{"entity": "journal", "iuid": "36a9781540764193bff9f269afb4b05e", "timestamp": "2026-04-14T08:40:14.913Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J.%20Cereb.%20Blood%20Flow%20Metab..json"}, "display": {"href": "https://publications.scilifelab.se/journal/J.%20Cereb.%20Blood%20Flow%20Metab."}}, "title": "J. Cereb. Blood Flow Metab.", "issn": "1559-7016", "issn-l": "0271-678X", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "d6f8fc37642e488783da206805ed9197", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d6f8fc37642e488783da206805ed9197.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d6f8fc37642e488783da206805ed9197"}}, "title": "Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats.", "authors": [{"family": "Song", "given": "Juan", "initials": "J"}, {"family": "Nilsson", "given": "Gisela", "initials": "G"}, {"family": "Xu", "given": "Yiran", "initials": "Y"}, {"family": "Zelco", "given": "Aura", "initials": "A"}, {"family": "Rocha-Ferreira", "given": "Eridan", "initials": "E"}, {"family": "Wang", "given": "Yafeng", "initials": "Y"}, {"family": "Zhang", "given": "Xiaoli", "initials": "X"}, {"family": "Zhang", "given": "Shan", "initials": "S"}, {"family": "Ek", "given": "Joakim", "initials": "J"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}, {"family": "Zhu", "given": "Changlian", "initials": "C"}, {"family": "Wang", "given": "Xiaoyang", "initials": "X", "orcid": "0000-0001-9717-8160", "researcher": {"href": "https://publications.scilifelab.se/researcher/70fbed19bca84bec93f558168444227a.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "J. Cereb. Blood Flow Metab.", "issn": "1559-7016", "volume": "42", "issue": "9", "pages": "1632-1649", "issn-l": "0271-678X"}, "abstract": "Germinal matrix hemorrhage (GMH) is a common complication in preterm infants and is associated with high risk of adverse neurodevelopmental outcomes. We used a rat GMH model and performed RNA sequencing to investigate the signaling pathways and biological processes following hemorrhage. GMH induced brain injury characterized by early hematoma and subsequent tissue loss. At 6 hours after GMH, gene expression indicated an increase in mitochondrial activity such as ATP metabolism and oxidative phosphorylation along with upregulation of cytoprotective pathways and heme metabolism. At 24 hours after GMH, the expression pattern suggested an increase in cell cycle progression and downregulation of neurodevelopmental-related pathways. At 72 hours after GMH, there was an increase in genes related to inflammation and an upregulation of ferroptosis. Hemoglobin components and genes related to heme metabolism and ferroptosis such as Hmox1, Alox15, and Alas2 were among the most upregulated genes. We observed dysregulation of processes involved in development, mitochondrial function, cholesterol biosynthesis, and inflammation, all of which contribute to neurodevelopmental deterioration following GMH. This study is the first temporal transcriptome profile providing a comprehensive overview of the molecular mechanisms underlying brain injury following GMH, and it provides useful guidance in the search for therapeutic interventions.", "doi": "10.1177/0271678X221098811", "pmid": "35491813", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9441725"}], "notes": [], "created": "2023-02-16T08:25:37.304Z", "modified": "2023-02-16T08:25:37.329Z"}, {"entity": "publication", "iuid": "224613e7ab0048afa546c615a18f079b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/224613e7ab0048afa546c615a18f079b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/224613e7ab0048afa546c615a18f079b"}}, "title": "An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.", "authors": [{"family": "Kannan", "given": "Pavitra", "initials": "P"}, {"family": "Schain", "given": "Martin", "initials": "M"}, {"family": "Kretzschmar", "given": "Warren W", "initials": "WW"}, {"family": "Weidner", "given": "Lora", "initials": "L"}, {"family": "Mitsios", "given": "Nicholas", "initials": "N"}, {"family": "Guly\u00e1s", "given": "Bal\u00e1zs", "initials": "B"}, {"family": "Blom", "given": "Hans", "initials": "H", "orcid": "0000-0002-5584-9170", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ce356a74dc84e0ea6af85397f11d869.json"}}, {"family": "Gottesman", "given": "Michael M", "initials": "MM"}, {"family": "Innis", "given": "Robert B", "initials": "RB"}, {"family": "Hall", "given": "Matthew D", "initials": "MD"}, {"family": "Mulder", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2017-06-00", "journal": {"volume": null, "issn": "1559-7016", "issue": null, "pages": "271678X16660984", "title": "J. Cereb. Blood Flow Metab.", "issn-l": "0271-678X"}, "abstract": "Changes in P-glycoprotein and ABCG2 densities may play a role in amyloid-beta accumulation in Alzheimer's disease. However, previous studies report conflicting results from different brain regions, without correcting for changes in vessel density. We developed an automated method to measure transporter density exclusively within the vascular space, thereby correcting for vessel density. We then examined variability in transporter density across brain regions, matter, and disease using two cohorts of post-mortem brains from Alzheimer's disease patients and age-matched controls. Changes in transporter density were also investigated in capillaries near plaques and on the mRNA level. P-glycoprotein density varied with brain region and matter, whereas ABCG2 density varied with brain matter. In temporal cortex, P-glycoprotein density was 53% lower in Alzheimer's disease samples than in controls, and was reduced by 35% in capillaries near plaque deposits within Alzheimer's disease samples. ABCG2 density was unaffected in Alzheimer's disease. No differences were detected at the transcript level. Our study indicates that region-specific changes in transporter densities can occur globally and locally near amyloid-beta deposits in Alzheimer's disease, providing an explanation for conflicting results in the literature. When differences in region and matter are accounted for, changes in density can be reproducibly measured using our automated method.", "doi": "10.1177/0271678X16660984", "pmid": "27488911", "labels": {"Fluorescence Tissue Profiling": "Technology development"}, "xrefs": [{"db": "pii", "key": "0271678X16660984"}], "notes": [], "created": "2017-05-03T12:58:51.602Z", "modified": "2021-07-05T13:48:51.522Z"}], "created": "2017-05-09T09:12:17.465Z", "modified": "2020-11-27T13:14:05.591Z"}