", "initials": "I"}, {"family": "Rasmusson", "given": "Annica J", "initials": "AJ"}, {"family": "Ramklint", "given": "Mia", "initials": "M"}, {"family": "Just", "given": "David", "initials": "D"}, {"family": "Ekselius", "given": "Lisa", "initials": "L"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}], "type": "journal article", "published": "2019-11-14", "journal": {"title": "Psychoneuroendocrinology", "issn": "0306-4530", "issn-l": null, "volume": "112", "issue": null, "pages": "104514"}, "abstract": "The bidirectional interaction between melatonin and the immune system has largely gone unexplored in a clinical context and especially in a psychiatric population. This study explored the association between melatonin during the day and inflammatory cytokines in young adult patients seeking psychiatric care.\r\n\r\nSamples and data were collected from 108 young adults (mean age 21, SD = 2) at an outpatient clinic for affective disorders. Daytime saliva melatonin levels were analyzed with enzyme-linked immunosorbent assay (ELISA) in relation to normalized serum expression levels of 72 inflammatory markers in a proximity extension assay (PEA). In a post hoc analysis the markers associated with melatonin were tested in a generalized linear model to see whether there is a relationship to anxiety disorder or depression.\r\n\r\nAfter Bonferroni correction for multiple testing, melatonin levels at 11:00 were positively correlated with CD5 (p = 4.2e-4). Melatonin levels after lunch were correlated with CCL2/MCP-1 (p = 4.2e-4), CCL3/MPI-1\u03b1 (p = 6.5e-4) and VEGF-A (p = 5.3e-6). In the generalized linear model, positive associations were found for the presence of any anxiety disorder with melatonin after lunch (p = 0.046), VEGF-A (p = 0.001) and CCL3/MPI-1\u03b1 (p = 0.001).\r\n\r\nDaytime saliva levels of melatonin were related to several inflammatory markers in young adults with psychiatric disorders. This observation likely reflects the bidirectional relationship between melatonin production and the immune system. These findings may have relevance for the understanding of psychiatric disorders and other conditions associated with low-grade inflammation.", "doi": "10.1016/j.psyneuen.2019.104514", "pmid": "31776047", "labels": {"Clinical Biomarkers": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support and Infrastructure": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "S0306-4530(19)31255-7"}], "notes": [], "created": "2019-12-06T08:10:30.672Z", "modified": "2023-04-14T13:55:54.183Z"}, {"entity": "publication", "iuid": "0e86b0163ab8494386109ae3f51cb69e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0e86b0163ab8494386109ae3f51cb69e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0e86b0163ab8494386109ae3f51cb69e"}}, "title": "Methylation of HPA axis related genes in men with hypersexual disorder", "authors": [{"family": "Jokinen", "given": "Jussi", "initials": "J"}, {"family": "Bostr\u00f6m", "given": "Adrian E", "initials": "AE"}, {"family": "Chatzittofis", "given": "Andreas", "initials": "A"}, {"family": "Ciuculete", "given": "Diana M", "initials": "DM"}, {"family": "\u00d6berg", "given": "Katarina G\u00f6rts", "initials": "KG"}, {"family": "Flanagan", "given": "John N", "initials": "JN"}, {"family": "Arver", "given": "Stefan", "initials": "S"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}], "type": "journal-article", "published": "2017-06-00", "journal": {"volume": "80", "issn": "0306-4530", "issue": null, "pages": "67-73", "title": "Psychoneuroendocrinology", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psyneuen.2017.03.007", "pmid": "28319850", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [], "notes": [], "created": "2017-10-25T15:15:16.501Z", "modified": "2020-01-21T13:56:10.087Z"}, {"entity": "publication", "iuid": "efc910bea38f4f88a004e0a8d58828eb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/efc910bea38f4f88a004e0a8d58828eb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/efc910bea38f4f88a004e0a8d58828eb"}}, "title": "Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction", "authors": [{"family": "Edvinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Br\u00e4nn", "given": "Emma", "initials": "E"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "White", "given": "Richard", "initials": "R"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M", "orcid": "0000-0002-1303-2218", "researcher": {"href": "https://publications.scilifelab.se/researcher/290dd535fb414c68bc49a8a2b7995770.json"}}, {"family": "Olivier", "given": "Jocelien", "initials": "J"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Bostr\u00f6m", "given": "Adrian