{"entity": "journal", "iuid": "7bd59978d9804863859b9cc4831218af", "timestamp": "2026-07-12T09:18:17.602Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J.%20Invest.%20Dermatol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/J.%20Invest.%20Dermatol."}}, "title": "J. Invest. Dermatol.", "issn": "1523-1747", "issn-l": "0022-202X", "publications_count": 6, "publications": [{"entity": "publication", "iuid": "47413d73c5cb40fbaa2da5d27272dd26", "links": {"self": {"href": "https://publications.scilifelab.se/publication/47413d73c5cb40fbaa2da5d27272dd26.json"}, "display": {"href": "https://publications.scilifelab.se/publication/47413d73c5cb40fbaa2da5d27272dd26"}}, "title": "Differential DNA Methylation of MicroRNA-Encoding Genes in Psoriatic Epidermis Highlights the Wnt Pathway.", "authors": [{"family": "Verma", "given": "Deepti", "initials": "D"}, {"family": "Kasic", "given": "Nada-Katarina", "initials": "NK"}, {"family": "Jeppsson", "given": "Freja", "initials": "F"}, {"family": "Eding", "given": "Cecilia Bivik", "initials": "CB"}, {"family": "\u0141ysiak", "given": "Ma\u0142gorzata", "initials": "M"}, {"family": "Fekri", "given": "Shora Zamani", "initials": "SZ"}, {"family": "Das", "given": "Jyotirmoy", "initials": "J"}, {"family": "Enerb\u00e4ck", "given": "Charlotta", "initials": "C"}], "type": "journal article", "published": "2023-08-00", "journal": {"title": "J. Invest. Dermatol.", "issn": "1523-1747", "volume": "143", "issue": "8", "pages": "1594-1597.e14", "issn-l": "0022-202X"}, "abstract": null, "doi": "10.1016/j.jid.2023.01.031", "pmid": "36858310", "labels": {"Clinical Genomics Link\u00f6ping": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0022-202X(23)00104-5"}], "notes": [], "created": "2023-12-03T05:52:00.066Z", "modified": "2023-12-03T05:52:00.070Z"}, {"entity": "publication", "iuid": "d909e7138f8d4a4bbf569e34763080a0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d909e7138f8d4a4bbf569e34763080a0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d909e7138f8d4a4bbf569e34763080a0"}}, "title": "Single-Cell Analysis Reveals Major Histocompatibility Complex II\u2012Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes.", "authors": [{"family": "Li", "given": "Dongqing", "initials": "D", "orcid": "0000-0003-0588-9390", "researcher": {"href": "https://publications.scilifelab.se/researcher/8d51ff81e8ec4cc5a429dd095a0c315f.json"}}, {"family": "Cheng", "given": "Shangli", "initials": "S", "orcid": "0000-0002-8501-086X", "researcher": {"href": "https://publications.scilifelab.se/researcher/0bf07f88c8ac4612afe3375e1401e253.json"}}, {"family": "Pei", "given": "Yu", "initials": "Y", "orcid": "0000-0002-6219-3587", "researcher": {"href": "https://publications.scilifelab.se/researcher/894972d5fc5b410fae8b1b2352ff2f30.json"}}, {"family": "Sommar", "given": "Pehr", "initials": "P", "orcid": "0000-0002-9789-9221", "researcher": {"href": "https://publications.scilifelab.se/researcher/a79e955554a84d189f83f289c46b011b.json"}}, {"family": "K\u00e4rner", "given": "Jaanika", "initials": "J", "orcid": "0000-0002-3548-5023", "researcher": {"href": "https://publications.scilifelab.se/researcher/20de765c88db4d40bc67a75253c38eb9.json"}}, {"family": "Herter", "given": "Eva K", "initials": "EK", "orcid": "0000-0001-5525-4663", "researcher": {"href": "https://publications.scilifelab.se/researcher/73cd22c3a7a34fe6903c6599b20089e8.json"}}, {"family": "Toma", "given": "Maria A", "initials": "MA", "orcid": "0000-0002-4766-2576", "researcher": {"href": "https://publications.scilifelab.se/researcher/80f80639a3774c5bb5007d1f9af63a0e.json"}}, {"family": "Zhang", "given": "Letian", "initials": "L", "orcid": "0000-0002-0987-0905", "researcher": {"href": "https://publications.scilifelab.se/researcher/7285787b20e54bb5bdc3fce0eab58939.json"}}, {"family": "Pham", "given": "Kim", "initials": "K", "orcid": "0000-0002-6628-1146", "researcher": {"href": "https://publications.scilifelab.se/researcher/dd9d80797f8c4923a837632347876e7c.json"}}, {"family": "Cheung", "given": "Yuen