{"entity": "journal", "iuid": "7076f9b5b7584cfeb1d06fe4d8aac120", "timestamp": "2026-07-18T03:00:52.070Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Environ.%20Sci.%20Technol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Environ.%20Sci.%20Technol."}}, "title": "Environ. Sci. Technol.", "issn": "1520-5851", "issn-l": "0013-936X", "publications_count": 18, "publications": [{"entity": "publication", "iuid": "e2949002d3f14561814c4d2a6201aa18", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e2949002d3f14561814c4d2a6201aa18.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e2949002d3f14561814c4d2a6201aa18"}}, "title": "Silicone-Foam Passive Air Samplers for Combined Target and Nontarget Chemical Profiling and Toxicity Assessment of Airborne Exposomes", "authors": [{"family": "Sunyer-Cald\u00fa", "given": "Adri\u00e0", "initials": "A", "orcid": "0000-0001-5134-1196", "researcher": {"href": "https://publications.scilifelab.se/researcher/c3345feac6fd4bf899478cae45137de7.json"}}, {"family": "Xie", "given": "Hongyu", "initials": "H", "orcid": "0000-0002-2422-0492", "researcher": {"href": "https://publications.scilifelab.se/researcher/e038d701867b464f87f94df18e108b42.json"}}, {"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Raptopoulou", "given": "Foteini", "initials": "F", "orcid": "0009-0006-2923-2448", "researcher": {"href": "https://publications.scilifelab.se/researcher/2bc964229f224e20893c5b0eac0261d1.json"}}, {"family": "Pesquet", "given": "Edouard", "initials": "E", "orcid": "0000-0002-6959-3284", "researcher": {"href": "https://publications.scilifelab.se/researcher/891cf06dc79d4befadb50970dae19885.json"}}, {"family": "Rian", "given": "May Britt", "initials": "MB", "orcid": "0000-0001-6153-2164", "researcher": {"href": "https://publications.scilifelab.se/researcher/dad5214e19c7402bbbbfe92fda00b82d.json"}}, {"family": "Schlesinger", "given": "Daniel", "initials": "D"}, {"family": "Norman", "given": "Michael", "initials": "M"}, {"family": "Jeon", "given": "Young June", "initials": "YJ", "orcid": "0009-0006-3575-6491", "researcher": {"href": "https://publications.scilifelab.se/researcher/7651a4c25ed44ccaa540b7c1dd3e72ba.json"}}, {"family": "Kim", "given": "Boram", "initials": "B"}, {"family": "Lee", "given": "Seung Bok", "initials": "SB"}, {"family": "Lee", "given": "Ji Eun", "initials": "JE"}, {"family": "Froment", "given": "Jean", "initials": "J", "orcid": "0000-0003-4844-2919", "researcher": {"href": "https://publications.scilifelab.se/researcher/6322367545114b6bac92761a16065e1b.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}], "type": "journal-article", "published": "2026-02-24", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "volume": "60", "issue": "7", "pages": "5628-5644", "issn-l": null}, "abstract": "Polluted air is a major global health risk factor, yet the chemical composition and toxicity of airborne gases and particles remain underexplored due to their complexity and difficulties in sampling. We recently introduced how polydimethylsiloxane (PDMS) foam\u2500or silicone foam\u2500can be synthesized for passive air sampling, enabling simple and cost-effective nontarget chemical profiling of indoor air. Here, we demonstrate expanded applications, indoors and outdoors, with commercial PDMS-foam, including for: (i) wide-scope target analysis of >220 priority substances by quantitative liquid- and gas chromatography-high-resolution mass spectrometry, (ii) microscopic characterization and nontarget profiling of accumulated fine particles, and (iii) effect-guided discovery of harmful substances, combining toxicological data with nontarget analysis in silico. Median method quantification limits were 0.12 ng/mL, 90% of target analytes had absolute recoveries between 70 and 130%, and hazardous substances were discovered, including ethylene glycols, insecticides, and UV filters. Microscopy revealed the accumulation of abundant fine particles, and the automated characterization of the fluorescent fraction revealed that most were <4 \u03bcm. Extracts from outdoor samples reduced human lung cell viability, and multivariate modeling flagged families of potentially toxic substances in a virtual effect-directed analysis. PDMS-foam disks require field calibration to determine their linear sampling rate(s), but current results and applications establish PDMS-foam as a multimodal passive sampler, enabling integrated chemical quantitation, toxicological analysis, and molecular discovery in air.", "doi": "10.1021/acs.est.5c16613", "pmid": "41665526", "labels": {"Exposomics": "Technology development"}, "xrefs": [], "notes": [], "created": "2026-02-11T07:09:54.108Z", "modified": "2026-02-25T13:40:00.058Z"}, {"entity": "publication", "iuid": "fae720ef3a8d42dc85bccd01c23b2bd4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fae720ef3a8d42dc85bccd01c23b2bd4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fae720ef3a8d42dc85bccd01c23b2bd4"}}, "title": "Persistence-Directed Testing of Chemicals Discharged from Offshore Oil Platforms Combined with Nontargeted Analysis", "authors": [{"family": "M\u00f8ller", "given": "Mette T", "initials": "MT", "orcid": "0000-0003-2216-6514", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5f327145efe4adca7b27f0318b0133c.json"}}, {"family": "Birch", "given": "Heidi", "initials": "H", "orcid": "0000-0002-7152-3832", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7a299dcbf7b4e6981b452007d3cac14.json"}}, {"family": "Sj\u00f8holm", "given": "Karina K", "initials": "KK", "orcid": "0000-0002-2964-3849", "researcher": {"href": "https://publications.scilifelab.se/researcher/e493845fefff470dbf37c9d10dd4fce5.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Wennberg", "given": "Aina C", "initials": "AC", "orcid": "0000-0003-3798-6574", "researcher": {"href": "https://publications.scilifelab.se/researcher/9fce082bcb7c4ecd8d2fe898e31226f0.json"}}, {"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Kronsbein", "given": "Pia M", "initials": "PM"}, {"family": "Kelland", "given": "Malcolm A", "initials": "MA", "orcid": "0000-0003-2295-5804", "researcher": {"href": "https://publications.scilifelab.se/researcher/1da5b7716bfd4d84950219be6d0eea63.