{"entity": "journal", "iuid": "3d50196008ef457595eea6b770ef8fde", "timestamp": "2026-07-20T15:37:59.342Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Eur%20J%20Surg%20Oncol.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Eur%20J%20Surg%20Oncol"}}, "title": "Eur J Surg Oncol", "issn": "1532-2157", "issn-l": "0748-7983", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "550244a1fd7b43d2b226e88bda919913", "links": {"self": {"href": "https://publications.scilifelab.se/publication/550244a1fd7b43d2b226e88bda919913.json"}, "display": {"href": "https://publications.scilifelab.se/publication/550244a1fd7b43d2b226e88bda919913"}}, "title": "External validation of plasma CSF1 as a preoperative prognostic marker in patients with resectable intrahepatic cholangiocarcinoma.", "authors": [{"family": "Akiki", "given": "Antonio", "initials": "A"}, {"family": "Jacobsson", "given": "Hanna", "initials": "H"}, {"family": "Nouairia", "given": "Ghada", "initials": "G"}, {"family": "Cornillet", "given": "Martin", "initials": "M"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK"}, {"family": "Sparrelid", "given": "Ernesto", "initials": "E"}, {"family": "Taflin", "given": "Helena", "initials": "H"}, {"family": "Jansson", "given": "Hannes", "initials": "H"}], "type": "journal article", "published": "2025-05-04", "journal": {"title": "Eur J Surg Oncol", "issn": "1532-2157", "volume": "51", "issue": "8", "pages": "110123", "issn-l": "0748-7983"}, "abstract": "Long-term prognosis after resection for intrahepatic cholangiocarcinoma (iCCA) remains poor and the preoperative oncological risk assessment is difficult. Two immune system-related plasma proteins, colony stimulating factor 1 (CSF1) and TNF-related apoptosis-inducing ligand (TRAIL), were previously indicated as prognostic factors in iCCA. This study aimed to externally validate CSF1 and TRAIL as preoperative prognostic markers for patients with resectable iCCA.\n\nPreoperative plasma CSF1 and TRAIL concentrations (pg/mL) were determined from prospectively collected biobank samples by multiplex immunoanalysis, for patients with resectable iCCA operated at two tertiary referral centers. Primary outcome was overall survival (OS), analyzed by Kaplan-Meier method and Cox regression. Secondary outcome was disease-free survival (DFS). Discrimination was evaluated with concordance indices (C-index) and prognostic performance assessed with calibration curves.\n\nSixty-one patients with resection for iCCA were included. CSF1 was associated with both OS (hazard ratio [HR] 1.03, 95 % confidence interval [CI] 1.01-1.05) and DFS (HR 1.02, 95 % CI 1.00-1.04). Median OS was eight months for patients with CSF1 levels in the upper quartile (\u2265158 pg/mL), compared to the overall median OS of 47 months. While TRAIL was not significantly associated with OS (P = 0.216), levels in the lower quartile (\u2264256 pg/mL) were associated with short DFS (P = 0.004). The C-index of CSF1 for OS was 0.70, with excellent calibration for three- and five-year OS.\n\nPreoperative plasma CSF1 was validated as a novel, well-calibrated predictor of poor survival in resectable iCCA, which could assist the preoperative risk assessment. Low plasma TRAIL was associated with early recurrence.", "doi": "10.1016/j.ejso.2025.110123", "pmid": "40347719", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "S0748-7983(25)00551-7"}], "notes": [], "created": "2025-05-21T09:41:10.600Z", "modified": "2025-05-21T09:41:10.603Z"}, {"entity": "publication", "iuid": "80df265c4d2b497f96f16322e923b55e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/80df265c4d2b497f96f16322e923b55e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/80df265c4d2b497f96f16322e923b55e"}}, "title": "Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer.", "authors": [{"family": "Ghanipour", "given": "L", "initials": "L"}, {"family": "Jirstr\u00f6m", "given": "K", "initials": "K"}, {"family": "Sundstr\u00f6m", "given": "M", "initials": "M"}, {"family": "Glimelius", "given": "B", "initials": "B"}, {"family": "Birgisson", "given": "H", "initials": "H"}], "type": "journal article", "published": "2017-02-00", "journal": {"volume": "43", "issn": "1532-2157", "issue": "2", "pages": "311-321", "title": "Eur J Surg Oncol", "issn-l": "0748-7983"}, "abstract": "Microsatellite instability arises due to defect mismatch repair (MMR) and occurs in 10-20% of sporadic colorectal cancer. The purpose was to investigate correlations between defect MMR, prognosis and heredity for colorectal cancer in first-degree relatives.\n\nTumour tissues from 318 patients consecutively operated for colorectal cancer were analysed for immunohistochemical expression of MLH1, MSH2 and MSH6 on tissue microarrays. Information on KRAS and BRAF mutation status was available for selected cases.\n\nForty-seven (15%) tumours displayed MSI. No correlation was seen between patients exhibiting MSI in the tumour and heredity (p\u00a0=\u00a00.789). Patients with proximal colon cancer and MSI had an improved cancer-specific survival (p\u00a0=\u00a00.006) and prolonged time to recurrence (p\u00a0=\u00a00.037). In a multivariate analysis including MSI status, gender, CEA, vascular and neural invasion, patients with MSS and proximal colon cancer had an impaired cancer-specific survival compared with patients with MSI (HR, 4.32; CI, 1.46-12.78). The same prognostic information was also seen in distal colon cancer; no recurrences seen in the eight patients with stages II and III distal colon cancer and MSI, but the difference was not statistically significant.\n\nNo correlation between MSI and heredity for colorectal cancer in first-degree relatives was seen. Patients with MSI tumours had improved survival.", "doi": "10.1016/j.ejso.2016.10.013", "pmid": "27836416", "labels": {"Tissue Profiling": "Service"}, "xrefs": [{"db": "pii", "key": "S0748-7983(16)30951-9"}], "notes": [], "created": "2017-05-03T12:59:18.221Z", "modified": "2017-06-12T11:37:32.856Z"}], "created": "2017-05-09T09:12:27.185Z", "modified": "2020-11-27T13:14:04.787Z"}