{"entity": "journal", "iuid": "cd8c88401cd7467e823547c8c0d83e4d", "timestamp": "2026-07-20T16:41:53.710Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/ESC%20Heart%20Failure.json"}, "display": {"href": "https://publications.scilifelab.se/journal/ESC%20Heart%20Failure"}}, "title": "ESC Heart Failure", "issn": "2055-5822", "issn-l": null, "publications_count": 2, "publications": [{"entity": "publication", "iuid": "eadf1280baee4e78b0d3f938fac7edec", "links": {"self": {"href": "https://publications.scilifelab.se/publication/eadf1280baee4e78b0d3f938fac7edec.json"}, "display": {"href": "https://publications.scilifelab.se/publication/eadf1280baee4e78b0d3f938fac7edec"}}, "title": "Elevated carbohydrate antigen 125 (CA125) is associated with incident heart failure and mortality in acute coronary syndrome.", "authors": [{"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Gu", "given": "Thomas", "initials": "T"}, {"family": "Grufman", "given": "Helena", "initials": "H"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Mokhtari", "given": "Arash", "initials": "A"}, {"family": "Ekelund", "given": "Ulf", "initials": "U"}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Gustafsson", "given": "Emma", "initials": "E"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A"}], "type": "journal article", "published": "2024-09-01", "journal": {"title": "ESC Heart Failure", "issn": "2055-5822", "issn-l": null}, "abstract": "Carbohydrate antigen 125 (CA125), a mucin produced by serosal cells in response to mechanical and inflammatory stimuli, has emerged as an important biomarker to guide risk stratification in heart failure (HF). The prognostic value of CA125 in acute coronary syndrome (ACS) patients is less explored.\n\nIn a cohort of 524 ACS patients (73% males, mean age 67 \u00b1 12 years), we assessed the associations between CA125 and the risk for HF and death during a median follow-up period of 27.3 months for incident HF and 39.5 months for mortality. Plasma CA125 was measured within 24 h after admission in the entire cohort and after 6 weeks in a subgroup of 115 elderly patients (>75 years of age). We also assessed the relationships between baseline CA125 and echocardiographic parameters of cardiac structure and function at 1 year post-ACS in this subgroup.\n\nBaseline CA125 was associated with incident HF in the entire cohort in a Cox proportional hazards model adjusted for age, sex, cardiovascular (CV) risk factors (diabetes, smoking, hypertension, previous HF, previous ACS and previous stroke), renal function and revascularization {hazard ratio [HR] 1.46 [95% confidence interval (CI) 1.10-1.93] per 1-standard deviation [SD] CA125 increase; P = 0.009}. In the detailed follow-up subgroup, elevated baseline CA125 predicted subsequent deterioration of left ventricular (LV) ejection fraction (LVEF), defined as a >5% absolute LVEF decrease in patients with LVEF \u2265 50% at discharge [odds ratio (OR) 3.31 (95% CI 1.15-9.54) per 1-SD baseline CA125 increase; P = 0.027]. We also found significant correlations between high baseline CA125 and larger LV volumes (LV end-diastolic volume index, Spearman's r = 0.329, P < 0.001; LV end-systolic volume index, r = 0.391, P < 0.001) and left atrial volume index (r = 0.320, P < 0.001) at 1 year post-ACS, indicative of adverse cardiac remodelling. Elevated baseline and follow-up CA125 were associated with increased mortality, independently of age and sex [HR 1.37 (95% CI 1.09-1.71), P = 0.006, per 1-SD baseline CA125; HR 1.98 (95% CI 1.06-3.67), P = 0.031, per increasing 6 week CA125 tertile]. The relationship between 6 week CA125 and incident mortality remained significant in the fully adjusted model [HR 2.23 (95% CI 1.15-4.35) per increasing CA125 tertile; P = 0.018].\n\nWe report independent associations between elevated CA125, LV dysfunction, cardiac remodelling, incident HF and mortality post-ACS. Our results warrant further evaluation of CA125 as a potential biomarker for risk stratification and management of ACS patients, both at the time of the acute coronary event and during follow-up.", "doi": "10.1002/ehf2.15037", "pmid": "39219224", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-27T22:19:59.396Z", "modified": "2024-11-27T22:19:59.411Z"}, {"entity": "publication", "iuid": "bd53cdd9312a4daeb054082f3ef37158", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bd53cdd9312a4daeb054082f3ef37158.