{"entity": "journal", "iuid": "e015e128de284e5a84b3c1ef256dd11a", "timestamp": "2026-07-18T02:27:55.860Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Immunity.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Immunity"}}, "title": "Immunity", "issn": "1097-4180", "issn-l": "1074-7613", "publications_count": 15, "publications": [{"entity": "publication", "iuid": "59d7ae58ceea4c3bb2eb1e766d18641a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/59d7ae58ceea4c3bb2eb1e766d18641a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/59d7ae58ceea4c3bb2eb1e766d18641a"}}, "title": "Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic colitis", "authors": [{"family": "Fransson", "given": "Jennifer", "initials": "J", "orcid": "0000-0003-4762-901X", "researcher": {"href": "https://publications.scilifelab.se/researcher/30428cafc89647768f6c69eecf98efcf.json"}}, {"family": "Sorini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-6803-8377", "researcher": {"href": "https://publications.scilifelab.se/researcher/975173f37f144f06b236817e224de7f0.json"}}, {"family": "Castillo", "given": "Francisca", "initials": "F"}, {"family": "Chi", "given": "Yuhao", "initials": "Y"}, {"family": "He", "given": "Ning", "initials": "N"}, {"family": "Suarez-Alvarez", "given": "Martin", "initials": "M"}, {"family": "Ulloa", "given": "Maria Alejandra", "initials": "MA"}, {"family": "Morales Castro", "given": "Rodrigo A", "initials": "RA"}, {"family": "Okhovat", "given": "Ali", "initials": "A"}, {"family": "Sounart", "given": "Hailey", "initials": "H", "orcid": "0009-0000-5772-3961", "researcher": {"href": "https://publications.scilifelab.se/researcher/7d2d0007b3d643588c5196d482cb2089.json"}}, {"family": "Zagami", "given": "Chiara", "initials": "C"}, {"family": "Cardoso", "given": "Rebeca F", "initials": "RF"}, {"family": "Das", "given": "Srustidhar", "initials": "S"}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications.scilifelab.se/researcher/8499e792cc394c42b4240ef5fb3fd06c.json"}}, {"family": "Mechling", "given": "Anna", "initials": "A"}, {"family": "Hedin", "given": "Charlotte R H", "initials": "CRH"}, {"family": "Smith", "given": "Philip", "initials": "P"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ", "orcid": "0000-0001-9522-9729", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c6a2dde2d8f40ef82dfba0cf1b52c0d.json"}}], "type": "journal-article", "published": "2026-06-00", "journal": {"title": "Immunity", "issn": "1074-7613", "volume": "59", "issue": "6", "pages": "1599-1615.e5", "issn-l": null}, "abstract": "Inflammatory bowel disease (IBD) is a complex disorder that is often resistant to immunomodulatory treatments. Here, to understand how immune, epithelial, and stromal compartments are rewired during disease initiation and progression, we leveraged T cell transfer and Il10-/- spontaneous colitis models, including anti-IL-12p40 intervention, and integrated time-course transcriptomic analyses at bulk, single-cell, and spatial resolution. These well-established models exhibited conserved features of chronic inflammation, including neutrophil infiltration, and impaired tissue regeneration. Comparison of murine transcriptional programs and human IBD datasets revealed neutrophil-associated inflammation and cytokine signaling as the most conserved pathways across species. We identified spatial heterogeneity in inflammatory modules and described three gene programs with differential spatial and temporal distributions, including one corresponding to tertiary lymphoid structures. When used together, these models recapitulate complementary aspects of human disease at both cellular and transcriptional levels. This high-resolution spatiotemporal atlas will guide future translational research aimed at optimizing therapeutic strategies for IBD.", "doi": "10.1016/j.immuni.2026.04.005", "pmid": "42097141", "labels": {"NGI Short read": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(26)00167-6"}], "notes": [], "created": "2026-05-11T11:50:48.709Z", "modified": "2026-06-29T07:40:31.984Z"}, {"entity": "publication", "iuid": "9d8e02af163b4c1abdc334d1ce8fb886", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9d8e02af163b4c1abdc334d1ce8fb886.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9d8e02af163b4c1abdc334d1ce8fb886"}}, "title": "Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity.", "authors": [{"family": "Henriques-Oliveira", "given": "Lu\u00eds", "initials": "L"}, {"family": "Altman", "given": "Abigail R", "initials": "AR"}, {"family": "Kurochkin", "given": "Ilia", "initials": "I"}, {"family": "Ascic", "given": "Ervin", "initials": "E"}, {"family": "Halitzki", "given": "Evelyn", "initials": "E"}, {"family": "Matei", "given": "Andreea-Medeea", "initials": "AM"}, {"family": "P\u00e9rtiga-Cabral", "given": "Diogo", "initials": "D"}, {"family": "Ulmert", "given": "Isabel", "initials": "I"}, {"family": "Holst", "given": "Signe", "initials": "S"}, {"family": "Nair", "given": "Malavika