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}, {"family": "Mayer", "given": "Philipp", "initials": "P", "orcid": "0000-0001-5138-7506", "researcher": {"href": "https://publications.scilifelab.se/researcher/8f103ddb642445e8a83d8f36d35f8aec.json"}}], "type": "journal-article", "published": "2025-11-11", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "volume": "59", "issue": "44", "pages": "24000-24011", "issn-l": null}, "abstract": "Persistent chemicals discharged into the sea can pose long-term, irreversible risks. New approaches are needed to elucidate the number and type of persistent chemicals, particularly in complex mixtures and high-volume discharges. We introduce a novel \"Persistence-Directed Testing\" approach that combines environmentally relevant biodegradation tests with nontarget analytical methods. Complex produced waters from two offshore oil platforms in the North Sea served as case studies. In the biodegradation tests, produced waters were diluted 1:200 with seawater from the site of discharge (inoculum). Biotic test systems and abiotic controls were incubated at 9 \u00b0C. At day 60 nontarget analyses were performed by Solid Phase Microextraction coupled to GC-MS and Solid Phase Extraction coupled to LC-HRMS. Primary biodegradation and persistence were determined based on biotic/abiotic peak area ratios. Over 600 chemicals passed the quality control filtering criteria, and the persistent fraction of chemicals discovered by GC-MS was 4% and that discovered by LC-HRMS was 32-44%. Spectral library matches and computational modeling of the LC-HRMS data annotated several persistent chemicals as N-substituted aromatic ring structures. These findings demonstrate the value of a persistence-directed approach in uncovering the hidden burden of unidentified persistent chemicals in environmental discharges and highlight the urgent need for enhanced treatment of produced water discharges.", "doi": "10.1021/acs.est.5c08802", "pmid": "41160886", "labels": {"Exposomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2025-10-30T08:48:01.502Z", "modified": "2026-02-02T16:53:06.335Z"}, {"entity": "publication", "iuid": "57c66b4fec014cb3a5e4976e7ce16789", "links": {"self": {"href": "https://publications.scilifelab.se/publication/57c66b4fec014cb3a5e4976e7ce16789.json"}, "display": {"href": "https://publications.scilifelab.se/publication/57c66b4fec014cb3a5e4976e7ce16789"}}, "title": "Fin Whale as a Sink of Legacy and Emerging Contaminants: First Integrated Chemical Exposomics and Gene Expression Analysis in Cetaceans", "authors": [{"family": "Fossi", "given": "Maria Cristina", "initials": "MC"}, {"family": "Limonta", "given": "Giacomo", "initials": "G", "orcid": "0000-0002-6634-3909", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5a99061b9b54e94909135192408132e.json"}}, {"family": "Baini", "given": "Matteo", "initials": "M", "orcid": "0000-0003-2237-7688", "researcher": {"href": "https://publications.scilifelab.se/researcher/5bee0fd6597646638c9fe8b6c60a4d0a.json"}}, {"family": "Urban R", "given": "Jorge", "initials": "J"}, {"family": "Athanassiadis", "given": "Ioannis", "initials": "I"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S"}, {"family": "Rosso", "given": "Massimiliano", "initials": "M"}, {"family": "Panti", "given": "Cristina", "initials": "C"}], "type": "journal-article", "published": "2025-06-17", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "volume": "59", "issue": "23", "pages": "11477-11492", "issn-l": null}, "abstract": "Cetaceans face numerous anthropogenic chemical stressors in global oceans, yet there is a lack of studies that simultaneously assess their cumulative exposure to both legacy and emerging contaminants and their combined effects. To evaluate the susceptibility of fin whale (Balaenoptera physalus) to chemical pollution, this study employed for the first time a multidiagnostic molecular approach that integrates chemical exposomics and gene expression analysis in live-sampled skin and blubber biopsies from two distinct populations: the endangered Mediterranean subpopulation (Italy) and the vulnerable population from the Sea of Cortez (Mexico). Both marine regions are biodiversity hotspots characterized by different anthropogenic impacts, making them ideal for the assessment of heterogeneous contaminants exposure and their effects. Results revealed distinct exposure profiles in the two populations, with Mediterranean fin whales exhibiting higher concentrations of legacy pollutants such as polychlorinated biphenyls (PCBs), as well as plasticizers, perfluoroalkyl substances (PFAS), while both populations showed traces of pharmaceuticals and lifestyle-related chemicals (e.g., paracetamol, diclofenac, nicotine, UV filters) and other substances not previously reported in whales. Supported by 32 network correlations with gene expression relevant to transcriptional regulation, endocrine disruption, lipid homeostasis, and inflammation, our findings suggest that complex anthropogenic chemical exposures may compromise the health and reproductive viability of the endangered Mediterranean fin whales, affirming their importance as a global sentinel species, which reflects marine ecosystem integrity within the \"One Health\" framework.", "doi": "10.1021/acs.est.5c00844", "pmid": "40456520", "labels": {"Exposomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2025-06-03T12:28:03.619Z", "modified": "2025-09-12T11:18:06.902Z"}, {"entity": "publication", "iuid": "e7370ad15707426fad587337016b4455", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e7370ad15707426fad587337016b4455.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e7370ad15707426fad587337016b4455"}}, "title": "Uranium Repartitioning during Microbial Driven Reductive Transformation of U(VI)-Sorbed Schwertmannite and Jarosite.", "authors": [{"family": "Yu", "given": "Changxun", "initials": "C", "orcid": "0000-0002-0635-3718", "researcher": {"href": "https://publications.scilifelab.se/researcher/1fb153d0c9374644916130ec411ed5ae.json"}}, {"family": "Johnson", "given": "Anders", "initials": "A", "orcid": "0000-0003-2943-5158", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b87d8091975457c9bc0f362c6a874c5.json"}}, {"family": "Karlsson", "given": "Andreas", "initials": "A"}, {"family": "Chernikov", "given": "Roman", "initials": "R"}, {"family": "Sj\u00f6berg", "given": "Viktor", "initials": "V"}, {"family": "Song", "given": "Zhaoliang", "initials": "Z", "orcid": "0000-0002-2219-5852", "researcher": {"href": "https://publications.scilifelab.se/researcher/98a4287cf3544cd48a03041db63b688e.json"}}, {"family": "Dopson", "given": "Mark", "initials": "M"}, {"family": "\u00c5str\u00f6m", "given": "Mats E", "initials": "ME"}], "type": "journal article", "published": "2024-10-15", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "58", "issue": "41", "pages": "18324-18334", "issn-l": "0013-936X"}, "abstract": "This study exposes U(VI)-sorbed schwertmannite and jarosite to biotic reductive incubations under field-relevant conditions and examines the changes in aqueous and solid-phase speciation of U, Fe, and S as well as associated microbial communities over 180 days. The chemical, X-ray absorption spectroscopy, X-ray diffraction, and microscopic data demonstrated that