{"entity": "journal", "iuid": "1f5e52b5debd487989af6c778befb9e6", "timestamp": "2026-07-15T17:19:00.356Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Genetics.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Genetics"}}, "title": "Genetics", "issn": "1943-2631", "issn-l": "0016-6731", "publications_count": 9, "publications": [{"entity": "publication", "iuid": "18f91b3acff84dd7bbb28f1ff7415c73", "links": {"self": {"href": "https://publications.scilifelab.se/publication/18f91b3acff84dd7bbb28f1ff7415c73.json"}, "display": {"href": "https://publications.scilifelab.se/publication/18f91b3acff84dd7bbb28f1ff7415c73"}}, "title": "Copy number variations and their effect on the plasma proteome.", "authors": [{"family": "Schmitz", "given": "Daniel", "initials": "D"}, {"family": "Li", "given": "Zhiwei", "initials": "Z"}, {"family": "Lo Faro", "given": "Valeria", "initials": "V"}, {"family": "Rask-Andersen", "given": "Mathias", "initials": "M"}, {"family": "Ameur", "given": "Adam", "initials": "A"}, {"family": "Rafati", "given": "Nima", "initials": "N"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2023-10-04", "journal": {"title": "Genetics", "issn": "1943-2631", "issn-l": "0016-6731", "volume": null, "issue": null, "pages": null}, "abstract": "Structural variations, including copy number variations (CNVs), affect around 20 million bases in the human genome and are common causes of rare conditions. CNVs are rarely investigated in complex disease research because most CNVs are not targeted on the genotyping arrays or the reference panels for genetic imputation. In this study, we characterize CNVs in a Swedish cohort (N = 1,021) using short-read whole genome sequencing (WGS) and use long-read WGS for validation in a sub-cohort (N = 15), and explore their effect on 438 plasma proteins. We detected 184,182 polymorphic CNVs and identified 15 CNVs to be associated with 16 proteins (p<8.22\u00d710-10). Of these, five CNVs could be perfectly validated using long-read sequencing, including a CNV which was associated to measurements of the osteoclast-associated immunoglobulin-like receptor (OSCAR) and located upstream of OSCAR, a gene important for bone health. Two other CNVs were identified to be clusters of many short repetitive elements and another represented a complex rearrangement including an inversion. Our findings provide insights into the structure of common CNVs and their effects on the plasma proteome, and highlights the importance of investigating common CNVs, also in relation to complex diseases.", "doi": "10.1093/genetics/iyad179", "pmid": "37793096", "labels": {"NGI Long read": "Collaborative", "National Genomics Infrastructure": "Collaborative", "NGI Uppsala (Uppsala Genome Center)": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pii", "key": "7289162"}], "notes": [], "created": "2023-10-10T08:55:38.883Z", "modified": "2024-01-16T13:48:32.020Z"}, {"entity": "publication", "iuid": "6c5dee338d06472182df2147770ff4cc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6c5dee338d06472182df2147770ff4cc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6c5dee338d06472182df2147770ff4cc"}}, "title": "A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits.", "authors": [{"family": "Devkota", "given": "Ranjan", "initials": "R"}, {"family": "Kaper", "given": "Delaney", "initials": "D"}, {"family": "Bodhicharla", "given": "Rakesh", "initials": "R"}, {"family": "Henricsson", "given": "Marcus", "initials": "M"}, {"family": "Bor\u00e9n", "given": "Jan", "initials": "J"}, {"family": "Pilon", "given": "Marc", "initials": "M", "orcid": "0000-0003-3919-2882", "researcher": {"href": "https://publications.scilifelab.se/researcher/d45c4ecf9afe463c971af2de53a770a8.json"}}], "type": "journal article", "published": "2021-08-26", "journal": {"title": "Genetics", "issn": "1943-2631", "volume": "219", "issue": "1", "issn-l": "0016-6731"}, "abstract": "Communicating editor: B. Grant The composition and biophysical properties of cellular membranes must be tightly regulated to maintain the proper functions of myriad processes within cells. To better understand the importance of membrane homeostasis, we assembled a panel of five Caenorhabditis elegans strains that show a wide span of membrane composition and properties, ranging from excessively rich in saturated fatty acids (SFAs) and rigid to excessively rich in polyunsaturated fatty acids (PUFAs) and fluid. The genotypes of the five strain are, from most rigid to most fluid: paqr-1(tm3262); paqr-2(tm3410), paqr-2(tm3410), N2 (wild-type), mdt-15(et14); nhr-49(et8), and mdt-15(et14); nhr-49(et8); acs-13(et54). We confirmed the excess SFA/rigidity-to-excess PUFA/fluidity gradient using the methods of fluorescence recovery after photobleaching (FRAP) and lipidomics analysis. The five strains were then studied for a variety of cellular and physiological