{"entity": "journal", "iuid": "db2192bc6c8446aebab8d6a9e14f1ea3", "timestamp": "2026-07-14T04:16:54.128Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J%20Pharm%20Sci.json"}, "display": {"href": "https://publications.scilifelab.se/journal/J%20Pharm%20Sci"}}, "title": "J Pharm Sci", "issn": "1520-6017", "issn-l": "0022-3549", "publications_count": 5, "publications": [{"entity": "publication", "iuid": "6b1112dd68b24c47921e56f86abb6d01", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6b1112dd68b24c47921e56f86abb6d01.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6b1112dd68b24c47921e56f86abb6d01"}}, "title": "High Sensitivity Detection of a Solubility Limiting Surface Transformation of Drug Particles by DNP SENS.", "authors": [{"family": "Viger-Gravel", "given": "Jasmine", "initials": "J"}, {"family": "Pinon", "given": "Arthur C", "initials": "AC"}, {"family": "Bj\u00f6rgvinsd\u00f3ttir", "given": "Sn\u00e6d\u00eds", "initials": "S"}, {"family": "Skantze", "given": "Urban", "initials": "U"}, {"family": "Svensk Ankarberg", "given": "Anna", "initials": "A"}, {"family": "Von Corswant", "given": "Christian", "initials": "C"}, {"family": "Schantz", "given": "Staffan", "initials": "S"}, {"family": "Emsley", "given": "Lyndon", "initials": "L"}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "J Pharm Sci", "issn": "1520-6017", "volume": "110", "issue": "6", "pages": "2452-2456", "issn-l": "0022-3549"}, "abstract": "We investigate the presence of a surface species for the active pharmaceutical ingredient (API) AZD9496 with dynamic nuclear polarization surface enhanced nuclear spectroscopy (DNP SENS). We show that using DNP we can elucidate the presence of an amorphous form of the API at the surface of crystalline particles of the salt form. The amorphous form of the API has distinguishable 13C chemical shifts when compared to the salt form under various acidic conditions. The predominant form in frozen particles of AZD9496 is the salt, and we provide evidence to suggest that the amorphous layer at the surface is mainly made up of the dissociated free form.", "doi": "10.1016/j.xphs.2020.12.037", "pmid": "33417900", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0022-3549(21)00004-6"}], "notes": [], "created": "2023-05-31T16:42:12.960Z", "modified": "2025-10-17T13:03:55.784Z"}, {"entity": "publication", "iuid": "da515f381ae84fb2815972a156725b79", "links": {"self": {"href": "https://publications.scilifelab.se/publication/da515f381ae84fb2815972a156725b79.json"}, "display": {"href": "https://publications.scilifelab.se/publication/da515f381ae84fb2815972a156725b79"}}, "title": "A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.", "authors": [{"family": "Matsson", "given": "P\u00e4r", "initials": "P"}, {"family": "Baranczewski", "given": "Pawel", "initials": "P"}, {"family": "Giacomini", "given": "Kathleen M", "initials": "KM"}, {"family": "Andersson", "given": "Tommy B", "initials": "TB"}, {"family": "Palm", "given": "Johan", "initials": "J"}, {"family": "Palm", "given": "Katrin", "initials": "K"}, {"family": "Charman", "given": "William N", "initials": "WN"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS"}], "type": "editorial", "published": "2021-01-00", "journal": {"title": "J Pharm Sci", "issn": "1520-6017", "volume": "110", "issue": "1", "pages": "2-11", "issn-l": "0022-3549"}, "abstract": "This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Per is one of the most cited researchers in his field, with more than 30,000 citations and an h-index of 95 as of September 2020. Importantly, these citations are distributed over the numerous fields he has explored, clearly showing the high impact the research has had on the discipline. We provide a short portrait of Per, with emphasis on his personality, driving forces and the inspirational sources that shaped his career as a world-leading scientist in the field. He is a curious scientist who deftly moves between disciplines and has continued to innovate, expand boundaries, and profoundly impact the pharmaceutical sciences throughout his career. He has developed new tools and provided insights that have significantly contributed to today's molecular and mechanistic approaches to research in the fields of intestinal absorption, cellular disposition, and exposure-efficacy relationships of pharmaceutical drugs. We want to celebrate these important contributions in this special issue of the Journal of Pharmaceutical Sciences in Per's honor.", "doi": "10.1016/j.xphs.2020.10.031", "pmid": "33096136", "labels": {"Bioinformatics Support for Computational Resources": "Service", "Drug Discovery and Development": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0022-3549(20)30623-7"}], "notes": [], "created": "2021-12-05T17:09:53.079Z", "modified": "2025-10-17T13:05:07.919Z"}, {"entity": "publication", "iuid": "2f59f8580bdd4dd1a18e63bb9cde2f07", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2f59f8580bdd4dd1a18e63bb9cde2f07.