{"entity": "journal", "iuid": "3bb058b4873745d2a9a11e9f0b7ccb87", "timestamp": "2026-07-14T04:19:25.286Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Nat.%20Immunol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Nat.%20Immunol."}}, "title": "Nat. Immunol.", "issn": "1529-2916", "issn-l": "1529-2908", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "552ba212eea247d8b241053070d1b005", "links": {"self": {"href": "https://publications.scilifelab.se/publication/552ba212eea247d8b241053070d1b005.json"}, "display": {"href": "https://publications.scilifelab.se/publication/552ba212eea247d8b241053070d1b005"}}, "title": "The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.", "authors": [{"family": "Linnerbauer", "given": "Mathias", "initials": "M", "orcid": "0000-0002-5528-5141", "researcher": {"href": "https://publications.scilifelab.se/researcher/27c1386bf72f4371acb131d333314da2.json"}}, {"family": "L\u00f6\u00dflein", "given": "Lena", "initials": "L", "orcid": "0000-0001-5705-9175", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b3e8a2756064eb886c83c2f0d2fddef.json"}}, {"family": "Vandrey", "given": "Oliver", "initials": "O"}, {"family": "Peter", "given": "Anne", "initials": "A"}, {"family": "Han", "given": "Yanan", "initials": "Y"}, {"family": "Tsaktanis", "given": "Thanos", "initials": "T"}, {"family": "Wogram", "given": "Emile", "initials": "E"}, {"family": "Needhamsen", "given": "Maria", "initials": "M"}, {"family": "Kular", "given": "Lara", "initials": "L", "orcid": "0000-0002-2907-6071", "researcher": {"href": "https://publications.scilifelab.se/researcher/09563004a20543dc934dd4d3b1ceebd7.json"}}, {"family": "Nagel", "given": "Lisa", "initials": "L"}, {"family": "Zissler", "given": "Julia", "initials": "J"}, {"family": "Andert", "given": "Marie", "initials": "M", "orcid": "0009-0005-5440-8153", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbedf36b1d214bd0b7e9f10a62465c33.json"}}, {"family": "Meszaros", "given": "Lisa", "initials": "L"}, {"family": "Hanspach", "given": "Jannis", "initials": "J"}, {"family": "Zuber", "given": "Finnja", "initials": "F"}, {"family": "Naumann", "given": "Ulrike J", "initials": "UJ"}, {"family": "Diebold", "given": "Martin", "initials": "M", "orcid": "0000-0001-9636-6936", "researcher": {"href": "https://publications.scilifelab.se/researcher/c78e07975fb042078617df5a4156c2cf.json"}}, {"family": "Wheeler", "given": "Michael A", "initials": "MA", "orcid": "0000-0002-0689-6384", "researcher": {"href": "https://publications.scilifelab.se/researcher/f271f2553bc54ad8851148c6516e99a3.json"}}, {"family": "Beyer", "given": "Tobias", "initials": "T"}, {"family": "Nirschl", "given": "Lucy", "initials": "L"}, {"family": "Cirac", "given": "Ana", "initials": "A"}, {"family": "Laun", "given": "Frederik B", "initials": "FB"}, {"family": "G\u00fcnther", "given": "Claudia", "initials": "C"}, {"family": "Winkler", "given": "J\u00fcrgen", "initials": "J"}, {"family": "B\u00e4uerle", "given": "Tobias", "initials": "T"}, {"family": "Jagodic", "given": "Maja", "initials": "M", "orcid": "0000-0003-0756-889X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b651ef39c6b0436992e2305f425eba72.json"}}, {"family": "Hemmer", "given": "Bernhard", "initials": "B", "orcid": "0000-0001-5985-6784", "researcher": {"href": "https://publications.scilifelab.se/researcher/77d4cc3106604923a485c1bd9d5d1cb2.json"}}, {"family": "Prinz", "given": "Marco", "initials": "M", "orcid": "0000-0002-0349-1955", "researcher": {"href": "https://publications.scilifelab.se/researcher/df8ed6029343466694a94817f0f479e0.json"}}, {"family": "Quintana", "given": "Francisco J", "initials": "FJ"}, {"family": "Rothhammer", "given": "Veit", "initials": "V", "orcid": "0000-0003-0296-843X", "researcher": {"href": "https://publications.scilifelab.se/researcher/39f7424a439943dbaf449e579769506a.json"}}], "type": "journal article", "published": "2024-03-00", "journal": {"title": "Nat. Immunol.", "issn": "1529-2916", "volume": "25", "issue": "3", "pages": "432-447", "issn-l": "1529-2908"}, "abstract": "Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including multiple sclerosis (MS). Several studies have demonstrated