{"entity": "journal", "iuid": "243e424bf83e49b3b624e0f920e1bd59", "timestamp": "2026-07-22T22:35:18.146Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J.%20Immunother..json"}, "display": {"href": "https://publications.scilifelab.se/journal/J.%20Immunother."}}, "title": "J. Immunother.", "issn": "1537-4513", "issn-l": "1524-9557", "publications_count": 1, "publications": [{"entity": "publication", "iuid": "ffaed83ff04c4f058b2fb20f13022ba5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ffaed83ff04c4f058b2fb20f13022ba5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ffaed83ff04c4f058b2fb20f13022ba5"}}, "title": "A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.", "authors": [{"family": "Omazic", "given": "Brigitta", "initials": "B"}, {"family": "Ayoglu", "given": "Burcu", "initials": "B"}, {"family": "L\u00f6hr", "given": "Matthias", "initials": "M"}, {"family": "Segersv\u00e4rd", "given": "Ralf", "initials": "R"}, {"family": "Verbeke", "given": "Caroline", "initials": "C"}, {"family": "Magalhaes", "given": "Isabelle", "initials": "I"}, {"family": "Potacova", "given": "Zuzana", "initials": "Z"}, {"family": "Mattsson", "given": "Jonas", "initials": "J"}, {"family": "Terman", "given": "Alexei", "initials": "A"}, {"family": "Ghazi", "given": "Sam", "initials": "S"}, {"family": "Albiin", "given": "Nils", "initials": "N"}, {"family": "Kartalis", "given": "Nikolaos", "initials": "N"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications.scilifelab.se/researcher/799bcf1cf8cf451296f4535dd4ca9dc0.json"}}, {"family": "Poiret", "given": "Thomas", "initials": "T"}, {"family": "Zhenjiang", "given": "Liu", "initials": "L"}, {"family": "Heuchel", "given": "Rainer", "initials": "R"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications.scilifelab.se/researcher/aba5822711b246b397fffacb7ae403b3.json"}}, {"family": "Permert", "given": "Johan", "initials": "J"}, {"family": "Maeurer", "given": "Markus J", "initials": "MJ"}, {"family": "Ringden", "given": "Olle", "initials": "O"}], "type": "journal article", "published": "2017-05-00", "journal": {"volume": "40", "issn": "1537-4513", "issue": "4", "title": "J. Immunother.", "pages": "132-139", "issn-l": "1524-9557"}, "abstract": "We examined the immunologic effects of allogeneic hematopoietic stem cell transplantation (HSCT) in the treatment of pancreatic ductal adenocarcinoma, a deadly disease with a median survival of 24 months for resected tumors and a 5-year survival rate of 6%. After adjuvant chemotherapy, 2 patients with resected pancreatic ductal adenocarcinoma underwent HSCT with HLA-identical sibling donors. Comparable patients who underwent radical surgery, but did not have a donor, served as controls (n=6). Both patients developed humoral and cellular (ie, HLA-A*01:01-restricted) immune responses directed against 2 novel tumor-associated antigens (TAAs), INO80E and UCLH3 after HSCT. Both TAAs were highly expressed in the original tumor tissue suggesting that HSCT promoted a clinically relevant, long-lasting cellular immune response. In contrast to untreated controls, who succumbed to progressive disease, both patients are tumor-free 9 years after diagnosis. Radical surgery combined with HSCT may cure pancreatic adenocarcinoma and change the cellular immune repertoire capable of responding to clinically and biologically relevant TAAs.", "doi": "10.1097/CJI.0000000000000164", "pmid": "28338506", "labels": {"Autoimmunity and Serology Profiling": "Collaborative", "Affinity Proteomics Stockholm": "Collaborative"}, "xrefs": [], "notes": [], "created": "2017-11-02T11:39:38.489Z", "modified": "2021-07-08T12:07:34.361Z"}], "created": "2017-11-02T11:39:38.512Z", "modified": "2020-11-27T13:14:04.952Z"}