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2f59f8580bdd4dd1a18e63bb9cde2f07"}}, "title": "A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.", "authors": [{"family": "Karlgren", "given": "Maria", "initials": "M"}, {"family": "Simoff", "given": "Ivailo", "initials": "I"}, {"family": "Backlund", "given": "Maria", "initials": "M"}, {"family": "Wegler", "given": "Christine", "initials": "C"}, {"family": "Keiser", "given": "Markus", "initials": "M"}, {"family": "Handin", "given": "Niklas", "initials": "N"}, {"family": "M\u00fcller", "given": "Janett", "initials": "J"}, {"family": "Lundquist", "given": "Patrik", "initials": "P"}, {"family": "Jareborg", "given": "Anne-Christine", "initials": "AC"}, {"family": "Oswald", "given": "Stefan", "initials": "S"}, {"family": "Artursson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2017-09-00", "journal": {"volume": "106", "issn": "1520-6017", "issue": "9", "pages": "2909-2913", "title": "J Pharm Sci", "issn-l": "0022-3549"}, "abstract": "Madin-Darby canine kidney (MDCK) II cells stably transfected with transport proteins are commonly used models for drug transport studies. However, endogenous expression of especially canine MDR1 (cMDR1) confounds the interpretation of such studies. Here we have established an MDCK cell line stably overexpressing the human MDR1 transporter (hMDR1; P-glycoprotein), and used CRISPR-Cas9 gene editing to knockout the endogenous cMDR1. Genomic screening revealed the generation of a clonal cell line homozygous for a 4-nucleotide deletion in the canine ABCB1 gene leading to a frameshift and a premature stop codon. Knockout of cMDR1 expression was verified by quantitative protein analysis and functional studies showing retained activity of the human MDR1 transporter. Application of this cell line allowed unbiased reclassification of drugs previously defined as both substrates and non-substrates in different studies using commonly used MDCK-MDR1 clones. Our new MDCK-hMDR1 cell line, together with a previously developed control cell line, both with identical deletions in the canine ABCB1 gene and lack of cMDR1 expression represent excellent in\u00a0vitro tools for use in drug discovery.", "doi": "10.1016/j.xphs.2017.04.018", "pmid": "28450237", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service", "Chemical Biology Consortium Sweden": "Technology development", "Drug Discovery and Development": "Technology development"}, "xrefs": [{"db": "pii", "key": "S0022-3549(17)30251-4"}], "notes": [], "created": "2017-10-17T09:29:45.458Z", "modified": "2025-10-17T13:05:08.756Z"}, {"entity": "publication", "iuid": "a72acfbdc0a84a53b32af9e94abf9c54", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a72acfbdc0a84a53b32af9e94abf9c54.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a72acfbdc0a84a53b32af9e94abf9c54"}}, "title": "Diffusion-Controlled Drug Release From the Mesoporous Magnesium Carbonate Upsalite(\u00ae).", "authors": [{"family": "Zhang", "given": "Peng", "initials": "P"}, {"family": "Zard\u00e1n G\u00f3mez de la Torre", "given": "Teresa", "initials": "T"}, {"family": "Forsgren", "given": "Johan", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CA"}, {"family": "Str\u00f8mme", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2016-02-00", "journal": {"volume": "105", "issn": "1520-6017", "issue": "2", "pages": "657-663", "title": "J Pharm Sci", "issn-l": "0022-3549"}, "abstract": "In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite(\u00ae) was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model compound. The weight of loaded drug corresponded to 30% of the weight of the carrier and the pores were filled to approximately 80%. The incorporated ibuprofen was found to be in an amorphous state and was physisorbed, rather than