traits and found to exhibit defects in: permeability, lipid peroxidation, growth at different temperatures, tolerance to SFA-rich diets, lifespan, brood size, vitellogenin trafficking, oogenesis, and autophagy during starvation. The excessively rigid strains often exhibited defects in opposite directions compared to the excessively fluid strains. We conclude that deviation from wild-type membrane homeostasis is pleiotropically deleterious for numerous cellular/physiological traits. The strains introduced here should prove useful to further study the cellular and physiological consequences of impaired membrane homeostasis.", "doi": "10.1093/genetics/iyab093", "pmid": "34125894", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9335940"}, {"db": "pii", "key": "6298595"}], "notes": [], "created": "2023-02-16T08:15:40.909Z", "modified": "2023-02-16T08:15:40.926Z"}, {"entity": "publication", "iuid": "1545152b79e74ee4ab17cde829054644", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1545152b79e74ee4ab17cde829054644.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1545152b79e74ee4ab17cde829054644"}}, "title": "Estimating divergence times from DNA sequences.", "authors": [{"family": "Sj\u00f6din", "given": "Per", "initials": "P"}, {"family": "McKenna", "given": "James", "initials": "J"}, {"family": "Jakobsson", "given": "Mattias", "initials": "M"}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Genetics", "issn": "1943-2631", "volume": "217", "issue": "4", "issn-l": "0016-6731"}, "abstract": "The patterns of genetic variation within and among individuals and populations can be used to make inferences about the evolutionary forces that generated those patterns. Numerous population genetic approaches have been developed in order to infer evolutionary history. Here, we present the \"Two-Two (TT)\" and the \"Two-Two-outgroup (TTo)\" methods; two closely related approaches for estimating divergence time based in coalescent theory. They rely on sequence data from two haploid genomes (or a single diploid individual) from each of two populations. Under a simple population-divergence model, we derive the probabilities of the possible sample configurations. These probabilities form a set of equations that can be solved to obtain estimates of the model parameters, including population split times, directly from the sequence data. This transparent and computationally efficient approach to infer population divergence time makes it possible to estimate time scaled in generations (assuming a mutation rate), and not as a compound parameter of genetic drift. Using simulations under a range of demographic scenarios, we show that the method is relatively robust to migration and that the TTo method can alleviate biases that can appear from drastic ancestral population size changes. We illustrate the utility of the approaches with some examples, including estimating split times for pairs of human populations as well as providing further evidence for the complex relationship among Neandertals and Denisovans and their ancestors.", "doi": "10.1093/genetics/iyab008", "pmid": "33769498", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "6117229"}, {"db": "pmc", "key": "PMC8049563"}], "notes": [], "created": "2022-11-09T15:44:43.651Z", "modified": "2024-01-16T13:48:40.066Z"}, {"entity": "publication", "iuid": "c95da5e9ba1841f4802e429f0e0a9b0e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c95da5e9ba1841f4802e429f0e0a9b0e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c95da5e9ba1841f4802e429f0e0a9b0e"}}, "title": "Substantial Heritable Variation in Recombination Rate on Multiple Scales in Honeybees and Bumblebees.", "authors": [{"family": "Kawakami", "given": "Takeshi", "initials": "T"}, {"family": "Wallberg", "given": "Andreas", "initials": "A"}, {"family": "Olsson", "given": "Anna", "initials": "A"}, {"family": "Wintermantel", "given": "Dimitry", "initials": "D"}, {"family": "de Miranda", "given": "Joachim R", "initials": "JR"}, {"family": "Allsopp", "given": "Mike", "initials": "M"}, {"family": "Rundl\u00f6f", "given": "Maj", "initials": "M"}, {"family": "Webster", "given": "Matthew T", "initials": "MT"}], "type": "journal article", "published": "2019-08-00", "journal": {"volume": "212", "issn": "1943-2631", "issue": "4", "pages": "1101-1119", "title": "Genetics", "issn-l": "0016-6731"}, "abstract": "Meiotic recombination shuffles genetic variation and promotes correct segregation of chromosomes. Rates of recombination vary on several scales, both within genomes and between individuals, and this variation is affected by both genetic and environmental factors. Social insects have extremely high rates of recombination, although the evolutionary causes of this are not known. Here, we estimate rates of crossovers and gene conversions in 22 colonies of the honeybee, Apis mellifera, and 9 colonies of the