{"entity": "journal", "iuid": "5667f4697aef4498972d4abbc43bf250", "timestamp": "2026-08-11T14:41:45.001Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/N.%20Engl.%20J.%20Med..json"}, "display": {"href": "https://publications.scilifelab.se/journal/N.%20Engl.%20J.%20Med."}}, "title": "N. Engl. J. Med.", "issn": "1533-4406", "issn-l": "0028-4793", "publications_count": 5, "publications": [{"entity": "publication", "iuid": "f4701608c6464c3288865cdcb70e61c9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f4701608c6464c3288865cdcb70e61c9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f4701608c6464c3288865cdcb70e61c9"}}, "title": "Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer.", "authors": [{"family": "Martling", "given": "Anna", "initials": "A", "orcid": "0000-0001-5998-4735", "researcher": {"href": "https://publications.scilifelab.se/researcher/dab7d4e9839b4cd5be9393a04b089d33.json"}}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I"}, {"family": "Nilbert", "given": "Mef", "initials": "M"}, {"family": "Gr\u00f6nberg", "given": "Henrik", "initials": "H"}, {"family": "Granath", "given": "Fredrik", "initials": "F"}, {"family": "Eklund", "given": "Martin", "initials": "M"}, {"family": "\u00d6resland", "given": "Tom", "initials": "T"}, {"family": "Iversen", "given": "Lene H", "initials": "LH"}, {"family": "Haapam\u00e4ki", "given": "Carola", "initials": "C"}, {"family": "Janson", "given": "Martin", "initials": "M"}, {"family": "Westberg", "given": "Karin", "initials": "K"}, {"family": "Segelman", "given": "Josefin", "initials": "J"}, {"family": "Ersson", "given": "Urban", "initials": "U"}, {"family": "Prytz", "given": "Mattias", "initials": "M"}, {"family": "Angenete", "given": "Eva", "initials": "E", "orcid": "0000-0001-9966-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/07bd63b6d277460ca830518ed23fa31e.json"}}, {"family": "Bergstr\u00f6m", "given": "Rebecka", "initials": "R", "orcid": "0000-0001-7609-0733", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c52bb8b2ae249049f0da222bcdfe932.json"}}, {"family": "Mayrhofer", "given": "Markus", "initials": "M"}, {"family": "Glimelius", "given": "Bengt", "initials": "B"}, {"family": "Lindberg", "given": "Johan", "initials": "J"}, {"family": "ALASCCA Study Group", "given": "", "initials": ""}], "type": "clinical trial, phase iii", "published": "2025-09-18", "journal": {"title": "N. Engl. J. Med.", "issn": "1533-4406", "volume": "393", "issue": "11", "pages": "1051-1064", "issn-l": "0028-4793"}, "abstract": "Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. Observational studies suggest that aspirin may also improve disease-free survival after diagnosis, particularly among patients with tumors harboring somatic PIK3CA mutations. However, data from randomized trials are lacking.\n\nWe conducted a double-blind, randomized, placebo-controlled trial involving patients with stage I, II, or III rectal cancer or stage II or III colon cancer with somatic alterations in PI3K pathway genes. The patients were assigned in a 1:1 ratio to receive 160 mg of aspirin or matched placebo once daily for 3 years. Patients with prespecified PIK3CA hotspot mutations in exon 9 or 20 (group A alterations) and those with other moderate- or high-impact somatic variants in PIK3CA, PIK3R1, or PTEN (group B alterations) were eligible for randomization. The primary end point was colorectal cancer recurrence, assessed in a time-to-event analysis, in patients with group A alterations. Secondary end points included colorectal cancer recurrence in patients with group B alterations, disease-free survival, and safety.\n\nAlterations in PI3K pathway genes were detected in 1103 of 2980 patients (37.0%) with complete genomic data. Of 515 patients with group A alterations and 588 patients with group B alterations, 314 and 312, respectively, were assigned to receive aspirin or placebo. The estimated 3-year cumulative incidence of recurrence was 7.7% with aspirin and 14.1% with placebo (hazard ratio, 0.49; 95% confidence interval [CI], 0.24 to 0.98; P = 0.04) among patients with group A alterations and 7.7% and 16.8%, respectively (hazard ratio, 0.42; 95% CI, 0.21 to 0.83), among those with group B alterations. The estimated 3-year disease-free survival was 88.5% with aspirin and 81.4% with placebo (hazard ratio, 0.61; 95% CI, 0.34 to 1.08) among patients with group A alterations and 89.1% and 78.7%, respectively (hazard ratio, 0.51; 95% CI, 0.29 to 0.88), among those with group B alterations. Severe adverse events occurred in 16.8% of aspirin recipients and 11.6% of placebo recipients.