{"entity": "journal", "iuid": "d43209ef5005486b80f741de67c88d81", "timestamp": "2026-07-20T16:24:13.715Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Nephrol%20Dial%20Transplant.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Nephrol%20Dial%20Transplant"}}, "title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "3428d78246ac475ca8349a74c8ffa043", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3428d78246ac475ca8349a74c8ffa043.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3428d78246ac475ca8349a74c8ffa043"}}, "title": "Osteoprotegerin predicts cardiovascular events in patients treated with hemodialysis.", "authors": [{"family": "Wu", "given": "Ping-Hsun", "initials": "PH"}, {"family": "Glerup", "given": "Rie Io", "initials": "RI"}, {"family": "Svensson", "given": "My Hanna Sofia", "initials": "MHS"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Christensen", "given": "Jeppe Hagstrup", "initials": "JH"}, {"family": "Linde", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Ljunggren", "given": "\u00d6sten", "initials": "\u00d6"}, {"family": "Fellstr\u00f6m", "given": "Bengt", "initials": "B"}], "type": "journal article", "published": "2021-06-04", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": null}, "abstract": "Disturbances in bone mineral metabolism are associated with increased mortality and cardiovascular events (CVEs). However, the association between bone-associated protein biomarkers, mortality, and CVEs independent of cytokine activation remains unknown. This study aimed to investigate bone-associated protein biomarkers, and the association with inflammatory cytokines, and cardiovascular outcomes.\n\nThis prospective study enrolled hemodialysis (HD) patients in Denmark between December 2010 and March 2011. Using a proximity extension proteomics assay, nine bone-associated proteins were examined: cathepsin D (CTSD), cathepsin L1 (CTSL1), dickkopf-related protein 1 (Dkk-1), fibroblast growth factor 23 (FGF-23), leptin, osteoprotegerin (OPG), receptor activator of nuclear factor kappa-\u0392 ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2). The importance of the bone-associated protein markers was evaluated by a random forest algorithm (RF). The association between bone-associated proteins with all-cause death, cardiovascular death, and CVEs was analyzed in multivariable Cox models adjusted for age, gender, comorbidities, laboratory data, and dialysis duration.\n\nWe enrolled 331 patients (63.7% men; mean [SD] age, 65 [14.6] years) in a prospective cohort study with five years follow-up. When adjusting for confounders, CTSL1 remained associated with all-cause death, and four biomarkers were associated with CVE. However, the association between bone markers and the outcomes was attenuated after adjusting for inflammatory proteins, and just OPG remained associated with CVE in the adjusted model. Evaluating the importance of bone markers by RF, OPG was the most important marker related to CVEs. OPG also improved the prediction of CVE when added clinical information alone in integrated discrimination improvement and net reclassification improvement analyses.\n\nOPG, a well-known bone biomarker, was associated with CVEs independent of cytokine activity. In contrast, the association between CVEs and the remaining three bone-associated proteins (TRAIL-R2, CTSD, and CTSL1) was affected by cytokine inflammation activity.", "doi": "10.1093/ndt/gfab192", "pmid": "34086939", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "6292121"}], "notes": [], "created": "2021-12-10T09:58:17.448Z", "modified": "2021-12-10T09:58:17.454Z"}, {"entity": "publication", "iuid": "76cc3a61a0034fd98d4b51bbf2930a27", "links": {"self": {"href": "https://publications.scilifelab.se/publication/76cc3a61a0034fd98d4b51bbf2930a27.json"}, "display": {"href": "https://publications.scilifelab.se/publication/76cc3a61a0034fd98d4b51bbf2930a27"}}, "title": "Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years.", "authors": [{"family": "Schulz", "given": "Christina-Alexandra", "initials": "CA"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Almgren", "given": "Peter", "initials": "P"}, {"family": "Petkovic", "given": "Marinka", "initials": "M"}, {"family": "Christensson", "given": "Anders", "initials": "A"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications.scilifelab.se/researcher/f23c2a10ac2a4d73a8f62b94855635f1.json"}}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}], "type": "journal article", "published": "2020-02-01", "journal": {"title": "Nephrol Dial Transplant", "issn": "1460-2385", "issn-l": null, "volume": "35", "issue": "2", "pages": "265-273"}, "abstract": "The kidney injury molecule-1 (KIM-1) has previously been associated with kidney function in rodents and humans. Yet its role as a predictive marker for future decline in kidney function has remained less clear.\n\nAt baseline (1991-1994), fasting plasma KIM-1 (p-KIM-1) was measured in 4739 participants of the population-based Malm\u00f6 Diet and Cancer Study. Creatinine and cystatin C were used to calculate estimated glomerular filtration rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Collaboration 2012 creatinine-cystatin C equation at baseline and follow-up examination (2007-2012). Incident CKD was defined as an eGFR <60 mL/min/1.73 m2 at follow-up.\n\nDuring a mean follow-up time of 16.6 years, high p-KIM-1 levels were associated with a greater decline in eGFR (quartile 1 -1.36 versus quartile 4 -1.54 mL/min/1.73 m2; P < 0.001). In multivariate analyses, the risk for incident CKD at the follow-up examination was higher among participants with baseline p-KIM-1 levels in the highest quartile {odds ratio [OR] 1.45 [95% confidence interval (CI) 1.10-1.92]} compared with those within the lowest quartile. The relative impact of baseline p-KIM-1 on incidence of CKD [OR 1.20 (95% CI 1.08-1.33) per 1 standard deviation (SD) increase in p-KIM-1] was comparable to those of age and systolic blood pressure (SBP) [OR 1.55 (95% CI 1.38-1.74) and OR 1.21 (95% CI 1.09-1.35) per 1 SD increase, respectively]. Adding p-KIM-1 to a conventional risk model resulted in significantly improved C-statistics (P = 0.04) and reclassified 9% of the individuals into the correct risk direction (continuous net reclassification improvement P = 0.02). Furthermore, the risk for hospitalization due to impaired renal function increased with increasing baseline p-KIM-1 [hazard ratio per 1 SD 1.43; (95% CI 1.18-1.74)] during a mean follow-up time of 19.2 years.\n\nOur results show that p-KIM-1 predicts the future decline of eGFR and risk of CKD in healthy middle-aged participants. Whether p-KIM-1 can be used to prioritize preventive action that needs to be further investigated.", "doi": "10.1093/ndt/gfy382", "pmid": "30629206", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "5284694"}, {"db": "pmc", "key": "PMC7049260"}], "notes": [], "created": "2020-01-23T16:05:01.488Z", "modified": "2023-04-14T13:55:52.809Z"}], "created": "2021-06-21T13:43:16.561Z", "modified": "2021-06-21T13:43:16.561Z"}