the U(VI)-sorbed schwertmannite underwent a rapid reductive dissolution and solid-phase transformation to goethite, during which the surface-sorbed U(VI) was partly reduced and mostly repartitioned to monomeric U(VI)/U(IV) complexes by carboxyl and phosphoryl ligands on biomass or organic substances. Furthermore, the microbial data suggest that these processes were likely driven by the consecutive developments of fermentative and sulfate- and iron- reducing microbial communities. In contrast, the U(VI)-sorbed jarosite only stimulated the growth of some fermentative communities and underwent very limited reductive dissolution and thus, remaining in its initial state with no detectable mineralogical transformation and solid-phase U reduction/repartitioning. Accordingly, these two biotic incubations did not induce increased risk of U reliberation to the aqueous phase. These findings have important implications for understanding the interactions of schwertmannite/jarosite with microbial communities and colinked behavior and fate of U following the establishment of reducing conditions in various acidic and U-rich settings.", "doi": "10.1021/acs.est.4c03645", "pmid": "39361056", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11483811"}], "notes": [], "created": "2025-02-28T14:13:50.568Z", "modified": "2025-02-28T14:13:50.786Z"}, {"entity": "publication", "iuid": "a33f84c19445476ea4ddd447d928debc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a33f84c19445476ea4ddd447d928debc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a33f84c19445476ea4ddd447d928debc"}}, "title": "Chemical Exposomics in Human Plasma by Lipid Removal and Large-Volume Injection Gas Chromatography\u2013High-Resolution Mass Spectrometry", "authors": [{"family": "Xie", "given": "Hongyu", "initials": "H", "orcid": "0000-0002-2422-0492", "researcher": {"href": "https://publications.scilifelab.se/researcher/e038d701867b464f87f94df18e108b42.json"}}, {"family": "Sdougkou", "given": "Kalliroi", "initials": "K", "orcid": "0000-0001-9463-655X", "researcher": {"href": "https://publications.scilifelab.se/researcher/975451f91bf44300a7e4b0dbb91ea401.json"}}, {"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Bergdahl", "given": "Ingvar A", "initials": "IA", "orcid": "0000-0003-1227-6859", "researcher": {"href": "https://publications.scilifelab.se/researcher/dac737f9a94e49e5b4edbbd540ef1be4.json"}}, {"family": "Rantakokko", "given": "Panu", "initials": "P"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}], "type": "journal-article", "published": "2024-10-08", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "volume": "58", "issue": "40", "pages": "17592-17605", "issn-l": null}, "abstract": null, "doi": "10.1021/acs.est.4c05942", "pmid": null, "labels": {"Exposomics": "Technology development"}, "xrefs": [], "notes": [], "created": "2024-09-25T08:26:23.102Z", "modified": "2024-12-09T08:21:15.255Z"}, {"entity": "publication", "iuid": "f2ec421abe844350b5ff5437d9a363ca", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f2ec421abe844350b5ff5437d9a363ca.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f2ec421abe844350b5ff5437d9a363ca"}}, "title": "Determining Marine Biodegradation Kinetics of Chemicals Discharged from Offshore Oil Platforms\u2500Whole Mixture Testing at High Dilutions Increases Environmental Relevance", "authors": [{"family": "M\u00f8ller", "given": "Mette T", "initials": "MT"}, {"family": "Birch", "given": "Heidi", "initials": "H", "orcid": "0000-0002-7152-3832", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7a299dcbf7b4e6981b452007d3cac14.json"}}, {"family": "Sj\u00f8holm", "given": "Karina K", "initials": "KK", "orcid": "0000-0002-2964-3849", "researcher": {"href": "https://publications.scilifelab.se/researcher/e493845fefff470dbf37c9d10dd4fce5.json"}}, {"family": "Skjolding", "given": "Lars M", "initials": "LM"}, {"family": "Xie", "given": "Hongyu", "initials": "H", "orcid": "0000-0002-2422-0492", "researcher": {"href": "https://publications.scilifelab.se/researcher/e038d701867b464f87f94df18e108b42.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Mayer", "given": "Philipp", "initials": "P", "orcid": "0000-0001-5138-7506", "researcher": {"href": "https://publications.scilifelab.se/researcher/8f103ddb642445e8a83d8f36d35f8aec.json"}}], "type": "journal-article", "published": "2024-10-01", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "volume": "58", "issue": "39", "pages": "17454-17463", "issn-l": null}, "abstract": "Offshore oil platforms discharge enormous volumes of produced water that contain mixtures of petrochemicals and production chemicals. It is crucial to avoid the discharge of particularly those chemicals that are persistent in the marine environment. This study aims to (1) develop a biodegradation testing approach for discharged chemicals by native marine microorganism, (2) determine how dilution affects biodegradation, and (3) determine biodegradation kinetics for many discharged chemicals at low and noninhibitory concentrations. Produced water from an offshore oil platform was diluted in the ratio of 1:20, 1:60, and 1:200 in seawater from the same location and incubated for 60 days at 10 \u00b0C. Automated solid-phase microextraction GC-MS was used as a sensitive analytical technique, and chemical-specific primary degradation was determined based on peak area ratios between biotic test systems and abiotic controls. Biodegradation was inhibited at lower dilutions, consistent with ecotoxicity tests. Biodegradation kinetics were determined at the highest dilution for 139 chemicals (43 tentatively identified), and 6 chemicals were found persistent (half-life >60 days). Nontargeted analysis by liquid chromatography-high-resolution MS was demonstrated as a proof-of-principle for a comprehensive assessment. Biodegradation testing of chemicals in discharges provides the possibility to assess hundreds of chemicals at once and find the persistent ones.", "doi": "10.1021/acs.est.4c05692", "pmid": "39292649", "labels": {"Exposomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2024-09-19T13:35:32.970Z", "modified": "2024-12-09T08:21:38.115Z"}, {"entity": "publication", "iuid": "365acf895bc04a4f8634782cc4578d55", "links": {"self": {"href": "https://publications.scilifelab.se/publication/365acf895bc04a4f8634782cc4578d55.json"}, "display": {"href": "https://publications.scilifelab.se/publication/365acf895bc04a4f8634782cc4578d55"}}, "title": "Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood.", "authors": [{"family": "Sdougkou", "given": "Kalliroi", "initials": "K", "orcid": "0000-0001-9463-655X", "researcher": {"href": "https://publications.scilifelab.se/researcher/975451f91bf44300a7e4b0dbb91ea401.