Sreekumar", "initials": "MS"}, {"family": "Cunha", "given": "Pedro P", "initials": "PP"}, {"family": "Park", "given": "Sun-Mi", "initials": "SM"}, {"family": "Vergani", "given": "Stefano", "initials": "S"}, {"family": "Kharas", "given": "Michael G", "initials": "MG"}, {"family": "Yuan", "given": "Joan", "initials": "J"}, {"family": "Lahl", "given": "Katharina", "initials": "K"}, {"family": "Rosa", "given": "F\u00e1bio F", "initials": "FF"}, {"family": "Pires", "given": "Cristiana F", "initials": "CF"}, {"family": "Pereira", "given": "Carlos-Filipe", "initials": "CF"}], "type": "journal article", "published": "2025-10-14", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "58", "issue": "10", "pages": "2419-2438.e13", "issn-l": "1074-7613"}, "abstract": "Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset diversification remains poorly understood. Here, we employed a sequential anchored screen of 70 transcription factors using direct cellular reprogramming to identify regulators that specify type 2 conventional DCs (cDC2s) and plasmacytoid DCs (pDCs). We identified PU.1, IRF4, and PRDM1 as inducers of a pro-inflammatory cDC2B-like fate and SPIB, IRF8, and IKZF2 as mediators of an immature lymphoid DC program. Transcriptomic profiling linked these triads to lineage-specific signatures and demonstrated their requirement for subset identity. Mechanistically, lineage divergence was driven by chromatin co-engagement at subset-specific sites early in reprogramming. Functionally, reprogrammed DCs employed distinct immune mechanisms to elicit orthogonal anti-tumor responses in different tumor models. Collectively, our findings uncover transcriptional circuits that control DC diversification and pave the way to generate patient-tailored DC subsets for cancer immunotherapy.", "doi": "10.1016/j.immuni.2025.08.001", "pmid": "40885192", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(25)00335-8"}], "notes": [], "created": "2025-11-17T07:37:31.694Z", "modified": "2025-11-17T07:37:31.699Z"}, {"entity": "publication", "iuid": "f6b93bc63d7447ab8768a84e8c6aa42a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f6b93bc63d7447ab8768a84e8c6aa42a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f6b93bc63d7447ab8768a84e8c6aa42a"}}, "title": "Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity.", "authors": [{"family": "Lautenbach", "given": "Maximilian Julius", "initials": "MJ"}, {"family": "Wyss", "given": "Katja", "initials": "K"}, {"family": "Yman", "given": "Victor", "initials": "V"}, {"family": "Foroogh", "given": "Fariba", "initials": "F"}, {"family": "Satarvandi", "given": "Donya", "initials": "D"}, {"family": "Mousavian", "given": "Zaynab", "initials": "Z"}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K"}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Sundling", "given": "Christopher", "initials": "C"}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2025-08-12", "journal": {"title": "Immunity", "issn": "1097-4180", "issn-l": "1074-7613", "volume": "58", "issue": "8", "pages": "2120-2136.e5"}, "abstract": "Malaria presents with varying degrees of severity. To improve clinical management and prevention, it is crucial to understand the pathogenesis and host response. We analyzed 1,463 plasma proteins during and after acute Plasmodium falciparum malaria in adult travelers and linked responses to peripheral immune cells by integrating with single-cell RNA sequencing (RNA-seq) data from a subset of donors. We identified extensive perturbations in over 250 proteins with diverse origins, including many not previously analyzed in malaria patients, such as hormones, circulating receptors, and intracellular or membrane-bound proteins from affected tissues. The protein profiles clustered participants according to disease severity, enabling the identification of a compressed 11-protein signature enriched in severe malaria. Conceptually, this study advances our understanding of malaria by linking systemic proteomic changes to immune cell communication and organ-specific responses. This resource, which includes an interactive platform to explore data, opens new avenues for hypothesis generation, biomarker discovery, and therapeutic target identification.", "doi": "10.1016/j.immuni.2025.06.014", "pmid": "40664217", "labels": {"Affinity Proteomics Stockholm": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service", "Affinity Proteomics Uppsala": "Service", "NGI Proteomics": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(25)00283-3"}], "notes": [], "created": "2025-11-17T08:54:30.240Z", "modified": "2025-11-26T11:07:57.819Z"}, {"entity": "publication", "iuid": "dec6144fecc1409397278c869b88da91", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dec6144fecc1409397278c869b88da91.