{"entity": "journal", "iuid": "42c460e073e64d7584fb27d478baa936", "timestamp": "2026-04-11T08:34:06.989Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Peptides.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Peptides"}}, "title": "Peptides", "issn": "1873-5169", "issn-l": "0196-9781", "publications_count": 1, "publications": [{"entity": "publication", "iuid": "fe4b514f9ac0418ab26e270cd972d4f5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fe4b514f9ac0418ab26e270cd972d4f5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fe4b514f9ac0418ab26e270cd972d4f5"}}, "title": "Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.", "authors": [{"family": "Bennet", "given": "H", "initials": "H"}, {"family": "Balhuizen", "given": "A", "initials": "A"}, {"family": "Medina", "given": "A", "initials": "A"}, {"family": "Dekker Nitert", "given": "M", "initials": "M"}, {"family": "Ottosson Laakso", "given": "E", "initials": "E"}, {"family": "Ess\u00e9n", "given": "S", "initials": "S"}, {"family": "Sp\u00e9gel", "given": "P", "initials": "P"}, {"family": "Storm", "given": "P", "initials": "P"}, {"family": "Krus", "given": "U", "initials": "U"}, {"family": "Wierup", "given": "N", "initials": "N"}, {"family": "Fex", "given": "M", "initials": "M"}], "type": "journal article", "published": "2015-09-00", "journal": {"volume": "71", "issn": "1873-5169", "issue": null, "pages": "113-120", "title": "Peptides", "issn-l": "0196-9781"}, "abstract": "Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate islet hormone secretion in a paracrine and autocrine manner in rodents. Hitherto, no studies demonstrate a role for this amine in human islet function, nor is it known if 5-HT signaling is involved in the development of beta cell dysfunction in type 2 diabetes (T2D). To clarify this, we performed a complete transcriptional mapping of 5-HT receptors and processing enzymes in human islets and investigated differential expression of these genes in non-diabetic and T2D human islet donors. We show the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. Two 5-HT receptors (HTR1D and HTR2A) were over-expressed in T2D islet donors. Both receptors (5-HT1d and 5-HT2a) were localized to human alpha, beta and delta cells. 5-HT inhibited both insulin and glucagon secretion in non-diabetic islet donors. In islets isolated from T2D donors the amine significantly increased release of insulin in response to glucose. Our results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non- diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D or arise as a consequence of an already dysfunctional islet.", "doi": "10.1016/j.peptides.2015.07.008", "pmid": "26206285", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [{"db": "pii", "key": "S0196-9781(15)00204-1"}], "notes": [], "created": "2017-05-02T12:56:35.098Z", "modified": "2020-01-21T13:56:06.541Z"}], "created": "2017-05-09T09:12:54.733Z", "modified": "2020-11-27T13:14:07.618Z"}