\n\nAspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with PIK3CA hotspot mutations in exon 9 or 20 and appeared to have a similar benefit among those with other somatic alterations in PI3K pathway genes. (Funded by the Swedish Research Council and others; ALASCCA ClinicalTrials.gov number, NCT02647099; EudraCT number, 2015-004240-19.).", "doi": "10.1056/NEJMoa2504650", "pmid": "40961426", "labels": {"Bioinformatics (NBIS)": "Collaborative", "Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Clinical Genomics Stockholm": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT02647099"}, {"db": "EudraCT", "key": "2015-004240-19"}], "notes": [], "created": "2025-10-06T11:47:12.777Z", "modified": "2025-11-18T20:46:30.247Z"}, {"entity": "publication", "iuid": "ce1c6e0b470b4be1864941da1192027e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ce1c6e0b470b4be1864941da1192027e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ce1c6e0b470b4be1864941da1192027e"}}, "title": "Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection.", "authors": [{"family": "Bladh", "given": "Oscar", "initials": "O"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbd194b3cef64f9f9341fd163a035235.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Aguilera", "given": "Katherina", "initials": "K"}, {"family": "Alm", "given": "Jessica J", "initials": "JJ"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2023-10-26", "journal": {"title": "N. Engl. J. Med.", "issn": "1533-4406", "issn-l": "0028-4793", "volume": "389", "issue": "17", "pages": "1626-1628"}, "abstract": null, "doi": "10.1056/NEJMc2310347", "pmid": "37888924", "labels": {"Affinity Proteomics Uppsala": "Collaborative"}, "xrefs": [], "notes": [], "created": "2023-11-29T18:59:02.968Z", "modified": "2023-11-29T19:04:13.870Z"}, {"entity": "publication", "iuid": "50236da8e62d47a6893f3e1eadcd5aec", "links": {"self": {"href": "https://publications.scilifelab.se/publication/50236da8e62d47a6893f3e1eadcd5aec.json"}, "display": {"href": "https://publications.scilifelab.se/publication/50236da8e62d47a6893f3e1eadcd5aec"}}, "title": "Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.", "authors": [{"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-11-24", "journal": {"title": "N. Engl. J. Med.", "issn": "1533-4406", "volume": "387", "issue": "21", "pages": "e55", "issn-l": "0028-4793"}, "abstract": null, "doi": "10.1056/NEJMc2213153", "pmid": "36416779", "labels": {"Affinity Proteomics Uppsala": "Collaborative"}, "xrefs": [{"db": "pii", "key": "10.1056/NEJMc2213153#sa2"}], "notes": [], "created": "2022-12-02T09:11:43.689Z", "modified": "2022-12-02T09:11:43.693Z"}, {"entity": "publication", "iuid": "9daa6b181d8d4874a7834d3bce284468", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9daa6b181d8d4874a7834d3bce284468.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9daa6b181d8d4874a7834d3bce284468"}}, "title": "Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbd194b3cef64f9f9341fd163a035235.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Bacchus", "given": "Philip", "initials": "P", "orcid": "0000-0001-9800-1957", "researcher": {"href": "https://publications.scilifelab.se/researcher/287bafef8b584a5cbd7bee05dbe3b5d0.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "letter", "published": "2022-10-06", "journal": {"title": "N. Engl. J. Med.", "issn": "1533-4406", "volume": "387", "issue": "14", "pages": "1333-1336", "issn-l": "0028-4793"}, "abstract": null, "doi": "10.1056/NEJMc2209651", "pmid": "36103621", "labels": {"Autoimmunity and Serology Profiling": "Collaborative", "Affinity Proteomics Uppsala": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC9511632"}], "notes": [], "created": "2022-10-02T20:52:13.937Z", "modified": "2022-12-02T09:11:42.533Z"}, {"entity": "publication", "iuid": "d37050f60f8445d88bc7a32cd5861667", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d37050f60f8445d88bc7a32cd5861667.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d37050f60f8445d88bc7a32cd5861667"}}, "title": "Genetically determined height and coronary artery disease.", "authors": [{"family": "Nelson", "given": "Christopher P", "initials": "CP"}, {"family": "Hamby", "given": "Stephen E", "initials": "SE"}, {"family": "Saleheen", "given": "Danish", "initials": "D"}, {"family": "Hopewell", "given": "Jenna C", "initials": "JC"}, {"family": "Zeng", "given": "Lingyao", "initials": "L"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL"}, {"family": "Kanoni", "given": "Stavroula", "initials": "S"}, {"family": "Willenborg", "given": "Christina", "initials": "C"}, {"family": "Burgess", "given": "Stephen", "initials": "S"}, {"family": "Amouyel", "given": "Phillipe", "initials": "P"}, {"family": "Anand", "given": "Sonia", "initials": "S"}, {"family": "Blankenberg", "given": "Stefan", "initials": "S"}, {"family": "Boehm", "given": "Bernhard