Ting", "initials": "YT", "orcid": "0000-0002-1140-3222", "researcher": {"href": "https://publications.scilifelab.se/researcher/0c34b39bca1247869376613ca9529711.json"}}, {"family": "Liu", "given": "Zhuang", "initials": "Z", "orcid": "0000-0001-8938-0086", "researcher": {"href": "https://publications.scilifelab.se/researcher/f6a97736a68f4bc2bb059487e75b85c9.json"}}, {"family": "Chen", "given": "Xingqi", "initials": "X", "orcid": "0000-0002-5657-2839", "researcher": {"href": "https://publications.scilifelab.se/researcher/ef7ddc09e57745909175e41ac2d1b647.json"}}, {"family": "Eidsmo", "given": "Liv", "initials": "L", "orcid": "0000-0001-9237-8374", "researcher": {"href": "https://publications.scilifelab.se/researcher/57e083936a8144a19f0b2eb14dab6898.json"}}, {"family": "Deng", "given": "Qiaolin", "initials": "Q", "orcid": "0000-0001-5934-7816", "researcher": {"href": "https://publications.scilifelab.se/researcher/b74efaba0fab49acb7164a45beca5cd9.json"}}, {"family": "Xu Land\u00e9n", "given": "Ning", "initials": "N", "orcid": "0000-0003-4868-3798", "researcher": {"href": "https://publications.scilifelab.se/researcher/c55a2caeb6cd4858aa3326b6e92d09c6.json"}}], "type": "journal article", "published": "2021-09-16", "journal": {"title": "J. Invest. Dermatol.", "issn": "1523-1747", "issn-l": "0022-202X"}, "abstract": "Pressure ulcer (PU) is a chronic wound often seen in patients with spinal cord injury and other bed-bound individuals, particularly in the elderly population. Despite its association with high mortality, the pathophysiology of PU remains poorly understood. In this study, we compared single-cell transcriptomic profiles of human epidermal cells from PU wound edges with those from uninjured skin and acute wounds in healthy donors. We identified significant shifts in the cell composition and gene expression patterns in PU. In particular, we found that major histocompatibility complex class II\u2012expressing keratinocytes were enriched in patients with worse healing outcomes. Furthermore, we showed that the IFN-\u03b3 in PU-derived wound fluid could induce major histocompatibility complex II expression in keratinocytes and that these wound fluid\u2012treated keratinocytes inhibited autologous T-cell activation. In line with this observation, we found that T cells from PUs enriched with major histocompatibility complex II+ keratinocytes produced fewer inflammatory cytokines. Overall, our study provides a high-resolution molecular map of human PU compared with that of acute wounds and intact skin, providing insights into PU pathology and the future development of tailored wound therapy.", "doi": "10.1016/j.jid.2021.07.176", "pmid": "34536485", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0022-202X(21)02167-9"}], "notes": [], "created": "2021-10-01T09:09:09.479Z", "modified": "2024-01-16T13:48:38.471Z"}, {"entity": "publication", "iuid": "e64d5c7a69724d43b309656b1b10139e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e64d5c7a69724d43b309656b1b10139e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e64d5c7a69724d43b309656b1b10139e"}}, "title": "MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.", "authors": [{"family": "Meisgen", "given": "Florian", "initials": "F"}, {"family": "Xu Land\u00e9n", "given": "Ning", "initials": "N"}, {"family": "Wang", "given": "Aoxue", "initials": "A"}, {"family": "R\u00e9thi", "given": "Bence", "initials": "B"}, {"family": "Bouez", "given": "Charbel", "initials": "C"}, {"family": "Zuccolo", "given": "Michela", "initials": "M"}, {"family": "Gueniche", "given": "Audrey", "initials": "A"}, {"family": "St\u00e5hle", "given": "Mona", "initials": "M"}, {"family": "Sonkoly", "given": "Enik\u00f6", "initials": "E"}, {"family": "Breton", "given": "Lionel", "initials": "L"}, {"family": "Pivarcsi", "given": "Andor", "initials": "A"}], "type": "journal article", "published": "2014-07-00", "journal": {"volume": "134", "issn": "1523-1747", "issue": "7", "pages": "1931-1940", "title": "J. Invest. Dermatol.", "issn-l": "0022-202X"}, "abstract": "Keratinocytes