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dec6144fecc1409397278c869b88da91"}}, "title": "Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.", "authors": [{"family": "Ols", "given": "Sebastian", "initials": "S"}, {"family": "Lenart", "given": "Klara", "initials": "K"}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R"}, {"family": "Miranda", "given": "Marcos C", "initials": "MC"}, {"family": "Brunette", "given": "Natalie", "initials": "N"}, {"family": "Kochmann", "given": "Jana", "initials": "J"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Skotheim", "given": "Rebecca", "initials": "R"}, {"family": "Philomin", "given": "Annika", "initials": "A"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Fiala", "given": "Brooke", "initials": "B"}, {"family": "Wrenn", "given": "Samuel", "initials": "S"}, {"family": "Marcandalli", "given": "Jessica", "initials": "J"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Thompson", "given": "Elizabeth A", "initials": "EA"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Gegenfurtner", "given": "Florian", "initials": "F"}, {"family": "Kumar", "given": "Azad", "initials": "A"}, {"family": "Chen", "given": "Man", "initials": "M"}, {"family": "Phad", "given": "Ganesh E", "initials": "GE"}, {"family": "Graham", "given": "Barney S", "initials": "BS"}, {"family": "Perez", "given": "Laurent", "initials": "L"}, {"family": "Borst", "given": "Andrew J", "initials": "AJ"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Ruckwardt", "given": "Tracy J", "initials": "TJ"}, {"family": "King", "given": "Neil P", "initials": "NP"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-10-10", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "56", "issue": "10", "pages": "2425-2441.e14", "issn-l": "1074-7613"}, "abstract": "Nanoparticles for multivalent display and delivery of vaccine antigens have emerged as a promising avenue for enhancing B cell responses to protein subunit vaccines. Here, we evaluated B cell responses in rhesus macaques immunized with prefusion-stabilized respiratory syncytial virus (RSV) F glycoprotein trimer compared with nanoparticles displaying 10 or 20 copies of the same antigen. We show that multivalent display skews antibody specificities and drives epitope-focusing of responding B cells. Antibody cloning and repertoire sequencing revealed that focusing was driven by the expansion of clonally distinct B cells through recruitment of diverse precursors. We identified two antibody lineages that developed either ultrapotent neutralization or pneumovirus cross-neutralization from precursor B cells with low initial affinity for the RSV-F immunogen. This suggests that increased avidity by multivalent display facilitates the activation and recruitment of these cells. Diversification of the B cell response by multivalent nanoparticle immunogens has broad implications for vaccine design.", "doi": "10.1016/j.immuni.2023.08.011", "pmid": "37689061", "labels": {"Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(23)00367-9"}], "notes": [], "created": "2023-12-01T13:22:16.559Z", "modified": "2024-11-25T10:13:18.599Z"}, {"entity": "publication", "iuid": "d1c6bed351434c519178da6c6291753d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d1c6bed351434c519178da6c6291753d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d1c6bed351434c519178da6c6291753d"}}, "title": "Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.", "authors": [{"family": "Zwijnenburg", "given": "Anthonie Johan", "initials": "AJ"}, {"family": "Pokharel", "given": "Jyoti", "initials": "J"}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R"}, {"family": "Zheng", "given": "Wenning", "initials": "W"}, {"family": "Hoffer", "given": "Elena", "initials": "E"}, {"family": "Shryki", "given": "Iman", "initials": "I"}, {"family": "Comet", "given": "Natalia Ramirez", "initials": "NR"}, {"family": "Ehrstr\u00f6m", "given": "Marcus", "initials": "M"}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S"}, {"family": "Eidsmo", "given": "Liv", "initials": "L"}, {"family": "Gerlach", "given": "Carmen", "initials": "C"}], "type": "journal article", "published": "2023-08-08", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "56", "issue": "8", "pages": "1955-1974.e10", "issn-l": "1074-7613"}, "abstract": "T cells differentiate into functionally distinct states upon antigen encounter. These states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. We aimed to identify surface markers that reflect the graded nature of CD8+ T cell differentiation and delineate functionally comparable states in mice and humans. CITEseq analyses revealed that graded expression of CX3CR1, encoding the chemokine receptor CX3CR1, correlated with the CD8+ T cell differentiation gradient. CX3CR1 expression distinguished human and murine CD8+ and CD4+ T cell states, as defined by migratory and functional properties. Graded CX3CR1 expression, refined with CD62L, accurately captured the high-dimensional T cell differentiation continuum. Furthermore, the CX3CR1 expression gradient delineated states with comparable properties in humans and mice in steady state and on longitudinally tracked virus-specific CD8+ T cells in both species. Thus, graded CX3CR1 expression