bumblebee, Bombus terrestris, using direct sequencing of 299 haploid drone offspring. We confirm that both species have extremely elevated crossover rates, with higher rates measured in the highly eusocial honeybee than the primitively social bumblebee. There are also significant differences in recombination rate between subspecies of honeybee. There is substantial variation in genome-wide recombination rate between individuals of both A. mellifera and B. terrestris and the distribution of these rates overlap between species. A large proportion of interindividual variation in recombination rate is heritable, which indicates the presence of variation in trans-acting factors that influence recombination genome-wide. We infer that levels of crossover interference are significantly lower in honeybees compared to bumblebees, which may be one mechanism that contributes to higher recombination rates in honeybees. We also find a significant increase in recombination rate with distance from the centromere, mirrored by methylation differences. We detect a strong transmission bias due to GC-biased gene conversion associated with noncrossover gene conversions. Our results shed light on the mechanistic causes of extreme rates of recombination in social insects and the genetic architecture of recombination rate variation.", "doi": "10.1534/genetics.119.302008", "pmid": "31152071", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service"}, "xrefs": [{"db": "pii", "key": "genetics.119.302008"}, {"db": "pmc", "key": "PMC6707477"}], "notes": [], "created": "2020-01-08T16:47:38.438Z", "modified": "2020-01-21T13:56:16.327Z"}, {"entity": "publication", "iuid": "c061cfb4e0ac42649fd2c7242bb1f8c9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c061cfb4e0ac42649fd2c7242bb1f8c9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c061cfb4e0ac42649fd2c7242bb1f8c9"}}, "title": "How Linked Selection Shapes the Diversity Landscape in Ficedula Flycatchers", "authors": [{"family": "Rettelbach", "given": "Agnes", "initials": "A"}, {"family": "Nater", "given": "Alexander", "initials": "A", "orcid": "0000-0002-4805-5575", "researcher": {"href": "https://publications.scilifelab.se/researcher/e92d7e509932438bbfccd2aa94c9c107.json"}}, {"family": "Ellegren", "given": "Hans", "initials": "H", "orcid": "0000-0002-5035-1736", "researcher": {"href": "https://publications.scilifelab.se/researcher/819e68cc7125446baec6165aabd2d19c.json"}}], "type": "journal-article", "published": "2019-05-01", "journal": {"volume": "212", "issn": "1943-2631", "issue": "1", "pages": "277-285", "title": "Genetics", "issn-l": "0016-6731"}, "abstract": "There is an increasing awareness that selection affecting linked neutral sites strongly influences on how diversity is distributed across the genome. In particular, linked selection is likely involved in the formation of heterogenous landscapes of genetic diversity, including genomic regions with locally reduced effective population sizes that manifest as dips in diversity, and \"islands\" of differentiation between closely related populations or species. Linked selection can be in the form of background selection or selective sweeps, and a long-standing quest in population genetics has been to unveil the relative importance of these processes. Here, we analyzed the theoretically expected reduction of diversity caused by linked selection in the collared flycatcher ( Ficedula albicollis) genome and compared this with population genomic data on the distribution of diversity across the flycatcher genome. By incorporating data on recombination rate variation and the density of target sites for selection (including both protein-coding genes and conserved noncoding elements), we found that background selection can explain most of the observed baseline variation in genetic diversity. However, positive selection was necessary to explain the pronounced local diversity dips in the collared flycatcher genome. We confirmed our analytical findings by comprehensive simulations. Therefore, our study demonstrates that even though both background selection and selective sweeps contribute to the heterogeneous diversity landscape seen in this avian system, they play different roles in shaping it.", "doi": "10.1534/genetics.119.301991", "pmid": "30872320", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "genetics.119.301991"}, {"db": "pmc", "key": "PMC6499528"}], "notes": [], "created": "2019-06-11T15:37:32.132Z", "modified": "2024-01-16T13:48:44.388Z"}, {"entity": "publication", "iuid": "c411673d88f94ce68794635c59d1eb32", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c411673d88f94ce68794635c59d1eb32.