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bd53cdd9312a4daeb054082f3ef37158"}}, "title": "The genomics of heart failure: design and rationale of the HERMES consortium.", "authors": [{"family": "Lumbers", "given": "R Thomas", "initials": "RT"}, {"family": "Shah", "given": "Sonia", "initials": "S"}, {"family": "Lin", "given": "Honghuang", "initials": "H"}, {"family": "Czuba", "given": "Tomasz", "initials": "T"}, {"family": "Henry", "given": "Albert", "initials": "A"}, {"family": "Swerdlow", "given": "Daniel I", "initials": "DI"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Andersson", "given": "Charlotte", "initials": "C"}, {"family": "Verweij", "given": "Niek", "initials": "N"}, {"family": "Holmes", "given": "Michael V", "initials": "MV"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Svensson", "given": "Per", "initials": "P"}, {"family": "Hemingway", "given": "Harry", "initials": "H"}, {"family": "Sallah", "given": "Neneh", "initials": "N"}, {"family": "Almgren", "given": "Peter", "initials": "P"}, {"family": "Aragam", "given": "Krishna G", "initials": "KG"}, {"family": "Asselin", "given": "Geraldine", "initials": "G"}, {"family": "Backman", "given": "Joshua D", "initials": "JD"}, {"family": "Biggs", "given": "Mary L", "initials": "ML"}, {"family": "Bloom", "given": "Heather L", "initials": "HL"}, {"family": "Boersma", "given": "Eric", "initials": "E"}, {"family": "Brandimarto", "given": "Jeffrey", "initials": "J"}, {"family": "Brown", "given": "Michael R", "initials": "MR"}, {"family": "Brunner-La Rocca", "given": "Hans-Peter", "initials": "HP"}, {"family": "Carey", "given": "David J", "initials": "DJ"}, {"family": "Chaffin", "given": "Mark D", "initials": "MD"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Chazara", "given": "Olympe", "initials": "O"}, {"family": "Chen", "given": "Xing", "initials": "X"}, {"family": "Chen", "given": "Xu", "initials": "X"}, {"family": "Chung", "given": "Jonathan H", "initials": "JH"}, {"family": "Chutkow", "given": "William", "initials": "W"}, {"family": "Cleland", "given": "John G F", "initials": "JGF"}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "de Denus", "given": "Simon", "initials": "S"}, {"family": "Dehghan", "given": "Abbas", "initials": "A"}, {"family": "Delgado", "given": "Graciela E", "initials": "GE"}, {"family": "Denaxas", "given": "Spiros", "initials": "S"}, {"family": "Doney", "given": "Alexander S", "initials": "AS"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Dudley", "given": "Samuel C", "initials": "SC"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Esko", "given": "T\u00f5nu", "initials": "T"}, {"family": "Fatemifar", "given": "Ghazaleh", "initials": "G"}, {"family": "Felix", "given": "Stephan B", "initials": "SB"}, {"family": "Finan", "given": "Chris", "initials": "C"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Fougerousse", "given": "Francoise", "initials": "F"}, {"family": "Fouodjio", "given": "Ren\u00e9", "initials": "R"}, {"family": "Ghanbari", "given": "Mohsen", "initials": "M"}, {"family": "Ghasemi", "given": "Sahar", "initials": "S"}, {"family": "Giedraitis", "given": "Vilmantas", "initials": "V"}, {"family": "Giulianini", "given": "Franco", "initials": "F"}, {"family": "Gottdiener", "given": "John S", "initials": "JS"}, {"family": "Gross", "given": "Stefan", "initials": "S"}, {"family": "Gu\u00f0bjartsson", "given": "Dan\u00edel F", "initials": "DF"}, {"family": "Gui", "given": "Hongsheng", "initials": "H"}, {"family": "Gutmann", "given": "Rebecca", "initials": "R"}, {"family": "Haggerty", "given": "Christopher M", "initials": "CM"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K"}, {"family": "Helgadottir", "given": "Anna", "initials": "A"}, {"family": "Hillege", "given": "Hans", "initials": "H"}, {"family": "Hyde", "given": "Craig L", "initials": "CL"}, {"family": "Jacob", "given": "Jaison", "initials": "J"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW"}, {"family": "Kamanu", "given": "Frederick", "initials": "F"}, {"family": "Kardys", "given": "Isabella", "initials": "I"}, {"family": "Kavousi", "given": "Maryam", "initials": "M"}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME"}, {"family": "K\u00f8ber", "given": "Lars", "initials": "L"}, {"family": "Koekemoer", "given": "Andrea", "initials": "A"}, {"family": "Kraus", "given": "Bill", "initials": "B"}, {"family": "Kuchenbaecker", "given": "Karoline", "initials": "K"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "London", "given": "Barry", "initials": "B"}, {"family": "Lotta", "given": "Luca A", "initials": "LA"}, {"family": "Lovering", "given": "Ruth C", "initials": "RC"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Magnusson", "given": "Patrik", "initials": "P"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Mann", "given": "Douglas", "initials": "D"}, {"family": "Margulies", "given": "Kenneth B", "initials": "KB"}, {"family": "Marston", "given": "Nicholas A", "initials": "NA"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "McMurray", "given": "John J V", "initials": "JJV"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Melloni", "given": "Giorgio", "initials": "G"}, {"family": "Mordi", "given": "Ify R", "initials": "IR"}, {"family": "Morley", "given": "Michael P", "initials": "MP"}, {"family": "Morris", "given": "Andrew D", "initials": "AD"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Morrison", "given": "Alanna C", "initials": "AC"}, {"family": "Nagle", "given": "Michael W", "initials": "MW"}, {"family": "Nelson", "given": "Christopher