provides a strategy to translate the behavior of distinct T cell differentiation states across species.", "doi": "10.1016/j.immuni.2023.06.025", "pmid": "37490909", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(23)00282-0"}], "notes": [], "created": "2023-10-11T12:34:48.216Z", "modified": "2024-10-15T13:15:22.239Z"}, {"entity": "publication", "iuid": "2c65d20ec1de42e5b486342f5520c9c4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2c65d20ec1de42e5b486342f5520c9c4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2c65d20ec1de42e5b486342f5520c9c4"}}, "title": "Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a.", "authors": [{"family": "Zitti", "given": "Beatrice", "initials": "B"}, {"family": "Hoffer", "given": "Elena", "initials": "E"}, {"family": "Zheng", "given": "Wenning", "initials": "W"}, {"family": "Pandey", "given": "Ram Vinay", "initials": "RV"}, {"family": "Schlums", "given": "Heinrich", "initials": "H"}, {"family": "Perinetti Casoni", "given": "Giovanna", "initials": "G"}, {"family": "Fusi", "given": "Irene", "initials": "I"}, {"family": "Nguyen", "given": "Lien", "initials": "L"}, {"family": "K\u00e4rner", "given": "Jaanika", "initials": "J"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Carrasco", "given": "Anna", "initials": "A"}, {"family": "Gahm", "given": "Jessica", "initials": "J"}, {"family": "Ehrstr\u00f6m", "given": "Marcus", "initials": "M"}, {"family": "Happaniemi", "given": "Staffan", "initials": "S"}, {"family": "Keita", "given": "\u00c5sa V", "initials": "\u00c5V"}, {"family": "Hedin", "given": "Charlotte R H", "initials": "CRH"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}, {"family": "Eidsmo", "given": "Liv", "initials": "L"}, {"family": "Bryceson", "given": "Yenan T", "initials": "YT"}], "type": "journal article", "published": "2023-06-13", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "56", "issue": "6", "pages": "1285-1302.e7", "issn-l": "1074-7613"}, "abstract": "The integrin CD49a marks highly cytotoxic epidermal-tissue-resident memory (TRM) cells, but their differentiation from circulating populations remains poorly defined. We demonstrate enrichment of RUNT family transcription-factor-binding motifs in human epidermal CD8+CD103+CD49a+ TRM cells, paralleled by high RUNX2 and RUNX3 protein expression. Sequencing of paired skin and blood samples revealed clonal overlap between epidermal CD8+CD103+CD49a+ TRM cells and circulating memory CD8+CD45RA-CD62L+ T cells. In vitro stimulation of circulating CD8+CD45RA-CD62L+ T cells with IL-15 and TGF-\u03b2 induced CD49a expression and cytotoxic transcriptional profiles in a RUNX2- and RUNX3-dependent manner. We therefore identified a reservoir of circulating cells with cytotoxic TRM potential. In melanoma patients, high RUNX2, but not RUNX3, transcription correlated with a cytotoxic CD8+CD103+CD49a+ TRM cell signature and improved patient survival. Together, our results indicate that combined RUNX2 and RUNX3 activity promotes the differentiation of cytotoxic CD8+CD103+CD49a+ TRM cells, providing immunosurveillance of infected and malignant cells.", "doi": "10.1016/j.immuni.2023.05.003", "pmid": "37269830", "labels": {"NGI Short read": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(23)00220-0"}], "notes": [], "created": "2023-10-11T12:37:29.638Z", "modified": "2023-10-19T13:10:17.377Z"}, {"entity": "publication", "iuid": "c35226a6bbeb4de1aec36368fac7ac9d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c35226a6bbeb4de1aec36368fac7ac9d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c35226a6bbeb4de1aec36368fac7ac9d"}}, "title": "Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.", "authors": [{"family": "Pushparaj", "given": "Pradeepa", "initials": "P"}, {"family": "Nicoletto", "given": "Andrea", "initials": "A"}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ"}, {"family": "Das", "given": "Hrishikesh", "initials": "H"}, {"family": "Castro Dopico", "given": "Xaquin", "initials": "X"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L"}, {"family": "Hanke", "given": "Leo", "initials": "L"}, {"family": "Chernyshev", "given": "Mark", "initials": "M"}, {"family": "Narang", "given": "Sanjana", "initials": "S"}, {"family": "Kim", "given": "Sungyong", "initials": "S"}, {"family": "Fischbach", "given": "Julian", "initials": "J"}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "McInerney", "given": "Gerald", "initials": "G"}, {"family": "H\u00e4llberg", "given": "B Martin", "initials": "BM"}, {"family": "Murrell", "given": "Ben", "initials": "B"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}], "type": "journal article", "published": "2023-01-10", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "56", "issue": "1", "pages": "193-206.e7", "issn-l": "1074-7613"}, "abstract": "The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent health care workers, focusing on the IGHV1-69 gene, which has the highest level of allelic variation of all IGHV genes. The IGHV1-69\u221720-using CAB-I47 