{"entity": "journal", "iuid": "44973cef6fbf443ea0fefbd71b736b2c", "timestamp": "2026-07-22T17:40:34.575Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Genes%20Dev..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Genes%20Dev."}}, "title": "Genes Dev.", "issn": "1549-5477", "issn-l": "0890-9369", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "fd8ad9ec383e498c9f373930bccf2c76", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fd8ad9ec383e498c9f373930bccf2c76.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fd8ad9ec383e498c9f373930bccf2c76"}}, "title": "Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain.", "authors": [{"family": "Zelco", "given": "Aura", "initials": "A"}, {"family": "B\u00f6rjesson", "given": "Vanja", "initials": "V"}, {"family": "de Kanter", "given": "Jurrian K", "initials": "JK"}, {"family": "Lebrero-Fernandez", "given": "Cristina", "initials": "C"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Rocha-Ferreira", "given": "Eridan", "initials": "E"}, {"family": "Nilsson", "given": "Gisela", "initials": "G"}, {"family": "Nair", "given": "Syam", "initials": "S"}, {"family": "Svedin", "given": "Pernilla", "initials": "P"}, {"family": "Bemark", "given": "Mats", "initials": "M"}, {"family": "Hagberg", "given": "Henrik", "initials": "H"}, {"family": "Mallard", "given": "Carina", "initials": "C"}, {"family": "Holstege", "given": "Frank C P", "initials": "FCP"}, {"family": "Wang", "given": "Xiaoyang", "initials": "X", "orcid": "0000-0001-9717-8160", "researcher": {"href": "https://publications.scilifelab.se/researcher/70fbed19bca84bec93f558168444227a.json"}}], "type": "journal article", "published": "2021-08-01", "journal": {"title": "Genes Dev.", "issn": "1549-5477", "issn-l": "0890-9369", "volume": "35", "issue": "15-16", "pages": "1190-1207"}, "abstract": "The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and after perinatal brain injury. We identified almost all known leukocyte subtypes and found differences between neonatal and adult border-associated macrophages, thus highlighting that neonatal border-associated macrophages are functionally immature with regards to immune responses compared with their adult counterparts. We also identified novel meningeal microglia-like cell populations that may participate in white matter development. Early after the hypoxic-ischemic insult, neutrophil numbers increased and they exhibited increased granulopoiesis, suggesting that the meninges are an important site of immune cell expansion with implications for the initiation of inflammatory cascades after neonatal brain injury. Our study provides a single-cell resolution view of the importance of meningeal leukocytes at the early stage of development in health and disease.", "doi": "10.1101/gad.348190.120", "pmid": "34301765", "labels": {"Clinical Genomics Gothenburg": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pii", "key": "gad.348190.120"}, {"db": "pmc", "key": "PMC8336895"}], "notes": [], "created": "2022-03-29T13:44:08.378Z", "modified": "2023-05-15T16:44:24.926Z"}, {"entity": "publication", "iuid": "5c6d158d23b64c578c3e49a06388e6b6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5c6d158d23b64c578c3e49a06388e6b6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5c6d158d23b64c578c3e49a06388e6b6"}}, "title": "RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.", "authors": [{"family": "Rao", "given": "Shuan", "initials": "S"}, {"family": "Sigl", "given": "Verena", "initials": "V"}, {"family": "Wimmer", "given": "Reiner Alois", "initials": "RA"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Jais", "given": "Alexander", "initials": "A"}, {"family": "Wagner", "given": "Gabriel", "initials": "G"}, {"family": "Handschuh", "given": "Stephan", "initials": "S"}, {"family": "Uribesalgo", "given": "Iris", "initials": "I"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A"}, {"family": "Kozieradzki", "given": "Ivona", "initials": "I"}, {"family": "Tortola", "given": "Luigi", "initials": "L"}, {"family": "Nitsch", "given": "Roberto", "initials": "R"}, {"family": "Cronin", "given": "Shane J", "initials": "SJ"}, {"family": "Orthofer", "given": "Michael", "initials": "M"}, {"family": "Branstetter", "given": "Daniel", "initials": "D"}, {"family": "Canon", "given": "Jude", "initials": "J"}, {"family": "Rossi", "given": "John", "initials": "J"}, {"family": "D'Arcangelo", "given": "Manolo", "initials": "M"}, {"family": "Botling", "given": "Johan", "initials": "J"}, {"family": "Micke", "given": "Patrick", "initials": "P"}, {"family": "Fleur", "given": "Linnea