{"entity": "journal", "iuid": "dd3f827991be4498bf34002b13b40af3", "timestamp": "2026-07-12T09:41:12.256Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Neuron.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Neuron"}}, "title": "Neuron", "issn": "1097-4199", "issn-l": "0896-6273", "publications_count": 6, "publications": [{"entity": "publication", "iuid": "2ad60769fa49433e9865d2124a284a9b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2ad60769fa49433e9865d2124a284a9b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2ad60769fa49433e9865d2124a284a9b"}}, "title": "Structure and dynamics of differential ligand binding in the human \u03c1-type GABAA receptor.", "authors": [{"family": "Cowgill", "given": "John", "initials": "J"}, {"family": "Fan", "given": "Chen", "initials": "C"}, {"family": "Haloi", "given": "Nandan", "initials": "N"}, {"family": "Tobiasson", "given": "Victor", "initials": "V", "orcid": "0000-0001-8920-017X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5208789057a94d0d9575476bf9c88d5a.json"}}, {"family": "Zhuang", "given": "Yuxuan", "initials": "Y"}, {"family": "Howard", "given": "Rebecca J", "initials": "RJ"}, {"family": "Lindahl", "given": "Erik", "initials": "E", "orcid": "0000-0003-1333-5398", "researcher": {"href": "https://publications.scilifelab.se/researcher/51600cedcf044bdda0f677deaeaf9fad.json"}}], "type": "journal article", "published": "2023-11-01", "journal": {"title": "Neuron", "issn": "1097-4199", "volume": "111", "issue": "21", "pages": "3450-3464.e5", "issn-l": "0896-6273"}, "abstract": "The neurotransmitter \u03b3-aminobutyric acid (GABA) drives critical inhibitory processes in and beyond the nervous system, partly via ionotropic type-A receptors (GABAARs). Pharmacological properties of \u03c1-type GABAARs are particularly distinctive, yet the structural basis for their specialization remains unclear. Here, we present cryo-EM structures of a lipid-embedded human \u03c11 GABAAR, including a partial intracellular domain, under apo, inhibited, and desensitized conditions. An apparent resting state, determined first in the absence of modulators, was recapitulated with the specific inhibitor (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid and blocker picrotoxin and provided a rationale for bicuculline insensitivity. Comparative structures, mutant recordings, and molecular simulations with and without GABA further explained the sensitized but slower activation of \u03c11 relative to canonical subtypes. Combining GABA with picrotoxin also captured an apparent uncoupled intermediate state. This work reveals structural mechanisms of gating and modulation with applications to \u03c1-specific pharmaceutical design and to our biophysical understanding of ligand-gated ion channels.", "doi": "10.1016/j.neuron.2023.08.006", "pmid": "37659407", "labels": {"Cryo-EM": "Service"}, "xrefs": [{"db": "pii", "key": "S0896-6273(23)00587-1"}], "notes": [], "created": "2023-09-19T08:21:37.127Z", "modified": "2023-12-04T09:50:38.972Z"}, {"entity": "publication", "iuid": "922d6aa32a44405abe942efb49092468", "links": {"self": {"href": "https://publications.scilifelab.se/publication/922d6aa32a44405abe942efb49092468.json"}, "display": {"href": "https://publications.scilifelab.se/publication/922d6aa32a44405abe942efb49092468"}}, "title": "Molecular anatomy of adult mouse leptomeninges.", "authors": [{"family": "Pietil\u00e4", "given": "Riikka", "initials": "R"}, {"family": "Del Gaudio", "given": "Francesca", "initials": "F"}, {"family": "He", "given": "Liqun", "initials": "L"}, {"family": "V\u00e1zquez-Li\u00e9banas", "given": "Elisa", "initials": "E"}, {"family": "Vanlandewijck", "given": "Michael", "initials": "M"}, {"family": "Muhl", "given": "Lars", "initials": "L"}, {"family": "Mocci", "given": "Giuseppe", "initials": "G"}, {"family": "Bj\u00f8rnholm", "given": "Katrine D", "initials": "KD"}, {"family": "Lindblad", "given": "Caroline", "initials": "C"}, {"family": "Fletcher-Sandersj\u00f6\u00f6", "given": "Alexander", "initials": "A"}, {"family": "Svensson", "given": "Mikael", "initials": "M"}, {"family": "Thelin", "given": "Eric