{"entity": "journal", "iuid": "2c9235d6d6fa494593b667f695517de0", "timestamp": "2026-08-16T10:40:24.098Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Obesity%20%28Silver%20Spring%29.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Obesity%20%28Silver%20Spring%29"}}, "title": "Obesity (Silver Spring)", "issn": "1930-739X", "issn-l": "1930-7381", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "b1486cd2f8e04ed5a94771fa99efe1eb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b1486cd2f8e04ed5a94771fa99efe1eb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b1486cd2f8e04ed5a94771fa99efe1eb"}}, "title": "DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI.", "authors": [{"family": "Maguolo", "given": "Alice", "initials": "A", "orcid": "0000-0002-8921-2012", "researcher": {"href": "https://publications.scilifelab.se/researcher/cac232a66c6745f7b74d2b52ec0d007a.json"}}, {"family": "J\u00f6nsson", "given": "Josefine", "initials": "J"}, {"family": "Perfilyev", "given": "Alexander", "initials": "A"}, {"family": "Maziarz", "given": "Marlena", "initials": "M"}, {"family": "Vaag", "given": "Allan", "initials": "A"}, {"family": "Malchau Carlsen", "given": "Emma", "initials": "E"}, {"family": "N\u00f8rgaard", "given": "Kirsten", "initials": "K"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Renault", "given": "Kristina M", "initials": "KM"}, {"family": "Ling", "given": "Charlotte", "initials": "C", "orcid": "0000-0003-0587-7154", "researcher": {"href": "https://publications.scilifelab.se/researcher/dd7c1ea934034c4db99f31a5a9b04691.json"}}], "type": "journal article", "published": "2025-01-00", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "volume": "33", "issue": "1", "pages": "177-189", "issn-l": "1930-7381"}, "abstract": "We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood BMI z score (BMIz).\n\nFrom the Treatment of Obese Pregnant Women (TOP) study, 232 mother-child pairs were included. We conducted an epigenome-wide association study on prePregBMI and CB DNAm (450k array), followed by causal mediation analyses to test whether DNAm may mediate effects of prePregBMI on BMIz at age 36 months (BMIz36).\n\nDNAm at 5345 CpG sites annotated to 2842 genes, which were overrepresented in biological processes linked to carbohydrate metabolism and plasma lipoprotein particle clearance, was associated with prePregBMI (false discovery rate < 10%). Causal mediation analyses of 168 methylation sites associated with BMIz36 (p < 0.05) and overlapping with the 5345 prePregBMI-associated sites identified two sites on SYT7 and DEAF1, partially mediating the effect of prePregBMI on BMIz36 (p \u2264 0.01). After cross-validation, a methylation risk score including these two sites could predict the highest quartile of BMIz36 and fat mass (in grams) with area under the curve = 0.72 (95% CI: 0.58-0.85) and area under the curve = 0.71 (95% CI: 0.58-0.85), respectively.\n\nCB DNAm at birth may partially mediate effects of prePregBMI on early childhood BMIz36, supporting its plausible role in influencing individual future obesity risk.", "doi": "10.1002/oby.24174", "pmid": "39663190", "labels": {"Clinical Genomics Lund": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11664306"}], "notes": [], "created": "2025-10-30T13:55:22.871Z", "modified": "2025-10-30T13:55:22.979Z"}, {"entity": "publication", "iuid": "89405fe000444fd2b106b684a83a8f5e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/89405fe000444fd2b106b684a83a8f5e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/89405fe000444fd2b106b684a83a8f5e"}}, "title": "Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes.", "authors": [{"family": "Katsogiannos", "given": "Petros", "initials": "P", "orcid": "0000-0001-8457-3372", "researcher": {"href": "https://publications.scilifelab.se/researcher/33ff018224d94d26b3194667db04018d.json"}}, {"family": "Kamble", "given": "Prasad