antibody and two similar antibodies isolated from an independent donor were critically dependent on allele usage. Neutralization was retained when reverting the V region to the germline IGHV1-69\u221720 allele but lost when reverting to other IGHV1-69 alleles. Structural data confirmed that two germline-encoded polymorphisms, R50 and F55, in the IGHV1-69 gene were required for high-affinity receptor-binding domain interaction. These results demonstrate that polymorphisms in IGH genes can influence the function of SARS-CoV-2 neutralizing antibodies.", "doi": "10.1016/j.immuni.2022.12.005", "pmid": "36574772", "labels": {"Structural Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC9742198"}, {"db": "pii", "key": "S1074-7613(22)00641-0"}], "notes": [], "created": "2023-05-31T19:07:26.930Z", "modified": "2023-05-31T19:09:10.354Z"}, {"entity": "publication", "iuid": "12ece6c4901347fab2888fd0883ac4f7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/12ece6c4901347fab2888fd0883ac4f7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/12ece6c4901347fab2888fd0883ac4f7"}}, "title": "Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.", "authors": [{"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Cai", "given": "Curtis", "initials": "C"}, {"family": "Wullimann", "given": "David", "initials": "D"}, {"family": "Niessl", "given": "Julia", "initials": "J"}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O"}, {"family": "Chen", "given": "Puran", "initials": "P"}, {"family": "Lange", "given": "Joshua", "initials": "J"}, {"family": "Cuapio", "given": "Angelica", "initials": "A"}, {"family": "Blennow", "given": "Ola", "initials": "O"}, {"family": "Hansson", "given": "Lotta", "initials": "L"}, {"family": "Mielke", "given": "Stephan", "initials": "S"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Perez-Potti", "given": "Andre", "initials": "A"}, {"family": "Sekine", "given": "Takuya", "initials": "T"}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Kammann", "given": "Tobias", "initials": "T"}, {"family": "Parrot", "given": "Tiphaine", "initials": "T"}, {"family": "Muvva", "given": "Jagadeeswara Rao", "initials": "JR"}, {"family": "Sobkowiak", "given": "Michal", "initials": "M"}, {"family": "Healy", "given": "Katie", "initials": "K"}, {"family": "Bogdanovic", "given": "Gordana", "initials": "G"}, {"family": "Muschiol", "given": "Sandra", "initials": "S"}, {"family": "S\u00f6derdahl", "given": "Gunnar", "initials": "G"}, {"family": "\u00d6sterborg", "given": "Anders", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Grifoni", "given": "Alba", "initials": "A"}, {"family": "Weiskopf", "given": "Daniela", "initials": "D"}, {"family": "Sette", "given": "Alessandro", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "S\u00e4llberg Chen", "given": "Margaret", "initials": "M"}, {"family": "Ljungman", "given": "Per", "initials": "P"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK"}, {"family": "Smith", "given": "C I Edvard", "initials": "CIE"}, {"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M"}], "type": "journal article", "published": "2022-09-13", "journal": {"title": "Immunity", "issn": "1097-4180", "issn-l": "1074-7613", "volume": "55", "issue": "9", "pages": "1732-1746.e5"}, "abstract": "Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.", "doi": "10.1016/j.immuni.2022.07.005", "pmid": "35961317", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9293955"}, {"db": "pii", "key": "S1074-7613(22)00338-7"}], "notes": [], "created": "2022-08-19T08:38:19.764Z", "modified": "2024-01-16T13:48:35.019Z"}, {"entity": "publication", "iuid": "3353d943335e440aadc61ccdfc970281", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3353d943335e440aadc61ccdfc970281.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3353d943335e440aadc61ccdfc970281"}}, "title": "Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.", "authors": [{"family": "Glaros", "given": "Vassilis", "initials": "V", "orcid": "0000-0001-6211-9515", "researcher": {"href": "https://publications.scilifelab.se/researcher/52e51bdbb2d2472582cc6387dc381746.json"}}, {"family": "Rauschmeier", "given": "Ren\u00e9", "initials": "R"}, {"family": "Artemov", "given": "Artem V", "initials": "AV"}, {"family": "Reinhardt", "given": "Annika", "initials": "A"}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Emmanouilidi", "given": "Aikaterini", "initials": "A", "orcid": "0000-0001-9431-6900", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c06a1851eea457199282fc3544563ef.json"}}, {"family": "Gustafsson", "given": "Charlotte", "initials": "C"}, {"family": "You", "given": "Yuanyuan", "initials": "Y", "orcid": "0000-0002-6047-2742", "researcher": {"href": "https://publications.scilifelab.se/researcher/890d05ba984e47d0a0c62a7f4b399158.json"}}, {"family": "Mirabello", "given": "Claudio", "initials": "C"}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Perez", "given": "Laurent", "initials": "L", "orcid": "0000-0002-8860-7928", "researcher": {"href": "https://publications.scilifelab.se/researcher/f237e3adf29144b294f06ffd3a7dd7bd.json"}}, {"family": "King", "given": "Neil P", "initials": "NP"}, {"family": "M\u00e5nsson", "given": "Robert", "initials": "R"}, {"family": "Angeletti", "given": "Davide", "initials": "D", "orcid": "0000-0002-5256-1972", "researcher": {"href": "https://publications.scilifelab.se/researcher/ae59c12bf82b4ad9a8d9ad8603d03d9c.