P", "initials": "EP"}, {"family": "Liu", "given": "Jianping", "initials": "J"}, {"family": "van Voorden", "given": "A Jantine", "initials": "AJ"}, {"family": "Torres", "given": "Monica", "initials": "M"}, {"family": "Antila", "given": "Salli", "initials": "S"}, {"family": "Xin", "given": "Li", "initials": "L"}, {"family": "Karlstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "Storm-Mathisen", "given": "Jon", "initials": "J"}, {"family": "Bergersen", "given": "Linda Hildegard", "initials": "LH"}, {"family": "Moggio", "given": "Aldo", "initials": "A"}, {"family": "Hansson", "given": "Emil M", "initials": "EM"}, {"family": "Ulvmar", "given": "Maria H", "initials": "MH"}, {"family": "Nilsson", "given": "Per", "initials": "P"}, {"family": "M\u00e4kinen", "given": "Taija", "initials": "T"}, {"family": "Andaloussi M\u00e4e", "given": "Maarja", "initials": "M"}, {"family": "Alitalo", "given": "Kari", "initials": "K"}, {"family": "Proulx", "given": "Steven T", "initials": "ST"}, {"family": "Engelhardt", "given": "Britta", "initials": "B"}, {"family": "McDonald", "given": "Donald M", "initials": "DM"}, {"family": "Lendahl", "given": "Urban", "initials": "U"}, {"family": "Andrae", "given": "Johanna", "initials": "J"}, {"family": "Betsholtz", "given": "Christer", "initials": "C"}], "type": "journal article", "published": "2023-09-25", "journal": {"title": "Neuron", "issn": "1097-4199", "issn-l": "0896-6273"}, "abstract": "Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically distinct cell types of the pia, inner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibroblast-like transcriptome present in the choroid plexus and median eminence. Newly identified transcriptional markers enabled molecular characterization of cell types responsible for adherence of arachnoid layers to one another and for the arachnoid barrier. These markers also proved useful in identifying the molecular features of leptomeningeal development, injury, and repair that were preserved or changed after traumatic brain injury. Together, the findings highlight the value of identifying fibroblast transcriptional subsets and their cellular locations toward advancing the understanding of leptomeningeal physiology and pathology.", "doi": "10.1016/j.neuron.2023.09.002", "pmid": "37776854", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0896-6273(23)00666-9"}], "notes": [], "created": "2023-11-27T21:45:04.084Z", "modified": "2024-01-16T13:48:32.073Z"}, {"entity": "publication", "iuid": "3e5c425e90cd4b8e82e9a2d6e76fb874", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e5c425e90cd4b8e82e9a2d6e76fb874.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e5c425e90cd4b8e82e9a2d6e76fb874"}}, "title": "Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration.", "authors": [{"family": "Munguba", "given": "Hermany", "initials": "H"}, {"family": "Nikouei", "given": "Kasra", "initials": "K"}, {"family": "Hochgerner", "given": "Hannah", "initials": "H"}, {"family": "Oberst", "given": "Polina", "initials": "P"}, {"family": "Kouznetsova", "given": "Alexandra", "initials": "A"}, {"family": "Ryge", "given": "Jesper", "initials": "J"}, {"family": "Mu\u00f1oz-Manchado", "given": "Ana Bel\u00e9n", "initials": "AB"}, {"family": "Close", "given": "Jennie", "initials": "J"}, {"family": "Batista-Brito", "given": "Renata", "initials": "R"}, {"family": "Linnarsson", "given": "Sten", "initials": "S"}, {"family": "Hjerling-Leffler", "given": "Jens", "initials": "J"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Neuron", "issn": "1097-4199", "issn-l": "0896-6273"}, "abstract": "Although cardinal cortical interneuron identity is established upon cell-cycle exit, it remains unclear whether specific interneuron subtypes are pre-established, and if so, how their identity is maintained prior to circuit integration. We conditionally removed Sox6 (Sox6-cKO) in migrating somatostatin (Sst+) interneurons and assessed the effects on their mature identity. In adolescent mice, five of eight molecular Sst+ subtypes were nearly absent in the Sox6-cKO cortex without a reduction in cell