O", "initials": "BO"}, {"family": "Clarke", "given": "Robert J", "initials": "RJ"}, {"family": "Collins", "given": "Rory", "initials": "R"}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Farrall", "given": "Martin", "initials": "M"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Hall", "given": "Alistair S", "initials": "AS"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Hengstenberg", "given": "Christian", "initials": "C"}, {"family": "Hovingh", "given": "G Kees", "initials": "GK"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kathiresan", "given": "Sekar", "initials": "S"}, {"family": "Kee", "given": "Frank", "initials": "F"}, {"family": "K\u00f6nig", "given": "Inke R", "initials": "IR"}, {"family": "Kooner", "given": "Jaspal", "initials": "J"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "M\u00e4rz", "given": "Winifred", "initials": "W"}, {"family": "McPherson", "given": "Ruth", "initials": "R"}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Nieminen", "given": "Markku S", "initials": "MS"}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Palmer", "given": "Colin N A", "initials": "CN"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Perola", "given": "Markus", "initials": "M"}, {"family": "Reilly", "given": "Muredach P", "initials": "MP"}, {"family": "Ripatti", "given": "Samuli", "initials": "S"}, {"family": "Roberts", "given": "Robert", "initials": "R"}, {"family": "Salomaa", "given": "Veikko", "initials": "V"}, {"family": "Shah", "given": "Svati H", "initials": "SH"}, {"family": "Schreiber", "given": "Stefan", "initials": "S"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Veronesi", "given": "Giovani", "initials": "G"}, {"family": "Wareham", "given": "Nicholas", "initials": "N"}, {"family": "Willer", "given": "Cristen J", "initials": "CJ"}, {"family": "Zalloua", "given": "Pierre A", "initials": "PA"}, {"family": "Erdmann", "given": "Jeanette", "initials": "J"}, {"family": "Deloukas", "given": "Panos", "initials": "P"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Schunkert", "given": "Heribert", "initials": "H"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Thompson", "given": "John R", "initials": "JR"}, {"family": "Samani", "given": "Nilesh J", "initials": "NJ"}, {"family": "CARDIoGRAM+C4D Consortium", "given": null, "initials": null}], "type": "journal article", "published": "2015-04-23", "journal": {"volume": "372", "issn": "1533-4406", "issue": "17", "pages": "1608-1618", "title": "N. Engl. J. Med.", "issn-l": "0028-4793"}, "abstract": "The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear.\n\nWe used a genetic approach to investigate the association between height and CAD, using 180 height-associated genetic variants. We tested the association between a change in genetically determined height of 1 SD (6.5 cm) with the risk of CAD in 65,066 cases and 128,383 controls. Using individual-level genotype data from 18,249 persons, we also examined the risk of CAD associated with the presence of various numbers of height-associated alleles. To identify putative mechanisms, we analyzed whether genetically determined height was associated with known cardiovascular risk factors and performed a pathway analysis of the height-associated genes.\n\nWe observed a relative increase of 13.5% (95% confidence interval [CI], 5.4 to 22.1; P<0.001) in the risk of CAD per 1-SD decrease in genetically determined height. There was a graded relationship between the presence of an increased number of height-raising variants and a reduced risk of CAD (odds ratio for height quartile 4 versus quartile 1, 0.74; 95% CI, 0.68 to 0.84; P<0.001). Of the 12 risk factors that we studied, we observed significant associations only with levels of low-density lipoprotein cholesterol and triglycerides (accounting for approximately 30% of the association). We identified several overlapping pathways involving genes associated with both development and atherosclerosis.\n\nThere is a primary association between a genetically determined shorter height and an increased risk of CAD, a link that is partly explained by the association between shorter height and an adverse lipid profile. Shared biologic processes that determine achieved height and the development of atherosclerosis may explain some of the association. (Funded by the British Heart Foundation and others.).", "doi": "10.1056/NEJMoa1404881", "pmid": "25853659", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "pmc", "key": "PMC4648271"}, {"db": "mid", "key": "EMS65988"}], "notes": [], "created": "2017-05-02T12:58:09.591Z", "modified": "2020-01-21T13:56:05.401Z"}], "created": "2017-05-09T09:12:51.017Z", "modified": "2020-11-27T13:14:04.875Z"}