{"entity": "journal", "iuid": "2009b99db9494f70b44254357b1d6f6e", "timestamp": "2026-03-10T03:55:41.706Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J.%20Oral%20Pathol.%20Med..json"}, "display": {"href": "https://publications.scilifelab.se/journal/J.%20Oral%20Pathol.%20Med."}}, "title": "J. Oral Pathol. Med.", "issn": "1600-0714", "issn-l": "0904-2512", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "2023de0c77cb44e4a8e75d4ca4ffc159", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2023de0c77cb44e4a8e75d4ca4ffc159.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2023de0c77cb44e4a8e75d4ca4ffc159"}}, "title": "A Unique Plasma Protein Signature Characterizes Squamous Cell Carcinoma of the Oral Tongue in Young Adults.", "authors": [{"family": "Gu", "given": "Xiaolian", "initials": "X", "orcid": "0000-0002-6574-3628", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b502390466749d18b3985c1930da1e0.json"}}, {"family": "Coates", "given": "Philip J", "initials": "PJ", "orcid": "0000-0003-1518-6306", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f0dd083f0964e72aac9864302cddbc4.json"}}, {"family": "Wang", "given": "Lixiao", "initials": "L"}, {"family": "Gnanasundram", "given": "Sivakumar Vadivel", "initials": "SV"}, {"family": "Sgaramella", "given": "Nicola", "initials": "N"}, {"family": "Attaran", "given": "Nima", "initials": "N"}, {"family": "Erdogan", "given": "Baris", "initials": "B"}, {"family": "Magan", "given": "Mustafa", "initials": "M"}, {"family": "Nylander", "given": "Karin", "initials": "K", "orcid": "0000-0002-4831-4100", "researcher": {"href": "https://publications.scilifelab.se/researcher/62805049d0b040aa8d9559d8bf448302.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "J. Oral Pathol. Med.", "issn": "1600-0714", "volume": "54", "issue": "8", "pages": "706-714", "issn-l": "0904-2512"}, "abstract": "The incidence of squamous cell carcinoma of the oral tongue (SCCOT) among young adults is increasing in several regions of the world. Age-dependent differences in the biology of SCCOT have been suspected.\n\nWe used the Olink Explore 3072 high-throughput platform to comprehensively quantify plasma proteins in 24 young (\u2264 40 years of age) and 50 old (> 50 years of age) individuals. Eight young and 20 old individuals were diagnosed with SCCOT, four young and nine old individuals with SCC at other oral subsites (SCCOO), and the remaining 12 young and 21 old individuals were healthy controls. Dimension reduction analysis, differential expression analysis, and functional enrichment analysis were performed to characterize young patient-specific biological signatures.\n\nPlasma levels of 2923 proteins were obtained. Principal component analysis indicated age-related expression patterns. Comparing young patients to young controls/old patients/old controls, differential abundance analysis showed that increases in protein levels of Peroxiredoxin 2 (PRDX2) and C-C motif chemokine ligand 26 (CCL26) and a decrease in Kallikrein related peptidase 4 (KLK4) were young patient-specific. Reactome pathway enrichment analysis identified \"Cellular response to chemical stress,\" \"Detoxification of reactive oxygen species\" and \"Cellular responses to stimuli\" as the top altered pathways in young patients with SCCOT.\n\nAbnormal cellular stress and aberrant immune regulation could thus be linked to cancer development in young patients. The unique plasma proteomic signature observed in young patients with SCCOT suggests that they constitute a specific group with distinct underlying pathophysiological processes.", "doi": "10.1111/jop.70020", "pmid": "40765509", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12419980"}], "notes": [], "created": "2025-11-25T19:19:06.154Z", "modified": "2025-11-25T19:21:48.766Z"}, {"entity": "publication", "iuid": "2eaa9e4176c54896b9e05102c6299463", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2eaa9e4176c54896b9e05102c6299463.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2eaa9e4176c54896b9e05102c6299463"}}, "title": "Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.", "authors": [{"family": "Jedlinski", "given": "Adam", "initials": "A"}, {"family": "Garvin", "given": "Stina", "initials": "S"}, {"family": "Johansson", "given": "Ann-Charlotte", "initials": "A"}, {"family": "Edqvist", "given": "Per-Henrik", "initials": "P"}, {"family": "Ponten", "given": "Fredrik", "initials": "F"}, {"family": "Roberg", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2017-10-00", "journal": {"volume": "46", "issn": "1600-0714", "issue": "9", "pages": "717-724", "title": "J. Oral Pathol. Med.", "issn-l": "0904-2512"}, "abstract": "The aims of this study were to validate in vitro drug sensitivity testing of head and neck squamous cell carcinoma (HNSCC) cell lines in an in vivo xenograft model and to identify treatment-induced changes in the epidermal growth factor receptor (EGFR) signaling pathway that could be used as markers for cetuximab treatment response.\r\n\r\nThe in vitro and in vivo cetuximab sensitivity of two HNSCC cell lines, UT-SCC-14 and UT-SCC-45, was assessed using a crystal violet assay and xenografts in nude mice, respectively. The expression of EGFR, phosphorylated EGFR (pEGFR), phosphorylated Src (pSrc), and Ki-67 was investigated by immunohistochemistry. To verify these results, the in vitro expression of EGFR and pEGFR was analyzed with ELISA in a panel of 10 HNSCC cell lines.\r\n\r\nA close correlation was found between in vitro and in vivo cetuximab sensitivity data in the two investigated HNSCC cell lines. In treatment sensitive UT-SCC-14 xenografts, there was a decrease in EGFR, pEGFR, and pSrc upon cetuximab treatment. Interestingly, in insensitive UT-SCC-45 xenografts, an increased expression of these three proteins was found. The change in EGFR and pEGFR expression in vivo was confirmed in cetuximab-sensitive and cetuximab-insensitive HNSCC cell lines using ELISA.\r\n\r\nHigh sensitivity to cetuximab was strongly associated with a treatment-induced reduction in pEGFR both in vivo and in vitro in a panel of HNSCC cell lines, suggesting that EGFR and pEGFR dynamics could be used as a predictive biomarker for cetuximab treatment response.", "doi": "10.1111/jop.12545", "pmid": "28036101", "labels": {"Tissue Profiling": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-05-08T07:55:59.236Z", "modified": "2017-11-05T12:39:35.466Z"}], "created": "2017-05-09T09:12:20.557Z", "modified": "2020-11-27T13:14:05.997Z"}