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Xie", "given": "Hongyu", "initials": "H", "orcid": "0000-0002-2422-0492", "researcher": {"href": "https://publications.scilifelab.se/researcher/e038d701867b464f87f94df18e108b42.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Fagerberg", "given": "Linn", "initials": "L"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Martin", "given": "Leah J", "initials": "LJ"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}], "type": "journal article", "published": "2024-09-17", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "58", "issue": "37", "pages": "16302-16315", "issn-l": "0013-936X"}, "abstract": "Chemical exposomes can now be comprehensively measured in human blood, but knowledge of their variability and longitudinal stability is required for robust application in cohort studies. Here, we applied high-resolution chemical exposomics to plasma of 46 adults, each sampled 6 times over 2 years in a multiomic cohort, resulting in 276 individual exposomes. In addition to quantitative analysis of 83 priority target analytes, we discovered and semiquantified substances that have rarely or never been reported in humans, including personal care products, pesticide transformation products, and polymer additives. Hierarchical cluster analysis for 519 confidently annotated substances revealed unique and distinctive coexposures, including clustered pesticides, poly(ethylene glycols), chlorinated phenols, or natural substances from tea and coffee; interactive heatmaps were publicly deposited to support open exploration of the complex (meta)data. Intraclass correlation coefficients (ICC) for all annotated substances demonstrated the relatively low stability of the exposome compared to that of proteome, microbiome, and endogenous small molecules. Implications are that the chemical exposome must be measured more frequently than other omics in longitudinal studies and four longitudinal exposure types are defined that can be considered in study design. In this small cohort, mixed-effect models nevertheless revealed significant associations between testosterone and perfluoroalkyl substances, demonstrating great potential for longitudinal exposomics in precision health research.", "doi": "10.1021/acs.est.4c05235", "pmid": "39236221", "labels": {"Exposomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2024-09-19T13:35:28.253Z", "modified": "2024-09-19T13:35:28.870Z"}, {"entity": "publication", "iuid": "c20f420a42dc4cf4b9b45324fc3a2817", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c20f420a42dc4cf4b9b45324fc3a2817.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c20f420a42dc4cf4b9b45324fc3a2817"}}, "title": "Enhancing Molecular Characterization of Dissolved Organic Matter by Integrative Direct Infusion and Liquid Chromatography Nontargeted Workflows.", "authors": [{"family": "Patrone", "given": "Jessica", "initials": "J", "orcid": "0009-0008-0953-3125", "researcher": {"href": "https://publications.scilifelab.se/researcher/af99fe472b134fa1b309902902d00b32.json"}}, {"family": "Vila-Costa", "given": "Maria", "initials": "M", "orcid": "0000-0003-1730-8418", "researcher": {"href": "https://publications.scilifelab.se/researcher/8284635eca674986a059f96127eac1bb.json"}}, {"family": "Dachs", "given": "Jordi", "initials": "J", "orcid": "0000-0002-4237-169X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b6a8f4a399c45899531fbac94a837a5.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Gago-Ferrero", "given": "Pablo", "initials": "P", "orcid": "0000-0002-5987-0399", "researcher": {"href": "https://publications.scilifelab.se/researcher/b8da00927802436280b942e26fa425ee.json"}}, {"family": "Gil-Solsona", "given": "Rub\u00e9n", "initials": "R", "orcid": "0000-0002-4269-1036", "researcher": {"href": "https://publications.scilifelab.se/researcher/faba74b49f304ceaa4b7d9c500f181a4.json"}}], "type": "journal article", "published": "2024-07-16", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "58", "issue": "28", "pages": "12454-12466", "issn-l": "0013-936X"}, "abstract": "Dissolved organic matter (DOM) in aquatic systems is a highly heterogeneous mixture of water-soluble organic compounds, acting as a major carbon reservoir driving biogeochemical cycles. Understanding DOM molecular composition is thus of vital interest for the health assessment of aquatic ecosystems, yet its characterization poses challenges due to its complex and dynamic chemical profile. Here, we performed a comprehensive chemical analysis of DOM from highly urbanized river and seawater sources and compared it to drinking water. Extensive analyses by nontargeted direct infusion (DI) and liquid chromatography (LC) high-resolution mass spectrometry (HRMS) through Orbitrap were integrated with novel computational workflows to allow molecular- and structural-level characterization of DOM. Across all water samples, over 7000 molecular formulas were calculated using both methods (\u223c4200 in DI and \u223c3600 in LC). While the DI approach was limited to molecular formula calculation, the downstream data processing of MS2 spectral information combining library matching and in silico predictions enabled a comprehensive structural-level characterization of 16% of the molecular space detected by LC-HRMS across all water samples. Both analytical methods proved complementary, covering a broad chemical space that includes more highly polar compounds with DI and more less polar ones with LC. The innovative integration of diverse analytical techniques and computational workflow introduces a robust and largely available framework in the field, providing a widely applicable approach that significantly contributes to understanding the complex molecular composition of DOM.", "doi": "10.1021/acs.est.4c00876", "pmid": "38958378", "labels": {"Exposomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11256763"}], "notes": [], "created": "2024-09-19T13:35:39.516Z", "modified": "2024-09-19T13:35:40.154Z"}, {"entity": "publication", "iuid": "6ca1a5c90b4c4045b65788781937d88a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6ca1a5c90b4c4045b65788781937d88a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6ca1a5c90b4c4045b65788781937d88a"}}, "title": "OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort.", "authors": [{"family": "Schillemans", "given": "Tessa", "initials": "T", "orcid": "0000-0002-1044-1630", "researcher": {"href": "https://publications.scilifelab.se/researcher/740a568c06564e148286fcd40a094341.json"}}, {"family": "Yan", "given": "Yingxiao", "initials": "Y", "orcid": "0000-0002-9196-7326", "researcher": {"href": "https://publications.scilifelab.se/researcher/4987cb247e0741298ab66cd95acdc1b5.json"}}, {"family": "Ribbenstedt", "given": "Anton", "initials": "A"}, {"family": "Donat-Vargas", "given": "Carolina", "initials": "C"}, {"family": "Lindh", "given": "Christian