number. Sox6-cKO cells displayed electrophysiological maturity and expressed genes enriched within the broad class of Sst+ interneurons. Furthermore, we could infer subtype identity prior to cortical integration (embryonic day 18.5), suggesting that the loss in subtype was due to disrupted subtype maintenance. Conversely, Sox6 removal at postnatal day 7 did not disrupt marker expression in the mature cortex. Therefore, Sox6 is necessary during migration for maintenance of Sst+ subtype identity, indicating that subtype maintenance requires active transcriptional programs.", "doi": "10.1016/j.neuron.2023.07.018", "pmid": "37625400", "labels": {"NGI Short read": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service"}, "xrefs": [{"db": "pii", "key": "S0896-6273(23)00580-9"}], "notes": [], "created": "2023-10-11T08:47:37.057Z", "modified": "2023-10-19T12:32:19.357Z"}, {"entity": "publication", "iuid": "f2b8e797bc1f449fa623e9ccef692699", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f2b8e797bc1f449fa623e9ccef692699.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f2b8e797bc1f449fa623e9ccef692699"}}, "title": "Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility.", "authors": [{"family": "Meijer", "given": "Mandy", "initials": "M"}, {"family": "Agirre", "given": "Eneritz", "initials": "E"}, {"family": "Kabbe", "given": "Mukund", "initials": "M"}, {"family": "van Tuijn", "given": "Cassandra A", "initials": "CA"}, {"family": "Heskol", "given": "Abeer", "initials": "A"}, {"family": "Zheng", "given": "Chao", "initials": "C"}, {"family": "Mendanha Falc\u00e3o", "given": "Ana", "initials": "A"}, {"family": "Bartosovic", "given": "Marek", "initials": "M"}, {"family": "Kirby", "given": "Leslie", "initials": "L"}, {"family": "Calini", "given": "Daniela", "initials": "D"}, {"family": "Johnson", "given": "Michael R", "initials": "MR"}, {"family": "Corces", "given": "M Ryan", "initials": "MR"}, {"family": "Montine", "given": "Thomas J", "initials": "TJ"}, {"family": "Chen", "given": "Xingqi", "initials": "X"}, {"family": "Chang", "given": "Howard Y", "initials": "HY"}, {"family": "Malhotra", "given": "Dheeraj", "initials": "D"}, {"family": "Castelo-Branco", "given": "Gon\u00e7alo", "initials": "G"}], "type": "journal article", "published": "2022-04-06", "journal": {"title": "Neuron", "issn": "1097-4199", "issn-l": "0896-6273", "volume": "110", "issue": "7", "pages": "1193-1210.e13"}, "abstract": "Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mouse and human OLG in a non-disease context, compatible with transitions to immune-competent states in MS. We identified BACH1 and STAT1 as transcription factors involved in immune gene regulation in oligodendrocyte precursor cells (OPCs). A subset of immune genes presents bivalency of H3K4me3/H3K27me3 in OPCs, with Polycomb inhibition leading to their increased activation upon interferon gamma (IFN-\u03b3) treatment. Some MS susceptibility single-nucleotide polymorphisms (SNPs) overlap with these regulatory regions in mouse and human OLG. Treatment of mouse OPCs with IFN-\u03b3 leads to chromatin architecture remodeling at these loci and altered expression of interacting genes. Thus, the susceptibility for MS may involve OLG, which therefore constitutes novel targets for immunological-based therapies for MS.", "doi": "10.1016/j.neuron.2021.12.034", "pmid": "35093191", "labels": {"Eukaryotic Single Cell Genomics (ESCG)": "Service", "Bioinformatics Support for Computational Resources": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Single cell": "Service"}, "xrefs": [{"db": "pii", "key": "S0896-6273(21)01089-8"}], "notes": [], "created": "2022-03-29T13:48:05.164Z", "modified": "2024-02-12T08:46:45.499Z"}, {"entity": "publication", "iuid": "b4782cdfe6284e678b37e60ddf9f30c8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b4782cdfe6284e678b37e60ddf9f30c8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b4782cdfe6284e678b37e60ddf9f30c8"}}, "title": "A spinal organ of proprioception for integrated motor action feedback.", "authors": [{"family": "Picton", "given": "Laurence