{"entity": "journal", "iuid": "baff494643c342258ba2c3676b44e087", "timestamp": "2026-08-18T02:34:56.843Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/J%20Dent%20Res.json"}, "display": {"href": "https://publications.scilifelab.se/journal/J%20Dent%20Res"}}, "title": "J Dent Res", "issn": "0022-0345", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "aee99a2b3ee84c29ab0177c5f5950126", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aee99a2b3ee84c29ab0177c5f5950126.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aee99a2b3ee84c29ab0177c5f5950126"}}, "title": "The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis.", "authors": [{"family": "W\u00e4nman", "given": "M", "initials": "M", "orcid": "0009-0000-7046-6138", "researcher": {"href": "https://publications.scilifelab.se/researcher/df75852e5e5d4f13bfbdc86607bb7037.json"}}, {"family": "Betn\u00e9r", "given": "S", "initials": "S", "orcid": "0000-0002-8257-3632", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d31e5c53ffb4999b66abf53c0dd3a77.json"}}, {"family": "Esberg", "given": "A", "initials": "A", "orcid": "0000-0002-4430-8125", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6610f154ad749a49a8f5d89382c6b1b.json"}}, {"family": "Holm", "given": "C K", "initials": "CK"}, {"family": "Isehed", "given": "C", "initials": "C"}, {"family": "Holmlund", "given": "A", "initials": "A"}, {"family": "Palmqvist", "given": "P", "initials": "P"}, {"family": "L\u00f6vgren", "given": "A", "initials": "A", "orcid": "0000-0003-2920-6654", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e630258bd0243bfbcf17f81085fcb71.json"}}, {"family": "Lindquist", "given": "S", "initials": "S"}, {"family": "H\u00e4nstr\u00f6m", "given": "L", "initials": "L"}, {"family": "Lerner", "given": "U H", "initials": "UH", "orcid": "0000-0002-3579-1960", "researcher": {"href": "https://publications.scilifelab.se/researcher/d311ede3c1164738b4bf253c7575e329.json"}}, {"family": "Kindstedt", "given": "E", "initials": "E"}, {"family": "Lundberg", "given": "P", "initials": "P"}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "J Dent Res", "issn": "0022-0345", "volume": "103", "issue": "10", "pages": "999-1007", "issn-l": null}, "abstract": "The sequalae of periodontitis include irreversible degradation of tooth-supporting structures and circulatory spread of inflammatory mediators. However, the serum protein profile in periodontitis is not well described, which is partly attributable to the limited number of studies based on large and well-characterized periodontitis cohorts. This study aims to identify novel, circulating inflammation-related proteins associated with periodontitis within the PerioGene North case-control study, which includes 478 cases with severe periodontitis and 509 periodontally healthy controls. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP) and a panel of 45 inflammation-related proteins were analyzed using targeted proteomics. A distinguishable serum protein profile was evident in periodontitis cases. The protein pattern could separate cases from controls with a sensitivity of 0.81 and specificity of 0.81 (area under the curve = 0.87). Adjusted levels for hs-CRP and 24 of the 45 proteins were different between cases and controls. High levels of hs-CRP and matrix metalloproteinase-12, and low levels of epidermal growth factor (EGF) and oxidized low-density lipoprotein receptor 1 (OLR-1) were detected among the cases. Furthermore, the levels of C-C motif chemokine-19, granulocyte colony-stimulating factor-3 (CSF-3), interleukin-7 (IL-7), and hs-CRP were significantly higher in cases with a high degree of gingival inflammation. The levels of CSF-3 and tumor necrosis factor ligand superfamily member-10 TNFSF-10 were higher in cases with many deep periodontal pockets. The PerioGene North study includes detailed clinical periodontal data and uncovers a distinct serum protein profile in periodontitis. The findings of lower EGF and OLR-1 among the cases are highlighted, as this has not been presented before. The role of EGF and OLR-1 in periodontitis pathogenesis and as possible future biomarkers should be further explored.", "doi": "10.1177/00220345241263320", "pmid": "39101637", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11402264"}], "notes": [], "created": "2024-11-27T22:20:50.976Z", "modified": "2024-11-27T22:20:51.306Z"}, {"entity": "publication", "iuid": "66acb228c0fe4207af5b7c2a2b3ad412", "links": {"self": {"href": "https://publications.scilifelab.se/publication/66acb228c0fe4207af5b7c2a2b3ad412.json"}, "display": {"href": "https://publications.scilifelab.se/publication/66acb228c0fe4207af5b7c2a2b3ad412"}}, "title": "Heritability of Caries Scores, Trajectories, and Disease Subtypes.", "authors": [{"family": "Haworth", "given": "S", "initials": "S", "orcid": "0000-0001-7793-7326", "researcher": {"href": "https://publications.scilifelab.se/researcher/43fa9fb331c849b58d4ac4b14f04fbda.json"}}, {"family": "Esberg", "given": "A", "initials": "A", "orcid": "0000-0002-4430-8125", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6610f154ad749a49a8f5d89382c6b1b.json"}}, {"family": "Lif Holgerson", "given": "P", "initials": "P"}, {"family": "Kuja-Halkola", "given": "R", "initials": "R"}, {"family": "Timpson", "given": "N J", "initials": "NJ"}, {"family": "Magnusson", "given": "P K E", "initials": "PKE"}, {"family": "Franks", "given": "P W", "initials": "PW"}, {"family": "Johansson", "given": "I", "initials": "I"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "J Dent Res", "issn": "0022-0345", "volume": "99", "issue": "3", "pages": "264-270", "issn-l": null}, "abstract": "Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to estimate the relative importance of genetic and environmental factors in the etiology of different caries outcomes using a twin-based design. Analysis included up to 41,678 twins in the Swedish Twin Register aged 7 to 97 y, and dental data were obtained from preexisting dental records. The outcome measures were 1) summary indices of caries experience, 2) parameters representing trajectory in caries progression derived from longitudinal modeling, and 3) caries scores in groups of biologically similar tooth surfaces derived from hierarchical clustering of tooth surfaces (termed caries clusters). Additive genetic factors explained between 49.1% and 62.7% of variation in caries scores and between 50.0% and 60.5% of variation in caries trajectories. Seven caries clusters were identified, which had estimates of heritability lying between 41.9% and 54.3%. Shared environmental factors were important for only some of these clusters and explained 16% of variation in fissure caries in molar teeth but little variation in other clusters of caries presentation. The genetic factors influencing these clusters were only partially overlapping, suggesting that different biological processes are important in different groups of tooth surfaces and that innate liability to some patterns of caries presentation may partially explain why groups of tooth surfaces form clusters within the mouth. These results provide 1) improved quantification of genetic factors in the etiology of caries and 2) new data about the role of genetics in terms of longitudinal changes in caries status and specific patterns of disease presentation, and they may help lay the foundations for personalized interventions in the future.", "doi": "10.1177/0022034519897910", "pmid": "31905308", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7036480"}], "notes": [], "created": "2021-01-07T17:01:45.040Z", "modified": "2021-12-07T13:55:12.669Z"}], "created": "2021-01-07T17:01:45.050Z", "modified": "2021-01-07T17:01:45.050Z"}