E", "initials": "AE"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}], "type": "journal-article", "published": "2017-06-00", "journal": {"volume": "80", "issn": "0306-4530", "issue": null, "pages": "15-25", "title": "Psychoneuroendocrinology", "issn-l": null}, "abstract": null, "doi": "10.1016/j.psyneuen.2017.02.027", "pmid": "28292683", "labels": {"Clinical Biomarkers": "Service", "Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "PLA and Single Cell Proteomics": "Collaborative", "Affinity Proteomics Uppsala": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-10-30T12:48:42.081Z", "modified": "2023-04-14T13:56:14.657Z"}, {"entity": "publication", "iuid": "a5b832bb673d4fdbae2def001be65d76", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a5b832bb673d4fdbae2def001be65d76.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a5b832bb673d4fdbae2def001be65d76"}}, "title": "Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study.", "authors": [{"family": "Br\u00e4nn", "given": "Emma", "initials": "E"}, {"family": "Papadopoulos", "given": "Fotios", "initials": "F"}, {"family": "Fransson", "given": "Emma", "initials": "E"}, {"family": "White", "given": "Richard", "initials": "R"}, {"family": "Edvinsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Hellgren", "given": "Charlotte", "initials": "C"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M", "orcid": "0000-0002-1303-2218", "researcher": {"href": "https://publications.scilifelab.se/researcher/290dd535fb414c68bc49a8a2b7995770.json"}}, {"family": "Bostr\u00f6m", "given": "Adrian", "initials": "A"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}, {"family": "Sundstr\u00f6m-Poromaa", "given": "Inger", "initials": "I"}, {"family": "Skalkidou", "given": "Alkistis", "initials": "A"}], "type": "journal article", "published": "2017-05-00", "journal": {"volume": "79", "issn": "1873-3360", "issue": null, "pages": "146-159", "title": "Psychoneuroendocrinology", "issn-l": "0306-4530"}, "abstract": "Recent studies indicate that the immune system adaptation during pregnancy could play a significant role in the pathophysiology of perinatal depression. The aim of this study was to investigate if inflammation markers in a late pregnancy plasma sample can predict the presence of depressive symptoms at eight weeks postpartum. Blood samples from 291 pregnant women (median and IQR for days to delivery, 13 and 7-23days respectively) comprising 63 individuals with postpartum depressive symptoms, as assessed by the Edinburgh postnatal depression scale (EPDS\u226512) and/or the Mini International Neuropsychiatric Interview (M.I.N.I.) and 228 controls were analyzed with an inflammation protein panel using multiplex proximity extension assay technology, comprising of 92 inflammation-associated markers. A summary inflammation variable was also calculated. Logistic regression, LASSO and Elastic net analyses were implemented. Forty markers were lower in late pregnancy among women with depressive symptoms postpartum. The difference remained statistically significant for STAM-BP (or otherwise AMSH), AXIN-1, ADA, ST1A1 and IL-10, after Bonferroni correction. The summary inflammation variable was ranked as the second best variable, following personal history of depression, in predicting depressive symptoms postpartum. The protein-level findings for STAM-BP and ST1A1 were validated in relation to methylation status of loci in the respective genes in a different population, using openly available data. This explorative approach revealed differences in late pregnancy levels of inflammation markers between women presenting with depressive symptoms postpartum and controls, previously not described in the literature. Despite the fact that the results do not support the use of a single inflammation marker in late pregnancy for assessing risk of postpartum depression, the use of STAM-BP or the novel notion of a summary inflammation variable developed in this work might be used in combination with other biological markers in the future.", "doi": "10.1016/j.psyneuen.2017.02.029", "pmid": "28285186", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Collaborative", "Affinity Proteomics Uppsala": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0306-4530(16)30787-9"}], "notes": [], "created": "2017-10-30T12:37:46.988Z", "modified": "2023-04-14T13:56:15.105Z"}], "created": "2017-10-18T09:09:26.827Z", "modified": "2020-11-27T13:14:07.538Z"}