{"entity": "journal", "iuid": "6ffb7319faeb47f3aae1c94ad61aad4b", "timestamp": "2026-03-05T07:57:31.832Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Pain%20Rep.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Pain%20Rep"}}, "title": "Pain Rep", "issn": "2471-2531", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "7382f4dc1f364e9198563a2b1fd3f450", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7382f4dc1f364e9198563a2b1fd3f450.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7382f4dc1f364e9198563a2b1fd3f450"}}, "title": "System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain-an explorative study.", "authors": [{"family": "J\u00f6nsson", "given": "Mika", "initials": "M", "orcid": "0000-0002-8668-4241", "researcher": {"href": "https://publications.scilifelab.se/researcher/1dca09627dc64b06a807765008b3775c.json"}}, {"family": "B\u00e4ckryd", "given": "Emmanuel", "initials": "E"}, {"family": "Ljunggren", "given": "Stefan", "initials": "S"}, {"family": "Ottosson", "given": "Nina", "initials": "N"}, {"family": "Jauregi-Miguel", "given": "Amaia", "initials": "A"}, {"family": "Liin", "given": "Sara I", "initials": "SI"}, {"family": "Checa", "given": "Antonio", "initials": "A"}, {"family": "Wheelock", "given": "Craig E", "initials": "CE"}, {"family": "Ghafouri", "given": "Bijar", "initials": "B"}], "type": "journal article", "published": "2025-08-00", "journal": {"title": "Pain Rep", "issn": "2471-2531", "volume": "10", "issue": "4", "pages": "e1305", "issn-l": null}, "abstract": "Neuroinflammation and oxidative dysfunction, and their reciprocal interplay, are critically involved in the pathophysiology of chronic neuropathic pain (NeuP). Numerous studies have investigated the crosstalk between inflammatory biomolecules such as cytokines, chemokines, and neuronal cells. However, the impact of immunomodulatory lipoproteins and oxylipins in NeuP pathophysiology is far less explored.\n\nUsing a combination of techniques, we uncovered altered lipoprotein composition in high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs) with complementary alterations in the plasma profile of oxylipins and cytokines among patients.\n\nLower level of apolipoproteins in patient HDL and 2 isoforms of acute phase serum amyloid A (SAA) with higher levels in patients was found. The constitutively expressed SAA4 was detected in 6 isoforms in patients, but only 2 isoforms were detected in healthy controls. In LDL, lysozyme C and 2 isoforms of SAA were exclusive to patients. Analysis of protein carbonylation showed oxidation of 6 proteins in HDL, of which 3 were unique to patients. No oxidized proteins were observed in LDL. Oxylipin analysis revealed 13 octadecanoids that were significantly downregulated in patients, of which 7 demonstrated significant activating effects on the Kv7.2/7.3 channel, which is anticipated to dampen neuronal signalling in sensory afferents. Among the significant octadecanoids, 9-HODE showed most prominent facilitating effects on Kv7.2/7.3 channel activation.\n\nThese results present a previously unexplored network of integrated alterations of lipoproteins, octadecanoids, and cytokines in patients suffering from NeuP, indicative of deviant immuno-protective functioning across several biological systems including lipid metabolic processes, inflammation, and Kv7.2/7.3 signalling.", "doi": "10.1097/PR9.0000000000001305", "pmid": "40612405", "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12226002"}, {"db": "pii", "key": "PAINREPORTS-D-24-0282"}], "notes": [], "created": "2025-11-18T09:19:59.841Z", "modified": "2025-11-18T09:19:59.933Z"}, {"entity": "publication", "iuid": "5327a3ebdfe244b481789f7baf594301", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5327a3ebdfe244b481789f7baf594301.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5327a3ebdfe244b481789f7baf594301"}}, "title": "Pain in idiopathic scoliosis not associated with known genetic variants for pain.", "authors": [{"family": "Cheng", "given": "Tian", "initials": "T", "orcid": "0000-0001-5013-6473", "researcher": {"href": "https://publications.scilifelab.se/researcher/b65aa57c2cae41ed8b5d808377eca30d.json"}}, {"family": "Diarbakerli", "given": "Elias", "initials": "E"}, {"family": "Simony", "given": "Ane", "initials": "A"}, {"family": "\u00d8sterheden Andersen", "given": "Mikkel", "initials": "M"}, {"family": "Danielsson", "given": "Aina", "initials": "A"}, {"family": "Kere", "given": "Juha", "initials": "J"}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E"}, {"family": "Gerdhem", "given": "Paul", "initials": "P"}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Pain Rep", "issn": "2471-2531", "issn-l": null, "volume": "10", "issue": "1", "pages": "e1227"}, "abstract": "Back pain is common in idiopathic scoliosis. The aim of this study was to study known genetic variants associated with pain in individuals with idiopathic scoliosis.\r\n\r\nWe included 1442 individuals with juvenile or adolescent idiopathic scoliosis from Sweden and Denmark. Single nucleotide variants (SNV) genotyping was performed on 37 SNVs. Pain was assessed using 2 questionnaires. The mean pain domain score on the Scoliosis Research Society 22 revised questionnaire (SRS-22r) ranging between 1 (worst) and 5 (best) was dichotomized into a \"back pain group\" (score <4) and a \"no back pain group\" (score \u22654). The EuroQol 5-dimensions (EQ-5D) 3 level pain domain was dichotomized into a \"no pain group\" and a \"pain group.\" Odds ratios were used to describe the associations.\r\n\r\nBased on the SRS-22r pain domain scores, 456 individuals (32%) reported back pain. Based on the EQ-5D questionnaire, 813 individuals (56%) reported moderate or extreme pain/discomfort. The odds ratio for the associations between the selected genetic variants and back pain or pain in general as measured with SRS-22r and EQ-5D-3L ranged between 0.88 to 1.17 and 0.86 to 1.16, with P-values ranging between 0.08 to 0.99 and 0.08 to 0.95.\r\n\r\nThis study suggests that known genetic variants associated with pain do not play a significant role in the development of pain in individuals with idiopathic scoliosis.", "doi": "10.1097/PR9.0000000000001227", "pmid": "39713503", "labels": {"NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics (NBIS)": null, "Bioinformatics Long-term Support WABI": "Service", "Bioinformatics Support, Infrastructure and Training": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11661741"}, {"db": "pii", "key": "PAINREPORTS-D-23-0205"}], "notes": [], "created": "2025-09-08T07:06:06.228Z", "modified": "2025-11-19T08:43:57.611Z"}], "created": "2025-09-08T07:06:06.333Z", "modified": "2025-09-08T07:06:06.333Z"}