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c411673d88f94ce68794635c59d1eb32"}}, "title": "Estimating the Fitness Effect of Deleterious Mutations During the Two Phases of the Life Cycle: A New Method Applied to the Root-Rot Fungus Heterobasidion parviporum.", "authors": [{"family": "Clergeot", "given": "Pierre-Henri", "initials": "PH"}, {"family": "Rode", "given": "Nicolas O", "initials": "NO", "orcid": "0000-0002-1121-4202", "researcher": {"href": "https://publications.scilifelab.se/researcher/6cf02c27d37f4f67be76b9ba4cd5686f.json"}}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ce5a8d7ac9a490eb2e261aeb75088d4.json"}}, {"family": "Brandstr\u00f6m Durling", "given": "Mikael", "initials": "M", "orcid": "0000-0001-6485-197X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7be72d0dcc48489495509b23c7ad3d38.json"}}, {"family": "Ihrmark", "given": "Katarina", "initials": "K"}, {"family": "Olson", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-8998-6096", "researcher": {"href": "https://publications.scilifelab.se/researcher/83a79139c2b94d9f97cf038e1cab8c03.json"}}], "type": "journal article", "published": "2019-03-00", "journal": {"volume": "211", "issn": "1943-2631", "issue": "3", "pages": "963-976", "title": "Genetics", "issn-l": "0016-6731"}, "abstract": "Many eukaryote species, including taxa such as fungi or algae, have a lifecycle with substantial haploid and diploid phases. A recent theoretical model predicts that such haploid-diploid lifecycles are stable over long evolutionary time scales when segregating deleterious mutations have stronger effects in homozygous diploids than in haploids and when they are partially recessive in heterozygous diploids. The model predicts that effective dominance-a measure that accounts for these two effects-should be close to 0.5 in these species. It also predicts that diploids should have higher fitness than haploids on average. However, an appropriate statistical framework to conjointly investigate these predictions is currently lacking. In this study, we derive a new quantitative genetic model to test these predictions using fitness data of two haploid parents and their diploid offspring, and genome-wide genetic distance between haploid parents. We apply this model to the root-rot basidiomycete fungus Heterobasidion parviporum-a species where the heterokaryotic (equivalent to the diploid) phase is longer than the homokaryotic (haploid) phase. We measured two fitness-related traits (mycelium growth rate and the ability to degrade wood) in both homokaryons and heterokaryons, and we used whole-genome sequencing to estimate nuclear genetic distance between parents. Possibly due to a lack of power, we did not find that deleterious mutations were recessive or more deleterious when expressed during the heterokaryotic phase. Using this model to compare effective dominance among haploid-diploid species where the relative importance of the two phases varies should help better understand the evolution of haploid-diploid life cycles.", "doi": "10.1534/genetics.118.301855", "pmid": "30598467", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "genetics.118.301855"}, {"db": "pmc", "key": "PMC6404244"}, {"db": "figshare", "key": "10.25386/genetics.6941477"}], "notes": [], "created": "2020-01-08T12:44:32.500Z", "modified": "2021-06-21T13:30:12.874Z"}, {"entity": "publication", "iuid": "7385440a648e4721bdf0bdfa5fa73032", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7385440a648e4721bdf0bdfa5fa73032.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7385440a648e4721bdf0bdfa5fa73032"}}, "title": "Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2.", "authors": [{"family": "Bodhicharla", "given": "Rakesh", "initials": "R"}, {"family": "Devkota", "given": "Ranjan", "initials": "R"}, {"family": "Ruiz", "given": "Mario", "initials": "M"}, {"family": "Pilon", "given": "Marc", "initials": "M", "orcid": "0000-0003-3919-2882", "researcher": {"href": "https://publications.scilifelab.se/researcher/d45c4ecf9afe463c971af2de53a770a8.json"}}], "type": "journal article", "published": "2018-09-00", "journal": {"title": "Genetics", "issn": "1943-2631", "volume": "210", "issue": "1", "pages": "189-201", "issn-l": "0016-6731"}, "abstract": "Maintenance of membrane properties is an essential aspect of cellular homeostasis of which the regulatory mechanisms remain mostly uncharacterized. In Caenorhabditis elegans, the PAQR-2 and IGLR-2 proteins act together as a plasma membrane sensor that responds to decreased fluidity by promoting fatty acid desaturation, hence restoring membrane fluidity. Here, we used mosaic analysis for paqr-2 and iglr-2, and tissue-specific paqr-2 expression, to show that membrane homeostasis is achieved cell nonautonomously. Specifically, we found that expression of paqr-2 in the hypodermis, gonad sheath cells, or intestine is sufficient to suppress systemic paqr-2 mutant phenotypes, including tail tip morphology, membrane fluidity in intestinal cells, cold and glucose intolerance, vitellogenin transport to the germline, germ cell development, and