{"entity": "journal", "iuid": "0fd55f96bf5e451e93e33c98069c6cf5", "timestamp": "2026-06-10T15:02:25.123Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Oncoimmunology.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Oncoimmunology"}}, "title": "Oncoimmunology", "issn": "2162-402X", "issn-l": "2162-4011", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "d0efba99df6248a3aee00ad4fb43df6a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d0efba99df6248a3aee00ad4fb43df6a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d0efba99df6248a3aee00ad4fb43df6a"}}, "title": "EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by \u03b3\u03b4T cells preserves neuronal and stem cell integrity.", "authors": [{"family": "Boutin", "given": "Lola", "initials": "L", "orcid": "0000-0001-7928-6731", "researcher": {"href": "https://publications.scilifelab.se/researcher/371c988cc4be47cf86c2c777922e3557.json"}}, {"family": "Liu", "given": "Mingzhi", "initials": "M", "orcid": "0000-0001-5842-8307", "researcher": {"href": "https://publications.scilifelab.se/researcher/6dc5d2bd77664158976f148e4088ae5c.json"}}, {"family": "D\u00e9chanet Merville", "given": "Julie", "initials": "J", "orcid": "0000-0001-7521-9531", "researcher": {"href": "https://publications.scilifelab.se/researcher/986ece668416414f806bf451c436de31.json"}}, {"family": "Bedoya-Reina", "given": "Oscar", "initials": "O", "orcid": "0009-0001-1703-2258", "researcher": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9.json"}}, {"family": "Wilhelm", "given": "Margareta T", "initials": "MT", "orcid": "0000-0002-0516-9724", "researcher": {"href": "https://publications.scilifelab.se/researcher/fa0ccfc8178142e4954e05e25613d751.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "14", "issue": "1", "pages": "2485535", "issn-l": "2162-4011"}, "abstract": "Medulloblastoma (MB) is a pediatric brain tumor that develops in the cerebellum, representing one of the most common malignant brain cancers in children. Standard treatments include surgery, chemotherapy, and radiation, but despite a 5-y survival rate of approximately 70%, these therapies often lead to significant neurological damage in the developing brain. This underscores the urgent need for less toxic, more effective therapeutic alternatives. Recent advancements in cancer immunotherapy, including immune checkpoint inhibitors and CAR-T cell therapy, have revolutionized cancer treatment. One promising avenue is the use of Gamma Delta (\u03b3\u03b4)T cells, a unique T cell population with potential advantages, such as non-alloreactivity, potent tumor cell lysis, and broad antigen recognition. However, their capacity to recognize and target MB cells remains underexplored. To investigate the therapeutic potential of \u03b3\u03b4T cells against MB, we analyzed the proportion and status of MB-infiltrated \u03b3\u03b4T cells within patient datasets. We next investigated the expression of \u03b3\u03b4T cell ligands on MB cells and identified the EphA2 receptor and the phosphoantigen/Butyrophilin complex as key ligands, activating V\u03b39 V\u03b41 and V\u03b39 V\u03b42 T cells, respectively, leading to significant MB cell lysis in both monolayer and spheroid models. Importantly, preliminary safety data showed that \u03b3\u03b4T cells did not target differentiated neurons or neuroepithelial stem cells derived from induced pluripotent stem cells, underscoring the selectivity and safety of this approach. In conclusion, \u03b3\u03b4T cells trigger an efficient and specific killing of MB and would offer a promising novel therapeutic strategy.", "doi": "10.1080/2162402X.2025.2485535", "pmid": "40190167", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11980450"}], "notes": [], "created": "2025-11-28T10:48:34.549Z", "modified": "2025-11-28T10:48:34.769Z"}, {"entity": "publication", "iuid": "d373e71c06094217863b00c08b3b5ee2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d373e71c06094217863b00c08b3b5ee2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d373e71c06094217863b00c08b3b5ee2"}}, "title": "Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection.", "authors": [{"family": "Ros\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Bergh", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Gogok", "given": "Peter", "initials": "P"}, {"family": "Evaldsson", "given": "Chamilly", "initials": "C"}, {"family": "Myhrinder", "given": "Anna Lanemo", "initials": "AL"}, {"family": "Hellqvist", "given": "Eva", "initials": "E"}, {"family": "Rasul", "given": "Abu", "initials": "A"}, {"family": "Bj\u00f6rkholm", "given": "Magnus", "initials": "M"}, {"family": "Jansson", "given": "Mattias", "initials": "M"}, {"family": "Mansouri", "given": "Larry", "initials": "L"}, {"family": "Liu", "given": "Anquan", "initials": "A"}, {"family": "Teh", "given": "Bin Tean", "initials": "BT"}, {"family": "Rosenquist", "given": "Richard", "initials": "R"}, {"family": "Klein", "given": "Eva", "initials": "E"}], "type": "journal article", "published": "2012-01-01", "journal": {"volume": "1", "issn": "2162-4011", "issue": "1", "pages": "18-27", "title": "Oncoimmunology", "issn-l": null}, "abstract": "Chronic lymphocytic leukemia (CLL) cells express the receptor for Epstein-Barr virus (EBV) and can be infected in vitro. Infected cells do not express the growth-promoting set of EBV-encoded genes and therefore they do not yield LCLs, in most experiments. With exceptional clones, lines were obtained however. We describe a new line, HG3, established by in vitro EBV-infection from an IGHV1-2 unmutated CLL patient clone. All cells expressed EBNA-2 and LMP-1, the EBV-encoded genes pivotal for transformation. The karyotype, FISH cytogenetics and SNP-array profile of the line and the patient's ex vivo clone showed biallelic 13q14 deletions with genomic loss of DLEU7, miR15a/miR16-1, the two micro-RNAs that are deleted in 50% of CLL cases. Further features of CLL cells were: expression of CD5/CD20/CD27/CD43 and release of IgM natural antibodies reacting with oxLDL-like epitopes on apoptotic cells (cf. stereotyped subset-1). Comparison with two LCLs established from normal B cells showed 32 genes expressed at higher levels (> 2-fold). Among these were LHX2 and LILRA. These genes may play a role in the development of the disease. LHX2 expression was shown in self-renewing multipotent hematopoietic stem cells, and LILRA4 codes for a receptor for bone marrow stromal cell antigen-2 that contributes to B cell development. Twenty-four genes were expressed at lower levels, among these PARD3 that is essential for asymmetric cell division. These genes may contribute to establish precursors of CLL clones by regulation of cellular phenotype in the hematopoietic compartment. Expression of CD5/CD20/CD27/CD43 and spontaneous production of natural antibodies may identify the CLL cell as a self-renewing B1 lymphocyte.", "doi": "10.4161/onci.1.1.18400", "pmid": "22720208", "labels": {"Array and Analysis Facility": null}, "xrefs": [{"db": "pii", "key": "2011ONCOIMM0075"}, {"db": "pmc", "key": "PMC3376971"}], "notes": [], "created": "2017-05-04T15:02:59.963Z", "modified": "2017-05-31T08:17:05.183Z"}], "created": "2017-05-09T09:12:26.385Z", "modified": "2020-11-27T13:14:09.363Z"}