{"entity": "journal", "iuid": "2dbbda9f91654215844bd6c14ae70d93", "timestamp": "2026-05-15T01:16:02.681Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Proteomes.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Proteomes"}}, "title": "Proteomes", "issn": "2227-7382", "issn-l": "2227-7382", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "6aea5c20a9e349c5b122a112cf62160d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d"}}, "title": "Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy.", "authors": [{"family": "Lemma", "given": "Mahlet", "initials": "M"}, {"family": "Petkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-8052-9646", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6.json"}}, {"family": "Bekele", "given": "Yonas", "initials": "Y"}, {"family": "Petros", "given": "Beyene", "initials": "B"}, {"family": "Howe", "given": "Rawleigh", "initials": "R"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Proteomes", "issn": "2227-7382", "volume": "8", "issue": "3", "pages": "24", "issn-l": "2227-7382"}, "abstract": "Treatment of HIV-1-infected patients results in improved clinical and immunological conditions, but severe non-AIDS-related conditions still persist. Novel proteomic platforms have identified inflammatory proteins where abundance is dysregulated in adult treated patients, whereas limited data are available in treated HIV-1 infection of children. Using a proteomic plasma profiling approach comprising 92 inflammation-related molecules, we analyzed specimens from 43 vertically HIV-1-infected children receiving antiretroviral treatment (ART) and matched controls in Ethiopia. The infected children were analyzed as a group and separately, according to age of treatment initiation. Proteins displaying a significantly different abundance between groups were hierarchically clustered and presented in heat maps. Random forest analysis was performed to pin-point proteins discriminating between groups; five proteins (STAMBP, CD5, TFG-\u03b1, TRANCE, AXIN1) were the strongest prediction factors for treated HIV-1 infection. TRANCE was previously linked to reduced bone mass levels in HIV-1-infected children. CCL4 chemokine, ligand to HIV-1 co-receptor CCR5, was the most critical protein for successful classification between children who initiated ART at different time points. Our data provide evidence that a dysregulated expression of proteins linked to immunological abnormalities and bone metabolism can be found in HIV-1-infected children with prolonged exposure to ART.", "doi": "10.3390/proteomes8030024", "pmid": "32906648", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "proteomes8030024"}, {"db": "pmc", "key": "PMC7563605"}], "notes": [], "created": "2020-12-10T16:30:02.494Z", "modified": "2021-11-10T12:47:23.760Z"}, {"entity": "publication", "iuid": "f8d2ff233a02478491ff3140d3fe9721", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f8d2ff233a02478491ff3140d3fe9721.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f8d2ff233a02478491ff3140d3fe9721"}}, "title": "Identification of Potential Plasma Biomarkers for Abdominal Aortic Aneurysm Using Tandem Mass Tag Quantitative Proteomics.", "authors": [{"family": "Henriksson", "given": "Anders E", "initials": "AE"}, {"family": "Lindqvist", "given": "Markus", "initials": "M"}, {"family": "Sihlbom", "given": "Carina", "initials": "C"}, {"family": "Bergstr\u00f6m", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Bylund", "given": "Dan", "initials": "D"}], "type": "journal article", "published": "2018-10-18", "journal": {"volume": "6", "issn": "2227-7382", "issue": "4", "title": "Proteomes", "issn-l": "2227-7382"}, "abstract": "Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA.", "doi": "10.3390/proteomes6040043", "pmid": "30340394", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pii", "key": "proteomes6040043"}, {"db": "pmc", "key": "PMC6313917"}], "notes": [], "created": "2020-01-27T22:56:43.438Z", "modified": "2024-01-16T13:46:32.181Z"}], "created": "2020-01-27T22:56:43.446Z", "modified": "2020-11-27T13:14:09.659Z"}