G", "initials": "PG", "orcid": "0000-0002-5627-8904", "researcher": {"href": "https://publications.scilifelab.se/researcher/abc6be36c0404251a6ae0edfac1efb8f.json"}}, {"family": "Pereira", "given": "Maria J", "initials": "MJ"}, {"family": "Sundbom", "given": "Magnus", "initials": "M"}, {"family": "Carlsson", "given": "Per-Ola", "initials": "PO"}, {"family": "Eriksson", "given": "Jan W", "initials": "JW"}, {"family": "Espes", "given": "Daniel", "initials": "D"}], "type": "clinical trial", "published": "2021-03-00", "journal": {"title": "Obesity (Silver Spring)", "issn": "1930-739X", "volume": "29", "issue": "3", "pages": "535-542", "issn-l": "1930-7381"}, "abstract": "This study aimed to compare cytokine and adipokine levels in patients with obesity with and without type 2 diabetes (T2D) at baseline and 6 months after Roux-en-Y gastric bypass (RYGB) with healthy controls.\n\nA total of 34 patients (21 with T2D) with BMI of 30 to 45 kg/m2 were compared with 25 healthy controls without obesity. Cytokines, adipokines, and peptides of relevance for inflammation and metabolism were analyzed in plasma.\n\nSignificant decreases in weight and glycated hemoglobin A1c were observed. At baseline, interleukin-6 (IL-6), IFN-\u03b2, IL-18, leptin, and hepatocyte growth factor were higher in all patients with obesity compared with healthy controls. In patients without T2D, TNF-\u03b1, IL-1\u03b1, IL-2, IL-15, and visfatin were also increased, whereas bone morphogenic protein-4 was decreased. Following RYGB, IL-6 and hepatocyte growth factor were still increased in both groups compared with controls. In T2D patients, IFN-\u03b2, IL-27, IL-1\u03b1, IL-2, regenerating islet-derived protein 3A, visfatin, and osteopontin were found to be increased. In patients without T2D, TNF-\u03b1, IL-1\u03b1, IL-2, IL-15, leptin, and visfatin remained increased.\n\nThe altered cytokine profile of patients with obesity persisted after RYGB despite large weight loss and improved metabolic status, thus reflecting an inherent inflammatory state.", "doi": "10.1002/oby.23093", "pmid": "33624436", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7986425"}], "notes": [], "created": "2021-12-06T08:37:33.647Z", "modified": "2021-12-06T08:37:33.756Z"}, {"entity": "publication", "iuid": "eb2b54dae41a4478a0c3241adc1f0cc0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/eb2b54dae41a4478a0c3241adc1f0cc0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/eb2b54dae41a4478a0c3241adc1f0cc0"}}, "title": "Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.", "authors": [{"family": "Silventoinen", "given": "Karri", "initials": "K", "orcid": "0000-0003-1759-3079", "researcher": {"href": "https://publications.scilifelab.se/researcher/87ff661db88949b09e7b399c349a7e9d.json"}}, {"family": "Jelenkovic", "given": "Aline", "initials": "A"}, {"family": "Latvala", "given": "Antti", "initials": "A"}, {"family": "Yokoyama", "given": "Yoshie", "initials": "Y"}, {"family": "Sund", "given": "Reijo", "initials": "R"}, {"family": "Sugawara", "given": "Masumi", "initials": "M"}, {"family": "Tanaka", "given": "Mami", "initials": "M"}, {"family": "Matsumoto", "given": "Satoko", "initials": "S"}, {"family": "Aaltonen", "given": "Sari", "initials": "S"}, {"family": "Piirtola", "given": "Maarit", "initials": "M"}, {"family": "Freitas", "given": "Duarte L", "initials": "DL"}, {"family": "Maia", "given": "Jos\u00e9 A", "initials": "JA"}, {"family": "\u00d6ncel", "given": "Sevgi Y", "initials": "SY"}, {"family": "Aliev", "given": "Fazil", "initials": "F"}, {"family": "Ji", "given": "Fuling", "initials": "F", "orcid": "0000-0002-3261-0204", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0fe35efe90044b0aa40828633d4f2be.json"}}, {"family": "Ning", "given": "Feng", "initials": "F"}, {"family": "Pang", "given": "Zengchang", "initials": "Z"}, {"family": "Rebato", "given": "Esther", "initials": "E"}, {"family": "Saudino", "given": "Kimberly J", "initials": "KJ"}, {"family": "Cutler", "given": "Tessa L", "initials": "TL"}, {"family": "Hopper", "given": "John