the involvement of pro-inflammatory glial subsets in the pathogenesis and propagation of inflammatory events in MS and its animal models. However, it has only recently become clear that the underlying heterogeneity of astrocytes and microglia can not only drive inflammation, but also lead to its resolution through direct and indirect mechanisms. Failure of these tissue-protective mechanisms may potentiate disease and increase the risk of conversion to progressive stages of MS, for which currently available therapies are limited. Using proteomic analyses of cerebrospinal fluid specimens from patients with MS in combination with experimental studies, we here identify Heparin-binding EGF-like growth factor (HB-EGF) as a central mediator of tissue-protective and anti-inflammatory effects important for the recovery from acute inflammatory lesions in CNS autoimmunity. Hypoxic conditions drive the rapid upregulation of HB-EGF by astrocytes during early CNS inflammation, while pro-inflammatory conditions suppress trophic HB-EGF signaling through epigenetic modifications. Finally, we demonstrate both anti-inflammatory and tissue-protective effects of HB-EGF in a broad variety of cell types in vitro and use intranasal administration of HB-EGF in acute and post-acute stages of autoimmune neuroinflammation to attenuate disease in a preclinical mouse model of MS. Altogether, we identify astrocyte-derived HB-EGF and its epigenetic regulation as a modulator of autoimmune CNS inflammation and potential therapeutic target in MS.", "doi": "10.1038/s41590-024-01756-6", "pmid": "38409259", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10907300"}, {"db": "pii", "key": "10.1038/s41590-024-01756-6"}], "notes": [], "created": "2024-11-25T10:19:50.350Z", "modified": "2025-02-28T14:15:42.709Z"}, {"entity": "publication", "iuid": "2bd624ebafa942a99f4c19129a9f55e3", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2bd624ebafa942a99f4c19129a9f55e3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2bd624ebafa942a99f4c19129a9f55e3"}}, "title": "Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19.", "authors": [{"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications.scilifelab.se/researcher/c9a74d3380a24c31930e6e671e685b5b.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications.scilifelab.se/researcher/8fec11dd18f941b7842610ad14237a35.json"}}, {"family": "Grip", "given": "Jonathan", "initials": "J"}, {"family": "Lindel\u00f6f", "given": "Linnea", "initials": "L", "orcid": "0000-0002-3654-8874", "researcher": {"href": "https://publications.scilifelab.se/researcher/65f6c8233c5547f2885b3e55bbec2601.json"}}, {"family": "Rooijackers", "given": "Olav", "initials": "O"}, {"family": "Pigazzini", "given": "Sara", "initials": "S"}, {"family": "Niemi", "given": "Mari", "initials": "M"}, {"family": "Cordioli", "given": "Mattia", "initials": "M"}, {"family": "Nkambule", "given": "Lindo", "initials": "L"}, {"family": "Maricic", "given": "Tomislav", "initials": "T"}, {"family": "Ekdahl", "given": "Kristina Nilsson", "initials": "KN"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications.scilifelab.se/researcher/090e842ed8ff4cf2a3fe5f8e58118e58.json"}}, {"family": "Eriksson", "given": "Oskar", "initials": "O", "orcid": "0000-0003-2418-6463", "researcher": {"href": "https://publications.scilifelab.se/researcher/be37c57d144c443d8d52df450b86a3fe.json"}}], "type": "letter", "published": "2022-06-00", "journal": {"title": "Nat. Immunol.", "issn": "1529-2916", "volume": "23", "issue": "6", "pages": "861-864", "issn-l": "1529-2908"}, "abstract": null, "doi": "10.1038/s41590-022-01227-w", "pmid": "35624204", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41590-022-01227-w"}], "notes": [], "created": "2022-08-29T14:11:07.067Z", "modified": "2024-01-16T13:48:36.311Z"}, {"entity": "publication", "iuid": "928af491ca2748b486065f9afcf6164e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/928af491ca2748b486065f9afcf6164e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/928af491ca2748b486065f9afcf6164e"}}, "title": "Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-\u03b2 