{"entity": "journal", "iuid": "be886c290a114f3fa88d98838b81ed5d", "timestamp": "2026-08-12T06:20:07.711Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Prog%20Neurobiol.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Prog%20Neurobiol"}}, "title": "Prog Neurobiol", "issn": "1873-5118", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "2a7d9ea2d442431f9aa88726812f7000", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2a7d9ea2d442431f9aa88726812f7000.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2a7d9ea2d442431f9aa88726812f7000"}}, "title": "Reactive astrocytes prevent maladaptive plasticity after ischemic stroke.", "authors": [{"family": "Aswendt", "given": "Markus", "initials": "M"}, {"family": "Wilhelmsson", "given": "Ulrika", "initials": "U"}, {"family": "Wieters", "given": "Frederique", "initials": "F"}, {"family": "Stokowska", "given": "Anna", "initials": "A"}, {"family": "Schmitt", "given": "Felix Johannes", "initials": "FJ"}, {"family": "Pallast", "given": "Niklas", "initials": "N"}, {"family": "de Pablo", "given": "Yolanda", "initials": "Y"}, {"family": "Mohammed", "given": "Lava", "initials": "L"}, {"family": "Hoehn", "given": "Mathias", "initials": "M"}, {"family": "Pekna", "given": "Marcela", "initials": "M"}, {"family": "Pekny", "given": "Milos", "initials": "M"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Prog Neurobiol", "issn": "1873-5118", "volume": "209", "pages": "102199", "issn-l": null}, "abstract": "Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive gliosis (GFAP-/-Vim-/-). Infarct volume and longitudinal functional connectivity changes were determined by in vivo T2-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Sensorimotor function was assessed with behavioral tests, and glial and neural plasticity responses were quantified in the peri-infarct region. Four weeks after stroke, GFAP-/-Vim-/- mice showed impaired recovery of sensorimotor function and aberrant restoration of global neuronal connectivity. These mice also exhibited maladaptive plasticity responses, shown by higher number of lost and newly formed functional connections between primary and secondary targets of cortical stroke regions and increased peri-infarct expression of the axonal plasticity marker Gap43. We conclude that reactive astrocytes modulate recovery-promoting plasticity responses after ischemic stroke.", "doi": "10.1016/j.pneurobio.2021.102199", "pmid": "34921928", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "S0301-0082(21)00213-6"}], "notes": [], "created": "2023-02-16T08:23:25.348Z", "modified": "2023-02-16T08:23:25.350Z"}, {"entity": "publication", "iuid": "d77e5ffa3ce742b99fbd970f63788646", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d77e5ffa3ce742b99fbd970f63788646.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d77e5ffa3ce742b99fbd970f63788646"}}, "title": "An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain.", "authors": [{"family": "Kalafateli", "given": "Aimilia Lydia", "initials": "AL"}, {"family": "Satir", "given": "Tugce Munise", "initials": "TM"}, {"family": "Vall\u00f6f", "given": "Daniel", "initials": "D"}, {"family": "Zetterberg", "given": "Henrik", "initials": "H"}, {"family": "Jerlhag", "given": "Elisabet", "initials": "E"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Prog Neurobiol", "issn": "1873-5118", "volume": "200", "pages": "101969", "issn-l": null}, "abstract": "Alcohol causes stimulatory behavioral responses by activating reward-processing brain areas including the laterodorsal (LDTg) and ventral tegmental areas (VTA) and the nucleus accumbens (NAc). Systemic administration of the amylin and calcitonin receptor agonist salmon calcitonin (sCT) attenuates alcohol-mediated behaviors, but the brain sites involved in this process remain unknown. Firstly, to identify potential sCT sites of action in the brain, we used immunohistochemistry after systemic administration of fluorescent-labeled sCT. We then performed behavioral experiments to explore how infused sCT into the aforementioned reward-processing brain areas affects acute alcohol-induced behaviors in mice and chronic alcohol consumption in rats. We show that peripheral sCT crosses the blood brain barrier and is detected in all the brain areas studied herein. sCT infused into the LDTg attenuates alcohol-evoked dopamine release in the NAc shell in mice and reduces alcohol intake in rats. sCT into the VTA blocks alcohol-induced locomotor stimulation and dopamine release in the NAc shell in mice and decreases alcohol intake in rats. Lastly, sCT into the NAc shell prevents alcohol-induced locomotor activity in mice. Our data suggest that central sCT modulates the ability of alcohol to activate reward-processing brain regions.", "doi": "10.1016/j.pneurobio.2020.101969", "pmid": "33278524", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "S0301-0082(20)30224-0"}], "notes": [], "created": "2023-02-16T08:18:21.481Z", "modified": "2023-02-16T08:18:21.552Z"}], "created": "2023-02-16T08:18:21.496Z", "modified": "2023-02-16T08:18:21.496Z"}