H", "initials": "CH"}, {"family": "Kiviranta", "given": "Hannu", "initials": "H"}, {"family": "Rantakokko", "given": "Panu", "initials": "P"}, {"family": "Wolk", "given": "Alicja", "initials": "A"}, {"family": "Landberg", "given": "Rikard", "initials": "R"}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A"}, {"family": "Brunius", "given": "Carl", "initials": "C"}], "type": "journal article", "published": "2024-01-16", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "58", "issue": "2", "pages": "1036-1047", "issn-l": "0013-936X"}, "abstract": "Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from the Swedish Mammography Cohort - Clinical (n = 657 subjects). OCs, PFAS, and multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma. POP-related omics features were selected using random forest followed by Spearman correlation adjusted for confounders. From these, CVD-related omics features were selected using conditional logistic regression. Finally, 29 (for OCs) and 12 (for PFAS) unique features associated with POPs and CVD. One omics subpattern, driven by lipids and inflammatory proteins, associated with MI (OR = 2.03; 95% CI = 1.47; 2.79), OCs, age, and BMI, and correlated negatively with PFAS. Another subpattern, driven by carnitines, associated with stroke (OR = 1.55; 95% CI = 1.16; 2.09), OCs, and age, but not with PFAS. This may imply that OCs and PFAS associate with different omics patterns with opposite effects on CVD risk, but more research is needed to disentangle potential modifications by other factors.", "doi": "10.1021/acs.est.3c06388", "pmid": "38174696", "labels": {"Chalmers Mass Spectrometry Infrastructure": "Collaborative", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10795192"}], "notes": [], "created": "2024-11-27T15:31:37.796Z", "modified": "2025-11-27T11:25:58.353Z"}, {"entity": "publication", "iuid": "98a6c5b3b3f64f71a494554a11926e35", "links": {"self": {"href": "https://publications.scilifelab.se/publication/98a6c5b3b3f64f71a494554a11926e35.json"}, "display": {"href": "https://publications.scilifelab.se/publication/98a6c5b3b3f64f71a494554a11926e35"}}, "title": "Phospholipid Removal for Enhanced Chemical Exposomics in Human Plasma", "authors": [{"family": "Sdougkou", "given": "Kalliroi", "initials": "K", "orcid": "0000-0001-9463-655X", "researcher": {"href": "https://publications.scilifelab.se/researcher/975451f91bf44300a7e4b0dbb91ea401.json"}}, {"family": "Xie", "given": "Hongyu", "initials": "H", "orcid": "0000-0002-2422-0492", "researcher": {"href": "https://publications.scilifelab.se/researcher/e038d701867b464f87f94df18e108b42.json"}}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Bergdahl", "given": "Ingvar A", "initials": "IA"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}], "type": "journal-article", "published": "2023-07-18", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "issn-l": null, "volume": "57", "issue": "28", "pages": "10173-10184"}, "abstract": "The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics protocol with an optimized phospholipid-removal step prior to targeted and non-targeted liquid chromatography high-resolution mass spectrometry. Increased injection volume with negligible matrix effect permitted sensitive multiclass targeted analysis of 77 priority analytes; median MLOQ = 0.05 ng/mL for 200 \u03bcL plasma. In non-targeted acquisition, mean total signal intensities of non-phospholipids were enhanced 6-fold in positive (max 28-fold) and 4-fold in negative mode (max 58-fold) compared to a control method without phospholipid removal. Moreover, 109 and 28% more non-phospholipid molecular features were detected by exposomics in positive and negative mode, respectively, allowing new substances to be annotated that were non-detectable without phospholipid removal. In individual adult plasma (100 \u03bcL, n = 34), 28 analytes were detected and quantified among 10 chemical classes, and quantitation of per- and polyfluoroalkyl substances (PFAS) was externally validated by independent targeted analysis. Retrospective discovery and semi-quantification of PFAS-precursors was demonstrated, and widespread fenuron exposure is reported in plasma for the first time. The new exposomics method is complementary to metabolomics protocols, relies on open science resources, and can be scaled to support large studies of the exposome.", "doi": "10.1021/acs.est.3c00663", "pmid": "37394749", "labels": {"Exposomics": "Technology development"}, "xrefs": [], "notes": [], "created": "2023-07-04T11:51:43.597Z", "modified": "2024-01-15T08:39:22.950Z"}, {"entity": "publication", "iuid": "402381e5e31d46bb88f0043f0bf9048a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/402381e5e31d46bb88f0043f0bf9048a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/402381e5e31d46bb88f0043f0bf9048a"}}, "title": "Nontarget Analysis of Polluted Surface Waters in Bangladesh Using Open Science Workflows", "authors": [{"family": "Bonnefille", "given": "B\u00e9nilde", "initials": "B", "orcid": "0000-0001-5141-7111", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb5cae7e57b1443a8b296824dc186b04.json"}}, {"family": "Karlsson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8009-0015", "researcher": {"href": "https://publications.scilifelab.se/researcher/eafec43f162b4440a528946488b6ea19.json"}}, {"family": "Rian", "given": "May Britt", "initials": "MB", "orcid": "0000-0001-6153-2164", "researcher": {"href": "https://publications.scilifelab.se/researcher/dad5214e19c7402bbbbfe92fda00b82d.json"}}, {"family": "Raqib", "given": "Rubhana", "initials": "R"}, {"family": "Parvez", "given": "Faruque", "initials": "F"}, {"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Islam", "given": "M Sirajul", "initials": "MS"}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications.scilifelab.se/researcher/f275a68856cb459ebbc933b18c3e315d.json"}}], "type": "journal-article", "published": "2023-05-02", "journal": {"title": "Environ. Sci. Technol.", "issn": "0013-936X", "issn-l": null, "volume": "57", "issue": "17", "pages": "6808-6824"}, "abstract": "Nontarget mass spectrometry has great potential to reveal patterns of water contamination globally through community science, but few studies are conducted in low-income countries, nor with open-source workflows, and few datasets are FAIR (Findable, Accessible, Interoperable, Reusable). Water was collected from urban and rural rivers around Dhaka, Bangladesh, and analyzed by liquid chromatography high-resolution mass spectrometry in four ionization modes (electrospray ionization \u00b1, atmospheric pressure chemical