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K"}, {"family": "Adameyko", "given": "Igor", "initials": "I"}, {"family": "Busslinger", "given": "Meinrad", "initials": "M"}, {"family": "Kreslavsky", "given": "Taras", "initials": "T", "orcid": "0000-0002-6672-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/94bb90e31ed1447a9835a1adae1c8daa.json"}}], "type": "journal article", "published": "2021-09-14", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "54", "issue": "9", "pages": "2005-2023.e10", "issn-l": "1074-7613"}, "abstract": "Cell fate decisions during early B cell activation determine the outcome of responses to pathogens and vaccines. We examined the early B cell response to T-dependent antigen in mice by single-cell RNA sequencing. Early after immunization, a homogeneous population of activated precursors (APs) gave rise to a transient wave of plasmablasts (PBs), followed a day later by the emergence of germinal center B cells (GCBCs). Most APs rapidly exited the cell cycle, giving rise to non-GC-derived early memory B cells (eMBCs) that retained an AP-like transcriptional profile. Rapid decline of antigen availability controlled these events; provision of excess antigen precluded cell cycle exit and induced a new wave of PBs. Fate mapping revealed a prominent contribution of eMBCs to the MBC pool. Quiescent cells with an MBC phenotype dominated the early response to immunization in primates. A reservoir of APs/eMBCs may enable rapid readjustment of the immune response when failure to contain a threat is manifested by increased antigen availability.", "doi": "10.1016/j.immuni.2021.08.017", "pmid": "34525339", "labels": {"Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S1074-7613(21)00349-6"}, {"db": "pmc", "key": "PMC7612941"}, {"db": "mid", "key": "EMS146190"}], "notes": [], "created": "2021-09-15T14:29:20.948Z", "modified": "2024-01-16T13:48:38.488Z"}, {"entity": "publication", "iuid": "6f4242f89b474bb994b3ba185d9cb75f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6f4242f89b474bb994b3ba185d9cb75f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6f4242f89b474bb994b3ba185d9cb75f"}}, "title": "Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.", "authors": [{"family": "Evren", "given": "Elza", "initials": "E"}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Tripathi", "given": "Kumar Parijat", "initials": "KP"}, {"family": "Sleiers", "given": "Natalie", "initials": "N"}, {"family": "Rives", "given": "In\u00e9s C\u00f3", "initials": "IC"}, {"family": "Alisjahbana", "given": "Arlisa", "initials": "A"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Sarhan", "given": "Dhifaf", "initials": "D"}, {"family": "Halle", "given": "Tor", "initials": "T"}, {"family": "Sorini", "given": "Chiara", "initials": "C"}, {"family": "Lepzien", "given": "Rico", "initials": "R"}, {"family": "Marquardt", "given": "Nicole", "initials": "N"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Botling", "given": "Johan", "initials": "J"}, {"family": "Karlsson", "given": "Mikael C I", "initials": "MCI"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ"}, {"family": "Willinger", "given": "Tim", "initials": "T"}], "type": "journal article", "published": "2021-02-09", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "54", "issue": "2", "pages": "259-275.e7", "issn-l": "1074-7613"}, "abstract": "The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect the development of lung macrophages from human hematopoiesis in vivo. Human CD34+ hematopoietic stem and progenitor cells (HSPCs) generated three macrophage populations, occupying separate anatomical niches in the lung. Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical CD14+ blood monocytes derived from HSPCs migrated into lung tissue and gave rise to human interstitial and alveolar macrophages. In contrast, non-classical CD16+ blood monocytes preferentially generated macrophages resident in the lung vasculature (pulmonary intravascular macrophages). Finally, single-cell RNA sequencing defined intermediate differentiation stages in human lung macrophage development from blood monocytes. This study identifies distinct developmental pathways from circulating monocytes to lung macrophages and reveals how cellular origin contributes to human macrophage identity, diversity, and localization in vivo.", "doi": "10.1016/j.immuni.2020.12.003", "pmid": "33382972", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(20)30531-8"}], "notes": [], "created": "2022-11-09T15:54:59.365Z", "modified": "2024-01-16T13:48:40.757Z"}, {"entity": "publication", "iuid": "2b5977da5b3448489e1540bbccf6f890", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2b5977da5b3448489e1540bbccf6f890.