represent the first line of defense against pathogens in the skin and have important roles in initiating and regulating inflammation during infection and autoimmunity. Here we investigated the role of miR-146a in the regulation of the innate immune response of keratinocytes. Toll-like receptor 2 (TLR2) stimulation of primary human keratinocytes resulted in an NF-\u03baB- and mitogen-activated protein kinase-dependent upregulation of miR-146a expression, which was surprisingly long lasting, contrasting with the rapid and transient induction of inflammatory mediators. Overexpression of miR-146a significantly suppressed the production of IL-8, CCL20, and tumor necrosis factor-\u03b1, which functionally suppressed the chemotactic attraction of neutrophils by keratinocytes. Inhibition of endogenous miR-146a induced the production of inflammatory mediators even in nonstimulated keratinocytes, and potentiated the effect of TLR2 stimulation. Transcriptomic profiling revealed that miR-146a suppresses the expression of a large number of immune-related genes in keratinocytes. MiR-146a downregulated interleukin-1 receptor-associated kinase 1 and TNF receptor-associated factor 6, two key adapter molecules downstream of TLR signaling, and suppressed NF-\u03baB promoter-binding activity as shown by promoter luciferase experiments. Together, these data identify miR-146a as a regulatory element in keratinocyte innate immunity, which prevents the production of inflammatory mediators under homeostatic conditions and serves as a potent negative feedback regulator after TLR2 stimulation.", "doi": "10.1038/jid.2014.89", "pmid": "24670381", "labels": {"Bioinformatics and Expression Analysis (BEA)": null}, "xrefs": [{"db": "pii", "key": "S0022-202X(15)36864-0"}], "notes": [], "created": "2017-05-04T15:03:19.386Z", "modified": "2017-05-30T12:42:22.708Z"}, {"entity": "publication", "iuid": "cc8b30d9114545e3824d54880a0cd264", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cc8b30d9114545e3824d54880a0cd264.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cc8b30d9114545e3824d54880a0cd264"}}, "title": "Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin.", "authors": [{"family": "St\u00e5hl", "given": "Patrik L", "initials": "PL"}, {"family": "Stranneheim", "given": "Henrik", "initials": "H"}, {"family": "Asplund", "given": "Anna", "initials": "A"}, {"family": "Berglund", "given": "Lisa", "initials": "L"}, {"family": "Pont\u00e9n", "given": "Fredrik", "initials": "F"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a4e6ca0f29b4ead8569e2729481c3e0.json"}}], "type": "comparative study", "published": "2011-02-00", "journal": {"volume": "131", "issn": "1523-1747", "issue": "2", "pages": "504-508", "title": "J. Invest. Dermatol.", "issn-l": "0022-202X"}, "abstract": "Here we demonstrate that intermittently sun-exposed human skin contains an extensive number of phenotypically intact cell compartments bearing missense and nonsense mutations in the p53 tumor suppressor gene. Deep sequencing of sun-exposed and shielded microdissected skin from mid-life individuals revealed that persistent p53 mutations had accumulated in 14% of all epidermal cells, with no apparent signs of a growth advantage of the affected cell compartments. Furthermore, 6% of the mutated epidermal cells encoded a truncated protein. The abundance of these events, not taking into account intron mutations and mutations in other genes that also may have functional implications, suggests an extensive tolerance of human cells to severe genetic alterations caused by UV light, with an estimated annual rate of accumulation of \u223c35,000 new persistent protein-altering p53 mutations in sun-exposed skin of a human