{"entity": "journal", "iuid": "9808a9a03a204a1fa9c4bb4c4b62ad0f", "timestamp": "2026-08-09T14:21:54.970Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Med.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Med"}}, "title": "Med", "issn": "2666-6340", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "4918eb19fe3f403c8395a0816dd07829", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4918eb19fe3f403c8395a0816dd07829.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4918eb19fe3f403c8395a0816dd07829"}}, "title": "Patient-derived organoids in precision cancer medicine.", "authors": [{"family": "Tong", "given": "Le", "initials": "L"}, {"family": "Cui", "given": "Weiyingqi", "initials": "W"}, {"family": "Zhang", "given": "Boya", "initials": "B"}, {"family": "Fonseca", "given": "Pedro", "initials": "P"}, {"family": "Zhao", "given": "Qian", "initials": "Q"}, {"family": "Zhang", "given": "Ping", "initials": "P"}, {"family": "Xu", "given": "Beibei", "initials": "B"}, {"family": "Zhang", "given": "Qisi", "initials": "Q"}, {"family": "Li", "given": "Zhen", "initials": "Z"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B"}, {"family": "Yang", "given": "Ying", "initials": "Y"}, {"family": "Si", "given": "Longlong", "initials": "L"}, {"family": "Lundqvist", "given": "Andreas", "initials": "A"}], "type": "journal article", "published": "2024-11-08", "journal": {"title": "Med", "issn": "2666-6340", "volume": "5", "issue": "11", "pages": "1351-1377", "issn-l": null}, "abstract": "Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that replicate the complex structure and function of human tissues. They offer a physiologically relevant model to address important questions in cancer research. The generation of patient-derived organoids (PDOs) from various human cancers allows for deeper insights into tumor heterogeneity and spatial organization. Additionally, interrogating non-tumor stromal cells increases the relevance in studying the tumor microenvironment, thereby enhancing the relevance of PDOs in personalized medicine. PDOs mark a significant advancement in cancer research and patient care, signifying a shift toward more innovative and patient-centric approaches. This review covers aspects of PDO cultures to address the modeling of the tumor microenvironment, including extracellular matrices, air-liquid interface and microfluidic cultures, and organ-on-chip. Specifically, the role of PDOs as preclinical models in gene editing, molecular profiling, drug testing, and biomarker discovery and their potential for guiding personalized treatment in clinical practice are discussed.", "doi": "10.1016/j.medj.2024.08.010", "pmid": "39341206", "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S2666-6340(24)00343-X"}], "notes": [], "created": "2025-04-28T14:09:56.200Z", "modified": "2025-10-17T13:04:27.064Z"}, {"entity": "publication", "iuid": "40debb001133430dacf91ed1b897a801", "links": {"self": {"href": "https://publications.scilifelab.se/publication/40debb001133430dacf91ed1b897a801.json"}, "display": {"href": "https://publications.scilifelab.se/publication/40debb001133430dacf91ed1b897a801"}}, "title": "Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals", "authors": [{"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications.scilifelab.se/researcher/ccb4db02b9784587b62020716ab87247.json"}}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Mielke", "given": "Stephan", "initials": "S", "orcid": "0000-0002-8325-9215", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbb6778eb9964f9cbd9ffc260892d609.json"}}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Bergman", "given": "Peter", "initials": "P", "orcid": "0000-0003-3306-3713", "researcher": {"href": "https://publications.scilifelab.se/researcher/397d11713c80456bb600b1e4c88ff843.json"}}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Valentini", "given": "Davide", "initials": "D"}, {"family": "Blennow", "given": "Ola", "initials": "O", "orcid": "0000-0002-7167-7882", "researcher": {"href": "https://publications.scilifelab.se/researcher/08ed03f808e84f50a0b599ce28b29d7d.json"}}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Gabarrini", "given": "Giorgio", "initials": "G", "orcid": "0000-0001-6936-4919", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbb92481579b4a23afefbbed5ad59a9a.json"}}, {"family": "Al-Manei", "given": "Khaled", "initials": "K", "orcid": "0000-0003-0787-5849", "researcher": {"href": "https://publications.scilifelab.se/researcher/289ad83f90da43adb6634178107db3de.json"}}, {"family": "Alkharaan", "given": "Hassan", "initials": "H"}, {"family": "Sobkowiak", "given": "Michal Jacek", "initials": "MJ", "orcid": "0000-0003-2932-1994", "researcher": {"href": "https://publications.scilifelab.se/researcher/14f1eb990edf472cac56f24d7cae330c.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J"}, {"family": "Mravinacova", "given": "Sara", "initials": "S"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Xu", "given": "Xinling", "initials": "X"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbf3f75938f0442a9b1ae5c98565f44a.json"}}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8dd8ee4264d4e4b912dacad3106f40a.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications.scilifelab.se/researcher/799bcf1cf8cf451296f4535dd4ca9dc0.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S", "orcid": "0000-0003-0461-4870", "researcher": {"href": "https://publications.scilifelab.se/researcher/d8a125a916b34de985de977dd8384650.json"}}, {"family": "Chen", "given": "Margaret S\u00e4llberg", "initials": "MS"}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Med", "issn": "2666-6340", "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1016/j.medj.2022.01.001", "pmid": "35075450", "labels": {"Autoimmunity and Serology Profiling": "Collaborative"}, "xrefs": [], "notes": [], "created": "2022-01-26T08:48:19.747Z", "modified": "2022-01-26T08:51:23.010Z"}], "created": "2020-12-21T13:10:23.908Z", "modified": "2020-12-21T13:10:23.908Z"}