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2b5977da5b3448489e1540bbccf6f890"}}, "title": "Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity.", "authors": [{"family": "Fenton", "given": "Thomas M", "initials": "TM"}, {"family": "J\u00f8rgensen", "given": "Peter B", "initials": "PB"}, {"family": "Niss", "given": "Kristoffer", "initials": "K"}, {"family": "Rubin", "given": "Samuel J S", "initials": "SJS"}, {"family": "M\u00f6rbe", "given": "Urs M", "initials": "UM"}, {"family": "Riis", "given": "Lene B", "initials": "LB"}, {"family": "Da Silva", "given": "Cl\u00e9ment", "initials": "C"}, {"family": "Plumb", "given": "Adam", "initials": "A"}, {"family": "Vandamme", "given": "Julien", "initials": "J"}, {"family": "Jakobsen", "given": "Henrik L", "initials": "HL"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Habtezion", "given": "Aida", "initials": "A"}, {"family": "Nielsen", "given": "Ole H", "initials": "OH"}, {"family": "Johansson-Lindbom", "given": "Bengt", "initials": "B"}, {"family": "Agace", "given": "William W", "initials": "WW"}], "type": "journal article", "published": "2020-03-17", "journal": {"title": "Immunity", "issn": "1097-4180", "volume": "52", "issue": "3", "pages": "557-570.e6", "issn-l": "1074-7613"}, "abstract": "The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free intestinal lamina propria (LP). SM-ILF and M-ILF showed distinct patterns of distribution along the length of the intestine, were linked to the systemic circulation through MAdCAM-1+ high endothelial venules and efferent lymphatics, and had immune profiles consistent with immune-inductive sites. IgA sequencing analysis indicated that human ILFs are sites where intestinal adaptive immune responses are initiated in an anatomically restricted manner. Our findings position ILFs as key inductive hubs for regional immunity in the human intestine, and the methods presented will allow future assessment of these compartments in health and disease.", "doi": "10.1016/j.immuni.2020.02.001", "pmid": "32160523", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(20)30072-8"}, {"db": "pmc", "key": "PMC7155934"}, {"db": "mid", "key": "NIHMS1568648"}], "notes": [], "created": "2020-07-03T05:24:52.368Z", "modified": "2021-11-10T12:53:00.374Z"}, {"entity": "publication", "iuid": "ac5d8c870c3c4541901880e117486f37", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ac5d8c870c3c4541901880e117486f37.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ac5d8c870c3c4541901880e117486f37"}}, "title": "A Call for Blood\u2014In Human Immunology", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}, {"family": "Duffy", "given": "Darragh", "initials": "D", "orcid": "0000-0002-8875-2308", "researcher": {"href": "https://publications.scilifelab.se/researcher/dce1a0fd17154c73b30f23c2a58bd390.json"}}, {"family": "Quintana-Murci", "given": "Lluis", "initials": "L", "orcid": "0000-0003-2429-6320", "researcher": {"href": "https://publications.scilifelab.se/researcher/ace3ac29b9a74fb68976820310224740.json"}}], "type": "journal-article", "published": "2019-06-00", "journal": {"volume": "50", "issn": "1074-7613", "issue": "6", "pages": "1335-1336", "title": "Immunity", "issn-l": null}, "abstract": null, "doi": "10.1016/j.immuni.2019.05.012", "pmid": "31216453", "labels": {"Cellular Immunomonitoring": "Technology development", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(19)30232-8"}], "notes": [], "created": "2019-06-30T19:15:40.149Z", "modified": "2024-01-16T13:48:44.317Z"}, {"entity": "publication", "iuid": "ecdd0ea759dd48d5938553600833739d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ecdd0ea759dd48d5938553600833739d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ecdd0ea759dd48d5938553600833739d"}}, "title": "Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells", "authors": [{"family": "Tibbitt", "given": "Christopher Andrew", "initials": "CA"}, {"family": "Stark", "given": "Julian Mario", "initials": "JM"}, {"family": "Martens", "given": "Liesbet", "initials": "L"}, {"family": "Ma", "given": "Junjie", "initials": "J"}, {"family": "Mold", "given": "Jeff Eron", "initials": "JE"}, {"family": "Deswarte", "given": "Kim", "initials": "K"}, {"family": "Oliynyk", "given": "Ganna", "initials": "G"}, {"family": "Feng", "given": "Xiaogang", "initials": "X"}, {"family": "Lambrecht", "given": "Bart Norbert", "initials": "BN"}, {"family": "De Bleser", "given": "Pieter", "initials": "P"}, {"family": "Nyl\u00e9n", "given": "Susanne", "initials": "S"}, {"family": "Hammad", "given": "Hamida", "initials": "H"}, {"family": "Arsenian Henriksson", "given": "Marie", "initials": "M"}, {"family": "Saeys", "given": "Yvan", "initials": "Y"}, {"family": "Coquet", "given": "Jonathan Marie", "initials": "JM"}], "type": "journal-article", "published": "2019-06-00", "journal": {"volume": "51", "issn": "1097-4180", "issue": "1", "pages": "169-184.e5", "title": "Immunity", "issn-l": "1074-7613"}, "abstract": "Naive