ionization \u00b1) with data-independent MS2 acquisition. The acquisition strategy was complementary: 19,427 and 7365 features were unique to ESI and APCI, respectively. The complexity of water pollution was revealed by >26,000 unique molecular features resolved by MS-DIAL, among which >20,000 correlated with urban sources in Dhaka. A major wastewater treatment plant was not a dominant pollution source, consistent with major contributions from uncontrolled urban drainage, a result that encourages development of further wastewater infrastructures. Matching of deconvoluted MS2 spectra to public libraries resulted in 62 confident annotations (i.e., Level 1-2a) and allowed semiquantification of 42 analytes including pharmaceuticals, pesticides, and personal care products. In silico structure prediction for the top 100 unknown molecular features associated with an urban source allowed 15 additional chemicals of anthropogenic origin to be annotated (i.e., Level 3). The authentic MS2 spectra were uploaded to MassBank Europe, mass spectral data were openly shared on the MassIVE repository, a tool (i.e., MASST) that could be used for community science environmental surveillance was demonstrated, and current limitations were discussed.", "doi": "10.1021/acs.est.2c08200", "pmid": "37083417", "labels": {"Exposomics": "Technology development"}, "xrefs": [{"db": "pmc", "key": "PMC10157886"}], "notes": [], "created": "2023-05-23T13:47:21.943Z", "modified": "2024-01-15T08:41:01.487Z"}, {"entity": "publication", "iuid": "ca551da4056640a692d62f80c4120eed", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ca551da4056640a692d62f80c4120eed.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ca551da4056640a692d62f80c4120eed"}}, "title": "Organochemical Characterization of Peat Reveals Decomposition of Specific Hemicellulose Structures as the Main Cause of Organic Matter Loss in the Acrotelm.", "authors": [{"family": "Serk", "given": "Henrik", "initials": "H", "orcid": "0000-0003-4803-3664", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d4f6829d106420ebb289795fbeb71fb.json"}}, {"family": "Nilsson", "given": "Mats B", "initials": "MB"}, {"family": "Figueira", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Kr\u00fcger", "given": "Jan Paul", "initials": "JP"}, {"family": "Leifeld", "given": "Jens", "initials": "J", "orcid": "0000-0002-7245-9852", "researcher": {"href": "https://publications.scilifelab.se/researcher/9eec2eca03d34177879e1832c58da8ac.json"}}, {"family": "Alewell", "given": "Christine", "initials": "C"}, {"family": "Schleucher", "given": "J\u00fcrgen", "initials": "J"}], "type": "journal article", "published": "2022-11-18", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "issn-l": "0013-936X"}, "abstract": "Peatlands store carbon in the form of dead organic residues. Climate change and human impact impose risks on the sustainability of the peatlands carbon balance due to increased peat decomposition. Here, we investigated molecular changes in the upper peat layers (0-40 cm), inferred from high-resolution vertical depth profiles, from a boreal peatland using two-dimensional 1H-13C nuclear magnetic resonance (NMR) spectroscopy, and comparison to \u03b413C, \u03b415N, and carbon and nitrogen content. Effects of hydrological conditions were investigated at respective sites: natural moist, drainage ditch, and natural dry. The molecular characterization revealed preferential degradation of specific side-chain linkages of xylan-type hemicelluloses within 0-14 cm at all sites, indicating organic matter losses up to 25%. In contrast, the xylan backbone, galactomannan-type hemicelluloses, and cellulose were more resistant to degradation and accumulated at the natural moist and drainage site. \u03b413C, \u03b415N, and carbon and nitrogen content did not correlate with specific hemicellulose structures but reflected changes in total carbohydrates. Our analysis provides novel insights into peat carbohydrate decomposition and indicates substantial organic matter losses in the acrotelm due to the degradation of specific hemicellulose structures. This suggests that variations in hemicellulose content and structure influence peat stability, which may have important implications with respect to climate change.", "doi": "10.1021/acs.est.2c03513", "pmid": "36399683", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [], "notes": [], "created": "2022-11-28T13:05:31.139Z", "modified": "2025-10-17T13:03:54.403Z"}, {"entity": "publication", "iuid": "dc75e1039071444c97665eeac886fd6a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dc75e1039071444c97665eeac886fd6a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dc75e1039071444c97665eeac886fd6a"}}, "title": "Expression Levels of hgcAB Genes and Mercury Availability Jointly Explain Methylmercury Formation in Stratified Brackish Waters.", "authors": [{"family": "Capo", "given": "Eric", "initials": "E", "orcid": "0000-0001-9143-7061", "researcher": {"href": "https://publications.scilifelab.se/researcher/a4017e9c8167487b882ee2d045d96494.json"}}, {"family": "Feng", "given": "Caiyan", "initials": "C"}, {"family": "Bravo", "given": "Andrea G", "initials": "AG"}, {"family": "Bertilsson", "given": "Stefan", "initials": "S"}, {"family": "Soerensen", "given": "Anne L", "initials": "AL", "orcid": "0000-0002-8490-8600", "researcher": {"href": "https://publications.scilifelab.se/researcher/80c5602b03254dd6a9bee71d0429b678.json"}}, {"family": "Pinhassi", "given": "Jarone", "initials": "J"}, {"family": "Buck", "given": "Moritz", "initials": "M"}, {"family": "Karlsson", "given": "Camilla", "initials": "C"}, {"family": "Hawkes", "given": "Jeffrey", "initials": "J", "orcid": "0000-0003-0664-2242", "researcher": {"href": "https://publications.scilifelab.se/researcher/cf1580e588fb405b95b1690038d93914.json"}}, {"family": "Bj\u00f6rn", "given": "Erik", "initials": "E", "orcid": "0000-0001-9570-8738", "researcher": {"href": "https://publications.scilifelab.se/researcher/d52d4c83dda84cea9e018199a8cfc304.json"}}], "type": "journal article", "published": "2022-09-20", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "issn-l": "0013-936X", "volume": "56", "issue": "18", "pages": "13119-13130"}, "abstract": "Neurotoxic methylmercury (MeHg) is formed by microbial methylation of inorganic divalent Hg (HgII) and constitutes severe environmental and human health risks. The methylation is enabled by hgcA and hgcB genes, but it is not known if the associated molecular-level processes are rate-limiting or enable accurate prediction of MeHg formation in nature. In this study, we investigated the relationships between hgc genes and MeHg across redox-stratified water columns in the brackish Baltic Sea. We showed, for the first