signaling", "authors": [{"family": "Lund", "given": "Harald", "initials": "H", "orcid": "0000-0001-8046-0805", "researcher": {"href": "https://publications.scilifelab.se/researcher/4fe4902c355449e4812008d4ad7a37e0.json"}}, {"family": "Pieber", "given": "Melanie", "initials": "M", "orcid": "0000-0002-4522-2489", "researcher": {"href": "https://publications.scilifelab.se/researcher/054b79afd3ec48d9adfb723b9ca0d3ae.json"}}, {"family": "Parsa", "given": "Roham", "initials": "R", "orcid": "0000-0002-0864-6098", "researcher": {"href": "https://publications.scilifelab.se/researcher/034a292f99404db0886159fdb225bfd6.json"}}, {"family": "Grommisch", "given": "David", "initials": "D", "orcid": "0000-0002-2666-1419", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba4e40cb43e64713b48caa02a0941d1a.json"}}, {"family": "Ewing", "given": "Ewoud", "initials": "E", "orcid": "0000-0001-8644-366X", "researcher": {"href": "https://publications.scilifelab.se/researcher/aea9350a4f864d8e8781ab111b4f9273.json"}}, {"family": "Kular", "given": "Lara", "initials": "L"}, {"family": "Han", "given": "Jinming", "initials": "J", "orcid": "0000-0002-6084-3275", "researcher": {"href": "https://publications.scilifelab.se/researcher/b0f73f656d114874bcfd64efd97883cb.json"}}, {"family": "Zhu", "given": "Keying", "initials": "K", "orcid": "0000-0001-7500-1532", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b85d1ae8136464788be19d62a8863d7.json"}}, {"family": "Nijssen", "given": "Jik", "initials": "J"}, {"family": "Hedlund", "given": "Eva", "initials": "E", "orcid": "0000-0001-6347-0075", "researcher": {"href": "https://publications.scilifelab.se/researcher/d517e76df2e944e09ddbe87b7e0329af.json"}}, {"family": "Needhamsen", "given": "Maria", "initials": "M"}, {"family": "Ruhrmann", "given": "Sabrina", "initials": "S"}, {"family": "Guerreiro-Cacais", "given": "Andr\u00e9 Ortlieb", "initials": "AO", "orcid": "0000-0002-4561-2823", "researcher": {"href": "https://publications.scilifelab.se/researcher/9b824181455243b19f4aa145a4545870.json"}}, {"family": "Berglund", "given": "Rasmus", "initials": "R"}, {"family": "Forteza", "given": "Maria J", "initials": "MJ"}, {"family": "Ketelhuth", "given": "Daniel F J", "initials": "DFJ"}, {"family": "Butovsky", "given": "Oleg", "initials": "O"}, {"family": "Jagodic", "given": "Maja", "initials": "M"}, {"family": "Zhang", "given": "Xing Mei", "initials": "XM"}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b0733d3c25145139f42cad897d6726b.json"}}], "type": "journal-article", "published": "2018-05-00", "journal": {"volume": "19", "issn": "1529-2908", "issue": "5", "pages": "1-7", "title": "Nat. Immunol.", "issn-l": null}, "abstract": "The cytokine transforming growth factor-\u03b2 (TGF-\u03b2) regulates the development and homeostasis of several tissue-resident macrophage populations, including microglia. TGF-\u03b2 is not critical for microglia survival but is required for the maintenance of the microglia-specific homeostatic gene signature1,2. Under defined host conditions, circulating monocytes can compete for the microglial niche and give rise to long-lived monocyte-derived macrophages residing in the central nervous system (CNS)3-5. Whether monocytes require TGF-\u03b2 for colonization of the microglial niche and maintenance of CNS integrity is unknown. We found that abrogation of TGF-\u03b2 signaling in CX3CR1+ monocyte-derived macrophages led to rapid onset of a progressive and fatal demyelinating motor disease characterized by myelin-laden giant macrophages throughout the spinal cord. Tgfbr2-deficient macrophages were characterized by high expression of genes encoding proteins involved in antigen presentation, inflammation and phagocytosis. TGF-\u03b2 is thus crucial for the functional integration of monocytes into the CNS microenvironment.", "doi": "10.1038/s41590-018-0091-5", "pmid": "29662171", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "mid", "key": "NIHMS1586138"}, {"db": "pmc", "key": "PMC7309278"}, {"db": "pii", "key": "10.1038/s41590-018-0091-5"}], "notes": [], "created": "2018-10-31T19:46:22.446Z", "modified": "2024-01-16T13:48:46.428Z"}], "created": "2018-10-31T19:46:22.459Z", "modified": "2020-11-27T13:14:04.678Z"}