{"entity": "journal", "iuid": "07ebdac3e3e74f8b8fcaf25a2e78c1d2", "timestamp": "2026-03-09T08:29:27.682Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Glia.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Glia"}}, "title": "Glia", "issn": "1098-1136", "issn-l": "0894-1491", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "76a1e6398a4d4115b774554b4b61f807", "links": {"self": {"href": "https://publications.scilifelab.se/publication/76a1e6398a4d4115b774554b4b61f807.json"}, "display": {"href": "https://publications.scilifelab.se/publication/76a1e6398a4d4115b774554b4b61f807"}}, "title": "Transcriptome network analysis links perinatal Staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus.", "authors": [{"family": "Gravina", "given": "Giacomo", "initials": "G"}, {"family": "Ardalan", "given": "Maryam", "initials": "M"}, {"family": "Chumak", "given": "Tetyana", "initials": "T"}, {"family": "Rydbeck", "given": "Halfdan", "initials": "H"}, {"family": "Wang", "given": "Xiaoyang", "initials": "X", "orcid": "0000-0001-9717-8160", "researcher": {"href": "https://publications.scilifelab.se/researcher/70fbed19bca84bec93f558168444227a.json"}}, {"family": "Ek", "given": "Carl Joakim", "initials": "CJ"}, {"family": "Mallard", "given": "Carina", "initials": "C", "orcid": "0000-0001-8953-919X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d0fa7de10554b5bb5a0e1ee64902aa1.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Glia", "issn": "1098-1136", "volume": "71", "issue": "9", "pages": "2234-2249", "issn-l": "0894-1491"}, "abstract": "Staphylococcus epidermidis (S. epidermidis) is the most common nosocomial pathogen in preterm infants and associated with increased risk of cognitive delay, however, underlying mechanisms are unknown. We employed morphological, transcriptomic and physiological methods to extensively characterize microglia in the immature hippocampus following S. epidermidis infection. 3D morphological analysis revealed activation of microglia after S. epidermidis. Differential expression combined with network analysis identified NOD-receptor signaling and trans-endothelial leukocyte trafficking as major mechanisms in microglia. In support, active caspase-1 was increased in the hippocampus and using the LysM-eGFP knock-in transgenic mouse, we demonstrate infiltration of leukocytes to the brain together with disruption of the blood-brain barrier. Our findings identify activation of microglia inflammasome as a major mechanism underlying neuroinflammation following infection. The results demonstrate that neonatal S. epidermidis infection share analogies with S. aureus and neurological diseases, suggesting a previously unrecognized important role in neurodevelopmental disorders in preterm born children.", "doi": "10.1002/glia.24389", "pmid": "37246946", "labels": {"Clinical Genomics Gothenburg": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-30T22:32:41.569Z", "modified": "2023-11-30T22:32:41.607Z"}, {"entity": "publication", "iuid": "200f9749c28742c2bd9c1629be8a4eb0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/200f9749c28742c2bd9c1629be8a4eb0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/200f9749c28742c2bd9c1629be8a4eb0"}}, "title": "Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo.", "authors": [{"family": "Nair", "given": "Syam", "initials": "S", "orcid": "0000-0001-8470-2162", "researcher": {"href": "https://publications.scilifelab.se/researcher/733eacd288ce4eefaad48c391436a319.json"}}, {"family": "Sobotka", "given": "Kristina S", "initials": "KS"}, {"family": "Joshi", "given": "Pooja", "initials": "P"}, {"family": "Gressens", "given": "Pierre", "initials": "P"}, {"family": "Fleiss", "given": "Bobbi", "initials": "B"}, {"family": "Thornton", "given": "Claire", "initials": "C"}, {"family": "Mallard", "given": "Carina", "initials": "C"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2019-06-00", "journal": {"title": "Glia", "issn": "1098-1136", "volume": "67", "issue": "6", "pages": "1047-1061", "issn-l": "0894-1491"}, "abstract": "Accumulating evidence suggests that changes in the metabolic signature of microglia underlie their response to inflammation. We sought to increase our knowledge of how pro-inflammatory stimuli induce metabolic changes. Primary microglia exposed to lipopolysaccharide (LPS)-expressed excessive fission leading to more fragmented mitochondria than tubular mitochondria. LPS-mediated Toll-like receptor 4 (TLR4) activation also resulted in metabolic reprogramming from oxidative phosphorylation to glycolysis. Blockade of mitochondrial fission by Mdivi-1, a putative mitochondrial division inhibitor led to the reversal of the metabolic shift. Mdivi-1 treatment also normalized the changes caused by LPS exposure, namely an increase in mitochondrial reactive oxygen species production and mitochondrial membrane potential as well as accumulation of key metabolic intermediate of TCA cycle succinate. Moreover, Mdivi-1 treatment substantially reduced LPS induced cytokine and chemokine production. Finally, we showed that Mdivi-1 treatment attenuated expression of genes related to cytotoxic, repair, and immunomodulatory microglia phenotypes in an in vivo neuroinflammation paradigm. Collectively, our data show that the activation of microglia to a classically pro-inflammatory state is associated with a switch to glycolysis that is mediated by mitochondrial fission, a process which may be a pharmacological target for immunomodulation.", "doi": "10.1002/glia.23587", "pmid": "30637805", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [], "notes": [], "created": "2020-01-23T16:10:15.580Z", "modified": "2021-06-21T11:52:41.828Z"}], "created": "2020-01-23T16:10:15.594Z", "modified": "2020-11-27T13:14:01.380Z"}