P", "initials": "CP"}, {"family": "Newton-Cheh", "given": "Christopher", "initials": "C"}, {"family": "Niessner", "given": "Alexander", "initials": "A"}, {"family": "Niiranen", "given": "Teemu", "initials": "T"}, {"family": "Nowak", "given": "Christoph", "initials": "C"}, {"family": "O'Donoghue", "given": "Michelle L", "initials": "ML"}, {"family": "Owens", "given": "Anjali T", "initials": "AT"}, {"family": "Palmer", "given": "Colin N A", "initials": "CNA"}, {"family": "Par\u00e9", "given": "Guillaume", "initials": "G"}, {"family": "Perola", "given": "Markus", "initials": "M"}, {"family": "Perreault", "given": "Louis-Philippe Lemieux", "initials": "LL"}, {"family": "Portilla-Fernandez", "given": "Eliana", "initials": "E"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Rice", "given": "Kenneth M", "initials": "KM"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Romaine", "given": "Simon P R", "initials": "SPR"}, {"family": "Roselli", "given": "Carolina", "initials": "C"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Ruff", "given": "Christian T", "initials": "CT"}, {"family": "Sabatine", "given": "Marc S", "initials": "MS"}, {"family": "Salo", "given": "Perttu", "initials": "P"}, {"family": "Salomaa", "given": "Veikko", "initials": "V"}, {"family": "van Setten", "given": "Jessica", "initials": "J"}, {"family": "Shalaby", "given": "Alaa A", "initials": "AA"}, {"family": "Smelser", "given": "Diane T", "initials": "DT"}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Stefansson", "given": "Kari", "initials": "K"}, {"family": "Stender", "given": "Steen", "initials": "S"}, {"family": "Stott", "given": "David J", "initials": "DJ"}, {"family": "Sveinbj\u00f6rnsson", "given": "Gar\u00f0ar", "initials": "G"}, {"family": "Tammesoo", "given": "Mari-Liis", "initials": "ML"}, {"family": "Tardif", "given": "Jean-Claude", "initials": "JC"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Teder-Laving", "given": "Maris", "initials": "M"}, {"family": "Teumer", "given": "Alexander", "initials": "A"}, {"family": "Thorgeirsson", "given": "Gu\u00f0mundur", "initials": "G"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Torp-Pedersen", "given": "Christian", "initials": "C"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Tuckwell", "given": "Danny", "initials": "D"}, {"family": "Tyl", "given": "Benoit", "initials": "B"}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Vaura", "given": "Felix", "initials": "F"}, {"family": "Veluchamy", "given": "Abirami", "initials": "A"}, {"family": "Visscher", "given": "Peter M", "initials": "PM"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "Voors", "given": "Adriaan A", "initials": "AA"}, {"family": "Wang", "given": "Xiaosong", "initials": "X"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Weeke", "given": "Peter E", "initials": "PE"}, {"family": "Weiss", "given": "Raul", "initials": "R"}, {"family": "White", "given": "Harvey D", "initials": "HD"}, {"family": "Wiggins", "given": "Kerri L", "initials": "KL"}, {"family": "Xing", "given": "Heming", "initials": "H"}, {"family": "Yang", "given": "Jian", "initials": "J"}, {"family": "Yang", "given": "Yifan", "initials": "Y"}, {"family": "Yerges-Armstrong", "given": "Laura M", "initials": "LM"}, {"family": "Yu", "given": "Bing", "initials": "B"}, {"family": "Zannad", "given": "Faiez", "initials": "F"}, {"family": "Zhao", "given": "Faye", "initials": "F"}, {"family": "Regeneron Genetics Center", "given": "", "initials": ""}, {"family": "Wilk", "given": "Jemma B", "initials": "JB"}, {"family": "Holm", "given": "Hilma", "initials": "H"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Lubitz", "given": "Steven A", "initials": "SA"}, {"family": "Lanfear", "given": "David E", "initials": "DE"}, {"family": "Shah", "given": "Svati", "initials": "S"}, {"family": "Dunn", "given": "Michael E", "initials": "ME"}, {"family": "Wells", "given": "Quinn S", "initials": "QS"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW"}, {"family": "Hingorani", "given": "Aroon D", "initials": "AD"}, {"family": "Dub\u00e9", "given": "Marie-Pierre", "initials": "MP"}, {"family": "Samani", "given": "Nilesh J", "initials": "NJ"}, {"family": "Lang", "given": "Chim C", "initials": "CC"}, {"family": "Cappola", "given": "Thomas P", "initials": "TP"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "ESC Heart Failure", "issn": "2055-5822", "issn-l": null, "volume": "8", "issue": "6", "pages": "5531-5541"}, "abstract": "The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.\n\nThe consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of \u22651.10 for common variants (allele frequency \u2265 0.05) and \u22651.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 \u00d7 10-8 under an additive genetic model.\n\nHERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.", "doi": "10.1002/ehf2.13517", "pmid": "34480422", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8712846"}], "notes": [], "created": "2021-09-07T11:11:45.925Z", "modified": "2023-06-19T13:01:08.136Z"}], "created": "2021-09-07T11:11:45.943Z", "modified": "2021-09-07T11:11:45.943Z"}