{"entity": "journal", "iuid": "43408491e6d342898266fffadadf7b33", "timestamp": "2026-07-22T16:49:41.579Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Eur.%20J.%20Epidemiol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Eur.%20J.%20Epidemiol."}}, "title": "Eur. J. Epidemiol.", "issn": "1573-7284", "issn-l": "0393-2990", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "0b4241ad42b14fed843bccebe6ab11be", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0b4241ad42b14fed843bccebe6ab11be.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0b4241ad42b14fed843bccebe6ab11be"}}, "title": "Oral contraceptive use increases bone density and reduces the risk of osteoporosis.", "authors": [{"family": "Ivansson", "given": "Emma L", "initials": "EL"}, {"family": "Johansson", "given": "Therese", "initials": "T"}, {"family": "Karlsson", "given": "Torgny", "initials": "T"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications.scilifelab.se/researcher/76265c54961046e99bdb0439f9ae1d34.json"}}], "type": "journal article", "published": "2025-09-00", "journal": {"title": "Eur. J. Epidemiol.", "issn": "1573-7284", "volume": "40", "issue": "9", "pages": "1123-1131", "issn-l": "0393-2990"}, "abstract": "Osteoporotic fractures, largely resulting from reduced estrogen levels after menopause and subsequent bone loss, are a leading cause of disability among older women. Although oral contraceptive pills (OCPs) contain estrogen, their long-term impact on bone health and osteoporosis risk remain uncertain. Here, we assessed the effect of OCP use on bone mineral density (BMD) and osteoporosis using data from 257,185 women from the UK Biobank, born 1936-1970. Time-dependent Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for osteoporosis, while multivariable linear regression was used to assess the effect of OCP use on BMD, measured as T-scores in standard deviation units based on quantitative ultrasound of the calcaneus. By the end of follow-up in 2020, 7.6% of the participants had received an osteoporosis diagnosis. The rate of osteoporosis was lower among ever OCP users (HR = 0.86; 95% CI 0.83-0.89; P = 2.8 \u00d7 10-17). OCP use was also associated with a higher BMD T-score (0.052; 0.038-0.067; P = 2.1 \u00d7 10-12) with an increasing effect with longer use. Use of OCPs for 0-1 years had no significant effect on BMD (P = 0.081). However, longer durations were associated with increased BMD T-scores compared to never users: 2-5 years (0.046; 0.027-0.065, P = 2.2 \u00d7 10-6), 6-10 years (0.062; 0.043-0.080; P = 3.5 \u00d7 10-12), 11-15 years (0.062; 0.042-0.081; P = 3.2 \u00d7 10-12) and 16 + years (0.064; 0.044-0.083; P = 1.2 \u00d7 10-10). We found prior OCP use to be associated with higher BMD and a reduced risk of osteoporosis, potentially offering long-term benefits and suggesting that OCP use could reduce osteoporotic complications in older women.", "doi": "10.1007/s10654-025-01273-2", "pmid": "40632378", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12537589"}, {"db": "pii", "key": "10.1007/s10654-025-01273-2"}], "notes": [], "created": "2025-11-28T10:41:18.514Z", "modified": "2025-11-28T10:41:18.557Z"}, {"entity": "publication", "iuid": "823e715bcc0e4ef089479230e12377ae", "links": {"self": {"href": "https://publications.scilifelab.se/publication/823e715bcc0e4ef089479230e12377ae.json"}, "display": {"href": "https://publications.scilifelab.se/publication/823e715bcc0e4ef089479230e12377ae"}}, "title": "Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.", "authors": [{"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Lampa", "given": "Erik", "initials": "E"}, {"family": "Dekkers", "given": "Koen", "initials": "K"}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahlm", "given": "Kristin", "initials": "K"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Alfredsson", "given": "Joakim", "initials": "J"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Cederlund", "given": "Kerstin", "initials": "K"}, {"family": "Duvernoy", "given": "Olov", "initials": "O"}, {"family": "Engvall", "given": "Jan E", "initials": "JE"}, {"family": "Eriksson", "given": "Maria