La", "initials": "L"}, {"family": "Edlund", "given": "Karolina", "initials": "K"}, {"family": "Bergqvist", "given": "Michael", "initials": "M"}, {"family": "Ekman", "given": "Simon", "initials": "S"}, {"family": "Lendl", "given": "Thomas", "initials": "T"}, {"family": "Popper", "given": "Helmut", "initials": "H"}, {"family": "Takayanagi", "given": "Hiroshi", "initials": "H"}, {"family": "Kenner", "given": "Lukas", "initials": "L"}, {"family": "Hirsch", "given": "Fred R", "initials": "FR"}, {"family": "Dougall", "given": "William", "initials": "W"}, {"family": "Penninger", "given": "Josef M", "initials": "JM"}], "type": "journal article", "published": "2017-10-15", "journal": {"title": "Genes Dev.", "issn": "1549-5477", "volume": "31", "issue": "20", "pages": "2099-2112", "issn-l": "0890-9369"}, "abstract": "Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas in mouse lung epithelial cells markedly impairs the progression of G12D KRas -driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis in human and murine lung cancer cells and promotes expansion of lung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration. Our data also indicate survival differences in G12D KRas -driven lung cancer between male and female mice, and we show that female sex hormones can promote lung cancer progression via the RANK pathway. These data uncover a direct role for RANK in lung cancer and may explain why female sex hormones accelerate lung cancer development. Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer.G12D", "doi": "10.1101/gad.304162.117", "pmid": "29118048", "labels": {"Clinical Genomics Uppsala": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pii", "key": "gad.304162.117"}, {"db": "pmc", "key": "PMC5733500"}], "notes": [], "created": "2019-12-20T07:50:21.577Z", "modified": "2019-12-20T07:50:21.600Z"}, {"entity": "publication", "iuid": "279a5dd9b15848b08dbc116b1892d9b4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/279a5dd9b15848b08dbc116b1892d9b4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/279a5dd9b15848b08dbc116b1892d9b4"}}, "title": "The epidermis coordinates auxin-induced stem growth in response to shade.", "authors": [{"family": "Procko", "given": "Carl", "initials": "C"}, {"family": "Burko", "given": "Yogev", "initials": "Y"}, {"family": "Jaillais", "given": "Yvon", "initials": "Y", "orcid": "0000-0003-4923-883X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8d2a09eab27a4815b435f82afbf8525d.json"}}, {"family": "Ljung", "given": "Karin", "initials": "K", "orcid": "0000-0003-2901-189X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f91b1e1f90c24559b915ebcd265804a4.json"}}, {"family": "Long", "given": "Jeff A", "initials": "JA"}, {"family": "Chory", "given": "Joanne", "initials": "J"}], "type": "journal article", "published": "2016-07-01", "journal": {"title": "Genes Dev.", "issn": "1549-5477", "volume": "30", "issue": "13", "pages": "1529-1541", "issn-l": "0890-9369"}, "abstract": "Growth of a complex multicellular organism requires coordinated changes in diverse cell types. These cellular changes generate organs of the correct size, shape, and functionality. In plants, the growth hormone auxin induces stem elongation in response to shade; however, which cell types of the stem perceive the auxin signal and contribute to organ growth is poorly understood. Here, we blocked the transcriptional response to auxin within specific tissues to show that auxin signaling is required in many cell types for correct hypocotyl growth in shade, with a key role for the epidermis. Combining genetic manipulations in Arabidopsis thaliana with transcriptional profiling of the hypocotyl epidermis from Brassica rapa, we show that auxin acts in the epidermis in part by inducing activity of the locally acting, growth-promoting brassinosteroid pathway. Our findings clarify cell-specific auxin function in the hypocotyl and highlight the complexity of cell type interactions within a growing organ.", "doi": "10.1101/gad.283234.116", "pmid": "27401556", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC4949326"}, {"db": "pii", "key": "30/13/1529"}, {"db": "medline", "key": "8711660"}], "notes": [], "created": "2023-04-12T14:14:44.604Z", "modified": "2025-10-17T13:03:19.491Z"}], "created": "2019-12-20T07:50:21.591Z", "modified": "2020-11-27T13:14:05.200Z"}