brood size. Finally, we show that the cell nonautonomous regulation of membrane homeostasis is conserved in human cells: HEK293 cells that express AdipoR2, a homolog of paqr-2, are able to normalize membrane fluidity in distant cells where AdipoR2 has been silenced. Finally, using C. elegans mutants and small interfering RNA against \u03949 stearoyl-CoA desaturase in HEK293 cells, we show that \u03949 desaturases are essential for the cell nonautonomous maintenance of membrane fluidity. We conclude that cells are able to share membrane components even when they are not in direct contact with each other, and that this contributes to the maintenance of membrane homeostasis in C. elegans and human cells.", "doi": "10.1534/genetics.118.301272", "pmid": "29997234", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "genetics.118.301272"}, {"db": "pmc", "key": "PMC6116961"}], "notes": [], "created": "2020-01-23T16:16:39.298Z", "modified": "2021-06-21T14:08:01.320Z"}, {"entity": "publication", "iuid": "725b691fbefb457a9acd5f5fd689c118", "links": {"self": {"href": "https://publications.scilifelab.se/publication/725b691fbefb457a9acd5f5fd689c118.json"}, "display": {"href": "https://publications.scilifelab.se/publication/725b691fbefb457a9acd5f5fd689c118"}}, "title": "Inferring Individual Inbreeding and Demographic History from Segments of Identity by Descent in Ficedula Flycatcher Genome Sequences", "authors": [{"family": "Kardos", "given": "Marty", "initials": "M"}, {"family": "Qvarnstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Ellegren", "given": "Hans", "initials": "H"}], "type": "journal-article", "published": "2017-03-00", "journal": {"volume": "205", "issn": "1943-2631", "issue": "3", "pages": "1319-1334", "title": "Genetics", "issn-l": "0016-6731"}, "abstract": null, "doi": "10.1534/genetics.116.198861", "pmid": "28100590", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "BioProject", "description": "Genetic variation in Ficedula flycatchers", "key": "PRJEB7359"}, {"db": "BioProject", "description": "Detecting QTL in natural populations", "key": "PRJEB11502"}], "notes": [], "created": "2017-10-19T20:22:23.226Z", "modified": "2024-01-16T13:48:48.342Z"}, {"entity": "publication", "iuid": "d3f3b77df7bb441495c74fa77e664015", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d3f3b77df7bb441495c74fa77e664015.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d3f3b77df7bb441495c74fa77e664015"}}, "title": "Natural Selection and Recombination Rate Variation Shape Nucleotide Polymorphism Across the Genomes of Three Related Populus Species.", "authors": [{"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Street", "given": "Nathaniel R", "initials": "NR"}, {"family": "Scofield", "given": "Douglas G", "initials": "DG"}, {"family": "Ingvarsson", "given": "P\u00e4r K", "initials": "PK"}], "type": "journal article", "published": "2016-03-00", "journal": {"volume": "202", "issn": "1943-2631", "issue": "3", "pages": "1185-1200", "title": "Genetics", "issn-l": "0016-6731"}, "abstract": "A central aim of evolutionary genomics is to identify the relative roles that various evolutionary forces have played in generating and shaping genetic variation within and among species. Here we use whole-genome resequencing data to characterize and compare genome-wide patterns of nucleotide polymorphism, site frequency spectrum, and population-scaled recombination rates in three species of Populus: Populus tremula, P. tremuloides, and P. trichocarpa. We find that P. tremuloides has the highest level of genome-wide variation, skewed allele frequencies, and population-scaled recombination rates, whereas P. trichocarpa harbors the lowest. Our findings highlight multiple lines of evidence suggesting that natural selection, due to both purifying and positive selection, has widely shaped patterns of nucleotide polymorphism at linked neutral sites in all three species. Differences in effective population sizes and rates of recombination largely explain the disparate magnitudes and signatures of linked selection that we observe among species. The present work provides the first phylogenetic comparative study on a genome-wide scale in forest trees. This information will also improve our ability to understand how various evolutionary forces have interacted to influence genome evolution among related species.", "doi": "10.1534/genetics.115.183152", "pmid": "26721855", "labels": {"Bioinformatics Support, Infrastructure and Training": null, "Bioinformatics Support and Infrastructure": null, "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": null}, "xrefs": [{"db": "pii", "key": "genetics.115.183152"}, {"db": "pmc", "key": "PMC4788117"}], "notes": [], "created": "2017-05-02T12:58:54.740Z", "modified": "2024-01-16T13:48:50.392Z"}], "created": "2017-05-09T09:12:53.373Z", "modified": "2020-11-27T13:14:08.367Z"}