J", "initials": "MJ"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hagstr\u00f6m", "given": "Emil", "initials": "E"}, {"family": "Hamrefors", "given": "Viktor", "initials": "V"}, {"family": "Hedner", "given": "Jan", "initials": "J"}, {"family": "Janzon", "given": "Magnus", "initials": "M"}, {"family": "Jernberg", "given": "Tomas", "initials": "T"}, {"family": "Johnson", "given": "Linda", "initials": "L"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindberg", "given": "Eva", "initials": "E"}, {"family": "Mannila", "given": "Maria", "initials": "M"}, {"family": "Nilsson", "given": "Ulf", "initials": "U"}, {"family": "Persson", "given": "Anders", "initials": "A"}, {"family": "Persson", "given": "Hans Lennart", "initials": "HL"}, {"family": "Persson", "given": "Margaretha", "initials": "M"}, {"family": "Ramnemark", "given": "Anna", "initials": "A"}, {"family": "Rosengren", "given": "Annika", "initials": "A"}, {"family": "Schmidt", "given": "Caroline", "initials": "C"}, {"family": "Skoglund Larsson", "given": "Linn", "initials": "L"}, {"family": "Sk\u00f6ld", "given": "C Magnus", "initials": "CM"}, {"family": "Swahn", "given": "Eva", "initials": "E"}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "Tor\u00e9n", "given": "Kjell", "initials": "K"}, {"family": "Waldenstr\u00f6m", "given": "Anders", "initials": "A"}, {"family": "Wollmer", "given": "Per", "initials": "P"}, {"family": "Zaigham", "given": "Suneela", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}], "type": "journal article", "published": "2024-01-00", "journal": {"title": "Eur. J. Epidemiol.", "issn": "1573-7284", "volume": "39", "issue": "1", "pages": "35-49", "issn-l": "0393-2990"}, "abstract": "Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.", "doi": "10.1007/s10654-023-01088-z", "pmid": "38165527", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10811042"}, {"db": "pii", "key": "10.1007/s10654-023-01088-z"}], "notes": [], "created": "2024-11-25T10:11:04.848Z", "modified": "2024-11-25T10:11:04.867Z"}, {"entity": "publication", "iuid": "d351e65476b84c9bbdcebfac581eb1df", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d351e65476b84c9bbdcebfac581eb1df.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d351e65476b84c9bbdcebfac581eb1df"}}, "title": "Clinical depression, antidepressant use and risk of future cardiovascular disease.", "authors": [{"family": "Rahman", "given": "Iffat", "initials": "I"}, {"family": "Humphreys", "given": "Keith", "initials": "K"}, {"family": "Bennet", "given": "Anna Michaela", "initials": "AM"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Pedersen", "given": "Nancy Lee", "initials": "NL"}, {"family": "Magnusson", "given": "Patrik Karl Erik", "initials": "PK"}], "type": "journal article", "published": "2013-07-00", "journal": {"volume": "28", "issn": "1573-7284", "issue": "7", "pages": "589-595", "title": "Eur. J. Epidemiol.", "issn-l": "0393-2990"}, "abstract": "Many studies have shown that depression contributes to a higher risk of developing cardiovascular disease (CVD). Use of antidepressants and its association with CVD development has also been investigated previously but the results have been conflicting. Further, depression and use of antidepressants have been more widely studied in relation to coronary heart disease rather than stroke. A population-based cohort study consisting of 36,654 Swedish elderly twins was conducted with a follow-up of maximum 4\u00a0years. Information on exposures, outcomes and covariates were collected from the Swedish national patient registers, the Swedish prescribed drug registry and the Swedish twin registry. Depression and antidepressant use were both associated with CVD development. The risk was most pronounced among depressed patients who did not use antidepressants (HR 1. 48, CI 1.10-2.00). When assessing the two main CVD outcomes coronary heart disease and ischemic stroke separately, the predominant association was found for ischemic stroke while it was absent for coronary heart disease. The association between depression and stroke also remained significant when restricting to depression diagnoses occurring at least 10\u00a0years before baseline. The study supports that depression is a possible risk factor for development of CVD. Moreover, the hazard rate for CVD outcomes was highest among depressed patients who had not used antidepressants. The association with clinical depression is more marked in relation to stroke and disappears in relation to development of coronary heart disease.", "doi": "10.1007/s10654-013-9821-z", "pmid": "23836399", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T14:57:53.117Z", "modified": "2020-01-21T13:56:05.395Z"}], "created": "2017-05-09T09:12:07.057Z", "modified": "2020-11-27T13:14:05.851Z"}