time, that hgc transcript abundance and the concentration of dissolved HgII-sulfide species were strong predictors of both the HgII methylation rate and MeHg concentration, implying their roles as principal joint drivers of MeHg formation in these systems. Additionally, we characterized the metabolic capacities of hgc+ microorganisms by reconstructing their genomes from metagenomes (i.e., hgc+ MAGs), which highlighted the versatility of putative HgII methylators in the water column of the Baltic Sea. In establishing relationships between hgc transcripts and the HgII methylation rate, we advance the fundamental understanding of mechanistic principles governing MeHg formation in nature and enable refined predictions of MeHg levels in coastal seas in response to the accelerating spread of oxygen-deficient zones.", "doi": "10.1021/acs.est.2c03784", "pmid": "36069707", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9494745"}], "notes": [], "created": "2022-11-29T09:47:11.811Z", "modified": "2023-10-04T10:56:50.418Z"}, {"entity": "publication", "iuid": "5f2e4baa8bb24a13a4e27bafb78c7f35", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5f2e4baa8bb24a13a4e27bafb78c7f35.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5f2e4baa8bb24a13a4e27bafb78c7f35"}}, "title": "Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities.", "authors": [{"family": "Coll", "given": "Claudia", "initials": "C", "orcid": "0000-0003-1100-1263", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5bdee5b986a4dfda04324367a6a8c4f.json"}}, {"family": "Bier", "given": "Raven", "initials": "R"}, {"family": "Li", "given": "Zhe", "initials": "Z", "orcid": "0000-0002-2379-0768", "researcher": {"href": "https://publications.scilifelab.se/researcher/45eed765d4944b9ebe33a7f4536ce36f.json"}}, {"family": "Langenheder", "given": "Silke", "initials": "S"}, {"family": "Gorokhova", "given": "Elena", "initials": "E"}, {"family": "Sobek", "given": "Anna", "initials": "A", "orcid": "0000-0002-1549-7449", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d5f089d428b4c1b9b0805dcbf4c6fbc.json"}}], "type": "journal article", "published": "2020-11-17", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "54", "issue": "22", "pages": "14380-14392", "issn-l": "0013-936X"}, "abstract": "Assessment of micropollutant biodegradation is essential to determine the persistence of potentially hazardous chemicals in aquatic ecosystems. We studied the dissipation half-lives of 10 micropollutants in sediment-water incubations (based on the OECD 308 standard) with sediment from two European rivers sampled upstream and downstream of wastewater treatment plant (WWTP) discharge. Dissipation half-lives (DT50s) were highly variable between the tested compounds, ranging from 1.5 to 772 days. Sediment from one river sampled downstream from the WWTP showed the fastest dissipation of all micropollutants after sediment RNA normalization. By characterizing sediment bacteria using 16S rRNA sequences, bacterial community composition of a sediment was associated with its capacity for dissipating micropollutants. Bacterial amplicon sequence variants of the genera Ralstonia, Pseudomonas, Hyphomicrobium, and Novosphingobium, which are known degraders of contaminants, were significantly more abundant in the sediment incubations where fast dissipation was observed. Our study illuminates the limitations of the OECD 308 standard to account for variation of dissipation rates of micropollutants due to differences in bacterial community composition. This limitation is problematic particularly for those compounds with DT50s close to regulatory persistence criteria. Thus, it is essential to consider bacterial community composition as a source of variability in regulatory biodegradation and persistence assessments.", "doi": "10.1021/acs.est.0c04393", "pmid": "33104348", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7676288"}], "notes": [], "created": "2020-12-08T23:52:07.112Z", "modified": "2021-11-10T12:45:14.866Z"}, {"entity": "publication", "iuid": "1e994159b3374183b4c8d606199303e3", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1e994159b3374183b4c8d606199303e3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1e994159b3374183b4c8d606199303e3"}}, "title": "Studies of Emission Processes of Polymer Additives into Water Using Quartz Crystal Microbalance-A Case Study on Organophosphate Esters.", "authors": [{"family": "Xiao", "given": "Linhong", "initials": "L", "orcid": "0000-0002-1780-705X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d935960d1cc4028b1eacad9dcb0483d.json"}}, {"family": "Zheng", "given": "Ziye", "initials": "Z", "orcid": "0000-0002-7898-341X", "researcher": {"href": "https://publications.scilifelab.se/researcher/66f7c8ba6f1d4e138fdf84618b25f30f.json"}}, {"family": "Irgum", "given": "Knut", "initials": "K"}, {"family": "Andersson", "given": "Patrik L", "initials": "PL", "orcid": "0000-0002-2088-6756", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8828c70fd7a4ce583bb9e53bfb677ea.json"}}], "type": "journal article", "published": "2020-04-21", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "54", "issue": "8", "pages": "4876-4885", "issn-l": "0013-936X"}, "abstract": "Plastic materials contain various additives, which can be released during the entire lifespan of plastics and pose a threat to the environment and human health. Despite our knowledge on leakage of additives from products, accurate and rapid approaches to study emission kinetics are largely lacking, in particular, methodologies that can provide in-depth understanding of polymer/additive interactions. Here, we report on a novel approach using quartz crystal microbalance (QCM) to measure emissions of additives to water from polymer films spin-coated on quartz crystals. The methodology, being accurate and reproducible with a standard error of \u00b12.4%, was applied to a range of organophosphate esters (OPEs) and polymers with varying physicochemical properties. The release of most OPEs reached an apparent steady-state within 10 h. The release curves for the studied OPEs could be fitted using a Weibull model, which shows that the release is a two-phase process with an initial fast phase driven by partitioning of OPEs readily available at or close to the polymer film surface, and a slower phase dominated by diffusion in the polymer. The kinetics of the first emission phase was mainly correlated with the hydrophobicity of the OPEs, whereas the diffusion phase was weakly correlated with molecular size. The developed QCM-based method for assessing and studying release of organic chemicals from a polymeric matrix is well suited for rapid screening of additives in efforts to identify more sustainable replacement polymer