CD4 + T cells differentiate into functionally diverse T helper (Th) cell subsets. Th2 cells play a pathogenic role in asthma, yet a clear picture of their transcriptional profile is lacking. We performed single-cell RNA sequencing (scRNA-seq) of T helper cells from lymph node, lung, and airways in the house dust mite (HDM) model of allergic airway disease. scRNA-seq resolved transcriptional profiles of naive CD4+ T, Th1, Th2, regulatory T (Treg) cells, and a CD4+ T cell population responsive to type I interferons. Th2 cells in the airways were enriched for transcription of many genes, including Cd200r1, Il6, Plac8, and Igfbp7, and their mRNA profile was supported by analysis of chromatin accessibility and flow cytometry. Pathways associated with lipid metabolism were enriched in Th2 cells, and experiments with inhibitors of key metabolic pathways supported roles for glucose and lipid metabolism. These findings provide insight into the differentiation of pathogenic Th2 cells in the context of allergy.", "doi": "10.1016/j.immuni.2019.05.014", "pmid": "31231035", "labels": {"National Genomics Infrastructure": "Service", "Eukaryotic Single Cell Genomics (ESCG)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service"}, "xrefs": [], "notes": [], "created": "2019-07-01T07:43:34.091Z", "modified": "2020-10-08T16:40:27.576Z"}, {"entity": "publication", "iuid": "c6ac13283afd4ea48ddc2b39be64df94", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c6ac13283afd4ea48ddc2b39be64df94.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c6ac13283afd4ea48ddc2b39be64df94"}}, "title": "Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.", "authors": [{"family": "Kristiansen", "given": "Trine A", "initials": "TA"}, {"family": "Jaensson Gyllenb\u00e4ck", "given": "Elin", "initials": "E"}, {"family": "Zriwil", "given": "Alya", "initials": "A"}, {"family": "Bj\u00f6rklund", "given": "Tomas", "initials": "T"}, {"family": "Daniel", "given": "Jeremy A", "initials": "JA"}, {"family": "Sitnicka", "given": "Ewa", "initials": "E"}, {"family": "Soneji", "given": "Shamit", "initials": "S"}, {"family": "Bryder", "given": "David", "initials": "D"}, {"family": "Yuan", "given": "Joan", "initials": "J"}], "type": "journal article", "published": "2016-08-16", "journal": {"volume": "45", "issn": "1097-4180", "issue": "2", "pages": "346-357", "title": "Immunity", "issn-l": "1074-7613"}, "abstract": "Hematopoietic stem cells (HSCs) undergo a functional switch in neonatal mice hallmarked by a decrease in self-renewing divisions and entry into quiescence. Here, we investigated whether the developmental attenuation of B-1a cell output is a consequence of a shift in stem cell state during ontogeny. Using cellular barcoding for in\u00a0vivo single-cell fate analyses, we found that fetal liver definitive HSCs gave rise to both B-1a and B-2 cells. Whereas B-1a potential diminished in all HSCs with time, B-2 output was maintained. B-1a and B-2 plasticity could be reinitiated in a subset of adult HSCs by ectopic expression of the RNA binding protein LIN28B, a key regulator of fetal hematopoiesis, and this coincided with the clonal reversal to fetal-like elevated self-renewal and repopulation potential. These results anchor the attenuation of B-1a cell output to fetal HSC behavior and demonstrate that the developmental decline in regenerative potential represents a reversible HSC state.", "doi": "10.1016/j.immuni.2016.07.014", "pmid": "27533015", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S1074-7613(16)30287-4"}], "notes": [], "created": "2017-05-03T12:59:52.312Z", "modified": "2024-01-16T13:48:49.647Z"}, {"entity": "publication", "iuid": "7cd022456df14149b700478d0b01a5d5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7cd022456df14149b700478d0b01a5d5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7cd022456df14149b700478d0b01a5d5"}}, "title": "Powerful Populations Respond to Viruses and Vaccines.", "authors": [{"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}], "type": "journal article", "published": "2015-12-15", "journal": {"title": "Immunity", "issn": "1097-4180", "issn-l": "1074-7613", "volume": "43", "issue": "6", "pages": "1035-1037"}, "abstract": "In this issue of Immunity, Andres-Terre et al. (2015) and Nakaya et al. (2015) perform multi-cohort meta-analyses of immune responses to viruses and vaccines. With increased statistical power and more diverse sampling populations, their findings promise to be more generally applicable and suggestive of novel mechanisms for regulating immunity.", "doi": "10.1016/j.immuni.2015.11.018", "pmid": "26682979", "labels": {"Cellular Immunomonitoring": "Technology development"}, "xrefs": [{"db": "pii", "key": "S1074-7613(15)00496-3"}], "notes": [], "created": "2019-03-25T19:58:35.704Z", "modified": "2023-11-28T12:53:33.917Z"}], "created": "2017-05-09T09:12:13.865Z", "modified": "2020-11-27T13:14:01.311Z"}