chemisorbed, to the surfaces of the pore walls. In contrast to ibuprofen in mesoporous silica, there was no detectable drug on the outer surface of the carrier particles. Two ibuprofen doses were loaded into Upsalite(\u00ae) particles with size fractions ranging from 25 \u03bcm to more than 200 \u03bcm. The initial release rate was controlled by the particle size; the dissolution rate of the loaded ibuprofen during this period was more than four times faster than that of the crystalline drug. An extended-release period of about 24 h followed the initial rapid-release period. The features of this extended-release period were dependent on the total drug concentration in the release medium. Detailed analysis of the diffusion of ibuprofen in Upsalite(\u00ae) provided the ibuprofen diffusion coefficient (9.8 \u00d7 10(-8) cm(2)/s), the constrictivity of the diffusion process (0.47) and the tortuosity of the carrier (15). This relatively high tortuosity value indicates that Upsalite(\u00ae) can be used not only to enhance the dissolution rate of poorly soluble drugs but also as a carrier in sustained-release applications by using larger particle sizes or even pellets of the material.", "doi": "10.1002/jps.24553", "pmid": "26087956", "labels": {"BioMaterial Interactions (BioMat)": null}, "xrefs": [{"db": "pii", "key": "S0022-3549(15)00037-4"}], "notes": [], "created": "2017-05-02T12:58:15.262Z", "modified": "2017-05-30T13:16:41.201Z"}, {"entity": "publication", "iuid": "bd08d776fa434ae89b3d06f940278595", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bd08d776fa434ae89b3d06f940278595.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bd08d776fa434ae89b3d06f940278595"}}, "title": "Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors.", "authors": [{"family": "Lazorova", "given": "Lucia", "initials": "L"}, {"family": "Hubatsch", "given": "Ina", "initials": "I"}, {"family": "Ekegren", "given": "Jenny K", "initials": "JK"}, {"family": "Gising", "given": "Johan", "initials": "J"}, {"family": "Nakai", "given": "Daisuke", "initials": "D"}, {"family": "Zaki", "given": "Noha M", "initials": "NM"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS"}, {"family": "Norinder", "given": "Ulf", "initials": "U"}, {"family": "Larhed", "given": "Mats", "initials": "M"}, {"family": "Artursson", "given": "Per", "initials": "P"}], "type": "journal article", "published": "2011-09-00", "journal": {"volume": "100", "issn": "1520-6017", "issue": "9", "pages": "3763-3772", "title": "J Pharm Sci", "issn-l": "0022-3549"}, "abstract": "The primary aim of this study was to identify structural features that alter the intestinal epithelial permeability and efflux in a series of novel HIV-1 protease inhibitors (PIs). Eleven PIs were selected containing a tertiary alcohol in a transition-state mimicking scaffold, in which two substituents (R(1) and R(2) ) were varied systematically. Indinavir was selected as a reference compound. The apical-to-basolateral permeability was investigated in 2/4/A1 and Caco-2 monolayers. In addition, the basolateral-to-apical permeability was investigated in the Caco-2 monolayers and the efflux ratios were calculated. The absence of active drug transport processes in 2/4/A1 cells allowed identification and modeling of structural elements affecting the passive permeability. For instance, small aromatic R(1) substituents and a small (bromo-) R(2) substituent were associated with a high passive permeability. Efflux studies in Caco-2 cells indicated that amide-substituted neutral hydrophobic amino acids, such as valine and leucine, in the R(1) position, reduced the apical-to-basolateral transport and enhanced the efflux. We conclude that our investigation revealed structural features that alter the intestinal epithelial permeability and efflux in the series of PIs and hope that these results can contribute to the synthesis of PIs with improved permeability and limited efflux properties.", "doi": "10.1002/jps.22570", "pmid": "21491458", "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC3210832"}, {"db": "pii", "key": "S0022-3549(15)31944-4"}], "notes": "Uppsala Drug Optimization and Pharmaceutical Profiling (UDOPP)\r\nADME of Therapeutics (UDOPP)", "created": "2017-05-04T14:56:44.698Z", "modified": "2025-10-17T13:04:30.753Z"}], "created": "2017-05-09T09:12:51.337Z", "modified": "2020-11-27T13:14:04.338Z"}