additives with lower emission potential.", "doi": "10.1021/acs.est.9b07607", "pmid": "32186175", "labels": {"Swedish NMR Centre": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC7884016"}], "notes": [], "created": "2020-11-24T20:27:47.355Z", "modified": "2025-10-17T13:03:56.977Z"}, {"entity": "publication", "iuid": "d0a86e672c904a24ab338bf0e45b366c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d0a86e672c904a24ab338bf0e45b366c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d0a86e672c904a24ab338bf0e45b366c"}}, "title": "Rainbow Trout Maintain Intestinal Transport and Barrier Functions Following Exposure to Polystyrene Microplastics.", "authors": [{"family": "A\u0161monait\u0117", "given": "Giedr\u0117", "initials": "G", "orcid": "0000-0002-4227-0792", "researcher": {"href": "https://publications.scilifelab.se/researcher/a302bcd21bb4413e82745682919cb25a.json"}}, {"family": "Sundh", "given": "Henrik", "initials": "H"}, {"family": "Asker", "given": "Noomi", "initials": "N"}, {"family": "Carney Almroth", "given": "Bethanie", "initials": "B", "orcid": "0000-0002-5037-4612", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fca4df111d54f7da54cf4ac65d993e1.json"}}], "type": "journal article", "published": "2018-12-18", "journal": {"volume": "52", "issn": "1520-5851", "issue": "24", "pages": "14392-14401", "title": "Environ. Sci. Technol.", "issn-l": "0013-936X"}, "abstract": "Ingestion has been proposed as a prominent exposure route for plastic debris in aquatic organisms, including fish. While the consequences of ingestion of large plastic litter are mostly understood, the impacts resulting from ingestion of microplastics (MPs) are largely unknown. We designed a study that aimed to assess impacts of MPs on fish intestinal physiology and examined integrity of extrinsic, physical and immunological barriers. Rainbow trout were exposed to polystyrene (PS) MPs (100-400 \u03bcm) via feed for a period of 4 weeks. Fish were fed four types of diets: control, diets containing virgin PS particles, or particles exposed to two different environmental matrices (sewage or harbor effluent). Extrinsic barrier disturbance in intestinal tissue was evaluated via histology. The paracellular permeability toward ions and molecules was examined using Ussing chambers and mRNA expression analysis of tight junction proteins. Active transport was monitored as transepithelial potential difference, short-circuits current and uptake rate of amino acid 3H-lysine. Immune status parameters were measured through mRNA expression level of cytokines, lysozyme activity, and hematological analysis of immune cells. We could not show that PS MPs induced inflammatory responses or acted as physical or chemical hazards upon ingestion. No measurable effects were exerted on fish intestinal permeability, active transport or electrophysiology.", "doi": "10.1021/acs.est.8b04848", "pmid": "30451503", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [], "notes": [], "created": "2020-01-23T16:15:40.763Z", "modified": "2021-06-21T13:52:39.912Z"}, {"entity": "publication", "iuid": "d059fc6d026d46aab9cf3540c800be00", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d059fc6d026d46aab9cf3540c800be00.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d059fc6d026d46aab9cf3540c800be00"}}, "title": "Thermodynamics of Hg(II) Bonding to Thiol Groups in Suwannee River Natural Organic Matter Resolved by Competitive Ligand Exchange, Hg LIII-Edge EXAFS and 1H NMR Spectroscopy", "authors": [{"family": "Song", "given": "Yu", "initials": "Y"}, {"family": "Jiang", "given": "Tao", "initials": "T"}, {"family": "Liem-Nguyen", "given": "Van", "initials": "V"}, {"family": "Sparrman", "given": "Tobias", "initials": "T", "orcid": "0000-0002-4442-6367", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0d27dbd2f014795b1f7aa164d34bada.json"}}, {"family": "Bj\u00f6rn", "given": "Erik", "initials": "E"}, {"family": "Skyllberg", "given": "Ulf", "initials": "U"}], "type": "journal-article", "published": "2018-08-07", "journal": {"volume": "52", "issn": "1520-5851", "issue": "15", "pages": "8292-8301", "title": "Environ. Sci. Technol.", "issn-l": "0013-936X"}, "abstract": null, "doi": "10.1021/acs.est.8b00919", "pmid": "29983050", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [], "notes": [], "created": "2018-10-22T10:53:13.529Z", "modified": "2025-10-17T13:03:58.585Z"}, {"entity": "publication", "iuid": "3e3990c8c3dc4cb79371f46b1a6681f7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e3990c8c3dc4cb79371f46b1a6681f7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e3990c8c3dc4cb79371f46b1a6681f7"}}, "title": "The synthetic progestin levonorgestrel is a potent androgen in the three-spined stickleback (Gasterosteus aculeatus).", "authors": [{"family": "Svensson", "given": "Johan", "initials": "J"}, {"family": "Fick", "given": "Jerker", "initials": "J"}, {"family": "Brandt", "given": "Ingvar", "initials": "I"}, {"family": "Brunstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2013-02-19", "journal": {"volume": "47", "issn": "1520-5851", "issue": "4", "pages": "2043-2051", "title": "Environ. Sci. Technol.", "issn-l": "0013-936X"}, "abstract": "The use of progestins has resulted in contamination of aquatic environments and some progestins have in experimental studies been shown to impair reproduction in fish and amphibians at low ng L(-1) concentrations. The mechanisms underlying their reproductive toxicity are largely unknown. Some progestins, such as levonorgestrel (LNG), exert androgenic effects in mammals by activating the androgen receptor (AR). Male three-spined stickleback (Gasterosteus aculeatus) kidneys produce spiggin, a gluelike glycoprotein used in nest building, and its production is directly governed by androgens. Spiggin is normally absent in females but its production in female kidneys can be induced by AR agonists. Spiggin serves as the best known biomarker for androgens in fish. We exposed adult female sticklebacks to LNG at 5.5, 40, and 358 ng L(-1) for 21 days. Androgenic effects were found at LNG concentrations \u226540 ng L(-1) including induction of spiggin transcription, kidney hypertrophy, and suppressed liver vitellogenin transcription. These are the first in vivo quantitative data showing that LNG is a potent androgen in fish supporting the contention that androgenic effects of certain progestins contribute to their reproductive toxicity.", "doi": "10.1021/es304305k", "pmid": "23362984", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Uppsala (Uppsala Genome Center)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T14:57:52.516Z", "modified": "2020-01-21T13:56:01.785Z"}], "created": "2017-05-09T09:12:37.873Z", "modified": "2020-11-27T13:14:04.324Z"}