L", "initials": "JL"}, {"family": "Ullemar", "given": "Vilhelmina", "initials": "V"}, {"family": "Almqvist", "given": "Catarina", "initials": "C"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Cozen", "given": "Wendy", "initials": "W"}, {"family": "Hwang", "given": "Amie E", "initials": "AE"}, {"family": "Mack", "given": "Thomas M", "initials": "TM"}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Bartels", "given": "Meike", "initials": "M"}, {"family": "van Beijsterveldt", "given": "Catharina E M", "initials": "CEM"}, {"family": "Nelson", "given": "Tracy L", "initials": "TL"}, {"family": "Whitfield", "given": "Keith E", "initials": "KE"}, {"family": "Sung", "given": "Joohon", "initials": "J"}, {"family": "Kim", "given": "Jina", "initials": "J"}, {"family": "Lee", "given": "Jooyeon", "initials": "J"}, {"family": "Lee", "given": "Sooji", "initials": "S"}, {"family": "Llewellyn", "given": "Clare H", "initials": "CH"}, {"family": "Fisher", "given": "Abigail", "initials": "A"}, {"family": "Medda", "given": "Emanuela", "initials": "E"}, {"family": "Nistic\u00f2", "given": "Lorenza", "initials": "L"}, {"family": "Toccaceli", "given": "Virgilia", "initials": "V"}, {"family": "Baker", "given": "Laura A", "initials": "LA"}, {"family": "Tuvblad", "given": "Catherine", "initials": "C"}, {"family": "Corley", "given": "Robin P", "initials": "RP"}, {"family": "Huibregtse", "given": "Brooke M", "initials": "BM", "orcid": "0000-0003-0977-7249", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9df70acb87f443eb6da650b151a679c.json"}}, {"family": "Derom", "given": "Catherine A", "initials": "CA"}, {"family": "Vlietinck", "given": "Robert F", "initials": "RF"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Knafo-Noam", "given": "Ariel", "initials": "A"}, {"family": "Mankuta", "given": "David", "initials": "D"}, {"family": "Abramson", "given": "Lior", "initials": "L"}, {"family": "Burt", "given": "S Alexandra", "initials": "SA"}, {"family": "Klump", "given": "Kelly L", "initials": "KL"}, {"family": "Silberg", "given": "Judy L", "initials": "JL"}, {"family": "Maes", "given": "Hermine H", "initials": "HH"}, {"family": "Krueger", "given": "Robert F", "initials": "RF"}, {"family": "McGue", "given": "Matt", "initials": "M"}, {"family": "Pahlen", "given": "Shandell", "initials": "S"}, {"family": "Gatz", "given": "Margaret", "initials": "M"}, {"family": "Butler", "given": "David A", "initials": "DA"}, {"family": "Harris", "given": "Jennifer R", "initials": "JR"}, {"family": "Nilsen", "given": "Thomas S", "initials": "TS"}, {"family": "Harden", "given": "K Paige", "initials": "KP"}, {"family": "Tucker-Drob", "given": "Elliot M", "initials": "EM"}, {"family": "Franz", "given": "Carol E", "initials": "CE"}, {"family": "Kremen", "given": "William S", "initials": "WS"}, {"family": "Lyons", "given": "Michael J", "initials": "MJ"}, {"family": "Lichtenstein", "given": "Paul", "initials": "P"}, {"family": "Jeong", "given": "Hoe-Uk", "initials": "HU"}, {"family": "Hur", "given": "Yoon-Mi", "initials": "YM"}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI"}, {"family": "S\u00f8rensen", "given": "Thorkild I A", "initials": "TIA"}, {"family": "Kaprio", "given": "Jaakko", "initials": "J"}], "type": "journal article", "published": "2019-05-00", "journal": {"volume": "27", "issn": "1930-739X", "issue": "5", "pages": "855-865", "title": "Obesity (Silver Spring)", "issn-l": "1930-7381"}, "abstract": "The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.\n\nA pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.\n\nUntil 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.\n\nLower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.", "doi": "10.1002/oby.22451", "pmid": "30950584", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC6478550"}, {"db": "mid", "key": "NIHMS1520745"}], "notes": [], "created": "2019-04-12T14:00:37.931Z", "modified": "2021-06-21T12:02:53.707Z"}], "created": "2017-05-09T09:12:23.229Z", "modified": "2020-11-27T13:14:08.066Z"}