individual.", "doi": "10.1038/jid.2010.302", "pmid": "20944651", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [{"db": "pii", "key": "S0022-202X(15)35132-0"}], "notes": [], "created": "2017-05-04T14:57:21.029Z", "modified": "2021-07-08T13:26:08.355Z"}, {"entity": "publication", "iuid": "ace41dfd8e0840279e4ac0c774e367a0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ace41dfd8e0840279e4ac0c774e367a0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ace41dfd8e0840279e4ac0c774e367a0"}}, "title": "High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma.", "authors": [{"family": "Jonsson", "given": "Anders", "initials": "A"}, {"family": "Tuominen", "given": "Rainer", "initials": "R"}, {"family": "Grafstr\u00f6m", "given": "Eva", "initials": "E"}, {"family": "Hansson", "given": "Johan", "initials": "J"}, {"family": "Egyhazi", "given": "Suzanne", "initials": "S"}], "type": "journal article", "published": "2010-12-00", "journal": {"volume": "130", "issn": "1523-1747", "issue": "12", "pages": "2809-2817", "title": "J. Invest. Dermatol.", "issn-l": "0022-202X"}, "abstract": "The p16(INK4A) tumor suppressor is often deleted, or otherwise inactivated, in malignant melanoma. To investigate the loss of p16(INK4A) in greater detail, we analyzed 77 cutaneous melanoma metastases. Of these 56 retained at least one p16(INK4A) allele, and 21 had biallelic deletions. Using methylation-specific PCR, direct sequencing, and immunohistochemical methods, we analyzed p16(INK4A) promoter methylation, mutations, and protein expression, respectively. In addition, 14 corresponding primary tumors were analyzed for protein expression. Results were compared to clinicopathological parameters and previously obtained data regarding mutations in proto-oncogenes NRAS and BRAF. Results revealed that p16(INK4A) promoter methylation was present in 15 of 59 (25%) metastases; nonsynonymous mutations in 9 of 56 (16%) metastases; and protein expression in 12 of 67 (18%) metastases. Protein expression was lost during progression from primary to metastatic tumors, 71% (10 of 14) and 43% (6 of 14) being positive, respectively. However, the genetic and epigenetic alterations of p16(INK4A) observed could not explain the lack of p16(INK4A) protein in 27 metastases, indicating the presence of additional inactivating mechanisms for p16(INK4A). Interestingly, p16(INK4A) promoter methylation was significantly overrepresented in NRAS-mutated samples compared to NRAS wild-type samples (P=0.0004), indicating an association between these two events.", "doi": "10.1038/jid.2010.216", "pmid": "20703244", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [{"db": "pii", "key": "S0022-202X(15)34650-9"}], "notes": [], "created": "2017-05-04T14:57:11.657Z", "modified": "2020-01-21T13:56:04.547Z"}, {"entity": "publication", "iuid": "15ef40b017654d21a684bf04354b27db", "links": {"self": {"href": "https://publications.scilifelab.se/publication/15ef40b017654d21a684bf04354b27db.json"}, "display": {"href": "https://publications.scilifelab.se/publication/15ef40b017654d21a684bf04354b27db"}}, "title": "Coexisting NRAS and BRAF mutations in primary familial melanomas with specific CDKN2A germline alterations.", "authors": [{"family": "Jovanovic", "given": "Braslav", "initials": "B"}, {"family": "Egyhazi", "given": "Suzanne", "initials": "S"}, {"family": "Eskandarpour", "given": "Malihe", "initials": "M"}, {"family": "Ghiorzo", "given": "Paola", "initials": "P"}, {"family": "Palmer", "given": "Jane M", "initials": "JM"}, {"family": "Bianchi Scarr\u00e0", "given": "Giovanna", "initials": "G"}, {"family": "Hayward", "given": "Nicholas K", "initials": "NK"}, {"family": "Hansson", "given": "Johan", "initials": "J"}], "type": "letter", "published": "2010-02-00", "journal": {"title": "J. Invest. Dermatol.", "issn": "1523-1747", "issn-l": "0022-202X", "volume": "130", "issue": "2", "pages": "618-620"}, "abstract": null, "doi": "10.1038/jid.2009.287", "pmid": "19759551", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null, "NGI Short read": "Service"}, "xrefs": [{"db": "pii", "key": "S0022-202X(15)34686-8"}, {"db": "pmc", "key": "PMC3665509"}, {"db": "mid", "key": "NIHMS468846"}], "notes": [], "created": "2017-05-04T14:57:11.959Z", "modified": "2022-08-19T09:04:31.750Z"}], "created": "2017-05-09T09:12:13.065Z", "modified": "2020-11-27T13:14:04.493Z"}