D", "initials": "LD"}, {"family": "Bertuzzi", "given": "Maria", "initials": "M"}, {"family": "Pallucchi", "given": "Irene", "initials": "I"}, {"family": "Fontanel", "given": "Pierre", "initials": "P"}, {"family": "Dahlberg", "given": "Elin", "initials": "E"}, {"family": "Bj\u00f6rnfors", "given": "E Rebecka", "initials": "ER"}, {"family": "Iacoviello", "given": "Francesco", "initials": "F"}, {"family": "Shearing", "given": "Paul R", "initials": "PR"}, {"family": "El Manira", "given": "Abdeljabbar", "initials": "A"}], "type": "journal article", "published": "2021-04-07", "journal": {"title": "Neuron", "issn": "1097-4199", "issn-l": "0896-6273", "volume": "109", "issue": "7", "pages": "1188-1201.e7"}, "abstract": "Proprioception is essential for behavior and provides a sense of our body movements in physical space. Proprioceptor organs are thought to be only in the periphery. Whether the central nervous system can intrinsically sense its own movement remains unclear. Here we identify a segmental organ of proprioception in the adult zebrafish spinal cord, which is embedded by intraspinal mechanosensory neurons expressing Piezo2 channels. These cells are late-born, inhibitory, commissural neurons with unique molecular and physiological profiles reflecting a dual sensory and motor function. The central proprioceptive organ locally detects lateral body movements during locomotion and provides direct inhibitory feedback onto rhythm-generating interneurons responsible for the central motor program. This dynamically aligns central pattern generation with movement outcome for efficient locomotion. Our results demonstrate that a central proprioceptive organ monitors self-movement using hybrid neurons that merge sensory and motor entities into a unified network.", "doi": "10.1016/j.neuron.2021.01.018", "pmid": "33577748", "labels": {"Eukaryotic Single Cell Genomics (ESCG)": "Service", "NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null, "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support and Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "S0896-6273(21)00040-4"}], "notes": [], "created": "2021-02-17T12:00:56.937Z", "modified": "2024-01-16T13:48:40.100Z"}, {"entity": "publication", "iuid": "21327877c2474a1eafc9e521fe6727bc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/21327877c2474a1eafc9e521fe6727bc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/21327877c2474a1eafc9e521fe6727bc"}}, "title": "OLM\u03b12 Cells Bidirectionally Modulate Learning", "authors": [{"family": "Siwani", "given": "Samer", "initials": "S"}, {"family": "Fran\u00e7a", "given": "Arthur S C", "initials": "ASC"}, {"family": "Mikulovic", "given": "Sanja", "initials": "S"}, {"family": "Reis", "given": "Amilcar", "initials": "A"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM"}, {"family": "Edwards", "given": "Steven J", "initials": "SJ"}, {"family": "Le\u00e3o", "given": "Richardson N", "initials": "RN"}, {"family": "Tort", "given": "Adriano B L", "initials": "ABL"}, {"family": "Kullander", "given": "Klas", "initials": "K"}], "type": "journal-article", "published": "2018-07-00", "journal": {"volume": "99", "issn": "0896-6273", "issue": "2", "pages": "404-412.e3", "title": "Neuron", "issn-l": null}, "abstract": "Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor \u03b12 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLM\u03b12 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLM\u03b12 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLM\u03b12 cell activation inhibits fear-related memories and that OLM\u03b12 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLM\u03b12 cells are an important component in the CA1 microcircuit regulating learning and memory processes.", "doi": "10.1016/j.neuron.2018.06.022", "pmid": "29983324", "labels": {"Integrated Microscopy Technologies Stockholm": "Collaborative", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": "Steven Edwards collaboration (Light-sheet)", "created": "2018-10-29T15:28:26.717Z", "modified": "2024-01-16T13:48:46.034Z"}], "created": "2018-10-29T15:23:14.164Z", "modified": "2020-11-27T13:14:01.317Z"}